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1. 发明申请

US20120283649A1 DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE AND USE OF A RESET MEMBER FOR A DRIVE MECHANISM 有权
标题翻译：用于药物递送装置的驱动机构和用于驱动机构的复位部件的使用
公开(公告)号：US20120283649A1
公开(公告)日：2012-11-08
申请号：US13395898
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne Macdonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne Macdonald
IPC分类号： A61M5/315
CPC分类号： A61M5/31535 , A61M5/24 , A61M5/31543 , A61M5/31555 , A61M5/3156 , A61M5/3158 , A61M5/31593 , A61M2005/2407
摘要： A plunger and a lever are arranged in a body and provided with engaging elements engaging the lever with the plunger. The lever is disengageable from the plunger by a shift of the lever, thus enabling a movement of the plunger relatively to the body in the proximal direction.
摘要翻译：柱塞和杠杆布置在主体中并且设置有与杠杆与柱塞接合的接合元件。杠杆通过杠杆的移动而与柱塞脱离，从而使得柱塞能够在近端方向上相对于身体移动。

2. 发明申请

US20120283648A1 DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE 有权
标题翻译：用于药物递送装置的驱动机构
公开(公告)号：US20120283648A1
公开(公告)日：2012-11-08
申请号：US13496536
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
IPC分类号： A61M5/31
CPC分类号： A61M5/24 , A61M5/31541 , A61M5/31555 , A61M5/31558 , A61M5/31561 , A61M5/31575 , A61M5/31593 , A61M2005/2407 , A61M2005/2488 , A61M2005/3142
摘要： A first output member is rotatable around an axis relatively to the body. A second output member is movable relatively to the body along the axis. The first output member and the second output member are rotationally coupled. A drive feature is provided to generate a rotation of the first output member. A part which is removable from and attachable to the body is provided so that the first output member is unidirectionally rotationally coupled with the drive feature when the part is attached to the body.
摘要翻译：第一输出构件可绕相对于身体的轴线旋转。第二输出构件可相对于主体沿轴线移动。第一输出构件和第二输出构件被旋转地联接。提供驱动特征以产生第一输出构件的旋转。提供从主体可移除并可附接到本体的部分，使得当部件附接到主体时，第一输出部件与驱动部件单方向地旋转耦合。

3. 发明授权

US09352098B2 Drive mechanism for a drug delivery device 有权
标题翻译：药物输送装置的驱动机构
公开(公告)号：US09352098B2
公开(公告)日：2016-05-31
申请号：US13395615
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
IPC分类号： A61M5/315
CPC分类号： A61M5/31541 , A61M5/31543 , A61M5/31555 , A61M5/31575 , A61M5/31585 , Y10T74/18992
摘要： A first input member and a second input member are arranged along a first axis and coupled in such a manner that a movement of the first input member along the first axis is converted into a rotational movement of the second input member with respect to the body . A first output member and a second output member are arranged along a second axis and coupled in such a manner that a rotational movement of the first output member is converted into a movement of the second output member along the second axis with respect to the body. The second input member and the first output member are releasably rotationally coupled.
摘要翻译：第一输入构件和第二输入构件沿着第一轴线布置并且以使得第一输入构件沿着第一轴线的运动被转换为第二输入构件相对于主体的旋转运动的方式联接。第一输出构件和第二输出构件沿着第二轴布置并且以使得第一输出构件的旋转运动相对于主体被转换成第二输出构件沿着第二轴线的运动的方式联接。第二输入构件和第一输出构件可释放地旋转地联接。

