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1. 发明申请

US20200332363A1 METHODS FOR PREDICTING RISK OF RECURRENCE AND/OR METASTASIS IN SOFT TISSUE SARCOMA 审中-公开
公开(公告)号：US20200332363A1
公开(公告)日：2020-10-22
申请号：US16306018
申请日：2017-06-05
申请人： Robert Willis Cook , Weiwei Shan , Derek Maetzold , CASTLE BIOSCIENCES, INC.
发明人： Robert Willis COOK , Weiwei SHAN , Derek MAETZOLD
IPC分类号： C12Q1/6886
摘要： The disclosure related to the development of a gene expression profile to predict soft tissue sarcoma (STS) recurrence, distant metastasis, or both. Analyses identified a 36-gene gene expression profile able to accurately predict risk in a cohort of soft tissue sarcoma tumors independent of histologic and pathologic grade. This discovery offers an opportunity to enhance current staging of STS to identify patients who have a higher risk of recurring, distant metastasis, or both.

2. 发明申请

US20140272986A1 DIAGNOSTIC TEST FOR PREDICTING METASTASIS AND RECURRENCE IN CUTANEOUS MELANOMA 审中-公开
标题翻译：用于预测梅毒中的转移和复发的诊断测试
公开(公告)号：US20140272986A1
公开(公告)日：2014-09-18
申请号：US14193378
申请日：2014-02-28
申请人： Castle Biosciences, Inc.
发明人： Robert Willis COOK , Derek MAETZOLD , Kristen OESCHLAGER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The invention as disclosed herein in encompasses a method for predicting the risk of metastasis of a primary cutaneous melanoma tumor, the method encompassing measuring the gene-expression levels of at least eight genes selected from a specific gene set in a sample taken from the primary cutaneous melanoma tumor; determining a gene-expression profile signature from the gene expression levels of the at least eight genes; comparing the gene-expression profile to the gene-expression profile of a predictive training set; and providing an indication as to whether the primary cutaneous melanoma tumor is a certain class of metastasis or treatment risk when the gene expression profile indicates that expression levels of at least eight genes are altered in a predictive manner as compared to the gene expression profile of the predictive training set.
摘要翻译：本文公开的本发明包括用于预测原发性皮肤黑素瘤肿瘤转移风险的方法，所述方法包括测量至少8种基因的基因表达水平，所述基因选自样品中的特定基因，其取自初级皮肤黑素瘤肿瘤; 从所述至少8个基因的基因表达水平确定基因表达谱特征; 将基因表达谱与预测训练集的基因表达谱比较; 并且当基因表达谱表明与基因表达谱相比，至少8种基因的表达水平以预测方式改变时，提供关于初级皮肤黑素瘤肿瘤是否是一定类型的转移或治疗风险的指征预测训练集。

3. 发明申请

US20160273052A1 DIAGNOSTIC TEST FOR PREDICTING METASTASIS AND RECURRENCE IN CUTANEOUS MELANOMA 审中-公开
标题翻译：用于预测梅毒中的转移和复发的诊断测试
公开(公告)号：US20160273052A1
公开(公告)日：2016-09-22
申请号：US15075133
申请日：2016-03-19
申请人： Castle Biosciences, Inc.
发明人： Robert Willis COOK , Derek MAETZOLD , Kristen OESCHLAGER
IPC分类号： C12Q1/68
摘要： The invention as disclosed herein in encompasses a method for predicting the risk of metastasis of a primary cutaneous melanoma tumor, the method encompassing measuring the gene-expression levels of at least eight genes selected from a specific gene set in a sample taken from the primary cutaneous melanoma tumor; determining a gene-expression profile signature from the gene expression levels of the at least eight genes; comparing the gene-expression profile to the gene-expression profile of a predictive training set; and providing an indication as to whether the primary cutaneous melanoma tumor is a certain class of metastasis or treatment risk when the gene expression profile indicates that expression levels of at least eight genes are altered in a predictive manner as compared to the gene expression profile of the predictive training set.
摘要翻译：本文公开的本发明包括用于预测原发性皮肤黑素瘤肿瘤转移风险的方法，所述方法包括测量至少8种基因的基因表达水平，所述基因选自样品中的特定基因，其取自初级皮肤黑素瘤肿瘤; 从所述至少8个基因的基因表达水平确定基因表达谱特征; 将基因表达谱与预测训练集的基因表达谱比较; 并且当基因表达谱表明与基因表达谱相比，至少8种基因的表达水平以预测方式改变时，提供关于初级皮肤黑素瘤肿瘤是否是一定类型的转移或治疗风险的指征预测训练集。

