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1. 发明申请

US20100028936A1 DETECTION OF CANCER CELLS IN VITRO USING SIGMA-2 RECEPTOR LIGANDS AS RADIOTRACERS 有权
标题翻译：使用SIGMA-2受体配体作为放射线检测体外检测癌细胞
公开(公告)号：US20100028936A1
公开(公告)日：2010-02-04
申请号：US12550220
申请日：2009-08-28
申请人： Robert Mach , Michael J. Welch , Douglas J. Rowland , Zhude Tu
发明人： Robert Mach , Michael J. Welch , Douglas J. Rowland , Zhude Tu
IPC分类号： C12Q1/02
CPC分类号： C07D295/13 , A61K31/47 , A61K31/495 , A61K51/04 , A61K51/0497 , C07C323/41 , C07D217/04 , C07D257/02
摘要： Methods for detection of cancer cells and for determining the proliferative status of cells in a tissue sample in vitro are disclosed. These methods comprise contacting a tissue sample with a radiolabeled compound or salt thereof of Formula wherein at least one of X, Y, and Z comprises a radioisotope, n is an integer from 2 to about 10; and each of A and A1 is a C1-C4 alkoxyl, a C1-C4 fluoroalkyl or a C1-C4 fluoroalkoxyl. The methods further comprise detecting the distribution of the radioisotope in the tissue sample, whereby a cell having a high density of the radioisotope compared to quiescent cells is diagnostic for a cancer cell.
摘要翻译：公开了用于检测癌细胞并用于测定体外组织样品中细胞增殖状态的方法。这些方法包括使组织样品与其中X，Y和Z中的至少一个包含放射性同位素的放射性标记的化合物或其盐接触，n为2至约10的整数; A和A1各自为C1-C4烷氧基，C1-C4氟烷基或C1-C4氟烷氧基。所述方法还包括检测组织样品中放射性同位素的分布，由此与静止细胞相比具有高密度放射性同位素的细胞是癌细胞的诊断。

2. 发明授权

US07612206B2 Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors 有权
标题翻译：用于成像实体瘤增殖状态的Sigma-2受体放射性示踪剂
公开(公告)号：US07612206B2
公开(公告)日：2009-11-03
申请号：US12044952
申请日：2008-03-08
申请人： Robert Mach , Michael J. Welch , Douglas J. Rowland , Zhude Tu
发明人： Robert Mach , Michael J. Welch , Douglas J. Rowland , Zhude Tu
IPC分类号： C07D491/00 , A61K51/00 , A61M36/14
CPC分类号： C07D295/13 , A61K31/47 , A61K31/495 , A61K51/04 , A61K51/0497 , C07C323/41 , C07D217/04 , C07D257/02
摘要： Novel benzamide compounds of Formula (I), Formula (II), and Formula (III), salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (II) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.
摘要翻译：式（I），式（II）和式（III）的新型苯甲酰胺化合物，其盐，水溶性盐，类似物和放射性标记的对应物作为用于成像实体瘤增殖状态的σ-2受体放射性示踪剂。用于诊断哺乳动物存在哺乳动物肿瘤的方法包括给予哺乳动物诊断成像可检测的有效量的具有式（I），式（II）和式（III）所示结构的苯甲酰胺化合物和检测化合物与哺乳动物肿瘤的结合。一种用于具有细胞表面σ-2受体的哺乳动物组织的诊断成像的方法，包括向哺乳动物施用具有式（I）式（II）和式（III）所示结构的化合物的诊断成像量，并检测图像的具有西格玛-2受体的大量细胞的组织。

