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1. 发明授权

US5463485A Terahertz repetition rate optical computing systems, and communication systems and logic elements using cross-phase modulation based optical processors 失效
标题翻译：太赫兹重复率光学计算系统，以及使用基于交叉相位调制的光学处理器的通信系统和逻辑元件
公开(公告)号：US5463485A
公开(公告)日：1995-10-31
申请号：US259877
申请日：1994-06-15
申请人： Robert R. Alfano , Ping-Pei Ho , Patrice Baldeck
发明人： Robert R. Alfano , Ping-Pei Ho , Patrice Baldeck
IPC分类号： G02B6/00 , G02F1/29 , G02F1/35 , G02F1/355 , G02F2/00 , G02F2/02 , G02F3/00 , H04B10/04 , H04B10/06 , H04B10/142 , H04B10/152 , G02F1/39
CPC分类号： G02F1/293 , G02F1/3515 , G02F2/004 , G02F2/02 , G02F3/00 , G02F1/3511
摘要： Optical communication systems, optical computing systems and optical logic elements which rely on the phenomina of cross-phase modulation to alter and control, either or simultaneously, the spectral, temporal or/and spatial properties of ultrashort light pulses for processing information with high speed repetition rates. A weak beam of ultrashort light pulses is modulated by an intense beam of ultrashort light pulses by copropagating both beams through a non-linear medium such that cross-phase modulation effects are realized.
摘要翻译：光通信系统，光学计算系统和光学逻辑元件，其依赖于交叉相位调制的方式来改变和控制超短光脉冲的光谱，时间或/和空间属性，用于处理具有高速重复的信息价格。超短光脉冲的弱光束由强光束的超短光脉冲调制，通过将两束光束共同传播通过非线性介质，从而实现交叉相位调制效应。

2. 发明授权

US5373381A Terahertz repetition rate optical computing systems, and communication systems and logic elements using cross-phase modulation based optical processors 失效
标题翻译：太赫兹重复率光学计算系统，以及使用基于交叉相位调制的光学处理器的通信系统和逻辑元件
公开(公告)号：US5373381A
公开(公告)日：1994-12-13
申请号：US806170
申请日：1991-12-12
申请人： Robert R. Alfano , Ping-Pei Ho , Patrice Baldeck
发明人： Robert R. Alfano , Ping-Pei Ho , Patrice Baldeck
IPC分类号： G02B6/00 , G02F1/29 , G02F1/35 , G02F1/355 , G02F2/00 , G02F2/02 , G02F3/00 , H04B10/04 , H04B10/06 , H04B10/142 , H04B10/152
CPC分类号： G02F1/293 , G02F1/3515 , G02F2/004 , G02F2/02 , G02F3/00 , G02F1/3511
摘要： Optical communication systems, optical computing systems and optical logic elements which rely on the phenomina of cross-phase modulation to alter and control, either or simultaneously, the spectral, temporal or/and spatial properties of ultrashort light pulses for processing information with high speed repetition rates. A weak beam of ultrashort light pulses is modulated by an intense beam of ultrashort light pulses by copropagating both beams through a non-linear medium such that cross-phase modulation effects are realized.
摘要翻译：光通信系统，光学计算系统和光学逻辑元件，其依赖于交叉相位调制的方式来改变和控制超短光脉冲的光谱，时间或/和空间属性，用于处理具有高速重复的信息价格。超短光脉冲的弱光束由强光束的超短光脉冲调制，通过将两束光束共同传播通过非线性介质，从而实现交叉相位调制效应。

3. 发明授权

US5150248A Terahertz repetition rate optical computing systems, and communication systems and logic elements using cross-phase modulation based optical processors 失效
标题翻译： TERAHERTZ重复率光学计算系统，以及使用基于相位调制的光学处理器的通信系统和逻辑元件
公开(公告)号：US5150248A
公开(公告)日：1992-09-22
申请号：US382752
申请日：1989-07-21
申请人： Robert R. Alfano , Ping-Pei Ho , Patrice Baldeck
发明人： Robert R. Alfano , Ping-Pei Ho , Patrice Baldeck
IPC分类号： G02B6/00 , G02F1/29 , G02F1/35 , G02F1/355 , G02F2/00 , G02F2/02 , G02F3/00 , H04B10/04 , H04B10/06 , H04B10/142 , H04B10/152
CPC分类号： G02F1/293 , G02F1/3515 , G02F2/004 , G02F2/02 , G02F3/00 , G02F1/3511
摘要： Optical communication systems, optical computing systems and optical logic elements which rely on the phenomena of cross-phase modulation to alter and control, either or simultaneously, the spectral, temporal or/and spatial properties of ultrashort light pulses for processing information with high speed repetition rates. A weak beam of ultrashort light pulses is modulated by an intense beam of ultrashort light pulses by copropagating both beams through a non-linear medium such that cross-phase modulation effects are realized.