4. 发明申请

US20130035647A1 Drive Mechanism for a Drug Delivery Device 有权
标题翻译：药物输送装置的驱动机制
公开(公告)号：US20130035647A1
公开(公告)日：2013-02-07
申请号：US13395615
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
IPC分类号： A61M5/24 , F16H25/20 , A61M5/315
CPC分类号： A61M5/31541 , A61M5/31543 , A61M5/31555 , A61M5/31575 , A61M5/31585 , Y10T74/18992
摘要： A first input member (6) and a second input member (7) are arranged along a first axis (4) and coupled in such a manner that a movement of the first input member along the first axis is converted into a rotational movement of the second input member with respect to the body (1). A first output member (8) and a second output member (9) are arranged along a second axis (5) and coupled in such a manner that a rotational movement of the first output member is converted into a movement of the second output member along the second axis with respect to the body. The second input member and the first output member are releasably rotationally coupled.
摘要翻译：第一输入构件（6）和第二输入构件（7）沿着第一轴线（4）布置并且以这样的方式联接，使得第一输入构件沿着第一轴线的运动被转换为第二输入构件相对于主体（1）。第一输出构件（8）和第二输出构件（9）沿着第二轴线（5）布置并且以这样的方式联接，使得第一输出构件的旋转运动被转换成第二输出构件沿着第二轴相对于身体。第二输入构件和第一输出构件可释放地旋转地联接。

5. 发明申请

US20130006193A1 DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE 有权
标题翻译：用于药物递送装置的驱动机构
公开(公告)号：US20130006193A1
公开(公告)日：2013-01-03
申请号：US13497378
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne Macdonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne Macdonald
IPC分类号： A61M5/315
CPC分类号： A61M5/3158 , A61M5/24 , A61M5/31541 , A61M5/31543 , A61M5/31555 , A61M5/31556 , A61M2005/2407 , A61M2005/2477 , A61M2005/3126
摘要： According to one aspect, a resettable drive assembly for a drug delivery device is provided for. The resettable drive assembly may comprise a housing having a proximal end and a distal end, a piston rod being rotatable with respect to the housing and being axially displaceable with respect to the housing between a proximal start position and a distal end position, a drive member for distally displacing the piston rod towards the end position when dispensing a dose, and a stop member. The drive assembly may be configured such that the drive member is operable to interact with the piston rod for forming an unlockable first interlock, the first interlock being operable to block proximal movement of the piston rod with respect to the drive member. The drive assembly may be configured such that the stop member is operable to interact with the piston rod for forming an unlockable second interlock, the second interlock being operable to block proximal movement of the piston rod with respect to the housing. The drive assembly may be configured such that, when the drive assembly is in a drive mode, the first and second interlocks are locked such that proximal movement of the piston rod from the end position to the start position is prevented by the first interlock and the second interlock. The drive assembly may be configured such that, for switching the drive assembly from the drive mode to a reset mode, the piston rod is rotatable with respect to the drive member for unlocking the first interlock and the stop member and the piston rod are rotatable with respect to each other for unlocking the second interlock. The drive assembly may be configured such that, when the drive assembly is in the reset mode, the first interlock and the second interlock are unlocked such that proximal movement of the piston rod to the start position is allowed. Further, a drug delivery device and a use of a spring are provided for.
摘要翻译：根据一个方面，提供了一种用于药物递送装置的可重置驱动组件。可重置驱动组件可以包括具有近端和远端的壳体，活塞杆可相对于壳体旋转并且能够在近端起始位置和远端位置之间相对于壳体轴向移动，驱动构件用于在分配剂量时将活塞杆朝向终端位置移动，以及止挡构件。驱动组件可以构造成使得驱动构件可操作以与活塞杆相互作用以形成可解锁的第一互锁，第一互锁可操作以阻止活塞杆相对于驱动构件的近端运动。驱动组件可以被配置为使得止动构件可操作以与活塞杆相互作用以形成可解锁的第二互锁，所述第二互锁可操作以阻止活塞杆相对于壳体的近端运动。驱动组件可以构造成使得当驱动组件处于驱动模式时，第一和第二互锁被锁定，使得活塞杆从终端位置到起始位置的近端运动通过第一互锁来防止，并且第二个互锁。驱动组件可以被配置成使得为了将驱动组件从驱动模式切换到复位模式，活塞杆可相对于驱动构件旋转，用于解锁第一联锁装置，止动构件和活塞杆可随着彼此相对以解锁第二互锁。驱动组件可以被构造成使得当驱动组件处于复位模式时，第一互锁和第二联锁被解锁，使得允许活塞杆的近端运动到起始位置。此外，提供了药物递送装置和弹簧的使用。

