专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07294635B2 Substituted isoquinolinones 有权
标题翻译：取代的异喹啉酮
公开(公告)号：US07294635B2
公开(公告)日：2007-11-13
申请号：US10956006
申请日：2004-09-29
申请人： Robert M. Scarborough , Kim A. Kane-MaGuire , Charles K. Marlowe , Mark S. Smyth , Xiaoming Zhang
发明人： Robert M. Scarborough , Kim A. Kane-MaGuire , Charles K. Marlowe , Mark S. Smyth , Xiaoming Zhang
IPC分类号： C07D407/04 , A61K31/506 , A61K31/4709
CPC分类号： C07D409/14 , C07D217/24 , C07D401/04 , C07D409/12
摘要： Isoquinolinone compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
摘要翻译：提供了可用于抑制ADP-血小板聚集的异喹啉酮化合物，特别是在治疗血栓形成和血栓形成相关病症或病症中。

2. 发明授权

US07205296B2 Substituted 2H-1,3-benzoxazin-4(3H)-ones 有权
标题翻译：取代的2H-1,3-苯并恶嗪-4（3H） - 酮
公开(公告)号：US07205296B2
公开(公告)日：2007-04-17
申请号：US11236051
申请日：2005-09-26
申请人： Robert M. Scarborough , Meenakshi S. Venkatraman , Xiaoming Zhang , Anjali Pandey
发明人： Robert M. Scarborough , Meenakshi S. Venkatraman , Xiaoming Zhang , Anjali Pandey
IPC分类号： C07D409/12 , C07D409/14 , A61K31/538
CPC分类号： C07D413/12 , C07D413/14
摘要： Substituted benzoxazin-4(3H)-ones are provided which are useful for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.
摘要翻译：提供了取代的苯并恶嗪-4（3H） - 酮，其可用于治疗患者的血栓形成和降低患者二次缺血事件的可能性和/或严重程度。

3. 发明授权

US07109332B2 2,4-dioxo-3-quinazolinylaryl sulfonylureas 失效
标题翻译： 2,4-二氧代-3-喹唑啉基芳基磺酰脲
公开(公告)号：US07109332B2
公开(公告)日：2006-09-19
申请号：US10956004
申请日：2004-09-29
申请人： Robert M. Scarborough , Wolin Huang , Anjali Pandey , Shawn M. Bauer , Xiaoming Zhang , Zhaozhong J. Jia
发明人： Robert M. Scarborough , Wolin Huang , Anjali Pandey , Shawn M. Bauer , Xiaoming Zhang , Zhaozhong J. Jia
IPC分类号： C07D409/12 , C07D409/14 , A61K31/517 , A61P7/02
CPC分类号： C07D409/12 , C07D409/14
摘要： 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: wherein R is a member selected from the group consisting of H and C1-6 alkyl; R1 is a member selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C3-5 cycloalkyl and C3-5 cycloalkyl-alkyl; R2 is a member selected from the group consisting of H, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, cyano and —C(O)R2a, wherein R2a is a member selected from the group consisting of C1-6 alkoxy and (C1-6 alkyl)0-2 amino; L is a 1 to 3 carbon linking group selected from the group consisting of —CH2—, —CH(CH3)—, —CH2CH2—, —CH2CH(CH3)— and —CH2CH2CH2—; L1 is a linking group selected from the group consisting of a bond and —CH2—; L2 is a linking group selected from the group consisting of a bond, —NH— and —CH2—; and Ar1 is an aromatic ring selected from the group consisting of benzene, pyridine and pyrimidine; are provided. The compounds are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
摘要翻译： 2,4-二氧代-3-喹唑啉基芳基磺酰脲类化合物，其具有下式：其中R是选自H和C 1-6烷基的成员; R 1是选自H，C 1-6烷基，C 1-6卤代烷基，C 1 -C 6烷基，C 1 -C 6烷基， 3-5个环烷基和C 3-5环烷基 - 烷基; R 2是选自H，卤素，C 1-6 - 烷基，C 2-6 - 烯基，C 1 -C 6烷基， C 1-6烷基，C 1-6烷氧基，氰基和-C（O）R 2a，其中R 2a是选自C 1-6烷氧基和（C 1-6烷基）烷基的成员， 0-2氨基; L是选自-CH 2 - ， - CH（CH 3 CH 3） - ， - CH 2 - ， - CH 2 CH 2（CH 3 CH 3） - 和-CH 2 CH _{2 CH 2 - ; L 1是选自键和-CH 2 - 的连接基团。 L 2是从由-NH-和-CH 2 - 的键组成的组中的连接基团。和Ar 1是选自苯，吡啶和嘧啶的芳环; 被提供。该化合物可用于抑制ADP-血小板聚集，特别是在治疗血栓形成和血栓相关病症或病症中。}