4. 发明授权

US5828484A Multiple-stage optical Kerr gate system 失效
标题翻译：多级光学克尔门系统
公开(公告)号：US5828484A
公开(公告)日：1998-10-27
申请号：US51987
申请日：1993-04-26
申请人： Ping-Pei Ho , Robert R. Alfano
发明人： Ping-Pei Ho , Robert R. Alfano
IPC分类号： G02F1/01 , G02F1/35 , H01S3/10
CPC分类号： G02F1/3515 , G02F1/3511 , G02F2203/26 , Y10S372/70
摘要： A multiple-stage optical Kerr gate system for gating a probe pulse of light. In a first embodiment, the system includes at least two optical Kerr gates, each Kerr gate including a polarizer, an optical Kerr cell actuable by a pump pulse, and an analyzer. In a second embodiment, at least one of the Kerr cells may be eliminated by arranging the respective sets of polarizers and analyzers so that they share a common Kerr cell. Gated pulses obtained using the present system typically have a signal to noise ratio that is at least 500 times better than that for gated pulses obtained using a single optical Kerr gate system. The system of the present invention may also include means for causing the pump pulse to arrive at the second Kerr cell (in the case of the first embodiment) or at a single Kerr cell a second time (in the case of the second embodiment) non-synchronously with the arrival of the probe pulse thereat. In this manner, gated pulses may be obtained that are much shorter in duration than pulses gated with a single optical Kerr gate system.
摘要翻译：用于门控光脉冲的多级光学克尔门系统。在第一实施例中，该系统包括至少两个光学克尔门，每个克尔门包括偏振器，可由泵浦脉冲致动的光学克尔单元和分析器。在第二实施例中，可以通过布置相应的偏振器和分析器组来消除克尔单元中的至少一个，使得它们共享公共克尔单元。使用本系统获得的门控脉冲通常具有比使用单个光学克尔门系统获得的门控脉冲的信噪比更好的500倍的信噪比。本发明的系统还可以包括用于使泵浦脉冲第二次（在第二实施例的情况下）到达第二克尔单元（在第一实施例的情况下）或单个克尔单元的装置与探针脉冲的到来同步。以这种方式，可以获得门控脉冲的持续时间短于用单个光学克尔门系统门控的脉冲。

5. 发明授权

US5799656A Optical imaging of breast tissues to enable the detection therein of calcification regions suggestive of cancer 失效
标题翻译：乳腺组织的光学成像可以在其中检测钙化区域，提示癌症
公开(公告)号：US5799656A
公开(公告)日：1998-09-01
申请号：US733558
申请日：1996-10-21
申请人： Robert R. Alfano , Ping-Pei Ho , Leming Wang , Xiangchun Liang , Pierre A. Galland
发明人： Robert R. Alfano , Ping-Pei Ho , Leming Wang , Xiangchun Liang , Pierre A. Galland
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B5/0091 , A61B5/4312
摘要： A method for detecting the presence of one or more calcifications within a portion of a turbid medium, such as a breast tissue. According to one aspect, the method involves illuminating at least a portion of the turbid medium with light, whereby light emerges from the turbid medium consisting of a ballistic component, a snake-like component and a diffuse component, temporally and/or spatially gating the emergent light to preferentially pass the ballistic and/or snake-like components, using the temporally and/or spatially gated light to form an image of the illuminated portion of the turbid medium, and examining the image for the presence of one or more calcifications. Wavelength difference images may also be used to highlight tumors and calcification regions. The foregoing method may be used to form optical images of breast tissues, with the presence in such images of calcifications suggestive of cancer being used to identify the corresponding breast tissues as good candidates for biopsy and screening for tumors.
摘要翻译：一种用于检测在混浊介质（例如乳房组织）的一部分内存在一种或多种钙化的方法。根据一个方面，该方法包括用光照射混浊介质的至少一部分，由此光从由弹道组件，蛇形部件和扩散部件组成的混浊介质中暂时和/或空间门控使用时间和/或空间门控的光来优先地通过弹道和/或蛇状部件以形成混浊介质的被照射部分的图像，并检查图像中是否存在一种或多种钙化。波长差图像也可用于突出肿瘤和钙化区域。上述方法可以用于形成乳腺组织的光学图像，存在这样的钙化图像，暗示癌症用于鉴定相应的乳腺组织作为肿瘤活检和筛选的良好候选物。