4. 发明申请

US20140271545A1 METHODS FOR PREDICTING RISK OF METASTASIS IN CUTANEOUS MELANOMA 审中-公开
标题翻译：用于预测US US OF OF TING TING。。。。。。。。。。。。。。。。。。。。。。
公开(公告)号：US20140271545A1
公开(公告)日：2014-09-18
申请号：US14193355
申请日：2014-02-28
申请人： Castle Biosciences, Inc.
发明人： Robert Willis COOK , Derek MAETZOLD , Kristen OESCHLAGER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The invention as disclosed herein in encompasses a method for predicting the risk of metastasis of a primary cutaneous melanoma tumor, the method encompassing measuring the gene-expression levels of at least eight genes selected from a specific gene set in a sample taken from the primary cutaneous melanoma tumor; determining a gene-expression profile signature from the gene expression levels of the at least eight genes; comparing the gene-expression profile to the gene-expression profile of a predictive training set; and providing an indication as to whether the primary cutaneous melanoma tumor is a certain class of metastasis or treatment risk when the gene expression profile indicates that expression levels of at least eight genes are altered in a predictive manner as compared to the gene expression profile of the predictive training set.
摘要翻译：本文公开的本发明包括用于预测原发性皮肤黑素瘤肿瘤转移风险的方法，所述方法包括测量至少8种基因的基因表达水平，所述基因选自样品中的特定基因，其取自初级皮肤黑素瘤肿瘤; 从所述至少8个基因的基因表达水平确定基因表达谱特征; 将基因表达谱与预测训练集的基因表达谱比较; 并且当基因表达谱表明与基因表达谱相比，至少8种基因的表达水平以预测方式改变时，提供关于初级皮肤黑素瘤肿瘤是否是一定类型的转移或治疗风险的指征预测训练集。

5. 发明申请

US20230077559A1 DIAGNOSTIC TEST FOR PREDICTING METASTASIS AND RECURRENCE IN CUTANEOUS MELANOMA 有权
公开(公告)号：US20230077559A1
公开(公告)日：2023-03-16
申请号：US17883223
申请日：2022-08-08
申请人： Castle Biosciences, Inc.
发明人： Robert Willis COOK , Derek MAETZOLD , Kristen OESCHLAGER
IPC分类号： C12Q1/6886
摘要： The invention as disclosed herein in encompasses a method for predicting the risk of metastasis of a primary cutaneous melanoma tumor, the method encompassing measuring the gene-expression levels of at least eight genes selected from a specific gene set in a sample taken from the primary cutaneous melanoma tumor; determining a gene-expression profile signature from the gene expression levels of the at least eight genes; comparing the gene-expression profile to the gene-expression profile of a predictive training set; and providing an indication as to whether the primary cutaneous melanoma tumor is a certain class of metastasis or treatment risk when the gene expression profile indicates that expression levels of at least eight genes are altered in a predictive manner as compared to the gene expression profile of the predictive training set.

6. 发明申请

US20220033882A1 METHODS OF DIAGNOSING AND TREATING PATIENTS WITH PIGMENTED SKIN LESIONS 有权
公开(公告)号：US20220033882A1
公开(公告)日：2022-02-03
申请号：US17392706
申请日：2021-08-03
申请人： CASTLE BIOSCIENCES, INC.
发明人： Robert Willis COOK , Derek MAETZOLD , Kyle R. COVINGTON , Olga ZOLOCHEVSKA
IPC分类号： C12Q1/6809 , C12Q1/6806 , G16B5/20 , G16B40/00
摘要： The present disclosure relates to methods for diagnosing a skin lesion as malignant or benign.

7. 发明申请

US20210238688A1 METHODS OF DIAGNOSING AND TREATING PATIENTS WITH CUTANEOUS SQUAMOUS CELL CARCINOMA 有权
公开(公告)号：US20210238688A1
公开(公告)日：2021-08-05
申请号：US16993401
申请日：2020-08-14
申请人： Castle Biosciences, Inc.
发明人： Robert Willis COOK , Kyle R. COVINGTON , Derek MAETZOLD , Sarah J KURLEY
IPC分类号： C12Q1/6886
摘要： The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).

8. 发明申请

US20210238687A1 METHODS OF DIAGNOSING AND TREATING PATIENTS WITH CUTANEOUS SQUAMOUS CELL CARCINOMA 有权
公开(公告)号：US20210238687A1
公开(公告)日：2021-08-05
申请号：US16779515
申请日：2020-01-31
申请人： Castle Biosciences, Inc.
发明人： Robert Willis COOK , Kyle R. COVINGTON , Derek MAETZOLD , Sarah J. KURLEY
IPC分类号： C12Q1/6886
摘要： The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).

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