6. 发明申请

US20120289907A1 Drive Assembly, Piston Rod, Drug Delivery Device, and Use of a Spring 审中-公开
标题翻译：驱动装置，活塞杆，药物输送装置和使用弹簧
公开(公告)号：US20120289907A1
公开(公告)日：2012-11-15
申请号：US13496587
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
IPC分类号： A61M5/315
CPC分类号： A61M5/24 , A61M5/31541 , A61M5/31543 , A61M5/31555 , A61M5/31556 , A61M5/31558 , A61M5/3156 , A61M5/3158 , A61M5/31585 , A61M5/31593 , A61M2005/2407 , A61M2005/2488 , A61M2005/31508 , A61M2205/581 , A61M2205/582
摘要： According to one aspect, a drive assembly for a drug delivery device is provided for. The drive assembly may comprise a housing (10A, 10B, 10C) having a proximal end (100P) and a distal end (100D), a piston rod (20) being axially displaceable and rotatable with respect to the housing (10A, 10B, 10C) between a first angular position and a second angular position, a drive member (30) being axially displaceable, and a rotational bias member (50) being operable to transfer a resilient bias to the piston rod (20). The drive assembly may be configured such that, for setting a dose, the drive member (30) is proximally axially displaceable with respect to the housing (10A, 10B, 10C) and the piston rod (20) from a rest position to a dose set position. When setting the dose, the piston rod (20) may be rotated in a first rotational direction and, subsequent to the rotation in the first rotational direction, rotated in a second rotational direction with respect to the housing and the drive member. For setting the dose, the drive member (30) may interact with the piston rod (20) to convert proximal axial movement of the drive member (30) with respect to the housing (10A, 10B, 10C) into rotational movement of the piston rod (20) in the first rotational direction towards the second angular position against the resilient bias and the rotational bias member (50) may interact with the piston rod (20) such that the piston rod (20) is rotated in the second rotational direction towards the first angular position with respect to the drive member (30) and the housing (10A, 10B, 10C) by means of the resilient bias. Further, a piston rod (20) and a use of a spring (80) are provided for.
摘要翻译：根据一个方面，提供了一种用于药物输送装置的驱动组件。驱动组件可以包括具有近端（100P）和远端（100D）的壳体（10A，10B，10C），活塞杆（20）可相对于壳体（10A，10B， 10C）位于第一角位置和第二角位置之间，可轴向移动的驱动构件（30）和可操作以将弹性偏压传递到活塞杆（20）的旋转偏置构件（50）。驱动组件可以被配置成使得为了设定剂量，驱动构件（30）可以相对于壳体（10A，10B，10C）和活塞杆（20）从静止位置向近端轴向移位到剂量设置位置。当设定剂量时，活塞杆（20）可沿第一旋转方向旋转，并且在第一旋转方向上的旋转之后，相对于壳体和驱动构件在第二旋转方向上旋转。为了设定剂量，驱动构件（30）可以与活塞杆（20）相互作用以将驱动构件（30）的相对于壳体（10A，10B，10C）的近侧轴向运动转换成活塞的旋转运动杆（20）沿第一旋转方向朝向第二角位置抵抗弹性偏压，并且旋转偏压构件（50）可与活塞杆（20）相互作用，使得活塞杆（20）沿第二旋转方向旋转通过弹性偏压相对于驱动构件（30）和壳体（10A，10B，10C）朝向第一角度位置。此外，提供活塞杆（20）和使用弹簧（80）。

