专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5320598A Iontophoretic delivery device and method of hydrating same 失效
公开(公告)号：US5320598A
公开(公告)日：1994-06-14
申请号：US881953
申请日：1992-05-12
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).

2. 发明授权

US5543098A Iontophoretic delivery device and method of making same 失效
标题翻译：离子电渗递送装置及其制造方法
公开(公告)号：US5543098A
公开(公告)日：1996-08-06
申请号：US197665
申请日：1994-02-17
申请人： Robert M. Myers , Felix A. Landrau
发明人： Robert M. Myers , Felix A. Landrau
IPC分类号： A61N1/30 , C04B35/00
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/0448
摘要： An electrically powered transdermal iontophoretic delivery device (10, 20) and a method of making same is provided. The device utilizes electrode assemblies (8, 9) composed of a substantially homogenous blend of a polymeric matrix containing about 5 to 50 vol % of a conductive filler which forms a conductive network through the matrix, and up to about 50 vol % of the agent to be iontophoretically delivered through the skin. In the case of the donor electrode assembly, the agent is typically a drug and preferably a water soluble drug salt. In the case of the counter electrode assembly, the agent is typically an electrolyte salt. The homogenous blend eliminates the need for separate electrode and agent containing layers which require lamination.
摘要翻译：提供电动透皮离子电渗递送装置（10,20）及其制造方法。该装置利用电极组件（8,9），该电极组件由包含约5至50体积％的导电填料的聚合物基质的基本上均匀的共混物组成，导电填料通过基体形成导电网络，并且至多约50vol％的试剂通过皮肤离子电渗输送。在供体电极组件的情况下，试剂通常是药物，优选水溶性药物盐。在反电极组件的情况下，试剂通常是电解质盐。均匀的共混物消除了对需要层压的单独的电极和含有层的层的需要。

3. 发明授权

US5158537A Iontophoretic delivery device and method of hydrating same 失效
标题翻译：静电输送装置及其液压方法
公开(公告)号：US5158537A
公开(公告)日：1992-10-27
申请号：US605046
申请日：1990-10-29
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21, 22). Alternatively, the liquid can be released from the pouches (21, 22) using pouch piercing pins (36, 37). The liquid released from the pouches (21, 22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31, 32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27, 28) are provided to carry the liquid from the gel layers (31, 32) to the drug and electrolyte layers (15, 16).
摘要翻译：提供了干态离子电渗药物输送装置（10,70,80）。该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。提供含液囊（21,22）。在某些实施方案中，液体包含在小袋内的可破坏胶囊中。水或其它液体可以通过挤压或弯曲袋（21,22）从袋中的胶囊释放。或者，可以使用袋刺穿销（36,37）从袋（21,22）中释放液体。从袋（21,22）释放的液体使药物和电解质储存器（15,16）水合，并激活装置。在另一个实施例中，装置（20,20a）具有最初与其各自的电极组件（8,9）分离的含液体凝胶层（31,32）。提供液体芯吸路径（27,28）以将液体从凝胶层（31,32）运送到药物和电解质层（15,16）。

4. 发明授权

US06317629B1 Iontophoretic drug delivery apparatus 失效
标题翻译：离子电渗药物输送装置
公开(公告)号：US06317629B1
公开(公告)日：2001-11-13
申请号：US08351381
申请日：1994-12-02
申请人： Ronald P. Haak , J. Richard Gyory , Robert M. Myers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , Linda M. Hearney
发明人： Ronald P. Haak , J. Richard Gyory , Robert M. Myers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , Linda M. Hearney
IPC分类号： A61N130
CPC分类号： A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/303
摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.
摘要翻译：提供了一种离子电渗疗法输送装置（10）。设备（10）具有电子电路（32），其具有安装在其上的电池（30）等电子部件。装置（10）还包括一对电极组件（18,19）。使用导电粘合剂（34）将电子电路（32）电连接到电极组件（18,19）。粘合剂也可以用于电连接电路（32）内的两个或更多个电子部件或将电子部件连接到电子电路（32）。在本发明的一个实践中，导电粘合剂（44）用作电极并将电路（32）电连接到含药剂的储存器（24,25）。在本发明的进一步实践中，导电粘合剂（93）用作试剂储存器并且包含待离子电渗传递的试剂。

