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    • 2. 发明申请
    • Adaptive command filtering for servomechanism control systems
    • 伺服机构控制系统的自适应命令过滤
    • US20050285558A1
    • 2005-12-29
    • US11129059
    • 2005-05-12
    • David WattMehmet AlpayMark UnrathJohn WenBen Potsaid
    • David WattMehmet AlpayMark UnrathJohn WenBen Potsaid
    • G05B13/04G05D23/275
    • G05B13/041
    • Preferred embodiments of the invention implement techniques for modifying the command trajectory, the architecture of a servomechanism control system, or both, to reduce the servo error during and/or after the command trajectory. An iterative refinement procedure generates for use by the servomechanism control system a corrective input, du, which significantly reduces the error between the desired and actual servomechanism control system outputs. In one embodiment, a uniquely identified plant model is employed in the iterative refinement procedure to compute an approximate gradient that improves the performance and reliability of the refinement procedure. In another embodiment, the actual plant response is used in place of the identified model in the iterative refinement procedure. This is accomplished by time-reversing the stored error signal from a training run, before applying it to the plant to generate an update to the corrective input signal du.
    • 本发明的优选实施例实现了用于修改命令轨迹,伺服机构控制系统的结构或两者的技术,以减少在命令轨迹期间和/或之后的伺服误差。 对伺服机构控制系统产生的迭代精制过程可用于校正输入du,这显着地减少了期望的和实际的伺服机构控制系统输出之间的误差。 在一个实施例中,在迭代细化过程中采用唯一识别的植物模型来计算提高细化过程的性能和可靠性的近似梯度。 在另一个实施例中,在迭代细化过程中使用实际植物响应来代替所识别的模型。 这是通过将训练运行中存储的误差信号时间反转,然后将其应用到工厂来产生对纠正输入信号du的更新来实现的。
    • 3. 发明授权
    • Adaptive command filtering for servomechanism control systems
    • 伺服机构控制系统的自适应命令过滤
    • US07345448B2
    • 2008-03-18
    • US11129059
    • 2005-05-12
    • David WattMehmet AlpayMark UnrathJohn WenBen Potsaid
    • David WattMehmet AlpayMark UnrathJohn WenBen Potsaid
    • G05B13/02
    • G05B13/041
    • Preferred embodiments of the invention implement techniques for modifying the command trajectory, the architecture of a servomechanism control system, or both, to reduce the servo error during and/or after the command trajectory. An iterative refinement procedure generates for use by the servomechanism control system a corrective input, du, which significantly reduces the error between the desired and actual servomechanism control system outputs. In one embodiment, a uniquely identified plant model is employed in the iterative refinement procedure to compute an approximate gradient that improves the performance and reliability of the refinement procedure. In another embodiment, the actual plant response is used in place of the identified model in the iterative refinement procedure. This is accomplished by time-reversing the stored error signal from a training run, before applying it to the plant to generate an update to the corrective input signal du.
    • 本发明的优选实施例实现了用于修改命令轨迹,伺服机构控制系统的结构或两者的技术,以减少在命令轨迹期间和/或之后的伺服误差。 对伺服机构控制系统产生的迭代精制过程可用于校正输入du,这显着地减少了期望的和实际的伺服机构控制系统输出之间的误差。 在一个实施例中,在迭代细化过程中采用唯一识别的植物模型来计算提高细化过程的性能和可靠性的近似梯度。 在另一个实施例中,在迭代细化过程中使用实际植物响应来代替所识别的模型。 这是通过将训练运行中存储的误差信号时间反转,然后将其应用到工厂来产生对纠正输入信号du的更新来实现的。
    • 6. 发明申请
    • Hydroxypropyl Substitution Used to Regulate Dissolution of a Chemical
    • 用于调节化学溶解度的羟丙基取代基
    • US20100215744A1
    • 2010-08-26
    • US12756962
    • 2010-04-08
    • David WattSteven B. Newhard
    • David WattSteven B. Newhard
    • A61K9/22A61K31/65A61P43/00
    • A61K31/65A61K9/2054
    • A method of producing a batch of a tetracycline-class component HPMC extended release pharmaceutical product having a desired dissolution profile, comprising: selecting a dissolution rate-controlling polymer comprising an HPMC component, the HPMC component having a selected % HP value; validating that the % HP in the selected HPMC component is such that a mean sample of the product complies with the desired dissolution profile over each time point in the dissolution profile, and preparing the product by preparing a formulation comprising a pharmaceutically effective amount of the tetracycline-class chemical and the selected HPMC component with the % HP value. There is also provided a method of predicting the dissolution rate profile over a number of dosage forms.
    • 一种生产具有所需溶出曲线的四环素类组分HPMC缓释药物产品的批次的方法,包括:选择包含HPMC组分的所述溶出速率控制聚合物,所述HPMC组分具有选定的HP值; 验证所选HPMC组分中的%HP是否使得产物的平均样品在溶出曲线中的每个时间点符合期望的溶出曲线,并且通过制备包含药学有效量的四环素的制剂来制备产品 - 化学品和所选HPMC组分,具有%HP值。 还提供了一种在许多剂型上预测溶出速率谱的方法。