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    • 10. 发明申请
    • SYSTEMS AND METHODS FOR OPTIMIZING INSULIN DOSAGE
    • 用于优化胰岛素剂量的系统和方法
    • WO2011157395A1
    • 2011-12-22
    • PCT/EP2011/002914
    • 2011-06-11
    • ROCHE DIAGNOSTICS GMBHF. HOFFMANN-LA ROCHE AG
    • BOUSAMRA, StevenWEINERT, StefanRASCH-MENGES, JuergenWALLING, P., DouglasPRICE, John, F.EIKMEIER, HeinoKRAELING, BirgitWERNER, KarlPORSCH, Ulrich
    • G06F19/00
    • A61B5/0002A61B5/05A61B5/14532A61B5/14546A61M31/00A61M2230/201C12Q1/006G06F19/00G06F19/3418G06F19/3456G16H10/20G16H10/40G16H20/17G16H80/00
    • Embodiments of a testing method suitable for diabetic persons to optimize their administered insulin dosage, in particular a basal rate testing method, comprise collecting one or more sampling sets of biomarker data, wherein each sampling set comprises a sufficient plurality of non-adverse sampling instances and wherein each sampling instance comprises an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and if the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when one or more biomarker sampling parameters fall within a target biomarker range.
    • 适合于糖尿病患者优化其给药胰岛素剂量,特别是基础测试方法的测试方法的实施方案包括收集生物标志物数据的一个或多个采样组,其中每个采样组包括足够多个非不利采样实例和 其中每个采样实例包括在遵守遵守标准记录的单个时间点读取可接受的生物标志物,从每个采样组确定生物标志物采样参数,将生物标志物采样参数与目标生物标志物范围进行比较,计算与 如果生物标志物采样参数落在目标生物标志物范围之外,则生物标志物采样参数,如果生物标志物采样参数落在目标生物标志物范围之外,如果胰岛素剂量不超过最大剂量,则通过胰岛素调节参数调整胰岛素剂量,并且退出 测试见面 如果调整后的胰岛素剂量被优化,则可以获得。 当一个或多个生物标志物采样参数落入目标生物标志物范围内时,胰岛素剂量被优化。