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1. 发明申请

US20050107357A1 2,4-dioxo-3-quinazolinylaryl sulfonylureas 失效
标题翻译： 2,4-二氧代-3-喹唑啉基芳基磺酰脲
公开(公告)号：US20050107357A1
公开(公告)日：2005-05-19
申请号：US10956004
申请日：2004-09-29
申请人： Robert Scarborough , Wolin Huang , Anjali Pandey , Shawn Bauer , Xiaoming Zhang , Zhaozhong Jia
发明人： Robert Scarborough , Wolin Huang , Anjali Pandey , Shawn Bauer , Xiaoming Zhang , Zhaozhong Jia
IPC分类号： A61K20060101 , A61K31/517 , A61P7/02 , C07D409/12 , C07D409/14 , C07D49/14
CPC分类号： C07D409/12 , C07D409/14
摘要： 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
摘要翻译：提供2,4-二氧代-3-喹唑啉基芳基磺酰脲化合物，其可用于抑制ADP-血小板聚集，特别是在治疗血栓形成和血栓形成相关病症或病症中。

2. 发明授权

US07109332B2 2,4-dioxo-3-quinazolinylaryl sulfonylureas 失效
标题翻译： 2,4-二氧代-3-喹唑啉基芳基磺酰脲
公开(公告)号：US07109332B2
公开(公告)日：2006-09-19
申请号：US10956004
申请日：2004-09-29
申请人： Robert M. Scarborough , Wolin Huang , Anjali Pandey , Shawn M. Bauer , Xiaoming Zhang , Zhaozhong J. Jia
发明人： Robert M. Scarborough , Wolin Huang , Anjali Pandey , Shawn M. Bauer , Xiaoming Zhang , Zhaozhong J. Jia
IPC分类号： C07D409/12 , C07D409/14 , A61K31/517 , A61P7/02
CPC分类号： C07D409/12 , C07D409/14
摘要： 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: wherein R is a member selected from the group consisting of H and C1-6 alkyl; R1 is a member selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C3-5 cycloalkyl and C3-5 cycloalkyl-alkyl; R2 is a member selected from the group consisting of H, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, cyano and —C(O)R2a, wherein R2a is a member selected from the group consisting of C1-6 alkoxy and (C1-6 alkyl)0-2 amino; L is a 1 to 3 carbon linking group selected from the group consisting of —CH2—, —CH(CH3)—, —CH2CH2—, —CH2CH(CH3)— and —CH2CH2CH2—; L1 is a linking group selected from the group consisting of a bond and —CH2—; L2 is a linking group selected from the group consisting of a bond, —NH— and —CH2—; and Ar1 is an aromatic ring selected from the group consisting of benzene, pyridine and pyrimidine; are provided. The compounds are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
摘要翻译： 2,4-二氧代-3-喹唑啉基芳基磺酰脲类化合物，其具有下式：其中R是选自H和C 1-6烷基的成员; R 1是选自H，C 1-6烷基，C 1-6卤代烷基，C 1 -C 6烷基，C 1 -C 6烷基， 3-5个环烷基和C 3-5环烷基 - 烷基; R 2是选自H，卤素，C 1-6 - 烷基，C 2-6 - 烯基，C 1 -C 6烷基， C 1-6烷基，C 1-6烷氧基，氰基和-C（O）R 2a，其中R 2a是选自C 1-6烷氧基和（C 1-6烷基）烷基的成员， 0-2氨基; L是选自-CH 2 - ， - CH（CH 3 CH 3） - ， - CH 2 - ， - CH 2 CH 2（CH 3 CH 3） - 和-CH 2 CH _{2 CH 2 - ; L 1是选自键和-CH 2 - 的连接基团。 L 2是从由-NH-和-CH 2 - 的键组成的组中的连接基团。和Ar 1是选自苯，吡啶和嘧啶的芳环; 被提供。该化合物可用于抑制ADP-血小板聚集，特别是在治疗血栓形成和血栓相关病症或病症中。}