4. 发明授权

US09044192B2 System and method for non-invasively measuring tissue viscoelasticity using surface waves 有权
标题翻译：使用表面波非侵入性地测量组织粘弹性的系统和方法
公开(公告)号：US09044192B2
公开(公告)日：2015-06-02
申请号：US12418111
申请日：2009-04-03
申请人： James F. Greenleaf , Mark R. Pittelkow , Randall R. Kinnick , Xiaoming Zhang
发明人： James F. Greenleaf , Mark R. Pittelkow , Randall R. Kinnick , Xiaoming Zhang
IPC分类号： A61B8/00 , A61B5/00
CPC分类号： A61B5/442 , A61B5/0051 , A61B8/485
摘要： A system and method for assessing tissue health based on the viscoelastic properties of the tissue. Surface waves are induced in the tissue and their propagation characteristics are then measured. The tissue viscoelastic properties are then determined from the surface wave measurements using a surface model.
摘要翻译：一种基于组织粘弹性评估组织健康的系统和方法。在组织中诱导表面波，然后测量它们的传播特性。然后使用表面模型从表面波测量中确定组织粘弹性。

5. 发明申请

US20130238732A1 INSTANT MESSAGING ROBOT TO PROVIDE PRODUCT INFORMATION 有权
标题翻译：即时消息机器人提供产品信息
公开(公告)号：US20130238732A1
公开(公告)日：2013-09-12
申请号：US13865768
申请日：2013-04-18
申请人： Xiaoming Zhang
发明人： Xiaoming Zhang
IPC分类号： H04L12/58
CPC分类号： G06Q30/0613 , G06F17/30569 , G06Q30/0269 , G06Q30/0611 , G06Q30/0625 , H04L51/02 , H04L51/04 , H04L67/10
摘要： Methods and systems to automatically respond to a request for product information are described. In one embodiment, a data collection module may collect product data over a network, identify that the product data is related to a particular product, and store the product data and an association between the product data and the particular product in a database. An instant messaging engine may receive a request for the product data after the product data is stored in the database and an interpreter module may identify, in response to the request, the request to correspond to the particular product and retrieve the product data based on the association between the particular product and the product data. The instant messaging engine may also transmit, using an instant messaging protocol, a response to the request, the response including the product data.
摘要翻译：描述自动响应产品信息请求的方法和系统。在一个实施例中，数据收集模块可以通过网络收集产品数据，识别产品数据与特定产品相关，并且存储产品数据以及数据库中的产品数据和特定产品之间的关联。在产品数据存储在数据库中之后，即时消息发送引擎可以接收对产品数据的请求，并且解释器模块可以响应于该请求识别与特定产品相对应的请求，并基于特定产品与产品数据之间的关联。即时消息引擎还可以使用即时消息传递协议来发送对请求的响应，该响应包括产品数据。

6. 发明申请

US20130110745A1 RULE GENERATION FOR EVENT PROCESSING SYSTEM 失效
标题翻译：事件处理系统规则生成
公开(公告)号：US20130110745A1
公开(公告)日：2013-05-02
申请号：US13285232
申请日：2011-10-31
申请人： Xiaoming Zhang
发明人： Xiaoming Zhang
IPC分类号： G06F15/18
CPC分类号： G06N5/025 , G06Q10/00 , G06Q40/00
摘要： A computer receives a plurality of input events, each input event comprising one or more factors. The computer processes each input event based on event processing rules that cause the computer to evaluate the one or more factors and assign each input event a Boolean output value. The computer generates an output event containing the one or more factors and the Boolean output value. The computer generates additional event processing rules based on output events for which the event processing rules caused the output events to have a false-negative or false-positive Boolean output value. The additional rules are then included in the event processing rules.
摘要翻译：计算机接收多个输入事件，每个输入事件包括一个或多个因素。计算机根据事件处理规则处理每个输入事件，这些事件处理规则使计算机评估一个或多个因素，并为每个输入事件分配布尔输出值。计算机生成包含一个或多个因子和布尔输出值的输出事件。计算机基于事件处理规则导致输出事件具有假负值或假阳性布尔输出值的输出事件生成附加事件处理规则。然后，附加规则将被包括在事件处理规则中。

7. 发明授权

US07769566B2 Methods for utilizing human perceptual systems for processing event log data 失效
标题翻译：利用人感知系统处理事件日志数据的方法
公开(公告)号：US07769566B2
公开(公告)日：2010-08-03
申请号：US12041888
申请日：2008-03-04
申请人： Xiaoming Zhang
发明人： Xiaoming Zhang
IPC分类号： G06F15/00 , G10L15/00
CPC分类号： G06F11/32
摘要： A method is provided for utilizing the human perceptual system by providing a spectrum of event log data for listening. Event log data is received. Events of the event log data are mapped to an x-axis of a spectrum based on time, where events of the event log data correspond to a time slot on the x-axis. Categories for the events are mapped to a y-axis of the spectrum, where the y-axis is a frequency axis, and where each of the categories respectively corresponds to a frequency of the multiple frequencies. The significance of the events of the event log data is mapped to a z-axis of the spectrum, where the z-axis is a magnitude axis. The time from the x-axis, the multiple frequencies from the y-axis, and the magnitude from z-axis of the spectrum are translated into sound.
摘要翻译：提供了一种通过提供用于收听的事件日志数据的频谱来利用人类感知系统的方法。收到事件日志数据。基于时间将事件日志数据的事件映射到频谱的x轴，其中事件日志数据的事件对应于x轴上的时隙。事件的类别被映射到频谱的y轴，其中y轴是频率轴，并且其中每个类别分别对应于多个频率的频率。事件日志数据的事件的重要性被映射到光谱的z轴，其中z轴是幅度轴。从x轴的时间，从y轴的多个频率和从频谱z轴的幅度被转换为声音。