7. 发明授权

US09446202B2 Drive mechanism for a drug delivery device and resilient element for a drive mechanism 有权
标题翻译：用于药物输送装置的驱动机构和用于驱动机构的弹性元件
公开(公告)号：US09446202B2
公开(公告)日：2016-09-20
申请号：US13395599
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
IPC分类号： A61M5/315 , A61M5/24
CPC分类号： A61M5/31543 , A61M5/31535 , A61M5/31555 , A61M5/3156 , A61M5/3158 , A61M5/31593 , A61M2005/2407
摘要： A plunger (4) having engaging means and a lever (5) are arranged in a body (1). The lever has a first pivot that is stationary with respect to the body in the direction of an axis, a second pivot, and a third pivot formed by an engaging element of the lever. The pivots are arranged in such a manner that a rotation of the lever with respect to the first pivot moves the second pivot and the third pivot in the same direction with respect to the axis. The engaging element and the engaging means are shaped such that the lever is disengaged from the plunger when the second pivot is moved relatively to the plunger in the proximal direction (30), and the plunger is engaged with the lever when the second pivot is moved in the distal direction (20).
摘要翻译：具有接合装置和杆（5）的柱塞（4）布置在主体（1）中。所述杠杆具有第一枢轴，所述第一枢轴在轴线方向相对于所述主体固定，第二枢轴和由所述杠杆的接合元件形成的第三枢轴。所述枢轴以这样的方式设置，即所述杆相对于所述第一枢轴的旋转使所述第二枢轴和所述第三枢轴沿相对于所述轴线的相同方向移动。接合元件和接合装置的形状使得当第二枢轴在近端方向（30）相对于柱塞移动时，杠杆与柱塞脱离，并且当第二枢轴移动时，柱塞与杠杆接合在远端方向（20）。

8. 发明授权

US09402960B2 Drive mechanism for a drug delivery device and use of a reset member for a drive mechanism 有权
标题翻译：用于药物输送装置的驱动机构以及使用用于驱动机构的复位构件
公开(公告)号：US09402960B2
公开(公告)日：2016-08-02
申请号：US13395898
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne Macdonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne Macdonald
IPC分类号： A61M5/315 , A61M5/24
CPC分类号： A61M5/31535 , A61M5/24 , A61M5/31543 , A61M5/31555 , A61M5/3156 , A61M5/3158 , A61M5/31593 , A61M2005/2407
摘要： A plunger and a lever are arranged in a body and provided with engaging elements engaging the lever with the plunger. The lever is disengageable from the plunger by a shift of the lever, thus enabling a movement of the plunger relatively to the body in the proximal direction.
摘要翻译：柱塞和杠杆布置在主体中并且设置有与杠杆与柱塞接合的接合元件。杠杆通过杠杆的移动而与柱塞脱离，从而使得柱塞能够在近端方向上相对于身体移动。

9. 发明申请

US20120283651A1 Drive Mechanism for a Drug Delivery Device and Resilient Element for a Drive Mechanism 有权
标题翻译：用于驱动机构的药物输送装置和弹性元件的驱动机构
公开(公告)号：US20120283651A1
公开(公告)日：2012-11-08
申请号：US13395599
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
IPC分类号： A61M5/315
CPC分类号： A61M5/31543 , A61M5/31535 , A61M5/31555 , A61M5/3156 , A61M5/3158 , A61M5/31593 , A61M2005/2407
摘要： A plunger (4) having engaging means and a lever (5) are arranged in a body (1). The lever has a first pivot that is stationary with respect to the body in the direction of an axis, a second pivot, and a third pivot formed by an engaging element of the lever. The pivots are arranged in such a manner that a rotation of the lever with respect to the first pivot moves the second pivot and the third pivot in the same direction with respect to the axis. The engaging element and the engaging means are shaped such that the lever is disengaged from the plunger when the second pivot is moved relatively to the plunger in the proximal direction (30), and the plunger is engaged with the lever when the second pivot is moved in the distal direction (20).
摘要翻译：具有接合装置和杆（5）的柱塞（4）布置在主体（1）中。所述杠杆具有第一枢轴，所述第一枢轴在轴线方向相对于所述主体固定，第二枢轴和由所述杠杆的接合元件形成的第三枢轴。所述枢轴以这样的方式设置，即所述杆相对于所述第一枢轴的旋转使所述第二枢轴和所述第三枢轴沿相对于所述轴线的相同方向移动。接合元件和接合装置的形状使得当第二枢轴在近端方向（30）相对于柱塞移动时，杠杆与柱塞脱离，并且当第二枢轴移动时，柱塞与杠杆接合在远端方向（20）。