3. 发明申请

US20060069093A1 Substituted 2H-1,3-benzoxazin-4(3H)-ones 有权
标题翻译：取代的2H-1,3-苯并恶嗪-4（3H） - 酮
公开(公告)号：US20060069093A1
公开(公告)日：2006-03-30
申请号：US11236051
申请日：2005-09-26
申请人： Robert Scarborough , Meenakshi Venkatraman , Xiaoming Zhang , Anjali Pandey
发明人： Robert Scarborough , Meenakshi Venkatraman , Xiaoming Zhang , Anjali Pandey
IPC分类号： A61K31/538 , C07D413/14
CPC分类号： C07D413/12 , C07D413/14
摘要： Substituted benzoxazin-4(3H)-ones are provided which are useful for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.
摘要翻译：提供了取代的苯并恶嗪-4（3H） - 酮，其可用于治疗患者的血栓形成和降低患者二次缺血事件的可能性和/或严重程度。

4. 发明申请

US20120088736A1 [4-(6-HALO-7-Substituted-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS and Forms and Methods Related Thereto 审中-公开
标题翻译： [4-（6-HALO-7-取代的-2,4-二氧代-1,4-二氢-2H-喹喔啉-3-基） - 苯基] -5-氯代 - 噻吩-2-基]噻吩并[ 相关方法
公开(公告)号：US20120088736A1
公开(公告)日：2012-04-12
申请号：US13271037
申请日：2011-10-11
申请人： Robert Scarborough , Carroll Anna Crew Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig M. Grant
发明人： Robert Scarborough , Carroll Anna Crew Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig M. Grant
IPC分类号： A61K31/517 , A61K31/727 , A61P7/02 , A61P7/00 , A61P9/10 , A61P25/00 , A61P29/00 , A61K31/616 , A61P9/00
CPC分类号： C07D409/12
摘要： The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.
摘要翻译：本发明提供式（I）的新型磺酰脲化合物及其药学上可接受的衍生物及其多晶型物和无定形形式。各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或其形式的步骤。

5. 发明授权

US08058284B2 [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto 有权
标题翻译： [4-（6-卤代-7-取代-2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基） - 苯基] -5-氯 - 噻吩-2-基 - 磺酰脲，形成和与之相关的方法
公开(公告)号：US08058284B2
公开(公告)日：2011-11-15
申请号：US11556490
申请日：2006-11-03
申请人： Robert Scarborough , Carroll Anna Scarborough, legal representative , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig M. Grant
发明人： Robert Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig M. Grant
IPC分类号： A61K31/517 , C07D409/12
CPC分类号： C07D409/12
摘要： The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.
摘要翻译：本发明提供式（I）的新型磺酰脲化合物及其药学上可接受的衍生物及其多晶型物和无定形形式。各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或其形式的步骤。

6. 发明申请

US20070123547A1 [4-(6-HALO-7-SUBSTITUTED-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS AND FORMS AND METHODS RELATED THERETO 有权
标题翻译： [4-（6-羟基-7-取代-2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基） - 苯基] -5-氯代 - 噻吩-2-基] - 磺酰基和形式方法相关
公开(公告)号：US20070123547A1
公开(公告)日：2007-05-31
申请号：US11556490
申请日：2006-11-03
申请人： Robert Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig Grant , Carroll Scarborough
发明人： Robert Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig Grant , Carroll Scarborough
IPC分类号： A61K31/517 , C07D409/02
CPC分类号： C07D409/12
摘要： The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.
摘要翻译：本发明提供式（I）的新型磺酰脲化合物及其药学上可接受的衍生物及其多晶型物和无定形形式。各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或其形式的步骤。

7. 发明授权

US07205296B2 Substituted 2H-1,3-benzoxazin-4(3H)-ones 有权
标题翻译：取代的2H-1,3-苯并恶嗪-4（3H） - 酮
公开(公告)号：US07205296B2
公开(公告)日：2007-04-17
申请号：US11236051
申请日：2005-09-26
申请人： Robert M. Scarborough , Meenakshi S. Venkatraman , Xiaoming Zhang , Anjali Pandey
发明人： Robert M. Scarborough , Meenakshi S. Venkatraman , Xiaoming Zhang , Anjali Pandey
IPC分类号： C07D409/12 , C07D409/14 , A61K31/538
CPC分类号： C07D413/12 , C07D413/14
摘要： Substituted benzoxazin-4(3H)-ones are provided which are useful for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.
摘要翻译：提供了取代的苯并恶嗪-4（3H） - 酮，其可用于治疗患者的血栓形成和降低患者二次缺血事件的可能性和/或严重程度。