8. 发明授权

US07557728B1 Using audio to detect changes to the performance of an application 失效
标题翻译：使用音频检测应用程序性能的变化
公开(公告)号：US07557728B1
公开(公告)日：2009-07-07
申请号：US12249680
申请日：2008-10-10
申请人： Richard M. Bicheno , Tim Dunn , Ian P. Hurworth , Xiaoming Zhang
发明人： Richard M. Bicheno , Tim Dunn , Ian P. Hurworth , Xiaoming Zhang
IPC分类号： G08B5/00
CPC分类号： G06F11/324 , G06F11/3409 , G06F2201/81
摘要： A system for monitoring the performance of an application comprises a computer system having one or more speakers and means for running an application, the computer system being configured to perform the steps of determining an output of an application that requires monitoring, assigning an audible sound to the output, running the application and allowing the application to reach a state of equilibrium, determining a baseline for the output when the application is in the state of equilibrium, monitoring the output to detect a change relative to the baseline, emitting the audible sound assigned to the output through at least one of the one or more speakers when the detected change varies from the baseline by a predetermined amount, and adjusting configurable parameters of the audible sound to indicate the existence of the detected change, the magnitude of the detected change relative to the baseline, and the degree of deviation from the baseline.
摘要翻译：用于监视应用的性能的系统包括具有一个或多个扬声器的计算机系统和用于运行应用的装置，所述计算机系统被配置为执行以下步骤：确定需要监视的应用的输出，将可听见的声音分配给输出，运行应用程序并允许应用程序达到平衡状态，当应用程序处于平衡状态时确定输出的基线，监视输出以检测相对于基线的变化，发出分配的声音通过所述一个或多个扬声器中的至少一个扬声器输出到所述检测到的变化，并且调整所述可听见的声音的可配置参数以指示检测到的变化的存在，所述检测到的变化相对的幅度到基线，以及偏离基线的程度。

9. 发明申请

US20070129429A1 Materials And Methods For Treating Coagulation Disorders 审中-公开
标题翻译：治疗凝血障碍的材料和方法
公开(公告)号：US20070129429A1
公开(公告)日：2007-06-07
申请号：US11551302
申请日：2006-10-20
申请人： Pascal Druzgala , Xiaoming Zhang , Jurg Pfister
发明人： Pascal Druzgala , Xiaoming Zhang , Jurg Pfister
IPC分类号： A61K31/366 , C07D405/02
CPC分类号： A61K31/366 , A61K31/37 , C07D311/56
摘要： This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.
摘要翻译：本发明涉及更容易被代谢药物解毒系统代谢的化合物。特别地，教导了被设计成在化合物的结构内包含酯的华法林类似物。本发明教导了在药物合成期间降低包括将酯基引入药物的药物的毒性的方法。本发明还涉及治疗凝血障碍的方法，其包括施用被设计为由血清或细胞内水解酶和酯酶代谢的化合物。还教导了含有华法林酯类药物组合物。

10. 发明授权

US06951877B2 Materials and methods for treating hypercholesterolemia 失效
标题翻译：治疗高胆固醇血症的材料和方法
公开(公告)号：US06951877B2
公开(公告)日：2005-10-04
申请号：US10624659
申请日：2003-07-21
申请人： Pascal Druzgala , Xiaoming Zhang
发明人： Pascal Druzgala , Xiaoming Zhang
IPC分类号： A61K31/22 , A61K31/343 , A61K31/353 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K31/56 , A61K31/573 , A61K31/575 , A61P3/06 , A61P43/00 , C07C69/675 , C07C69/708 , C07C69/732 , C07D207/34 , C07D209/12 , C07D209/18 , C07D209/24 , C07D209/42 , C07D213/30 , C07D213/55 , C07D213/80 , C07D215/12 , C07D215/14 , C07D239/42 , C07D307/79 , C07D307/80 , C07D311/72 , C07J3/00 , C07J5/00 , C07J9/00 , A61K31/44
CPC分类号： C07D239/42 , A61K31/405 , A61K31/47 , A61K31/505 , C07C69/675 , C07C69/708 , C07C69/732 , C07C2602/28 , C07D207/34 , C07D209/12 , C07D209/24 , C07D213/55 , C07D215/14 , C07D307/80 , C07D311/72
摘要： The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive metabolite by hydrolytic enzymes. Compounds of the present invention can be advantageously used to treat patients suffering hypercholesterolemia.
摘要翻译：本发明提供新的HMG-CoA还原酶抑制剂。在优选的实施方案中，本发明的HMG-CoA还原酶抑制剂可以通过水解酶而失活至初级无活性代谢物。本发明的化合物可有利地用于治疗患有高胆固醇血症的患者。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式