3. 发明授权

US07390902B2 Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors 有权
标题翻译：用于成像实体瘤增殖状态的Sigma-2受体放射性示踪剂
公开(公告)号：US07390902B2
公开(公告)日：2008-06-24
申请号：US10903771
申请日：2004-07-30
申请人： Robert H. Mach , Michael J. Welch , Douglas J. Rowland, Jr. , Zhude Tu
发明人： Robert H. Mach , Michael J. Welch , Douglas J. Rowland, Jr. , Zhude Tu
IPC分类号： C07D451/14
CPC分类号： C07D295/13 , A61K31/47 , A61K31/495 , A61K51/04 , A61K51/0497 , C07C323/41 , C07D217/04 , C07D257/02
摘要： Novel benzamide compounds of Formula (I), Formula (II) and Formula (III, salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (II) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.
摘要翻译：式（I），式（II）和式（III）的新型苯甲酰胺化合物，用于成像实体瘤增殖状态的σ-2受体放射性示踪剂的盐，水溶性盐，类似物和放射性标记的对应物。对于哺乳动物肿瘤的存在，其中包括给予哺乳动物诊断成像可检测的有效量的具有式（I），式（II）和式（III）所示结构的苯甲酰胺化合物，并检测该化合物与一种用于具有细胞表面σ-2受体的哺乳动物组织的诊断成像的方法，包括向哺乳动物施用具有式（I）式（II）和式（III）所示结构的化合物的诊断成像量）并用σ-2受体检测具有充足细胞的组织的图像。

4. 发明授权

US07893266B2 Detection of cancer cells in vitro using sigma-2 receptor ligands as radiotracers 有权
标题翻译：使用σ-2受体配体作为放射性示踪剂检测体外癌细胞
公开(公告)号：US07893266B2
公开(公告)日：2011-02-22
申请号：US12550220
申请日：2009-08-28
申请人： Robert H. Mach , Michael J. Welch , Douglas J. Rowland , Zhude Tu
发明人： Robert H. Mach , Michael J. Welch , Douglas J. Rowland , Zhude Tu
IPC分类号： C07D491/00
CPC分类号： C07D295/13 , A61K31/47 , A61K31/495 , A61K51/04 , A61K51/0497 , C07C323/41 , C07D217/04 , C07D257/02
摘要： Methods for detection of cancer cells and for determining the proliferative status of cells in a tissue sample in vitro are disclosed. These methods comprise contacting a tissue sample with a radiolabeled compound or salt thereof of Formula wherein at least one of X, Y, and Z comprises a radioisotope, n is an integer from 2 to about 10; and each of A and A1 is a C1-C4 alkoxyl, a C1-C4 fluoroalkyl or a C1-C4 fluoroalkoxyl. The methods further comprise detecting the distribution of the radioisotope in the tissue sample, whereby a cell having a high density of the radioisotope compared to quiescent cells is diagnostic for a cancer cell.
摘要翻译：公开了用于检测癌细胞并用于测定体外组织样品中细胞增殖状态的方法。这些方法包括使组织样品与其中X，Y和Z中的至少一个包含放射性同位素的放射性标记的化合物或其盐接触，n为2至约10的整数; A和A1各自为C1-C4烷氧基，C1-C4氟烷基或C1-C4氟烷氧基。所述方法还包括检测组织样品中放射性同位素的分布，由此与静止细胞相比具有高密度放射性同位素的细胞是癌细胞的诊断。

5. 发明授权

US08423361B1 Speech-to-text processing based on a time-ordered classification of audio file segments 有权
标题翻译：基于音频文件段的时间排序分类的语音到文本处理
公开(公告)号：US08423361B1
公开(公告)日：2013-04-16
申请号：US13420398
申请日：2012-03-14
申请人： Walter W. Chang , Michael J. Welch
发明人： Walter W. Chang , Michael J. Welch
IPC分类号： G10L15/26
CPC分类号： G10L15/34 , G10L15/26 , G10L15/32 , G10L25/81
摘要： This specification describes technologies relating to multi core processing for parallel speech-to-text processing. In some implementations, a computer-implemented method is provided that includes the actions of receiving an audio file; analyzing the audio file to identify portions of the audio file as corresponding to one or more audio types; generating a time-ordered classification of the identified portions, the time-ordered classification indicating the one or more audio types and position within the audio file of each portion; generating a queue using the time-ordered classification, the queue including a plurality of jobs where each job includes one or more identifiers of a portion of the audio file classified as belonging to the one or more speech types; distributing the jobs in the queue to a plurality of processors; performing speech-to-text processing on each portion to generate a corresponding text file; and merging the corresponding text files to generate a transcription file.
摘要翻译：本说明书描述了用于并行语音到文本处理的与多核心处理有关的技术。在一些实现中，提供了包括接收音频文件的动作的计算机实现的方法; 分析音频文件以识别与一个或多个音频类型相对应的音频文件的部分; 生成所识别的部分的时间排序分类，指示每个部分的音频文件内的一个或多个音频类型和位置的时间排序分类; 使用所述时间排序分类来生成队列，所述队列包括多个作业，其中每个作业包括被分类为属于所述一个或多个语音类型的所述音频文件的一部分的一个或多个标识符; 将队列中的作业分发到多个处理器; 对每个部分执行语音对文本处理以生成相应的文本文件; 并合并相应的文本文件以生成转录文件。

