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1. 发明授权

US5593998A 2,4-diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides 失效
标题翻译： 2,4-二氨基-5,6-二取代 - 和5,6,7-三取代-5-脱氮啶啶类作为杀虫剂
公开(公告)号：US5593998A
公开(公告)日：1997-01-14
申请号：US647550
申请日：1996-05-15
申请人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Munirathnam K. Chaguturu , Partha S. Ray , Brian D. Bennett
发明人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Munirathnam K. Chaguturu , Partha S. Ray , Brian D. Bennett
IPC分类号： C07D487/04 , A01N43/54 , A61K31/535
CPC分类号： C07D487/04
摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 5-deazapteridine compound of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, U, V, and W are as defined herein; agriculturally acceptable salts thereof; methods for using the same; and certain novel 5-deazapteridine per se.
摘要翻译：一种杀虫组合物，其包含与农业上可接受的载体的混合物，杀虫有效量的下式的5-去氮萘啶化合物：其中R1，R2，R3，R4，U，V和W为本文定义; 农业上可接受的盐; 使用方法; 和某些新的5-脱氮啶本身。

2. 发明授权

US5547954A 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides 失效
标题翻译： 2,4-二氨基-5,6-二取代 - 和5,6,7-三取代-5-脱氮啶二酸作为杀虫剂
公开(公告)号：US5547954A
公开(公告)日：1996-08-20
申请号：US249586
申请日：1994-05-26
申请人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Munirathnam K. Chaguturu , Partha S. Ray , Brian D. Bennett
发明人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Munirathnam K. Chaguturu , Partha S. Ray , Brian D. Bennett
IPC分类号： C07D487/04 , A01N43/54
CPC分类号： C07D487/04
摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 5-deazapteridine compound of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, U, V, and W are as defined herein; agriculturally acceptable salts thereof; methods for using the same; and certain novel 5-deazapteridine per se.
摘要翻译：一种杀虫组合物，其包含与农业上可接受的载体的混合物，杀虫有效量的下式的5-去氮萘啶化合物：其中R1，R2，R3，R4，U，V和W为本文定义; 农业上可接受的盐; 使用方法; 和某些新的5-脱氮啶本身。

3. 发明授权

US5532370A 2,4-diamino-5,6-disubstituted- and 5,6,7-trisubstituted 5-deazapteridines as insecticides 失效
标题翻译： 2,4-二氨基-5,6-二取代 - 和5,6,7-三取代的5-取代二甲基吡啶作为杀虫剂
公开(公告)号：US5532370A
公开(公告)日：1996-07-02
申请号：US425524
申请日：1995-04-20
申请人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Munirathnam K. Chaguturu , Partha S. Ray , Brian D. Bennett
发明人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Munirathnam K. Chaguturu , Partha S. Ray , Brian D. Bennett
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 5-deazapteridine compound of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, U, V, and W are as defined herein; agriculturally acceptable salts thereof; methods for using the same; and certain novel 5-deazapteridines per se.
摘要翻译：一种杀虫组合物，其包含与农业上可接受的载体的混合物，杀虫有效量的下式的5-去氮萘啶化合物：其中R1，R2，R3，R4，U，V和W为本文定义; 农业上可接受的盐; 使用方法; 和某些新的5-脱氮二苯胺本身。

4. 发明授权

US5521192A Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives 失效
标题翻译：杀虫剂5-取代-2,4-二氨基嘧啶衍生物
公开(公告)号：US5521192A
公开(公告)日：1996-05-28
申请号：US237481
申请日：1994-05-03
申请人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Albert C. Lew , Munirathnam K. Chaguturu , Partha S. Ray , Walter H. Yeager
发明人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Albert C. Lew , Munirathnam K. Chaguturu , Partha S. Ray , Walter H. Yeager
IPC分类号： A01N43/54 , A01N43/78 , A01N43/84 , A01N47/18 , A01N47/20 , A01N55/00 , C07D239/00 , C07D401/00 , C07D409/00 , C07D413/00 , C07F7/08
CPC分类号： C07F7/0812 , A01N43/54 , A01N43/84 , A01N47/18 , A01N47/20 , A01N55/00
摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a compound of the formula: ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.7, R.sup.8, m, n, and p are as defined herein, and agriculturally acceptable salts thereof, and methods of using the same.
摘要翻译：一种杀虫组合物，其包含与农业上可接受的载体的混合物，杀虫有效量的下式化合物：其中R，R 1，R 2，R 3，R 7，R 8，m，n和p为如本文所定义，及其农业上可接受的盐，及其使用方法。