6. 发明授权

US06208886B1 Non-linear optical tomography of turbid media 失效
标题翻译：浑浊介质的非线性光学层析成像
公开(公告)号：US06208886B1
公开(公告)日：2001-03-27
申请号：US09054743
申请日：1998-04-03
申请人： Robert R. Alfano , Yici Guo , Feng Liu , Ping Pei Ho
发明人： Robert R. Alfano , Yici Guo , Feng Liu , Ping Pei Ho
IPC分类号： A61B500
CPC分类号： A61B5/0073 , A61B5/4519
摘要： An apparatus utilizing non-linear optical signals for use in constructing a three-dimensional tomographic map of an in vivo biological tissue for medical disease detection purposes. In one embodiment, said apparatus comprises a stage for supporting the in vivo biological tissue; a laser for illuminating the in vivo biological tissue with a focused beam of laser light, the light emerging from the in vivo biological tissue comprising fundamental light, harmonic wave light, and fluorescence due to multi-photon excitation; a filter for selectively passing only at least one of the harmonic wave light and the fluorescence; one or more detectors for individually detecting each of the harmonic wave light and the fluorescence selectively passed; and a mechanism for moving the laser relative to the stage in x, y and z directions.
摘要翻译：一种利用非线性光信号用于构建用于医学疾病检测目的的体内生物组织的三维断层图的装置。在一个实施方案中，所述装置包括用于支撑体内生物组织的载物台; 用聚焦光束照射体内生物组织的激光，从体内生物组织出射的光包括基本光，谐波光和由于多光子激发引起的荧光; 用于选择性地仅通过谐波光和荧光中的至少一个的滤光器; 一个或多个检测器，用于单独检测每个谐波光和选择性地通过的荧光; 以及用于在x，y和z方向上相对于舞台移动激光的机构。

7. 发明授权

US5644429A 2-dimensional imaging of translucent objects in turbid media 失效
标题翻译：半透明物体在混浊介质中的二维成像
公开(公告)号：US5644429A
公开(公告)日：1997-07-01
申请号：US654800
申请日：1996-05-29
申请人： Robert R. Alfano , Ping-Pei Ho , Xiangchun Liang
发明人： Robert R. Alfano , Ping-Pei Ho , Xiangchun Liang
IPC分类号： A61B5/00 , G01N21/47 , G02B27/46
CPC分类号： A61B5/0091 , A61B5/4312 , G01N21/4795 , A61B5/7257
摘要： A method of forming 2 dimensional image of a translucent object in or behind a turbid medium. In one embodiment, the method comprises the steps of illuminating the translucent object through one side of the turbid medium with an ultrafast pulse of light, the light emergent from the opposite side of the turbid medium consisting of a ballistic component, a snake-like component and a diffuse component. The emergent light is then temporally and spatially gated to preferentially pass the ballistic component and the snake-like component. Preferably, the temporal and spatial gating is achieved by positioning the Kerr cell of an optical Kerr gate at the 2F spectral plane of a 4F Kerr-Fourier imaging system. At the appropriate time, that portion of the Kerr cell located at the focal point of the 2F spectral plane is gated open, allowing predominantly ballistic and snake-like components of the transilluminated light to pass therethrough. A cooled CCD detector is positioned at the 4F spectral plane to form a 2-dimensional image of the temporally and spatially gated light.
摘要翻译：在混浊介质中或其后形成半透明物体的二维图像的方法。在一个实施例中，该方法包括如下步骤：以超快脉冲光照射半透明物体的一侧，该光从混浊介质的相反侧出射，该混浊介质由弹道组件，蛇状部件和漫射分量。射出的光然后被时间和空间门控以优先通过弹道组件和蛇状部件。优选地，时间和空间门控通过将光学克尔门的克尔单元定位在4F克尔傅立叶成像系统的2F频谱平面来实现。在适当的时间，位于2F光谱平面的焦点处的克尔单元的该部分是开门的，允许透射的光的主要弹道和蛇状部件通过。冷却的CCD检测器位于4F光谱平面处，以形成时间和空间门控光的二维图像。

