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1. 发明授权

US5467767A Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy 失效
标题翻译：使用时间分辨荧光光谱法确定组织是否恶性的方法与非恶性肿瘤相反
公开(公告)号：US5467767A
公开(公告)日：1995-11-21
申请号：US112291
申请日：1993-08-27
申请人： Robert R. Alfano , Asima Pradhan , Guichen C. Tang , Leming Wang , Yury Budansky , Bidyut B. Das
发明人： Robert R. Alfano , Asima Pradhan , Guichen C. Tang , Leming Wang , Yury Budansky , Bidyut B. Das
IPC分类号： A61B5/00 , B23K26/06 , G01N21/64 , A61B6/00
CPC分类号： G01N21/6408 , A61B5/0071 , A61B5/0084 , A61B5/0091 , A61B5/4312 , B23K26/0624 , G01N21/6486 , A61B5/0075 , A61B5/0086 , G01N2021/6417
摘要： A method for determining if tissue is malignant as opposed to non-malignant (i.e., benign tumor tissue, benign tissue, or normal tissue). In one embodiment, the method comprises irradiating a human breast tissue sample with light at a wavelength of about 310 nm and measuring the time-resolved fluorescence emitted therefrom at about 340 nm. The time-resolved fluorescence profile is then compared to similar profiles obtained from known malignant and non-malignant human breast tissues. By fitting the profiles to the formula I(t)=A.sub.1 e.sup.(-t/.tau. 1.sup.) +A.sub.2 e.sup.(-t/.tau. 2.sup.), one can quantify the differences between tissues of various conditions. For example, non-malignant human breast tissues exhibit a slow component (.tau..sub.2) which is less than 1.6 ns whereas malignant human breast tissues exhibit a slow component (.tau..sub.2) which is greater than 1.6 ns. In addition, non-malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is greater than 0.85 whereas malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is less than 0.6. This technique can be used with different excitation and/or emission wavelengths, and can be applied to the detection of malignancies (or other abnormal states) in tissues other than human breast tissue.
摘要翻译：与非恶性（即良性肿瘤组织，良性组织或正常组织）相反，确定组织是否为恶性的方法。在一个实施方案中，该方法包括用约310nm波长的光照射人乳房组织样品，并测量在约340nm发射的时间分辨荧光。然后将时间分辨的荧光图谱与从已知的恶性和非恶性人乳腺组织获得的相似特征进行比较。通过拟合公式I（t）= A1e（-t / tau1）+ A2e（-t / tau2），可以量化各种条件的组织之间的差异。例如，非恶性人乳腺组织表现出小于1.6ns的缓慢成分（tau 2），而恶性人乳腺组织表现出大于1.6ns的缓慢成分（tau 2）。此外，非恶性人乳腺组织表现出快于慢振幅（A1 / A2）的比值大于0.85，而恶性人乳腺组织表现出快于慢振幅（A1 / A2）的比值小于0.6 。该技术可以用于不同的激发和/或发射波长，并且可以应用于除人乳腺组织以外的组织中的恶性肿瘤（或其他异常状态）的检测。

