专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120058198A1 METHODS FOR TREATING AND PREVENTING PNEUMONIA AND VENTILATOR-ASSOCIATED TRACHEOBRONCHITIS 审中-公开
标题翻译：治疗和预防肺炎和呼吸道相关TRACHEOBRONCHITIS的方法
公开(公告)号：US20120058198A1
公开(公告)日：2012-03-08
申请号：US13259615
申请日：2010-03-26
申请人： Robert W. Clarke , Richard Batycky , Wesley H. Dehaan , David L. Hava , Michael M. Lipp , John Hanrahan
发明人： Robert W. Clarke , Richard Batycky , Wesley H. Dehaan , David L. Hava , Michael M. Lipp , John Hanrahan
IPC分类号： A61P31/04 , A61K33/06 , A61K33/14
CPC分类号： A61K33/06 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K33/14 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The invention relates to methods for treating bacterial infection of the respiratory tract, including pneumonias, such as ventilator-associated pneumonia, and to methods for treating ventilator-associated tracheobronchitis, comprising administering an effective amount of a salt formulation as an aerosol to the respiratory tract of an individual in need thereof. The formulations can also be used to reduce transmission of pathogen which can infect the respiratory tract, cause pneumonia or cause ventilator-associated tracheobronchitis.
摘要翻译：本发明涉及治疗呼吸道细菌感染的方法，包括呼吸机相关性肺炎等肺炎，以及治疗与呼吸机相关的气管支气管炎的方法，包括向呼吸道施用有效量的作为气雾剂的盐制剂的需要的个人。制剂也可用于减少可感染呼吸道，引起肺炎或引起呼吸机相关气管支气管炎的病原体的传播。

2. 发明申请

US20120107414A1 PHARMACEUTICAL FORMULATIONS AND METHODS FOR TREATING RESPIRATORY TRACT INFECTIONS 审中-公开
标题翻译：药物制剂和治疗呼吸道感染的方法
公开(公告)号：US20120107414A1
公开(公告)日：2012-05-03
申请号：US13259651
申请日：2010-03-26
申请人： Michael M. Lipp , Robert W. Clarke , David L. Hava , Richard Batycky , John Hanrahan
发明人： Michael M. Lipp , Robert W. Clarke , David L. Hava , Richard Batycky , John Hanrahan
IPC分类号： A61K33/42 , A61K33/10 , A61K33/06 , A61K33/00 , A61K33/04 , A61K33/22 , A61K31/19 , A61K31/734 , A61K31/20 , A61K31/191 , A61K31/194 , A61K31/375 , A61K31/192 , A61P31/00 , A61K33/14
CPC分类号： A61K31/19 , A61K9/0078 , A61K31/194 , A61K31/20 , A61K31/734 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/10 , A61K33/14 , A61K33/42 , A61K45/06 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The present invention relates to pharmaceutical formulations for treating a respiratory tract infection or a pulmonary disease in an individual, comprising a calcium salt and a sodium salt, wherein the ratio of Ca+2 to Na+ is from about 4:1 (mole:mole) to about 16:1 (mole:mole). The invention also relates to methods of treating (including prophylactically treating) and reducing the spread of a respiratory tract infection, methods of treating (including prophylactically treating) a pulmonary disease or an acute exacerbation of a pulmonary disease, and methods of reducing the spread of an acute exacerbation of a pulmonary disease, comprising administering a pharmaceutical formulation that comprises a calcium salt and a sodium salt.
摘要翻译：本发明涉及用于治疗个体中的呼吸道感染或肺部疾病的药物制剂，其包含钙盐和钠盐，其中Ca + 2与Na +的比例为约4:1（摩尔：摩尔）至约16：1（摩尔：摩尔）。本发明还涉及治疗（包括预防性治疗）和减少呼吸道感染扩散的方法，治疗（包括预防性治疗）肺部疾病或肺部疾病急性加重的方法，以及减少是肺疾病的急性恶化，包括施用包含钙盐和钠盐的药物制剂。

3. 发明申请

US20120070417A1 ANTI-INFLUENZA FORMULATIONS AND METHODS 审中-公开
标题翻译：抗流感制剂和方法
公开(公告)号：US20120070417A1
公开(公告)日：2012-03-22
申请号：US13259659
申请日：2010-03-26
申请人： Richard Batycky , David L. Hava , Robert W. Clarke , Michal M. Lipp
发明人： Richard Batycky , David L. Hava , Robert W. Clarke , Michal M. Lipp
IPC分类号： A61K33/14 , A61K38/21 , A61K31/19 , A61K31/715 , A61P31/16 , A61K31/7105 , A61K31/351 , A61K31/195 , A61K31/245 , A61K38/47 , A61K31/713
CPC分类号： A61K47/183 , A61K9/0075 , A61K9/0078 , A61K9/1617 , A61K9/1694 , A61K31/125 , A61K31/155 , A61K31/196 , A61K31/454 , A61K33/06 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions that contain a calcium salt as an active ingredient and also comprise another anti-influenza agent, and to methods for treating or preventing influenza virus infection.
摘要翻译：本发明涉及含有钙盐作为活性成分并且还包含另一种抗流感药物的药物组合物，以及用于治疗或预防流感病毒感染的方法。

