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1. 发明申请

US20090288222A1 Transgenic plants overexpressing a plant vacuolar Pyrophosphatase 有权
标题翻译：转基因植物过表达植物液泡焦磷酸酶
公开(公告)号：US20090288222A1
公开(公告)日：2009-11-19
申请号：US12384115
申请日：2009-03-31
申请人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
发明人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8242 , C12N15/8261 , Y02A40/146
摘要： Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower, fruit, root structures, increased salt tolerance, enhanced drought and freeze tolerance. Methods of making such plants are also described.
摘要翻译：描述了转基因植物，其被设计为过表达液泡H + -PPase。用拟南芥AVP-1转化的烟草和矮牵牛等植物显示具有增加的分生活性，导致更大的叶，茎，花，果实，根结构，增加的耐盐性，增强的干旱和冷冻耐受性。还描述了制备这种植物的方法。

2. 发明授权

US08058515B2 Plant cells and plants overexpressing vacuolar proton pyrophosphatases 有权
标题翻译：植物细胞和植物过表达液泡质子焦磷酸酶
公开(公告)号：US08058515B2
公开(公告)日：2011-11-15
申请号：US11119683
申请日：2005-05-02
申请人： Roberto A. Gaxiola , Seth L. Alper , Gerald R. Fink
发明人： Roberto A. Gaxiola , Seth L. Alper , Gerald R. Fink
IPC分类号： A01H5/00 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8242 , C12N15/8261 , Y02A40/146
摘要： The present invention relates to a transgenic plant, comprising one or more plant cells transformed with exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plants grown from seed are also described. Plant cells (e.g., root cells, stem cells, leaf cells) comprising exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant cells are also the subject of the present invention. Also encompassed by the present invention are methods of making a transgenic plant described herein. The present invention also relates to a method of increasing the yield of a plant, a method of making a plant which is larger than its corresponding wild type plant, and a method of producing a transgenic plant with increased salt tolerance.
摘要翻译：本发明涉及转基因植物，其包含用外源核酸转化的一种或多种植物细胞，其增加植物中液泡焦磷酸酶的表达。本发明还包括本文所述的转基因植物的转基因后代和种子。还描述了从种子生长的后代转基因植物。包含增加植物细胞中液泡焦磷酸酶表达的外源核酸的植物细胞（例如根细胞，干细胞，叶细胞）也是本发明的主题。本发明还包括制备本文所述的转基因植物的方法。本发明还涉及提高植物产量的方法，制备大于其相应野生型植物的植物的方法，以及生产具有增加的耐盐性的转基因植物的方法。

3. 发明授权

US08697950B2 Vacuolar pyrophosphatases and uses in plants 有权
标题翻译：真空焦磷酸酶及其在植物中的应用
公开(公告)号：US08697950B2
公开(公告)日：2014-04-15
申请号：US11890795
申请日：2007-08-07
申请人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
发明人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
IPC分类号： A01H5/00 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8259 , C12N15/8261 , C12N15/8273 , Y02A40/146
摘要： The present invention relates to a transgenic plant which is tolerant to a salt, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. The present invention also relates to a transgenic plant with increased Pi uptake, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plant grown from seed are also described.
摘要翻译：本发明涉及对盐具有耐受性的转基因植物，其包含用外源核酸转化的一种或多种植物细胞，其改变植物中液泡焦磷酸酶的表达。本发明还涉及具有增加的Pi摄取的转基因植物，其包含用外源核酸转化的一种或多种植物细胞，其改变植物中液泡焦磷酸酶的表达。本发明还包括本文所述的转基因植物的转基因后代和种子。还描述了从种子生长的后代转基因植物。

