专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07412279B2 Systems and methods for targeted magnetic resonance imaging of the vascular system 失效
标题翻译：用于血管系统靶向磁共振成像的系统和方法
公开(公告)号：US07412279B2
公开(公告)日：2008-08-12
申请号：US10209416
申请日：2002-07-30
申请人： Robert M. Weisskoff , Peter D. Caravan , Sonia Witte , Randall B. Lauffer , Alan P. Carpenter, Jr.
发明人： Robert M. Weisskoff , Peter D. Caravan , Sonia Witte , Randall B. Lauffer , Alan P. Carpenter, Jr.
IPC分类号： A61B5/05
CPC分类号： A61B5/416 , A61B5/055
摘要： This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Methods and systems of the invention allow for improved anatomical information to be obtained from MRI images and allow the clinician to develop more effective treatment plans. In one aspect, the invention provides a method of determining the presence or absence of a stationary target within the vascular system of a mammal wherein two MRI data sets representing images of the vascular system and the stationary target are acquired after administration of a targeted MRI contrast agent. In another embodiment, both a targeted MRI contrast agent and a vascular MRI contrast agent are administered to a mammal, and both a vascular MRI and a targeted MRI data set are acquired.
摘要翻译：本发明涉及基于MRI的方法和系统，其可用于诊断和临床评估血管系统内心血管疾病相关的静止目标（例如血栓和动脉粥样硬化病变）的存在，位置和大小。本发明的方法和系统允许从MRI图像获得改进的解剖信息，并允许临床医生开发更有效的治疗计划。一方面，本发明提供一种确定哺乳动物血管系统中静止靶的存在或不存在的方法，其中在施用靶向MRI对比后获取表示血管系统和静止靶的图像的两个MRI数据集代理商在另一个实施方案中，向哺乳动物施用靶向MRI造影剂和血管MRI造影剂，并且获取血管MRI和靶向MRI数据组。

2. 发明授权

US07060250B2 Diagnostic imaging contrast agents with extended blood retention 失效
公开(公告)号：US07060250B2
公开(公告)日：2006-06-13
申请号：US10755506
申请日：2004-01-12
申请人： Thomas J. McMurry , Hironao Sijiki , Daniel M. Scott , Randall B. Lauffer
发明人： Thomas J. McMurry , Hironao Sijiki , Daniel M. Scott , Randall B. Lauffer
IPC分类号： A61B5/055 , C07C61/00
CPC分类号： A61K49/085 , A61B6/507 , A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , C07F9/091
摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.

3. 发明授权

US06223165B1 Method and apparatus to connect consumer to expert 有权
标题翻译：将消费者与专家联系起来的方法和设备
公开(公告)号：US06223165B1
公开(公告)日：2001-04-24
申请号：US09488130
申请日：2000-01-20
申请人： Randall B. Lauffer
发明人： Randall B. Lauffer
IPC分类号： G06F1760
CPC分类号： H04M3/5191 , G06F19/00 , G06Q10/0631 , G06Q10/06311 , G06Q10/063112 , G06Q10/0639 , G06Q10/06398 , G06Q20/102 , G06Q30/02 , G06Q30/0206 , G06Q30/0241 , G06Q30/06 , G06Q30/0601 , G06Q30/0613 , G06Q50/24 , G06Q99/00 , H01L29/4908 , H01L29/66757 , H01L29/78675 , H04W4/021 , H04W4/029
摘要： This invention provides for a method of (or apparatus for) facilitating the delivery of advice to consumers using a server unit which can store and display the names and characteristics of experts and then rapidly assist in connecting the expert and consumer for real-time communication. The server can also have the ability to receive keywords from the consumer, match those keywords to one or more experts, and tell the consumer how to contact an expert.
摘要翻译：本发明提供了一种使用可以存储和显示专家的名称和特性的服务器单元促进向消费者传递建议的（或装置）的方法，然后快速协助连接专家和消费者进行实时通信。服务器还可以从消费者接收关键字，将这些关键字与一个或多个专家相匹配，并告诉消费者如何联系专家。