5. 发明授权

US5405317A Iontophoretic delivery device 失效
标题翻译：离子电渗输送装置
公开(公告)号：US5405317A
公开(公告)日：1995-04-11
申请号：US938033
申请日：1992-10-30
申请人： Robert M. Myers , Mark G. Stahl , Felix A. Landrau , J. Richard Gyory
发明人： Robert M. Myers , Mark G. Stahl , Felix A. Landrau , J. Richard Gyory
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448
摘要： An electrically powered iontophoretic delivery device is provided. The device utilizes electrodes composed of a preferably hydrophobic polymeric matrix. The matrix contains about 10 to 50 vol % of a material capable of absorbing a liquid solvent, typically water, to provide a plurality of ion conducting pathways through the matrix. The matrix also contains about 5 to 40 vol % of a chemical species which is able to undergo either oxidation or reduction during operation of the device. Preferably, the solvent absorbing material is a hydrophilic polymer such as polyvinylpyrrolidone. For the anodic electrode, the chemical species should be able to undergo oxidation and is preferably either silver or zinc. For the cathodic electrode, the chemical species should be able to undergo reduction and is preferably silver chloride or a reducible metal.
摘要翻译： PCT No.PCT / US91 / 03164 Sec。 371日期：1992年10月30日 102（e）日期1992年10月30日PCT 1991年5月7日PCT PCT。第WO91 / 16946号公报日期为1991年11月14日。提供电动离子电渗输送装置。该装置使用由优选疏水性聚合物基质构成的电极。该基质含有约10至50vol％的能够吸收液体溶剂（通常为水）的材料，以提供穿过基质的多个离子传导途径。该基质还含有约5至40体积％的化学物质，其能够在装置的操作期间经历氧化或还原。溶剂吸收材料优选为聚乙烯吡咯烷酮等亲水性聚合物。对于阳极电极，化学物质应该能够经历氧化，并且优选是银或锌。对于阴极电极，化学物质应该能够还原，并且优选为氯化银或可还原金属。

6. 发明授权

US5288289A Iontophoretic delivery device and method of hydrating same 失效
标题翻译：离子渗透输送装置及其水合方法
公开(公告)号：US5288289A
公开(公告)日：1994-02-22
申请号：US881909
申请日：1992-05-12
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).
摘要翻译：提供了干态离子电渗药物输送装置（10,70,80）。该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。提供含液囊（21,22）。在某些实施方案中，液体包含在小袋内的可破坏胶囊中。水或其它液体可以通过挤压或弯曲袋（21,22）从袋中的胶囊释放。或者，可以使用袋刺穿销（36,37）从袋（21,22）释放液体。从袋（21,22）释放的液体使药物和电解质储存器（15,16）水合，并激活装置。在另一个实施例中，装置（20,20a）具有最初与其各自的电极组件（8,9）分离的含液体凝胶层（31,32）。提供液体芯吸路径（27,28）以将液体从凝胶层（31,32）运送到药物和电解质层（15,16）。

7. 发明授权

US5618265A Iontophoretic delivery device with single lamina electrode 失效
标题翻译：带单层电极的离子电渗输送装置
公开(公告)号：US5618265A
公开(公告)日：1997-04-08
申请号：US592083
申请日：1996-01-26
申请人： Robert M. Myers , Felix A. Landrau
发明人： Robert M. Myers , Felix A. Landrau
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/0448
摘要： An electrically powered transdermal iontophoretic delivery device (10, 20) and a method of making same is provided. The device utilizes electrode assemblies (8, 9 ) composed of a substantially homogenous blend of a polymeric matrix containing about 5 to 50 vol % of a conductive filler which forms a conductive network through the matrix, and up to about 50 vol % of the agent to be iontophoretically delivered through the skin. In the case of the donor electrode assembly, the agent is typically a drug and preferably a water soluble drug salt. In the case of the counter electrode assembly, the agent is typically an electrolyte salt. The homogenous blend eliminates the need for separate electrode and agent containing layers which require lamination.
摘要翻译：提供电动透皮离子电渗递送装置（10,20）及其制造方法。该装置利用电极组件（8,9），该电极组件由包含约5至50体积％的导电填料的聚合物基质的基本上均匀的共混物构成，该导电填料通过基质形成导电网络，并且至多约50体积％通过皮肤离子电渗输送。在供体电极组件的情况下，试剂通常是药物，优选水溶性药物盐。在反电极组件的情况下，试剂通常是电解质盐。均匀的共混物消除了对需要层压的单独的电极和含有层的层的需要。

8. 发明授权

US08080259B2 Sustained delivery of an active agent using an implantable system 有权
标题翻译：使用可植入系统持续递送活性剂
公开(公告)号：US08080259B2
公开(公告)日：2011-12-20
申请号：US12655399
申请日：2009-12-29
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61K9/20 , A61K9/22 , A61K9/24 , A61F2/00
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译：本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。不可渗透的储存器分为水溶胀剂室和活性剂配制室。来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。交付期限达2年。

9. 发明授权

US06635268B2 Sustained delivery of an active agent using an implantable system 有权
公开(公告)号：US06635268B2
公开(公告)日：2003-10-21
申请号：US10108303
申请日：2002-03-28
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61F200
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.

10. 发明授权

US06169920A Iontophoretic drug delivery apparatus 失效
公开(公告)号：US06169920A
公开(公告)日：2001-01-02
申请号：US08320387
申请日：1994-10-11
申请人： Ronald P. Haak , Robert M. Meyers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , J. Richard Gyory
发明人： Ronald P. Haak , Robert M. Meyers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , J. Richard Gyory
IPC分类号： A61N130
CPC分类号： A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/303
摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式