4. 发明授权

US08168864B2 Transgenic pollen expressing exogenous plant vacuolar pyrophosphatase and methods for increasing seed production in plants 有权
标题翻译：表达外源植物液泡焦磷酸酶的转基因花粉和增加植物种子生产的方法
公开(公告)号：US08168864B2
公开(公告)日：2012-05-01
申请号：US11135165
申请日：2005-05-23
申请人： Roberto A. Gaxiola , Seth L. Alper , Gerald R. Fink
发明人： Roberto A. Gaxiola , Seth L. Alper , Gerald R. Fink
IPC分类号： A01H5/00 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8242 , C12N15/8261 , Y02A40/146
摘要： Methods are provided for imparting desirable phenotypic traits to transgenic plants, among them being increased tolerance to external stresses such as drought, freezing temperatures, high salt conditions, and the like. In addition, the present invention is directed toward methods for increasing the yield of seeds from plants by using the pollen from a transgenic plant transformed to overexpress a vacuolar proton-pumping pyrophosphatase to fertilize plants, and to the pollen of transgenic plants itself.
摘要翻译：提供了赋予转基因植物所需表型性状的方法，其中包括对外部胁迫如干旱，冷冻温度，高盐条件等的增加的耐受性。此外，本发明涉及通过使用转化来过表达液泡质子泵送焦磷酸酶以转化植物的转基因植物的花粉以及转基因植物本身的花粉来提高种子从植物产量的方法。

5. 发明授权

US08003852B2 Transgenic plants overexpressing a plant vacuolar pyrophosphatase 有权
标题翻译：过表达植物液泡焦磷酸酶的转基因植物
公开(公告)号：US08003852B2
公开(公告)日：2011-08-23
申请号：US12384115
申请日：2009-03-31
申请人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
发明人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
IPC分类号： A01H5/00 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8242 , C12N15/8261 , Y02A40/146
摘要： Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower, fruit, root structures, increased salt tolerance, enhanced drought and freeze tolerance. Methods of making such plants are also described.
摘要翻译：描述了转基因植物，其被设计为过表达液泡H + -PPase。用拟南芥AVP-1转化的烟草和矮牵牛等植物显示具有增加的分生活性，导致更大的叶，茎，花，果实，根结构，增加的耐盐性，增强的干旱和冷冻耐受性。还描述了制备这种植物的方法。

6. 发明授权

US07534933B2 Transgenic plants overexpressing a plant vacuolar H + -ATPase 有权
标题翻译：转基因植物过表达植物液泡H +（质子）焦磷酸酶
公开(公告)号：US07534933B2
公开(公告)日：2009-05-19
申请号：US10344658
申请日：2001-03-24
申请人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
发明人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
IPC分类号： C12N15/82
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8242 , C12N15/8261 , Y02A40/146
摘要： Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower, fruit, root structures, increased salt tolerance, enhanced drought and freeze tolerance. Methods of making such plants are also described.
摘要翻译：描述了转基因植物，其被设计为过表达液泡H + -PPase。用拟南芥AVP-1转化的烟草和矮牵牛等植物显示具有增加的分生活性，导致更大的叶，茎，花，果实，根结构，增加的耐盐性，增强的干旱和冷冻耐受性。还描述了制备这种植物的方法。

7. 发明申请

US20120184491A1 Methods and Compound to Inhibit Ca2+ Permeable Cation Conductance 有权
标题翻译：方法和化合物抑制Ca2 +透过阳离子电导
公开(公告)号：US20120184491A1
公开(公告)日：2012-07-19
申请号：US13351611
申请日：2012-01-17
申请人： Frederick Sachs , Philip Gottlieb , Thomas Suchyna , Seth L. Alper , David H. Vandorpe , Chang Xu
发明人： Frederick Sachs , Philip Gottlieb , Thomas Suchyna , Seth L. Alper , David H. Vandorpe , Chang Xu
IPC分类号： A61K38/16 , C12N5/02 , A61P7/06
CPC分类号： A61K38/1767
摘要： The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.
摘要翻译：本发明提供用于抑制患有镰状细胞性贫血的个体的红细胞的钙渗透性阳离子电导的方法和组合物。该方法包括将细胞暴露于肽GsMTx4和/或其变体。

