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1. 发明授权

US07455975B2 Electrochemical detection of nucleic acid sequences 失效
标题翻译：核酸序列的电化学检测
公开(公告)号：US07455975B2
公开(公告)日：2008-11-25
申请号：US11619232
申请日：2007-01-03
申请人： Robert W. Henkens , John P. O'Daly , Marek Wojciechowski , Honghua Zhang , Najih Naser , R. Michael Roe , Thomas N. Stewart , Deborah M. Thompson , Rebecca Sundseth , Steven E. Wegner
发明人： Robert W. Henkens , John P. O'Daly , Marek Wojciechowski , Honghua Zhang , Najih Naser , R. Michael Roe , Thomas N. Stewart , Deborah M. Thompson , Rebecca Sundseth , Steven E. Wegner
IPC分类号： C12Q1/68
CPC分类号： G01N33/5082 , C12Q1/6825 , C12Q2600/156 , G01N33/5008 , C12Q2565/607 , C12Q2563/113
摘要： An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.
摘要翻译：描述了特异性检测所选择的核酸片段的电化学检测系统。该系统利用与所选择的核酸片段互补并特异性杂交的生物探针，例如核酸或肽核酸探针，以便在施加电流电位时产生可测量的电流。电化学信号可以量化。

2. 发明授权

US06391558B1 Electrochemical detection of nucleic acid sequences 有权
标题翻译：核酸序列的电化学检测
公开(公告)号：US06391558B1
公开(公告)日：2002-05-21
申请号：US09549853
申请日：2000-04-14
申请人： Robert W. Henkens , John P. O'Daly , Marek Wojciechowski , Honghua Zhang , Najih Naser , R. Michael Roe , Thomas N. Stewart , Deborah M. Thompson , Rebecca Sundseth , Steven E. Wegner
发明人： Robert W. Henkens , John P. O'Daly , Marek Wojciechowski , Honghua Zhang , Najih Naser , R. Michael Roe , Thomas N. Stewart , Deborah M. Thompson , Rebecca Sundseth , Steven E. Wegner
IPC分类号： C12Q168
CPC分类号： G01N33/5438 , C12Q1/6825 , C12Q2600/156 , Y02A50/53 , Y02A50/54 , Y02A50/58 , C12Q2565/519 , C12Q2563/113
摘要： An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.
摘要翻译：描述了特异性检测所选择的核酸片段的电化学检测系统。该系统利用与所选择的核酸片段互补并特异性杂交的生物探针，例如核酸或肽核酸探针，以便在施加电流电位时产生可测量的电流。电化学信号可以量化。

3. 发明授权

US07169358B2 Electrochemical detection of nucleic acid sequences 有权
标题翻译：核酸序列的电化学检测
公开(公告)号：US07169358B2
公开(公告)日：2007-01-30
申请号：US10082714
申请日：2002-02-25
申请人： Robert W. Henkens , John P. O'Daly , Marek Wojciechowski , Honghua Zhang , Najih Naser , R. Michael Roe , Thomas N. Stewart , Deborah M. Thompson , Rebecca Sundseth , Steven E. Wegner
发明人： Robert W. Henkens , John P. O'Daly , Marek Wojciechowski , Honghua Zhang , Najih Naser , R. Michael Roe , Thomas N. Stewart , Deborah M. Thompson , Rebecca Sundseth , Steven E. Wegner
IPC分类号： G01N15/06 , G01N21/76 , G01N21/00 , B32B5/02 , C07H21/00 , C12Q1/68
CPC分类号： G01N33/5438 , C12Q1/6825 , C12Q2600/156 , Y02A50/53 , Y02A50/54 , Y02A50/58 , C12Q2565/519 , C12Q2563/113
摘要： An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.
摘要翻译：描述了特异性检测所选择的核酸片段的电化学检测系统。该系统利用与所选择的核酸片段互补并特异性杂交的生物探针，例如核酸或肽核酸探针，以便在施加电流电位时产生可测量的电流。电化学信号可以量化。

4. 发明申请

US20070111202A1 ELECTROCHEMICAL DETECTION OF NUCLEIC ACID SEQUENCES 失效
标题翻译：核酸序列的电化学检测
公开(公告)号：US20070111202A1
公开(公告)日：2007-05-17
申请号：US11619232
申请日：2007-01-03
申请人： Robert Henkens , John O'Daly , Marek Wojciechowski , Honghua Zhang , Najih Naser , R. Roe , Thomas Stewart , Deborah Thompson , Rebecca Sundseth , Steven Wegner
发明人： Robert Henkens , John O'Daly , Marek Wojciechowski , Honghua Zhang , Najih Naser , R. Roe , Thomas Stewart , Deborah Thompson , Rebecca Sundseth , Steven Wegner
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： G01N33/5082 , C12Q1/6825 , C12Q2600/156 , G01N33/5008 , C12Q2565/607 , C12Q2563/113
摘要： An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.
摘要翻译：描述了特异性检测所选择的核酸片段的电化学检测系统。该系统利用与所选择的核酸片段互补并特异性杂交的生物探针，例如核酸或肽核酸探针，以便在施加电流电位时产生可测量的电流。电化学信号可以量化。

5. 发明授权

US6103192A Immobilizing and processing specimens on matrix materials for the identification of nucleic acid sequences 失效
标题翻译：固定和处理基质材料上的标本以鉴定核酸序列
公开(公告)号：US6103192A
公开(公告)日：2000-08-15
申请号：US60282
申请日：1998-04-14
申请人： Marilyn J. Stapleton , Rebecca Sundseth , Ke Wei
发明人： Marilyn J. Stapleton , Rebecca Sundseth , Ke Wei
IPC分类号： B01L3/00 , G01N21/00
CPC分类号： B01L3/5029 , B01L2300/021 , B01L2400/0406 , Y10S436/81
摘要： The invention is a method and device for collecting and processing a biological specimen for the analyses of nucleic acids. A device comprises a matrix to which cells and viruses adhere and a handle to manipulate the matrix. The devices are used to collect, dry, transport, store and process small amounts of blood or other tissue. The matrix of the device is transferred to a reaction tube and amplifying reagents added to it. Nucleic acid sequences and relative quantities are detected and analyzed from the same specimen. The relative amounts of amplified nucleic acid from one or more particular RNA sequences are compared to one another and to the amount of amplified nucleic acid from DNA sequences serving as an internal control for the number of biological units per specimen. The relative amounts of amplified viral sequences from suspected viruses in the biological specimen and from recombinant viral particles serving as a viral quantitation standard enable estimation of viral burden in a given quantity of specimen.
摘要翻译：本发明是用于收集和处理用于核酸分析的生物样本的方法和装置。装置包括细胞和病毒粘附的基质和操纵基质的手柄。这些装置用于收集，干燥，运输，储存和处理少量血液或其他组织。将装置的基质转移到反应管中并加入其中的放大试剂。从相同的样品中检测和分析核酸序列和相对量。将来自一个或多个特定RNA序列的扩增核酸的相对量彼此进行比较，并将其作为用于每个标本的生物单位数的内部对照的DNA序列的扩增核酸的量。来自生物样本中的疑似病毒和用作病毒定量标准的重组病毒颗粒的扩增病毒序列的相对量可以估计给定量的标本中病毒载量。

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