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1. 发明授权

US10362983B2 Near infrared photonic prostatoscopy analyzer 有权
公开(公告)号：US10362983B2
公开(公告)日：2019-07-30
申请号：US14710222
申请日：2015-05-12
申请人： Robert R. Alfano , Wubao Wang , Yang Pu , Yury Budansky , Laura Sordillo , Guichen Tang , James Eastham
发明人： Robert R. Alfano , Wubao Wang , Yang Pu , Yury Budansky , Laura Sordillo , Guichen Tang , James Eastham
IPC分类号： A61B1/00 , A61B1/31 , A61B5/00
摘要： A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers/light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.

2. 发明申请

US20150320319A1 NEAR INFRARED PHOTONIC PROSTATOSCOPY ANALYZER 审中-公开
标题翻译：近红外光子显微镜分析仪
公开(公告)号：US20150320319A1
公开(公告)日：2015-11-12
申请号：US14710222
申请日：2015-05-12
申请人： ROBERT R. ALFANO , Wubao Wang , Yang Pu , Yury Budansky , Laura Sordillo , Guichen Tang , James Eastham
发明人： ROBERT R. ALFANO , Wubao Wang , Yang Pu , Yury Budansky , Laura Sordillo , Guichen Tang , James Eastham
IPC分类号： A61B5/00 , A61B1/00 , A61B1/31
CPC分类号： A61B5/4381 , A61B1/00142 , A61B1/00165 , A61B1/00172 , A61B1/31 , A61B5/0062 , A61B5/0066 , A61B5/0086
摘要： A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers/light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.
摘要翻译：直肠近红外（NIR）扫描偏振成像系统使用NIR光子预分析仪（NIRPPA）进行前列腺癌检测。 NIRPPA包括便携式直肠近红外扫描偏振成像单元和基于光纤的直肠探针，其能够通过不同波长和深度的直肠记录前列腺的2D图像，并获得前列腺的三维（3D）图像，前列腺内异常组织的3D位置。具有选定发射波长的二极管激光器/发光二极管（LED）用于对应于四个组织光学窗口（＃I，650nm-950nm;＃II,1,100nm-1,350）的650nm至2,400nm的NIR光谱范围 nm;＃III，1,600nm-1,870nm;和#IV，2100nm-2,300nm）。前列腺中水（H2O），氧血红蛋白（HbO2）和脱氧血红蛋白（Hb）的指纹吸收被用作前列腺癌检测的天然生物标志物。

3. 发明授权

US07038208B2 Systems and methods for non-destructively detecting material abnormalities beneath a coated surface 有权
标题翻译：用于非破坏性地检测涂层表面下的材料异常的系统和方法
公开(公告)号：US07038208B2
公开(公告)日：2006-05-02
申请号：US10653473
申请日：2003-09-02
申请人： Robert R. Alfano , Iosif Zeylikovich , Wubao Wang , Jamal Ali , Vincent Benischek , Yury Budansky
发明人： Robert R. Alfano , Iosif Zeylikovich , Wubao Wang , Jamal Ali , Vincent Benischek , Yury Budansky
IPC分类号： G01N21/88
CPC分类号： G01N21/8806 , G01N21/8422
摘要： The present invention provides systems and methods for non-destructively detecting material abnormalities beneath a coated surface, comprising a mid-infrared (MIR) illumination unit for illuminating an area of the coated surface, and an MIR 2-D imager, which includes an MIR CCD or CMOS camera, for capturing an image of a material abnormalities under the illuminated area of the coated surface. In addition, the system may further comprise a scanning unit for moving the system to a next area.
摘要翻译：本发明提供用于非破坏性地检测涂覆表面下方的材料异常的系统和方法，包括用于照射涂覆表面的区域的中红外（MIR）照明单元和包括MIR的MIR 2-D成像器 CCD或CMOS相机，用于捕获涂层表面照明区域下材料异常的图像。另外，该系统还可以包括用于将系统移动到下一个区域的扫描单元。