8. 发明申请

US20050113399A1 Substituted isoquinolinones 有权
标题翻译：取代的异喹啉酮
公开(公告)号：US20050113399A1
公开(公告)日：2005-05-26
申请号：US10956006
申请日：2004-09-29
申请人： Robert Scarborough , Kim Kane-MaGuire , Charles Marlowe , Mark Smyth , Xiaoming Zhang
发明人： Robert Scarborough , Kim Kane-MaGuire , Charles Marlowe , Mark Smyth , Xiaoming Zhang
IPC分类号： A61K31/4709 , A61K31/506 , C07D217/24 , C07D401/04 , C07D409/12 , C07D49/14
CPC分类号： C07D409/14 , C07D217/24 , C07D401/04 , C07D409/12
摘要： Isoquinolinone compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
摘要翻译：提供了可用于抑制ADP-血小板聚集的异喹啉酮化合物，特别是在治疗血栓形成和血栓形成相关病症或病症中。

9. 发明授权

US09044192B2 System and method for non-invasively measuring tissue viscoelasticity using surface waves 有权
标题翻译：使用表面波非侵入性地测量组织粘弹性的系统和方法
公开(公告)号：US09044192B2
公开(公告)日：2015-06-02
申请号：US12418111
申请日：2009-04-03
申请人： James F. Greenleaf , Mark R. Pittelkow , Randall R. Kinnick , Xiaoming Zhang
发明人： James F. Greenleaf , Mark R. Pittelkow , Randall R. Kinnick , Xiaoming Zhang
IPC分类号： A61B8/00 , A61B5/00
CPC分类号： A61B5/442 , A61B5/0051 , A61B8/485
摘要： A system and method for assessing tissue health based on the viscoelastic properties of the tissue. Surface waves are induced in the tissue and their propagation characteristics are then measured. The tissue viscoelastic properties are then determined from the surface wave measurements using a surface model.
摘要翻译：一种基于组织粘弹性评估组织健康的系统和方法。在组织中诱导表面波，然后测量它们的传播特性。然后使用表面模型从表面波测量中确定组织粘弹性。

10. 发明申请

US20130238732A1 INSTANT MESSAGING ROBOT TO PROVIDE PRODUCT INFORMATION 有权
标题翻译：即时消息机器人提供产品信息
公开(公告)号：US20130238732A1
公开(公告)日：2013-09-12
申请号：US13865768
申请日：2013-04-18
申请人： Xiaoming Zhang
发明人： Xiaoming Zhang
IPC分类号： H04L12/58
CPC分类号： G06Q30/0613 , G06F17/30569 , G06Q30/0269 , G06Q30/0611 , G06Q30/0625 , H04L51/02 , H04L51/04 , H04L67/10
摘要： Methods and systems to automatically respond to a request for product information are described. In one embodiment, a data collection module may collect product data over a network, identify that the product data is related to a particular product, and store the product data and an association between the product data and the particular product in a database. An instant messaging engine may receive a request for the product data after the product data is stored in the database and an interpreter module may identify, in response to the request, the request to correspond to the particular product and retrieve the product data based on the association between the particular product and the product data. The instant messaging engine may also transmit, using an instant messaging protocol, a response to the request, the response including the product data.
摘要翻译：描述自动响应产品信息请求的方法和系统。在一个实施例中，数据收集模块可以通过网络收集产品数据，识别产品数据与特定产品相关，并且存储产品数据以及数据库中的产品数据和特定产品之间的关联。在产品数据存储在数据库中之后，即时消息发送引擎可以接收对产品数据的请求，并且解释器模块可以响应于该请求识别与特定产品相对应的请求，并基于特定产品与产品数据之间的关联。即时消息引擎还可以使用即时消息传递协议来发送对请求的响应，该响应包括产品数据。

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