2. 发明授权

US5348018A Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy 失效
标题翻译：使用时间分辨荧光光谱法确定组织是否恶性的方法与非恶性肿瘤相反
公开(公告)号：US5348018A
公开(公告)日：1994-09-20
申请号：US797723
申请日：1991-11-25
申请人： Robert R. Alfano , Asima Pradhan , Guichen C. Tang , Leming Wang , Yury Budansky , Bidyut Baran Das
发明人： Robert R. Alfano , Asima Pradhan , Guichen C. Tang , Leming Wang , Yury Budansky , Bidyut Baran Das
IPC分类号： A61B5/00 , B23K26/06 , G01N21/64 , A61B6/00
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0084 , A61B5/0091 , A61B5/4312 , B23K26/0624 , G01N21/6408 , A61B5/0075 , A61B5/0086 , G01N2021/6417
摘要： A method for determining if tissue is malignant as opposed to non-malignant (i.e., benign tumor tissue, benign tissue, or normal tissue), In one embodiment, the method comprises irradiating a human breast tissue sample with light at a wavelength of about 310 nm and measuring the time-resolved fluorescence emitted therefrom at about 340 nm. The time-resolved fluorescence profile is then compared to similar profiles obtained from known malignant and non-malignant human breast tissues. By fitting the profiles to the formula I(t)=A.sub.1 e(-t/.tau..sub.1)+A.sub.2 e(-t/.tau..sub.2) one can quantify the differences between tissues of various conditions. For example, non-malignant human breast tissues exhibit a slow component (.tau..sub.2) which is less than 1.6 ns whereas malignant human breast tissues exhibit a slow component (.tau..sub.2) which is greater than 1.6 ns. In addition, non-malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is greater than 0.85 whereas malignant human breast tissues exhibit a ratio of fast to slow amplitudes (A.sub.1 /A.sub.2) which is less than 0.6. This technique can be used with different excitation and/or emission wavelengths, and can be applied to the detection of malignancies (or other abnormal states) in tissues other than human breast tissue.
摘要翻译：与非恶性（即，良性肿瘤组织，良性组织或正常组织）相反，用于确定组织是否为恶性的方法。在一个实施方案中，该方法包括用约310的波长的光照射人乳房组织样品并测量在约340nm处从其发射的时间分辨荧光。然后将时间分辨的荧光图谱与从已知的恶性和非恶性人乳腺组织获得的相似特征进行比较。通过拟合公式I（t）= A1e（-t / tau1）+ A2e（-t / tau2），可以量化各种条件的组织之间的差异。例如，非恶性人乳腺组织表现出小于1.6ns的缓慢成分（tau 2），而恶性人乳腺组织表现出大于1.6ns的缓慢成分（tau 2）。此外，非恶性人乳腺组织表现出快于慢振幅（A1 / A2）的比值大于0.85，而恶性人乳腺组织表现出快于慢振幅（A1 / A2）的比值小于0.6 。该技术可以用于不同的激发和/或发射波长，并且可以应用于除人乳腺组织以外的组织中的恶性肿瘤（或其他异常状态）的检测。

3. 发明授权

US5849595A Method for monitoring the effects of chemotherapeutic agents on neoplasmic media 失效
标题翻译：监测化疗药物对肿瘤细胞的影响的方法
公开(公告)号：US5849595A
公开(公告)日：1998-12-15
申请号：US537591
申请日：1995-10-02
申请人： Robert R. Alfano , Guichen C. Tang , Stimson P. Schantz
发明人： Robert R. Alfano , Guichen C. Tang , Stimson P. Schantz
IPC分类号： A61B5/00 , G01N21/64 , G01N21/00
CPC分类号： A61B5/6848 , A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/415 , A61B5/418 , G01N21/6428 , Y10S426/805 , Y10S426/811
摘要： A method for monitoring the effects of a chemotherapeutic agent on a neoplasm medium. The method is premised on the discovery that chemotherapeutic agent, such as retinoic acid, affects the fluorescence spectroscopy of neoplasmic media and that such differences can be monitored, for example, by comparing the spectral profiles, spectral peaks, and spectral bandwidths of fluorescence at various wavelengths of the medium before and after administration of the chemotherapeutic agent. Differences in the excitation spectroscopy of the medium can also be used to monitor the effects of the agent.
摘要翻译：用于监测化疗剂对肿瘤介质的影响的方法。该方法的前提是化学治疗剂（例如视黄酸）影响肿瘤荧光光谱的发现，并且可以例如通过比较各种荧光的光谱分布，光谱峰值和光谱带宽来监测这些差异施用化疗剂前后培养基的波长。培养基的激发光谱的差异也可用于监测药剂的作用。

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