4. 发明授权

US5422096A Hydroxy-aryl metal chelates for diagnostic NMR imaging 失效
标题翻译：用于诊断NMR成像的羟基 - 芳基金属螯合物
公开(公告)号：US5422096A
公开(公告)日：1995-06-06
申请号：US254963
申请日：1994-06-07
申请人： Randall B. Lauffer , Scott K. Larsen
发明人： Randall B. Lauffer , Scott K. Larsen
IPC分类号： A61K49/06 , A61K49/00
CPC分类号： A61K49/06 , Y10T436/24
摘要： An NMR contrast agent composition contains a complex of a selected metal ion and a selected ligand. The ion is selected from the group consisting of gadolinium (III), iron (III), manganese (II), manganese (III), chromium (III), copper (II), dysprosium (III), terbium (III), holmium (III), erbium (III), europium (II), and europium (III); and the ligand is a linear two-nitrogen compound having one 2-hydroxy-aryl group at one of the nitrogens; or the ligand is a linear two-nitrogen compound having one or two 2-hydroxy-aryl groups at each of the nitrogens; or the ligand is a linear three-, four-, or five-nitrogen compound having one or two 2-hydroxy-aryl substituents at each of one or more of the nitrogens, or the ligand is a heterocyclic compound having a ring containing three or four nitrogens, and having a 2-hydroxy-aryl substitent at one or more of the nitrogens; or the ligand is a heterocyclic compound having a ring containing 4 nitrogens, and having a carboxyl group at two of the nitrogens and an aromatic substituent at the other two of the nitrogens.
摘要翻译： NMR造影剂组合物含有所选择的金属离子和所选择的配体的络合物。离子选自钆（III），铁（III），锰（II），锰（III），铬（III），铜（II），镝（III），铽（III），钬（III），铒（III），铕（II）和铕（III）; 并且配位体是在一个氮原子上具有一个2-羟基 - 芳基的直链二氮化合物; 或者配体是在每个氮原子上具有一个或两个2-羟基 - 芳基的线性二氮化合物; 或者配体是在一个或多个氮的每一个上具有一个或两个2-羟基 - 芳基取代基的线性三，四或五氮化合物，或者配体是具有环的三价或四个氮，并且在一个或多个氮上具有2-羟基 - 芳基取代基; 或者配体是具有含有4个氮的环的杂环化合物，并且在两个氮原子处具有羧基，在另外两个氮原子具有芳香族取代基。

5. 发明授权

US4880008A Vivo enhancement of NMR relaxivity 失效
标题翻译：体内增强核磁共振弛豫度
公开(公告)号：US4880008A
公开(公告)日：1989-11-14
申请号：US860540
申请日：1986-05-07
申请人： Randall B. Lauffer
发明人： Randall B. Lauffer
IPC分类号： A61K49/06
CPC分类号： A61K49/06
摘要： A method of decreasing the NMR relaxation times (T.sub.1 or T.sub.2) of water protons in contact with a biological tissue, the method involving administering to a human patient an NMR contrast agent comprising a paramagnetic ion complexed with a chelating substance, the contrast agent being characterized in that it is capable of binding non-covalently and non-immunologically to a component of the tissue, and as a result of such binding is capable of enhancing relaxivity of the water protons by a factor of at least 2, compared to the relaxivity induced by the paramagnetic substance alone free in solution, and subjecting the patient to NMR imaging.
摘要翻译：一种降低与生物组织接触的水质子的NMR松弛时间（T1或T2）的方法，该方法涉及向人类患者施用包含与螯合物质复合的顺磁离子的NMR造影剂，所述造影剂被表征因为其能够非共价和非免疫学地结合组织的组分，并且作为这种结合的结果，与诱导的松弛度相比，能够将水质的松弛性提高至少2倍通过单独的顺磁性物质在溶液中游离，并对患者进行NMR成像。

6. 发明授权

US08394356B2 Diagnostic imaging contrast agents with extended blood retention 失效
公开(公告)号：US08394356B2
公开(公告)日：2013-03-12
申请号：US13220103
申请日：2011-08-29
申请人： Thomas J. McMurry , Hironao Sijiki , Daniel M. Scott , Randall B. Lauffer
发明人： Thomas J. McMurry , Hironao Sijiki , Daniel M. Scott , Randall B. Lauffer
IPC分类号： A61B5/055 , A61B5/05
CPC分类号： A61K49/085 , A61B6/507 , A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , C07F9/091
摘要： The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.

7. 发明申请

US20100208028A1 Method and System to Connect Consumers to Information 有权
标题翻译：将消费者连接到信息的方法和系统
公开(公告)号：US20100208028A1
公开(公告)日：2010-08-19
申请号：US12768664
申请日：2010-04-27
申请人： Randall B. Lauffer
发明人： Randall B. Lauffer
IPC分类号： H04N7/14 , G06Q30/00 , G06Q40/00 , G06Q50/00 , H04M3/00
CPC分类号： H04M3/5191 , G06F19/00 , G06Q10/0631 , G06Q10/06311 , G06Q10/063112 , G06Q10/0639 , G06Q10/06398 , G06Q20/102 , G06Q30/02 , G06Q30/0206 , G06Q30/0241 , G06Q30/06 , G06Q30/0601 , G06Q30/0613 , G06Q50/24 , G06Q99/00 , H01L29/4908 , H01L29/66757 , H01L29/78675 , H04W4/021 , H04W4/029
摘要： This invention provides for a method of (or apparatus for) facilitating the delivery of advice to consumers using a server unit which can store and display the names and characteristics of experts and then rapidly assist in connecting the expert and consumer for real-time communication. The server can also have the ability to receive keywords from the consumer, match those keywords to one or more experts, and tell the consumer how to contact an expert.
摘要翻译：本发明提供了一种使用可以存储和显示专家的名称和特性的服务器单元促进向消费者传递建议的（或装置）的方法，然后快速协助连接专家和消费者进行实时通信。服务器还可以从消费者接收关键字，将这些关键字与一个或多个专家相匹配，并告诉消费者如何联系专家。