4. 发明申请

US20120083531A1 CALCIUM CITRATE AND CALCIUM LACTATE FORMULATIONS FOR ALTERATION OF BIOPHYSICAL PROPERTIES OF MUCOSAL LINING 审中-公开
标题翻译：柠檬酸钙和柠檬酸钙配方用于改变粘膜内衬的生物物理特性
公开(公告)号：US20120083531A1
公开(公告)日：2012-04-05
申请号：US13259666
申请日：2010-03-26
申请人： Robert W. Clarke , Richard Batycky , David L. Hava , Michal M. Lipp
发明人： Robert W. Clarke , Richard Batycky , David L. Hava , Michal M. Lipp
IPC分类号： A61K31/194 , A61P11/00 , A61K31/19 , A61P31/00 , C07C59/08 , C07C59/265
CPC分类号： A61K9/0075 , A61K9/0078 , A61K47/02 , A61K47/12 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to pharmaceutical compositions suitable for inhalation, comprising as an active ingredient calcium lactate or calcium citrate. The invention also relates to methods of treating, preventing, and reducing the spread of an infection of the respiratory tract, comprising administering a pharmaceutical composition that comprises calcium lactate or calcium citrate as an active ingredient.
摘要翻译：本发明涉及适于吸入的药物组合物，其包含乳酸钙或柠檬酸钙作为活性成分。本发明还涉及治疗，预防和减少呼吸道感染扩散的方法，包括给予包含乳酸钙或柠檬酸钙作为活性成分的药物组合物。

5. 发明申请

US20070104658A1 Use of simple amino acids to form porous particles 审中-公开
公开(公告)号：US20070104658A1
公开(公告)日：2007-05-10
申请号：US11637353
申请日：2006-12-12
申请人： Richard Batycky , Michael Lipp , Ralph Niven
发明人： Richard Batycky , Michael Lipp , Ralph Niven
IPC分类号： A61K9/14
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/0082 , A61K9/145 , A61K31/137 , A61K31/685 , A61K47/183
摘要： Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.

6. 发明申请

US20070104657A1 Particulate compositions for pulmonary delivery 有权
公开(公告)号：US20070104657A1
公开(公告)日：2007-05-10
申请号：US11633750
申请日：2006-12-05
申请人： Richard Batycky , David Edwards , Michael Lipp
发明人： Richard Batycky , David Edwards , Michael Lipp
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/1694
摘要： This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (σ) is greater than 2, optimally greater than 3.

7. 发明申请

US20060039987A1 Method and apparatus for producing dry particles 审中-公开
公开(公告)号：US20060039987A1
公开(公告)日：2006-02-23
申请号：US11255879
申请日：2005-10-24
申请人： Richard Batycky , Blair Jackson , Lloyd Johnston , Jeffrey Mintzes , Ernest Penachio
发明人： Richard Batycky , Blair Jackson , Lloyd Johnston , Jeffrey Mintzes , Ernest Penachio
IPC分类号： A61K39/395 , A61K38/28 , A61K31/56 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1688 , A61K9/1694 , A61K31/137 , A61K38/27 , A61K38/28 , B01D1/18 , B01F3/0803 , B01F5/0619 , B01J2/04 , B01J2/10
摘要： Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.

8. 发明申请

US20050058607A1 Control of process humidity to produce large, porous particles 有权
公开(公告)号：US20050058607A1
公开(公告)日：2005-03-17
申请号：US10977088
申请日：2004-10-29
申请人： Donghao Chen , Richard Batycky , LIoyd Johnson , Jeffrey Mintzes
发明人： Donghao Chen , Richard Batycky , LIoyd Johnson , Jeffrey Mintzes
IPC分类号： A61K9/72 , A61K9/00 , A61K9/14 , A61K9/16 , A61K47/24 , A61L9/04 , B05D7/00 , E02F5/10 , F26B3/00
CPC分类号： A61K9/0075 , A61K9/1694 , Y10S514/951
摘要： Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.

9. 发明申请

US20050191360A1 Particles for inhalation having rapid release properties 审中-公开
标题翻译：具有快速释放性能的吸入颗粒
公开(公告)号：US20050191360A1
公开(公告)日：2005-09-01
申请号：US11051497
申请日：2005-02-04
申请人： Richard Batycky , Michael Lipp
发明人： Richard Batycky , Michael Lipp
IPC分类号： A61K9/00 , A61K9/14 , A61K38/29 , A61K47/24
CPC分类号： A61K9/0075 , A61K47/24
摘要： The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled PTH formulations are disclosed. Improved formulations comprising DPPC, PTH and sodium citrate which are useful in the treatment of lowered PTH conditions are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion. Kits containing receptacles of the formulations are also disclosed.
摘要翻译：本发明一般涉及具有包含磷脂，生物活性剂和赋形剂以及其肺部递送的颗粒的制剂。公开了干粉吸入PTH制剂。公开了可用于治疗降低的PTH病症的包含DPPC，PTH和柠檬酸钠的改进制剂。此外，本发明涉及一种用于肺部递送生物活性剂的方法，其包括向需要治疗的患者的呼吸道施用有效量的包含生物活性剂或其任何组合的颗粒，其中释放来自施用颗粒的试剂以快速方式发生。还公开了含有制剂的容器的试剂盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式