4. 发明授权

US07312713B2 Methods and systems for detection of ice formation on surfaces 有权
标题翻译：用于检测表面冰层的方法和系统
公开(公告)号：US07312713B2
公开(公告)日：2007-12-25
申请号：US11303190
申请日：2005-12-15
申请人： Robert R. Alfano , Wubao Wang , Henry Sztul , Yury Budansky
发明人： Robert R. Alfano , Wubao Wang , Henry Sztul , Yury Budansky
IPC分类号： G08B19/02
CPC分类号： B64D15/20 , G08B19/02
摘要： A system for detecting ice formation on metal, painted metal and other material surfaces can include a transparent window having an exterior surface upon which ice can form; a light source and optics configured and arranged to illuminate the exterior surface of the window from behind the exterior surface; and a detector and optics configured and arranged to receive light backscattered by the exterior surface and any ice disposed on the exterior surface and determine the thickness of the ice layer. For example, the system can be used with aircraft by placing one or more windows in the wings of the aircraft. The system is used for a novel optical method for real-time on-board detection and warning of ice formation on surfaces of airplanes, unmanned aerial vehicles (UAVs), and other vehicles and stationary structures to improve their safety and operation.
摘要翻译：用于检测金属，涂漆金属和其他材料表面上的冰的系统可以包括具有外部表面的透明窗口，冰面可以在其上形成; 光源和光学构造和布置成从外表面后面照亮窗户的外表面; 以及配置和布置成接收由外表面反向散射的光和设置在外表面上的任何冰的检测器和光学器件，并且确定冰层的厚度。例如，该系统可以与飞机一起使用，将一个或多个窗口放置在飞行器的机翼中。该系统用于飞机，无人机（UAV），其他车辆和固定式结构表面实时车载检测和警告冰面的新型光学方法，以提高其安全性和运行性。

5. 发明授权

US06853926B2 Systems and methods for non-destructively detecting material abnormalities beneath a coated surface 失效
标题翻译：用于非破坏性地检测涂层表面下的材料异常的系统和方法
公开(公告)号：US06853926B2
公开(公告)日：2005-02-08
申请号：US10455662
申请日：2003-06-05
申请人： Robert R. Alfano , Iosif Zeylikovich , Wubao Wang , Jamal Ali , Vincent Benischek , Yury Budansky
发明人： Robert R. Alfano , Iosif Zeylikovich , Wubao Wang , Jamal Ali , Vincent Benischek , Yury Budansky
IPC分类号： G01N21/88 , G01N21/89 , G01B5/28
CPC分类号： G01N21/88 , G01N21/8422 , G01N2021/889 , G01N2021/8918
摘要： The present invention provides systems and methods for non-destructively detecting material abnormalities beneath a coated surface, comprising a mid-infrared (MIR) detection unit for illuminating an area of the coated surface and detecting light reflected from the illuminated area of the coated surface, and a processing unit for producing an image from optical characteristics received from the MIR detection unit. In addition, the system may further comprise a scanning unit for moving the MIR detection unit to a next area.
摘要翻译：本发明提供用于非破坏性地检测涂覆表面下方的材料异常的系统和方法，包括用于照射涂覆表面的区域并检测从涂覆表面的被照射区域反射的光的中红外（MIR）检测单元，以及处理单元，用于从从MIR检测单元接收的光学特性产生图像。另外，该系统还可以包括用于将MIR检测单元移动到下一个区域的扫描单元。

