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1. 发明授权

US06074846A Hepatitis C virus asialoglycoproteins 失效
公开(公告)号：US06074846A
公开(公告)日：2000-06-13
申请号：US442805
申请日：1995-05-17
申请人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Oui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Oui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： G01N33/576 , A61K35/16 , A61K38/00 , A61K38/10 , A61K39/00 , A61K39/29 , A61P1/16 , A61P31/12 , C07K14/18 , C12N1/19 , C12N5/10 , C12N15/09 , C12N15/51 , C12P21/02 , C12P21/04 , C07K1/00 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.

2. 发明申请

US20080318275A1 Hepatitis C virus asialoglycoproteins 审中-公开
标题翻译：丙型肝炎病毒脱唾液酸糖蛋白
公开(公告)号：US20080318275A1
公开(公告)日：2008-12-25
申请号：US12077147
申请日：2008-03-17
申请人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： C12P21/04
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
摘要翻译：两种丙型肝炎病毒包膜蛋白（E1和E2）不表达唾液酸化。这些蛋白质在低等真核生物或其末端糖基化被阻断的哺乳动物细胞中的重组表达导致与天然HCV糖蛋白更相似的重组蛋白质。当通过GNA凝集素亲和力分离时，E1和E2蛋白聚集成病毒样颗粒。

3. 发明授权

US07105303B2 Antibodies to hepatitis C virus asialoglycoproteins 失效
标题翻译：丙型肝炎病毒脱唾液酸糖蛋白抗体
公开(公告)号：US07105303B2
公开(公告)日：2006-09-12
申请号：US09929782
申请日：2001-08-13
申请人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： G01N33/53
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
摘要翻译：两种丙型肝炎病毒包膜蛋白（E1和E2）不表达唾液酸化。这些蛋白质在低等真核生物或其末端糖基化被阻断的哺乳动物细胞中的重组表达导致与天然HCV糖蛋白更相似的重组蛋白质。当通过GNA凝集素亲和力分离时，E1和E2蛋白聚集成病毒样颗粒。

4. 发明授权

US5942234A Hepatitis C virus asialoglycoproteins 失效
公开(公告)号：US5942234A
公开(公告)日：1999-08-24
申请号：US443260
申请日：1995-05-17
申请人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： G01N33/576 , A61K35/16 , A61K38/00 , A61K38/10 , A61K39/00 , A61K39/29 , A61P1/16 , A61P31/12 , C07K14/18 , C12N1/19 , C12N5/10 , C12N15/09 , C12N15/51 , C12P21/02 , C12P21/04 , C07K1/00 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.

5. 发明授权

US06274148B1 Hepatitis C virus asialoglycoproteins 失效
标题翻译：丙型肝炎病毒脱唾液酸糖蛋白
公开(公告)号：US06274148B1
公开(公告)日：2001-08-14
申请号：US08249843
申请日：1994-05-26
申请人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： A61K3929
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
摘要翻译：两种丙型肝炎病毒包膜蛋白（E1和E2）不表达唾液酸化。这些蛋白质在低等真核生物或其末端糖基化被阻断的哺乳动物细胞中的重组表达导致与天然HCV糖蛋白更相似的重组蛋白质。当通过GNA凝集素亲和力分离时，E1和E2蛋白聚集成病毒样颗粒。

6. 发明授权

US6074852A Hepatitis C virus asialoglycoproteins 失效
公开(公告)号：US6074852A
公开(公告)日：2000-06-13
申请号：US443900
申请日：1995-05-17
申请人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： G01N33/576 , A61K35/16 , A61K38/00 , A61K38/10 , A61K39/00 , A61K39/29 , A61P1/16 , A61P31/12 , C07K14/18 , C12N1/19 , C12N5/10 , C12N15/09 , C12N15/51 , C12P21/02 , C12P21/04 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.

7. 发明申请

US20050089843A1 Antibodies to hepatitis C virus asialoglycoproteins 审中-公开
标题翻译：丙型肝炎病毒脱唾液酸糖蛋白抗体
公开(公告)号：US20050089843A1
公开(公告)日：2005-04-28
申请号：US10964054
申请日：2004-10-12
申请人： Robert Ralston , Frank Marcus , Kent Thudium , Barbara Gervase , John Hall , Kim Berger , Qui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert Ralston , Frank Marcus , Kent Thudium , Barbara Gervase , John Hall , Kim Berger , Qui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： G01N33/576 , A61K35/16 , A61K38/00 , A61K38/10 , A61K39/00 , A61K39/29 , A61P1/16 , A61P31/12 , C07K14/18 , C12N1/19 , C12N5/10 , C12N15/09 , C12N15/51 , C12P21/02 , C12P21/04 , C12Q1/70 , C07H21/04 , C07K14/02 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
摘要翻译：两种丙型肝炎病毒包膜蛋白（E1和E2）不表达唾液酸化。这些蛋白质在低等真核生物或其末端糖基化被阻断的哺乳动物细胞中的重组表达导致与天然HCV糖蛋白更相似的重组蛋白质。当通过GNA凝集素亲和力分离时，E1和E2蛋白聚集成病毒样颗粒。