8. 发明授权

US06861045B1 Contrast-enhanced diagnostic imaging method for monitoring interventional therapies 失效
标题翻译：用于监测介入治疗的对比增强诊断成像方法
公开(公告)号：US06861045B1
公开(公告)日：2005-03-01
申请号：US09887706
申请日：2000-09-08
申请人： Randall B. Lauffer , Stephen O. Dunham
发明人： Randall B. Lauffer , Stephen O. Dunham
IPC分类号： G01R33/48 , A61B5/055 , A61K49/00 , A61K49/06 , A61K49/08
CPC分类号： A61K49/10 , A61K49/0052 , A61K49/085 , A61K49/103 , A61K49/106
摘要： The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SDTBM). These contrast agents exhibit state-dependent binding to one or more components of a targeted tissue or tissue component and provide a detectable change in the signal characteristics of the agent once bound to the targeted tissue. As a result, these agents exhibit a binding affinity for, and thus image contrast of, the targeted tissue which changes as the tissue-state changes during therapy.
摘要翻译：本发明涉及用于监测介入治疗功效的对比度增强诊断成像方法。在该方法中有用的造影剂包括图像增强部分（IEM）和状态依赖性组织结合部分（SDTBM）。这些造影剂表现出与目标组织或组织成分的一种或多种组分的状态依赖性结合，并提供一旦结合到目标组织的药剂的信号特征的可检测变化。结果，这些试剂表现出随着组织状态在治疗期间改变而变化的靶组织的结合亲和力，并因此对其进行图像对比。

9. 发明授权

US06652835B1 Targeting multimeric imaging agents through multilocus binding 失效
标题翻译：通过多位点结合靶向多聚体成像剂
公开(公告)号：US06652835B1
公开(公告)日：2003-11-25
申请号：US09627719
申请日：2000-07-28
申请人： Randall B. Lauffer , Thomas J. McMurry , Stephane Dumas , Andrew Kolodziej , John Amedio , Peter Caravan , Zhaoda Zhang
发明人： Randall B. Lauffer , Thomas J. McMurry , Stephane Dumas , Andrew Kolodziej , John Amedio , Peter Caravan , Zhaoda Zhang
IPC分类号： A61B5055
CPC分类号： A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/085 , A61K49/10 , A61K49/124 , A61K49/128 , A61K49/14
摘要： The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites. The compounds consist of: a) two or more Image Enhancing Moieties (IEMs) (or signal-generating moiety) comprising multiple subunits; b) two or more Target Binding Moieties (TBMs), providing for in vivo localization and multimer rigidification; and c) a scaffold framework for attachment of the above moieties. d) optional linkers for attachment of the IEMs to scaffold. This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for contrast enhancement of diagnostic imaging.
摘要翻译：本发明涉及用于诊断成像的造影剂。特别地，本发明涉及新颖的多聚体化合物，其在结合内源蛋白质或其他生理学相关位点时表现出改善的松弛性能。所述化合物包括：a）包含多个亚基的两个或更多个图像增强部分（IEM）（或产生信号的部分）; b）两个或更多个目标结合部分（TBM），用于体内定位和多聚体硬化; 和c）用于连接上述部分的支架框架。d）用于将IEM连接到支架上的任选接头。本发明还涉及包含这些化合物的药物组合物以及使用化合物和组合物用于诊断成像的对比度增强的方法。

10. 发明授权

US4899755A Hepatobiliary NMR contrast agents 失效
标题翻译：肝胆核磁共振造影剂
公开(公告)号：US4899755A
公开(公告)日：1990-02-13
申请号：US731841
申请日：1985-05-08
申请人： Randall B. Lauffer , Thomas J. Brady
发明人： Randall B. Lauffer , Thomas J. Brady
IPC分类号： G01R33/28 , A61B5/055 , A61B10/00 , A61K49/00 , A61K49/06
CPC分类号： A61K49/06
摘要： A method of altering proton NMR relaxation times in the liver or bile duct of a human patient involving administering to the patient an agent characterized in that it is taken up preferentially by human hepatocytes, compared to human reticuloendothelial cells, and it contains a paramagnetic substance capable of altering the proton NMR relaxation times in the hepatocytes.
摘要翻译：在人类肝脏或胆管中改变质子NMR弛豫时间的方法包括向患者施用特征在于与人网状内皮细胞相比优先被人类肝细胞摄取的药剂，并且其含有顺磁性物质在肝细胞中改变质子NMR弛豫时间。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式