10. 发明授权

US09375535B2 Drive mechanism for a drug delivery device 有权
标题翻译：药物输送装置的驱动机构
公开(公告)号：US09375535B2
公开(公告)日：2016-06-28
申请号：US13497378
申请日：2010-09-29
申请人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne Macdonald
发明人： Robert Veasey , Simon Lewis Bilton , Christopher Jones , Garen Kouyoumjian , Catherine Anne Macdonald
IPC分类号： A61M5/00 , A61M5/315 , A61M5/24 , A61M5/31
CPC分类号： A61M5/3158 , A61M5/24 , A61M5/31541 , A61M5/31543 , A61M5/31555 , A61M5/31556 , A61M2005/2407 , A61M2005/2477 , A61M2005/3126
摘要： According to one aspect, a resettable drive assembly for a drug delivery device is provided for. The resettable drive assembly may comprise a housing having a proximal end and a distal end, a piston rod being rotatable with respect to the housing and being axially displaceable with respect to the housing between a proximal start position and a distal end position, a drive member for distally displacing the piston rod towards the end position when dispensing a dose, and a stop member. The drive assembly may be configured such that the drive member is operable to interact with the piston rod for forming an unlockable first interlock, the first interlock being operable to block proximal movement of the piston rod with respect to the drive member. The drive assembly may be configured such that the stop member is operable to interact with the piston rod for forming an unlockable second interlock, the second interlock being operable to block proximal movement of the piston rod with respect to the housing. The drive assembly may be configured such that, when the drive assembly is in a drive mode, the first and second interlocks are locked such that proximal movement of the piston rod from the end position to the start position is prevented by the first interlock and the second interlock. The drive assembly may be configured such that, for switching the drive assembly from the drive mode to a reset mode, the piston rod is rotatable with respect to the drive member for unlocking the first interlock and the stop member and the piston rod are rotatable with respect to each other for unlocking the second interlock. The drive assembly may be configured such that, when the drive assembly is in the reset mode, the first interlock and the second interlock are unlocked such that proximal movement of the piston rod to the start position is allowed. Further, a drug delivery device and a use of a spring are provided for.
摘要翻译：根据一个方面，提供了一种用于药物递送装置的可重置驱动组件。可重置驱动组件可以包括具有近端和远端的壳体，活塞杆可相对于壳体旋转并且能够在近端起始位置和远端位置之间相对于壳体轴向移动，驱动构件用于在分配剂量时将活塞杆朝向终端位置移动，以及止挡构件。驱动组件可以构造成使得驱动构件可操作以与活塞杆相互作用以形成可解锁的第一互锁，第一互锁可操作以阻止活塞杆相对于驱动构件的近端运动。驱动组件可以被配置为使得止动构件可操作以与活塞杆相互作用以形成可解锁的第二互锁，所述第二互锁可操作以阻止活塞杆相对于壳体的近端运动。驱动组件可以构造成使得当驱动组件处于驱动模式时，第一和第二互锁被锁定，使得活塞杆从终端位置到起始位置的近端运动通过第一互锁来防止，并且第二个互锁。驱动组件可以被配置成使得为了将驱动组件从驱动模式切换到复位模式，活塞杆可相对于驱动构件旋转，用于解锁第一联锁装置，止动构件和活塞杆可随着彼此相对以解锁第二互锁。驱动组件可以被构造成使得当驱动组件处于复位模式时，第一互锁和第二联锁被解锁，使得允许活塞杆的近端运动到起始位置。此外，提供了药物递送装置和弹簧的使用。

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