8. 发明授权

US5441957A Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ 失效
标题翻译：减少镰状红细胞脱水并延缓红细胞镰刀发生的方法
公开(公告)号：US5441957A
公开(公告)日：1995-08-15
申请号：US154114
申请日：1993-11-18
申请人： Carlo Brugnara , Seth L. Alper
发明人： Carlo Brugnara , Seth L. Alper
IPC分类号： A61K31/415 , A61K31/495 , A61K31/38
CPC分类号： A61K31/415 , Y10S514/815
摘要： The present invention provides a chemical class of active compounds to be used as efficacious drugs in the treatment of sickle cell disease. The active compounds include imidazole derivatives, nitroimidazole derivatives, and triazole derivatives. These compounds are to be administered by any preferred route of administration including oral, intramuscular, intravenous, and any other parenteral route. If desired, these drugs may also be administered transmucosally, or subcutaneously, or using a dermal patch on the skin. In addition, the methodology is effective for both long term and short term therapy; may be employed prophylactically and/or therapeutically; and may be used in emergency, acute crisis clinical situations.
摘要翻译：本发明提供了用作治疗镰状细胞病的有效药物的化学类别的活性化合物。活性化合物包括咪唑衍生物，硝基咪唑衍生物和三唑衍生物。这些化合物将通过任何优选的给药途径施用，包括口服，肌内，静脉内和任何其它肠胃外途径。如果需要，这些药物也可以透皮粘膜或皮下施用，或者在皮肤上使用皮肤贴剂。此外，该方法对于长期和短期治疗都是有效的; 可以预防和/或治疗地使用; 并可用于紧急，急性危机临床情况。

9. 发明授权

US5273992A Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ 失效
标题翻译：减少镰状红细胞脱水并延缓红细胞镰刀发生的方法
公开(公告)号：US5273992A
公开(公告)日：1993-12-28
申请号：US970929
申请日：1992-11-02
申请人： Carlo Brugnara , Seth L. Alper
发明人： Carlo Brugnara , Seth L. Alper
IPC分类号： A61K31/415
CPC分类号： A61K31/415 , Y10S514/815
摘要： The present invention provides a chemical class of active compounds to be used as efficacious drugs in the treatment of sickle cell disease. The active compounds include imidazole derivatives, nitroimidazole derivatives, and triazole derivatives. These compounds are to be administered by any preferred route of administration including oral, intramuscular, intravenous, and any other parenteral route. If desired, these drugs may also be administered transmucosally, or subcutaneously, or using a dermal patch on the skin. In addition, the methodology is effective for both long term and short term therapy; may be employed prophylactically and/or therapeutically; and may be used in emergency, acute crisis clinical situations.
摘要翻译：本发明提供了用作治疗镰状细胞病的有效药物的化学类别的活性化合物。活性化合物包括咪唑衍生物，硝基咪唑衍生物和三唑衍生物。这些化合物将通过任何优选的给药途径施用，包括口服，肌内，静脉内和任何其它肠胃外途径。如果需要，这些药物也可以透皮粘膜或皮下施用，或者在皮肤上使用皮肤贴剂。此外，该方法对于长期和短期治疗都是有效的; 可以预防和/或治疗地使用; 并可用于紧急，急性危机临床情况。

10. 发明授权

US09211313B2 Methods and compound to inhibit Ca2+ permeable cation conductance 有权
标题翻译：抑制Ca2 +渗透性阳离子电导的方法和化合物
公开(公告)号：US09211313B2
公开(公告)日：2015-12-15
申请号：US13351611
申请日：2012-01-17
申请人： Frederick Sachs , Philip Gottlieb , Thomas Suchyna , Seth L. Alper , David H. Vandorpe , Chang Xu
发明人： Frederick Sachs , Philip Gottlieb , Thomas Suchyna , Seth L. Alper , David H. Vandorpe , Chang Xu
IPC分类号： A61K38/16 , A61K38/17
CPC分类号： A61K38/1767
摘要： The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.
摘要翻译：本发明提供用于抑制患有镰状细胞性贫血的个体的红细胞的钙渗透性阳离子电导的方法和组合物。该方法包括将细胞暴露于肽GsMTx4和/或其变体。

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