6. 发明授权

US08060506B1 Document analyzer and metadata generation 有权
标题翻译：文档分析器和元数据生成
公开(公告)号：US08060506B1
公开(公告)日：2011-11-15
申请号：US12917505
申请日：2010-11-02
申请人： Walter Chang , Michael J. Welch
发明人： Walter Chang , Michael J. Welch
IPC分类号： G06F17/30
CPC分类号： G06F17/3071 , G06F17/30719
摘要： A document analyzer receives a collection of text-based terms associated with a document. The document analyzer performs a statistical analysis on the text-based terms to identify a distribution of where the text-based terms appear in the document and relative frequency indicating how often the text-based terms appear in the document. The document analyzer utilizes the distribution and relative frequency information derived from the statistical analysis to rank multiple themes associated with the document. For example, a received listing of multiple themes may not be presented in any useful order, although it can be assumed that the themes in the listing are present in the document. Based on application of distribution and relative frequency information derived from the analysis, the document analyzer can identify which themes are most relevant to the document as a whole and/or which of themes correspond to different portions (e.g., pages or sections) of the document.
摘要翻译：文档分析器接收与文档相关联的基于文本的术语的集合。文档分析器对基于文本的术语进行统计分析，以识别基于文本的术语在文档中出现的位置的分布，以及指示基于文本的术语出现在文档中的频率的相对频率。文档分析器利用从统计分析得到的分布和相对频率信息来排列与文档相关联的多个主题。例如，收到的多个主题的列表可能不会以任何有用的顺序呈现，尽管可以假设列表中的主题存在于文档中。基于从分析得到的分布和相对频率信息的应用，文档分析器可以识别哪些主题与整个文档最相关，和/或哪个主题对应于文档的不同部分（例如，页面或部分）。

7. 发明申请

US20090068105A1 ISATIN ANALOGUES AND USES THEREFOR 有权
标题翻译： ISATIN类似物及其用途
公开(公告)号：US20090068105A1
公开(公告)日：2009-03-12
申请号：US11847330
申请日：2007-08-29
申请人： Robert H. Mach , Michael J. Welch , Wenhua Chu , Dong Zhou , Justin Rothfuss
发明人： Robert H. Mach , Michael J. Welch , Wenhua Chu , Dong Zhou , Justin Rothfuss
IPC分类号： A61K51/04 , C07D403/12 , A61K101/02
CPC分类号： C07D403/14 , A61K51/0446 , A61K51/0455 , C07D403/12
摘要： Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vivo imaging of apoptosis by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译：公开了包括Michael受体（IMA）的靛红类似物的新型靛红类似物。进一步公开的是靛红类似物的合成方法，以及通过正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）技术对胱天蛋白酶-3和半胱天冬酶-7的抑制以及细胞凋亡的体内成像的方法，。

