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2. 发明申请

WO2014016334A1 DIRECTIONAL FREEZING 审中-公开
标题翻译：方向冷冻
公开(公告)号：WO2014016334A1
公开(公告)日：2014-01-30
申请号：PCT/EP2013/065604
申请日：2013-07-24
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： DITTRICH, Jürgen , ZIEGLER, Günther
IPC分类号： F26B5/06
CPC分类号： F26B5/06 , A61K9/19 , F25C1/10 , F25C1/16
摘要： The invention relates to an apparatus and a method of freezing a liquid substance contained in a receptacle (1,2,3,4,5,6,8), comprising the steps of: providing the liquid substance in the receptacle, providing a cooling chamber (20) and a cooling device (12) having a cooling surface (7); setting the temperature of the cooling surface (7) to less than -130°C, starting a freezing procedure by placing the receptacle on the cooling surface to make surface contact between the receptacle and the cooling surface to cool the receptacle and thereby to have a portion of the liquid substance, which is contained in the receptacle in proximity of the cooling surface, form a seed or initial zone of nucleation; and continuing the freezing procedure to completely freeze the substance such that, starting from the seed or initial zone of nucleation, directional freezing of the liquid substance with a propagating crystallisation front occurs at or near melting point temperature of the substance at the crystallisation front. The step of continuing the freezing procedure includes transferring the receptacle from the cooling surface to a region of the cooling chamber before or after the liquid substance contained in the receptacle has been completely frozen, with the cooling temperature within said region of the cooling chamber being set to a value in the range between -60°C and -5°C.
摘要翻译：本发明涉及一种冷冻容纳在容器（1,2,3,4,5,6,8）中的液体物质的装置和方法，包括以下步骤：将液体物质提供在容器中，提供冷却（20）和具有冷却表面（7）的冷却装置（12）。将冷却表面（7）的温度设定为小于-130℃，通过将容器放置在冷却表面上来开始冷冻程序，以在容器和冷却表面之间进行表面接触以冷却容器，从而具有容纳在冷却表面附近的容器中的液体物质的一部分形成晶种或初始的成核区域; 并继续冷冻程序以使物质完全冷冻，使得从成核的种子或初始区域开始，在结晶前沿物质的熔点温度或接近温度时，会发生具有传播结晶前沿的液体物质的定向冷冻。继续冷冻步骤的步骤包括在容器内所含的液体物质已被完全冷冻之前或之后将容器从冷却表面转移到冷却室的区域，冷却室的所述区域内的冷却温度被设定到-60℃和-5℃之间的值。

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