6. 发明授权

US09322769B2 Method and apparatus for detecting degree of spoilage of food 有权
标题翻译：检测食品腐败程度的方法和装置
公开(公告)号：US09322769B2
公开(公告)日：2016-04-26
申请号：US14309598
申请日：2014-06-19
申请人： Robert R. Alfano , Yang Pu , Wubao Wang
发明人： Robert R. Alfano , Yang Pu , Wubao Wang
IPC分类号： G01J3/00 , G01N21/27 , G01N33/12 , G01N21/64
CPC分类号： G01N21/27 , G01N21/6486 , G01N33/12
摘要： A method detects the degree of spoilage of food by exposing a food sample to an excitation wave having a first wavelength of about 340 nm or about 380 nm, wherein the excitation wave has a bandwidth of 40 nm or less. The excitation wave is permitted to interact with the food sample and return emission spectra. A detector detects the emission spectra. A predetermined threshold value is established which defines when a food sample is or is not spoiled. The emission spectra is analyzed at a second wavelength of about 400 nm, about 450 nm or about 530 nm to provide a test or measured value of the emission spectra indicative of the degree of spoilage of the food sample. Whether or not a food sample is spoiled beyond the predetermined threshold is determined by comparing the measured value to the predetermined threshold value.
摘要翻译：一种方法通过将食物样品暴露于第一波长为约340nm或约380nm的激发波来检测食物的变质程度，其中激发波具有40nm或更小的带宽。激发波被允许与食物样品相互作用并返回发射光谱。检测器检测发射光谱。建立了一个预定的阈值，其定义何时食物样本是否被损坏。在约400nm，约450nm或约530nm的第二波长处分析发射光谱，以提供指示食物样品的变质程度的发射光谱的测试值或测量值。通过将测量值与预定阈值进行比较来确定食物样品是否损坏超过预定阈值。

7. 发明申请

US20140300891A1 METHOD AND APPARATUS FOR DETECTING DEGREE OF SPOILAGE OF FOOD 有权
标题翻译：检测食物的程度的方法和装置
公开(公告)号：US20140300891A1
公开(公告)日：2014-10-09
申请号：US14309598
申请日：2014-06-19
申请人： ROBERT R. ALFANO , Yang Pu , Wubao Wang
发明人： ROBERT R. ALFANO , Yang Pu , Wubao Wang
IPC分类号： G01N33/02 , G01N21/27 , G01N21/33
CPC分类号： G01N21/27 , G01N21/6486 , G01N33/12
摘要： A method detects the degree of spoilage of food by exposing a food sample to an excitation wave having a first wavelength of about 340 nm or about 380 nm, wherein the excitation wave has a bandwidth of 40 nm or less. The excitation wave is permitted to interact with the food sample and return emission spectra. A detector detects the emission spectra. A predetermined threshold value is established which defines when a food sample is or is not spoiled. The emission spectra is analyzed at a second wavelength of about 400 nm, about 450 nm or about 530 nm to provide a test or measured value of the emission spectra indicative of the degree of spoilage of the food sample. Whether or not a food sample is spoiled beyond the predetermined threshold is determined by comparing the measured value to the predetermined threshold value.
摘要翻译：一种方法通过将食物样品暴露于第一波长为约340nm或约380nm的激发波来检测食物的变质程度，其中激发波具有40nm或更小的带宽。激发波被允许与食物样品相互作用并返回发射光谱。检测器检测发射光谱。建立了一个预定的阈值，其定义何时食物样本是否被损坏。在约400nm，约450nm或约530nm的第二波长处分析发射光谱，以提供指示食物样品的变质程度的发射光谱的测试值或测量值。通过将测量值与预定阈值进行比较来确定食物样品是否损坏超过预定阈值。

8. 发明申请

US20070216536A1 METHODS AND SYSTEMS FOR DETECTION OF ICE FORMATION ON SURFACES 有权
标题翻译：用于检测表面上冰块形成的方法和系统
公开(公告)号：US20070216536A1
公开(公告)日：2007-09-20
申请号：US11303190
申请日：2005-12-15
申请人： Robert Alfano , Wubao Wang , Henry Sztul , Yury Budansky
发明人： Robert Alfano , Wubao Wang , Henry Sztul , Yury Budansky
IPC分类号： G08B19/02
CPC分类号： B64D15/20 , G08B19/02
摘要： A system for detecting ice formation on metal, painted metal and other material surfaces can include a transparent window having an exterior surface upon which ice can form; a light source and optics configured and arranged to illuminate the exterior surface of the window from behind the exterior surface; and a detector and optics configured and arranged to receive light backscattered by the exterior surface and any ice disposed on the exterior surface and determine the thickness of the ice layer. For example, the system can be used with aircraft by placing one or more windows in the wings of the aircraft. The system is used for a novel optical method for real-time on-board detection and warning of ice formation on surfaces of airplanes, unmanned aerial vehicles (UAVs), and other vehicles and stationary structures to improve their safety and operation.
摘要翻译：用于检测金属，涂漆金属和其他材料表面上的冰的系统可以包括具有外部表面的透明窗口，冰面可以在其上形成; 光源和光学构造和布置成从外表面后面照亮窗户的外表面; 以及配置和布置成接收由外表面反向散射的光和设置在外表面上的任何冰的检测器和光学器件，并且确定冰层的厚度。例如，该系统可以与飞机一起使用，将一个或多个窗口放置在飞行器的机翼中。该系统用于飞机，无人机（UAV），其他车辆和固定式结构表面实时车载检测和警告冰面的新型光学方法，以提高其安全性和运行性。