8. 发明授权

US5636050A Apparatus using optical deflection 失效
标题翻译：使用光学偏转的装置
公开(公告)号：US5636050A
公开(公告)日：1997-06-03
申请号：US186265
申请日：1994-02-15
申请人： Robert R. Alfano , Ping-Pei Ho , Lina Yang , Quan Z. Wang
发明人： Robert R. Alfano , Ping-Pei Ho , Lina Yang , Quan Z. Wang
IPC分类号： G01J11/00 , G02B26/00
CPC分类号： G01J11/00
摘要： An optical streak camera includes an optical collimator, an all optical deflector, a detector and a display.
摘要翻译：光学条纹照相机包括光学准直仪，全光学偏转器，检测器和显示器。

9. 发明授权

US06631289B2 System and method of fluorescence spectroscopic imaging for characterization and monitoring of tissue damage 失效
公开(公告)号：US06631289B2
公开(公告)日：2003-10-07
申请号：US09767125
申请日：2001-01-22
申请人： Robert R. Alfano , Jing Tang , Ping Pei Ho
发明人： Robert R. Alfano , Jing Tang , Ping Pei Ho
IPC分类号： A61B600
CPC分类号： G01N21/6486 , A61B5/0059 , A61B5/445 , A61B5/4523 , G01N21/6428 , G01N21/6456
摘要： A method for monitoring a biological tissue includes illuminating the tissue, including a fluorophore, with a wavelength of light, the wavelength selected for exciting the fluorophore, determining a fluorescent emission of the fluorophore, the emission indicating the presence of the fluorophore, and correlating an emission of the fluorophore to an extent and degree of damage to the tissue. Damage to the tissue includes a breakdown of the fluorophore, resulting in a reduced level of emission. The fluorophore can include one of collagen and elastin. The fluorophore can include tryptophan, nicotinamide adenine dinucleotide, flavin and porphyrin. Correlating the emission of the fluorophore to the extent and degree of damage further includes processing a correlation of the emission over time, controlling the power of a laser welder based on the processed correlation, and preventing overheating of the tissue by the laser welder.

10. 发明授权

US06495833B1 Sub-surface imaging under paints and coatings using early light spectroscopy 失效
标题翻译：使用早期光谱的涂料和涂料下的表面成像
公开(公告)号：US06495833B1
公开(公告)日：2002-12-17
申请号：US09598705
申请日：2000-06-21
申请人： Robert R. Alfano , Ping-Pei Ho
发明人： Robert R. Alfano , Ping-Pei Ho
IPC分类号： G01N2188
CPC分类号： G01N21/4795 , G01N21/359 , G01N21/8422
摘要： A system for non-destructively imaging surfaces through a coating, in accordance with the present invention, includes a near-infrared (NIR) light source for illuminating a coated surface. A detector is positioned in an operative relationship with the NIR light source to receive light backscattered from the coated surface and from the coating. A gating device is positioned in an operative relationship with the detector to selectively permit light to pass to the detector to measure optical characteristics of the backscattered light such that determinations of a state of a surface below the coating is determined based on the optical characteristics of the backscattered light. Methods for performing the non-destructive imaging of the present invention are also disclosed.
摘要翻译：根据本发明的用于通过涂层非破坏性地成像表面的系统包括用于照射涂覆表面的近红外（NIR）光源。检测器与NIR光源处于可操作的关系中，以接收从涂覆表面和涂层反射的光。选通装置与检测器处于可操作的关系中，以选择性地允许光通过检测器以测量背向散射光的光学特性，使得基于涂层的光学特性确定涂层下面的表面状态的确定背散射光。还公开了用于执行本发明的非破坏性成像的方法。

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