5. 发明授权

US5534518A Insecticidal substituted-2,4-diaminoquinazolines 失效
公开(公告)号：US5534518A
公开(公告)日：1996-07-09
申请号：US267340
申请日：1994-06-28
申请人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Albert C. Lew , Munirathnam K. Chaguturu , Partha S. Ray , Walter H. Yeager , Ian R. Silverman , John W. Buser , James J. Fiordeliso , John A. Dixson
发明人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Albert C. Lew , Munirathnam K. Chaguturu , Partha S. Ray , Walter H. Yeager , Ian R. Silverman , John W. Buser , James J. Fiordeliso , John A. Dixson
IPC分类号： A01N43/54 , A01N55/00 , C07D239/95 , C07D401/12 , C07D405/04 , C07D409/04 , A61K31/505
CPC分类号： C07D401/12 , A01N43/54 , A01N55/00 , C07D239/95 , C07D405/04 , C07D409/04
摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 2,4-diaminoquinazoline compound of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.6, R.sup.7, W, X, Y, and Z are as defined herein; methods of using the same; novel 2,4-diaminoquinazolines per se; and intermediates in the preparation thereof.

6. 发明授权

US5587379A Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives 失效
公开(公告)号：US5587379A
公开(公告)日：1996-12-24
申请号：US446354
申请日：1995-05-22
申请人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Albert C. Lew , Munirathnam K. Chaguturu , Partha S. Ray , Walter H. Yeager
发明人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Albert C. Lew , Munirathnam K. Chaguturu , Partha S. Ray , Walter H. Yeager
IPC分类号： A01N43/54 , A01N43/78 , A01N43/84 , A01N47/18 , A01N47/20 , A01N55/00 , C07D239/00 , C07D401/00 , C07D409/00 , C07D413/00 , C07F7/08
CPC分类号： C07F7/0812 , A01N43/54 , A01N43/84 , A01N47/18 , A01N47/20 , A01N55/00
摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a compound of the formula: ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.7, R.sup.8, m, n, and p are as defined herein, and agriculturally acceptable salts thereof, and methods of using the same.

7. 发明授权

US5627189A Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives 失效
标题翻译：杀虫剂5-取代-2,4-二氨基嘧啶衍生物
公开(公告)号：US5627189A
公开(公告)日：1997-05-06
申请号：US555249
申请日：1995-11-08
申请人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Albert C. Lew , Munirathnam K. Chaguturu , Partha S. Ray , Walter H. Yeager
发明人： Robert N. Henrie, II , Clinton J. Peake , Thomas G. Cullen , Albert C. Lew , Munirathnam K. Chaguturu , Partha S. Ray , Walter H. Yeager
IPC分类号： A01N43/54 , A01N43/78 , A01N43/84 , A01N47/18 , A01N47/20 , A01N55/00 , C07D239/00 , C07D401/00 , C07D409/00 , C07D413/00 , C07F7/08 , A61K31/535
CPC分类号： C07F7/0812 , A01N43/54 , A01N43/84 , A01N47/18 , A01N47/20 , A01N55/00
摘要： An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a compound of the formula: ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.7, R.sup.8, m, n, and p are as defined herein, and agriculturally acceptable salts thereof, and methods of using the same.
摘要翻译：一种杀虫组合物，其包含与农业上可接受的载体的混合物，杀虫有效量的下式化合物：其中R，R 1，R 2，R 3，R 7，R 8，m，n和p为如本文所定义，及其农业上可接受的盐，及其使用方法。