9. 发明授权

US06280386B1 Apparatus for enhancing the visibility of a luminous object inside tissue and methods for same 失效
标题翻译：用于提高组织内发光物体的可视性的装置及其方法
公开(公告)号：US06280386B1
公开(公告)日：2001-08-28
申请号：US09098258
申请日：1998-06-16
申请人： Robert R. Alfano , Stavros G. Demos , Wubao Wang , Jamal Ali
发明人： Robert R. Alfano , Stavros G. Demos , Wubao Wang , Jamal Ali
IPC分类号： A61B500
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0086 , A61B5/4312 , A61B5/4375 , A61B5/441
摘要： Imaging of objects within tissue is enhanced by applying a contrast agent to a sample to be imaged to augment the emissions from an object, thereby forming a luminous object. The tissue is then illuminated and two image signals are recorded. The contrast agent is selected to bind to the object and provide spectral characteristics significantly different from that of the tissue for the two recorded image signals. The two image signals are subtracted to substantially minimize an image component resulting from the tissue and enhance an image component from the luminous object. The imaging methods and apparatus are particularly well suited for medical imaging where the object is diseased tissue such as tumors.
摘要翻译：通过将对比剂施加到要成像的样品以增加物体的排放物从而形成发光物体来增强组织内物体的成像。然后照亮组织并记录两个图像信号。选择造影剂以结合对象并提供与两个记录的图像信号的组织显着不同的光谱特征。减去两个图像信号以基本上最小化由组织产生的图像分量并增强来自发光体的图像分量。成像方法和装置特别适用于物体是诸如肿瘤的病变组织的医学成像。

10. 发明授权

US6091983A Imaging of objects in turbid media based upon the preservation of polarized luminescence emitted from contrast agents 失效
标题翻译：基于保存从造影剂发射的极化发光的物体在浑浊介质中成像
公开(公告)号：US6091983A
公开(公告)日：2000-07-18
申请号：US797027
申请日：1997-02-07
申请人： Robert R. Alfano , Stavros G. Demos , Wubao Wang
发明人： Robert R. Alfano , Stavros G. Demos , Wubao Wang
IPC分类号： A61B5/00
CPC分类号： A61B5/0091 , A61B5/4312 , A61B5/0059
摘要： A method and system for imaging an object in a turbid medium. According to one embodiment, the method involves (a) making the object luminescent by adding to the object a contrast agent of the type that emits at least partially polarized light when appropriately excited with polarized radiation; (b) exciting the luminescent object through the turbid medium with polarized radiation so as to cause luminescent light to be emitted from the luminescent object, the luminescent light initially being at least partially polarized; (c) after the luminescent light has emerged from the turbid medium, the luminescent light consisting of a ballistic component, a snake-like component and a diffuse component, detecting a pair of complementary polarization components of the luminescent light; and (d) forming an image of the object using the pair of complementary polarization components.
摘要翻译：用于对浑浊介质中的物体进行成像的方法和系统。根据一个实施例，该方法包括：（a）通过向对象添加当用偏振辐射适当地激发时发射至少部分偏振光的类型的造影剂来使物体发光; （b）通过具有偏振辐射的混浊介质激发发光物体，从而使发光从发光物体发射，发光光最初至少部分极化; （c）在从混浊介质出射发光后，检测出发光光的一对互补极化分量的由弹道成分，蛇状成分和扩散成分构成的发光; 和（d）使用该对互补偏振分量形成对象的图像。

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