8. 发明授权

US08688445B2 Multi-core processing for parallel speech-to-text processing 有权
标题翻译：并行语音对文本处理的多核处理
公开(公告)号：US08688445B2
公开(公告)日：2014-04-01
申请号：US12332309
申请日：2008-12-10
申请人： Walter W. Chang , Michael J. Welch
发明人： Walter W. Chang , Michael J. Welch
IPC分类号： G10L15/26
CPC分类号： G10L15/34 , G10L15/26 , G10L15/32 , G10L25/81
摘要： This specification describes technologies relating to multi core processing for parallel speech-to-text processing. In some implementations, a computer-implemented method is provided that includes the actions of receiving an audio file; analyzing the audio file to identify portions of the audio file as corresponding to one or more audio types; generating a time-ordered classification of the identified portions, the time-ordered classification indicating the one or more audio types and position within the audio file of each portion; generating a queue using the time-ordered classification, the queue including a plurality of jobs where each job includes one or more identifiers of a portion of the audio file classified as belonging to the one or more speech types; distributing the jobs in the queue to a plurality of processors; performing speech-to-text processing on each portion to generate a corresponding text file; and merging the corresponding text files to generate a transcription file.
摘要翻译：本说明书描述了用于并行语音到文本处理的与多核心处理有关的技术。在一些实现中，提供了包括接收音频文件的动作的计算机实现的方法; 分析音频文件以识别与一个或多个音频类型相对应的音频文件的部分; 生成所识别的部分的时间排序分类，指示每个部分的音频文件内的一个或多个音频类型和位置的时间排序分类; 使用所述时间排序分类来生成队列，所述队列包括多个作业，其中每个作业包括被分类为属于所述一个或多个语音类型的所述音频文件的一部分的一个或多个标识符; 将队列中的作业分发到多个处理器; 对每个部分执行语音对文本处理以生成相应的文本文件; 并合并相应的文本文件以生成转录文件。

9. 发明申请

US20130124979A1 Method and Apparatus for Capturing, Analyzing, and Converting Scripts 有权
标题翻译：捕获，分析和转换脚本的方法和设备
公开(公告)号：US20130124979A1
公开(公告)日：2013-05-16
申请号：US12713008
申请日：2010-02-25
申请人： Walter Chang , Michael J. Welch
发明人： Walter Chang , Michael J. Welch
IPC分类号： G06F17/00
CPC分类号： G06F17/218 , G06F17/27
摘要： Methods and apparatus for capturing, analyzing, and converting documents are provided. Provided in some embodiments is a method that includes obtaining a script document comprising script elements, assessing a layout of the script document, wherein the layout comprises a physical location of the script elements within the script document, determining an identification of one or more of the script elements based at least in part on the physical location of the one or more script elements within the script document, and assessing the one of the script elements using a finite state machine, wherein the finite state machine assesses one or more of the script elements preceding or following the one of the script elements to determine an accuracy of the identification of the one or more of the script elements determined.
摘要翻译：提供了用于捕获，分析和转换文档的方法和设备。在一些实施例中提供了一种方法，其包括获得包括脚本元素的脚本文档，评估脚本文档的布局，其中布局包括脚本文档内的脚本元素的物理位置，确定脚本文档中的一个或多个的标识脚本元素至少部分地基于脚本文档中的一个或多个脚本元素的物理位置，以及使用有限状态机来评估该脚本元素之一，其中该有限状态机评估一个或多个脚本元素在所述脚本元素之一之前或之后，确定所确定的所述一个或多个所述脚本元素的识别的准确性。

10. 发明授权

US08436140B2 Natriuretic peptide-mediated imaging of atherosclerotic plaque 有权
标题翻译：利钠肽介导的动脉粥样硬化斑块成像
公开(公告)号：US08436140B2
公开(公告)日：2013-05-07
申请号：US12454810
申请日：2009-05-22
申请人： Pamela K. Woodard , Michael J. Welch , Geoffrey E. Woodard , Rafaella Rossin
发明人： Pamela K. Woodard , Michael J. Welch , Geoffrey E. Woodard , Rafaella Rossin
IPC分类号： C07K9/00
CPC分类号： A61K51/088 , A61K49/0008 , A61K49/085 , A61K49/14 , G01N33/57492
摘要： Tracers comprising an oligopeptide comprising a fragment of a natriuretic peptide, wherein the fragment comprises the sequence Arg-Ile-Asp-Arg-Ile (SEQ ID NO.: 1), and a signaling moiety, are disclosed. Further disclosed are methods of imaging atherosclerotic plaque by PET scanning or MRI using a tracer.
摘要翻译：包含含有利尿钠肽片段的寡肽的示踪剂，其中所述片段包含序列Arg-Ile-Asp-Arg-Ile（SEQ ID NO：1）和信号传导部分。还公开了通过使用示踪剂的PET扫描或MRI对动脉粥样硬化斑块进行成像的方法。

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