8. 发明授权

US08949063B2 Testing framework for control devices 有权
标题翻译：控制设备的测试框架
公开(公告)号：US08949063B2
公开(公告)日：2015-02-03
申请号：US13620532
申请日：2012-09-14
申请人： Nathan John Walter Kube , Frank Marcus
发明人： Nathan John Walter Kube , Frank Marcus
IPC分类号： G05B23/00 , G05B23/02 , G06F11/263 , G06F11/36
CPC分类号： G06F11/263 , G05B19/058 , G05B23/0256 , G06F11/273 , G06F11/277 , G06F11/3684
摘要： The present disclosure generally relates to the automated testing of a system that includes software or hardware components. In some embodiments, a testing framework generates a set of test cases for a system under test using a grammar. Each test case may perform an action, such as provide an input to the system under test, and result in an output from the system under test. The inputs and outputs are then compared to the expected results to determine whether the system under test is performing correctly. Specifically, the system under test may be analyzed to determine whether it is capable of properly processing control instructions and input signals and/or generating expected output control signals and additional control/feedback information. The data can then be interpreted in the grammar system and/or used as input to a fault isolation engine to determine anomalies in the system under test.
摘要翻译：本公开通常涉及包括软件或硬件组件的系统的自动化测试。在一些实施例中，测试框架使用语法为被测系统生成一组测试用例。每个测试用例可以执行一个操作，例如向被测系统提供输入，并产生被测系统的输出。然后将输入和输出与预期结果进行比较，以确定被测系统是否正确执行。具体地，可以分析被测系统以确定其是否能够适当地处理控制指令和输入信号和/或产生期望的输出控制信号和附加的控制/反馈信息。然后可以在语法系统中解释数据和/或用作故障隔离引擎的输入，以确定被测系统中的异常。

9. 发明申请

US20120173931A1 TESTING AND MITIGATION FRAMEWORK FOR NETWORKED DEVICES 有权
标题翻译：网络设备的测试和缓解框架
公开(公告)号：US20120173931A1
公开(公告)日：2012-07-05
申请号：US13198663
申请日：2011-08-04
申请人： Nathan John Walter Kube , Daniel MaIcolm Hoffman , Frank Marcus
发明人： Nathan John Walter Kube , Daniel MaIcolm Hoffman , Frank Marcus
IPC分类号： G06F11/28
CPC分类号： G06F11/3409 , G01R31/3181 , G05B23/0256 , G06F11/2252 , G06F11/263 , G06F11/27 , G06F11/2733 , G06F11/277 , G06F11/30 , G06F11/3006 , G06F11/3447 , G06F11/36 , G06F11/3684 , G06F17/40
摘要： The present disclosure generally relates to the automated testing of a system that includes software or hardware components. In some embodiments, a testing framework generates a set of test cases for a system under test using a grammar. Each test case may perform an action, such as provide an input to the system under test, and result in an output from the system under test. The inputs and outputs are then compared to the expected results to determine whether the system under test is performing correctly. The data can then be interpreted in the grammar system or used as input to a fault isolation engine to determine anomalies in the system under test. Based on identified faults, one or more mitigation techniques may be implemented in an automated fashion.
摘要翻译：本公开通常涉及包括软件或硬件组件的系统的自动化测试。在一些实施例中，测试框架使用语法为被测系统生成一组测试用例。每个测试用例可以执行一个操作，例如向被测系统提供输入，并产生被测系统的输出。然后将输入和输出与预期结果进行比较，以确定被测系统是否正确执行。然后可以在语法系统中解释数据，或将其用作故障隔离引擎的输入，以确定被测系统中的异常。基于所识别的故障，可以以自动方式实现一个或多个缓解技术。

10. 发明申请

US20060231156A1 Apparatus and method for exposing a container to a controlled environment 有权
标题翻译：将容器暴露于受控环境的装置和方法
公开(公告)号：US20060231156A1
公开(公告)日：2006-10-19
申请号：US11405227
申请日：2006-04-17
申请人： Frank Marcus , James Sanfilippo , John Sanfilippo
发明人： Frank Marcus , James Sanfilippo , John Sanfilippo
IPC分类号： B65B31/00
CPC分类号： B65B31/041
摘要： An apparatus and method for exposing a container to a controlled environment. The apparatus includes an elongated rail with first, second, and third manifolds positioned in substantial alignment with the container. The first, second, and third manifolds are adapted for providing flow of a gas therethrough. At least one gas flow regulator is operably attached to the first, second, and third manifolds. At least one nozzle is positioned adjacent the second manifold. The at least one nozzle is adapted for providing a composite gas stream exiting through the second manifold. The method includes providing an elongated rail with first, second, and third manifolds positioned in substantial alignment with the container. A flow of a gas is regulated through the first, second, and third manifolds. A composite gas stream is provided exiting through the second manifold.
摘要翻译：一种用于将容器暴露于受控环境的装置和方法。该装置包括细长轨道，其中第一，第二和第三歧管被定位成与容器基本对齐。第一，第二和第三歧管适于提供气体通过其中的流动。至少一个气体流量调节器可操作地附接到第一，第二和第三歧管。至少一个喷嘴邻近第二歧管定位。所述至少一个喷嘴适于提供离开所述第二歧管的复合气流。该方法包括提供细长轨道，其具有与容器基本对准的第一，第二和第三歧管。通过第一，第二和第三歧管来调节气体的流动。提供离开第二歧管的复合气流。

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