8. 发明申请

US20220356451A1 METHODS TO REPROGRAM SOMATIC CELLS TO ALTERNATIVE CELL FATES OR PRIMITIVE CELL STATES 有权
公开(公告)号：US20220356451A1
公开(公告)日：2022-11-10
申请号：US17597776
申请日：2020-07-23
申请人： Tania Ray , Partha S. Ray
发明人： Tania Ray , Partha S. Ray
IPC分类号： C12N5/077 , C12N15/113
摘要： Induced overexpression of defined exogenous transcription factors (TFs), or alternatively treatment with specific pathway modulatory cocktails, can reprogram somatic cells to pluripotency or alternate cell states. A barrier to initiating reprogramming lies in the starting cell's molecular identity, enforced by lineage-instructive TFs. However, it remained unclear whether repression of such somatic lineage-defining TFs of the starting cell in the absence of exogenous TFs is sufficient to induce cell reprogramming Using an intra-species somatic cell hybrid model, SNAI2 and PRRX1 were identified as the most critical determinants of mesenchymal commitment in rat embryonic fibroblasts (REFs) and demonstrate that siRNA-mediated transient knockdown of these individual factors is adequate to convert REFs into functional adipocytes, chondrocytes or osteocytes without requiring the provision of exogenous TFs. Additionally, it was shown that siRNA-mediated transient knockdown of SNAI2 alone, in the absence of exogenous TFs, is sufficient to transform REFs to a dedifferentiated pluripotent stem-like cell (dPSC) state that forms embryoid bodies and is capable of triple germ layer differentiation. These results establish for the first time that transient repression of a single somatic lineage-defining TF can effectively induce transdifferentiation to alternative somatic cell states or dedifferentiation to dPSCs in the absence of exogenous TFs or small molecule cocktails.

9. 发明申请

US20110150979A1 METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT OF PRIMARY AND METASTATIC BASAL-LIKE BREAST CANCER AND OTHER CANCER TYPES 审中-公开
标题翻译：原发性和基础型乳腺癌和其他癌症类型的诊断，预防和治疗方法
公开(公告)号：US20110150979A1
公开(公告)日：2011-06-23
申请号：US12852453
申请日：2010-08-07
申请人： Partha S. Ray , Sanjay Bagaria , Xiaojiang Cui , Jinhua Wang
发明人： Partha S. Ray , Sanjay Bagaria , Xiaojiang Cui , Jinhua Wang
IPC分类号： A61K9/127 , C12Q1/68 , A61K31/713 , A61K31/7088 , A61K39/395 , A61K31/138 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q1/6881 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： In one embodiment, a method of theranostic classification of a breast cancer tumor is provided, comprising obtaining a breast cancer tumor sample from a subject, detecting an expression level of FOXC1, comparing the expression level of FOXC1 to a predetermined cutoff level, and classifying the breast cancer tumor sample as belonging to a theranostic basal-like breast cancer tumor subtype or a theranostic hybrid basal-like breast cancer tumor subtype when the expression level of FOXC1 is higher than the predetermined cutoff level. In other embodiments, methods for predicting a prognosis of a basal-like breast cancer and methods of treating a basal-like breast cancer are provided,
摘要翻译：在一个实施方案中，提供了乳腺癌肿瘤的分类分类方法，包括从受试者获得乳腺癌肿瘤样品，检测FOXC1的表达水平，将FOXC1的表达水平与预定的截止水平进行比较，并将当FOXC1的表达水平高于预定的截止水平时，乳腺癌肿瘤样品属于非特异性基底样乳腺癌肿瘤亚型或特异性混合基底样乳腺癌肿瘤亚型。在其他实施方案中，提供了用于预测基底样乳腺癌的预后的方法和治疗基底样乳腺癌的方法，

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