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1. 发明授权

US06833371B2 Pyrazolopyrimidines 失效
标题翻译：吡唑并嘧啶
公开(公告)号：US06833371B2
公开(公告)日：2004-12-21
申请号：US10286687
申请日：2002-11-01
申请人： Robert N. Atkinson , Michael F. Gross , Albert M. van Rhee
发明人： Robert N. Atkinson , Michael F. Gross , Albert M. van Rhee
IPC分类号： A61K31519
CPC分类号： C07D487/04 , A61K31/519
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
摘要翻译：提供的化合物，组合物和方法可用于通过电压依赖性钠通道抑制钠离子通量来治疗疾病。更具体地，本发明提供了可用于治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的吡唑并嘧啶类，组合物和方法，其通过阻断与所述病症的发作或复发有关的钠通道。本发明的化合物，组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。

2. 发明授权

US07098335B2 Pyrazolopyrimidine compositions 失效
标题翻译：吡唑并嘧啶组合物
公开(公告)号：US07098335B2
公开(公告)日：2006-08-29
申请号：US10987089
申请日：2004-11-12
申请人： Robert N. Atkinson , Michael F. Gross , Albert M. van Rhee
发明人： Robert N. Atkinson , Michael F. Gross , Albert M. van Rhee
IPC分类号： C07D487/00 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
摘要翻译：提供的化合物，组合物和方法可用于通过电压依赖性钠通道抑制钠离子通量来治疗疾病。更具体地，本发明提供了可用于治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的吡唑并嘧啶类，组合物和方法，其通过阻断与所述病症的发作或复发有关的钠通道。本发明的化合物，组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。

3. 发明授权

US07132439B2 Bis-benzimidazoles and related compounds as potassium channel modulators 有权
公开(公告)号：US07132439B2
公开(公告)日：2006-11-07
申请号：US10437732
申请日：2003-05-13
申请人： Xiaodong Wang , Alan B. Fulp , Albert M. van Rhee , Kerry L. Spear
发明人： Xiaodong Wang , Alan B. Fulp , Albert M. van Rhee , Kerry L. Spear
IPC分类号： A61K31/4164 , A61K31/421 , C07D235/04 , C07D403/10
CPC分类号： C07D235/20 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/04
摘要： The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.

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