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1. 发明申请

US20140248322A1 DENTAL COMPOSITIONS CONTAINING SILICA MICROBEADS 审中-公开
标题翻译：含有二氧化硅微球的牙科组合物
公开(公告)号：US20140248322A1
公开(公告)日：2014-09-04
申请号：US14278447
申请日：2014-05-15
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K8/02 , A61Q11/00 , A61K8/25
CPC分类号： A61K8/025 , A61K6/0008 , A61K6/0235 , A61K8/25 , A61K8/29 , A61K2800/412 , A61K2800/621 , A61Q11/00
摘要： A dental treatment system for the relief of dental hypersensitivity and related disorders, including a dentition delivery formulation and a plurality of generally spherical vitreous microspheres generally homogeneously dispersed in the dentition delivery formulation, wherein each respective microsphere has a coating containing calcium and phosphate and wherein each respective microsphere is between about 0.01 micron and about 10 microns in diameter.
摘要翻译：一种用于缓解牙齿超敏反应和相关疾病的牙科治疗系统，包括通常均匀地分散在牙列传递制剂中的牙列传递制剂和多个通常为球形的玻璃体微球，其中每个相应的微球具有含有钙和磷酸盐的涂层，相应的微球直径在约0.01微米至约10微米之间。

2. 发明授权

US08568696B2 Grinding method for the manipulation or preservation of calcium phosphate hybrid properties 有权
标题翻译：用于操作或保存磷酸钙混合物性能的研磨方法
公开(公告)号：US08568696B2
公开(公告)日：2013-10-29
申请号：US12186940
申请日：2008-08-06
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K9/50 , C01F11/00 , A61K9/16 , A61K6/00 , C08K3/32
CPC分类号： A61K9/16 , A61K6/0052 , A61K8/19 , A61K8/20 , A61K8/24 , A61K8/25 , A61K8/42 , A61K9/1611 , A61K9/1617 , A61Q11/00 , C01F11/00 , C08K2003/325
摘要： A solid state method of encouraging the physical interfacing of an organic component to a substantially crystalline inorganic component, including adding predetermined amounts of a substantially crystalline inorganic precursor and a predetermined amount of an organic precursor to yield an admixture, maintaining the admixture in a substantially liquid-free environment, and impacting the precursors together with sufficient energy to fuse the precursors into hybrid compounds. The so-formed hybrid compounds substantially retain the long range crystalline order characteristics of the substantially crystalline inorganic precursor.
摘要翻译：鼓励将有机组分物理接合到基本上结晶的无机组分的固体方法，包括加入预定量的基本上结晶的无机前体和预定量的有机前体以产生混合物，将混合物保持在基本上液体中并且将前体与足够的能量一起冲击前体以将前体融合成杂化化合物。如此形成的杂化化合物基本上保持了基本上结晶的无机前体的长程结晶顺序特征。

3. 发明授权

US08556553B2 Hybrid organic/inorganic chemical hybrid systems, including functionalized calcium phosphate hybrid systems, and a solid-state method for producing the same 有权
标题翻译：混合有机/无机化学混合体系，包括功能化磷酸钙混合体系，以及其制备方法
公开(公告)号：US08556553B2
公开(公告)日：2013-10-15
申请号：US12018627
申请日：2008-01-23
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K9/50 , B23C1/00 , A61K9/16 , A61K6/00 , C01F11/00 , C08K3/32
CPC分类号： A61K9/16 , A61K6/0082 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/86 , A61K9/1611 , A61K9/1617 , A61Q11/00 , B23C2220/00 , C01B25/32 , C01F11/00 , C08K2003/325 , Y10T409/30
摘要： A solid-state method of producing functionalized moieties, including placing predetermined amounts of inorganic and inorganic materials and milling media into a vessel rotatably connected to a turntable platform, an amount of an organic material into the vessel, rotating the vessel in a first direction while turning the turntable platform in a second direction counter to the first direction, milling the inorganic and organic materials into smaller respective organic and inorganic particles, and fusing portions of organic particles to inorganic parties to define functionalized moieties. The inorganic material may include calcium phosphates of varying phases, structure, and composition. The organic material may include anionic surfactants, cationic surfactants, neutral surfactants, carboxylic acids, polymers, copolymers, block copolymers, and combinations thereof.
摘要翻译：一种制备官能化部分的固态方法，包括将预定量的无机和无机材料和研磨介质放置在可旋转地连接到转盘平台的容器中，将一定量的有机材料装入容器中，使容器沿第一方向旋转同时将转盘平台沿与第一方向相反的第二方向转动，将无机和有机材料研磨成更小的各自的有机和无机颗粒，并将有机颗粒的部分熔融到无机聚合物中以限定官能化部分。无机材料可以包括不同阶段，结构和组成的磷酸钙。有机材料可以包括阴离子表面活性剂，阳离子表面活性剂，中性表面活性剂，羧酸，聚合物，共聚物，嵌段共聚物及其组合。

4. 发明申请

US20100068159A1 FUNCTIONALIZED CALCIUM PHOSPHATE HYBRID SYSTEMS FOR CONFECTIONERY AND FOODSTUFF APPLICATIONS 有权
标题翻译：功能化磷酸钙混合系统用于食品和食品应用
公开(公告)号：US20100068159A1
公开(公告)日：2010-03-18
申请号：US12210137
申请日：2008-09-12
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K8/24 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/361 , A61K8/365 , A61K9/16 , A61K9/1611 , A61K9/1617 , A61Q11/02 , C01F11/00 , C08K2003/325 , Y10T409/30
摘要： A method of whitening teeth, including an application of functionalized calcium phosphate additives generated via a solid-state method. The additives were produced by placing predetermined amounts of inorganic and inorganic materials and milling media into a vessel rotatably connected to a turntable platform, an amount of an organic material into the vessel, rotating the vessel in a first direction while turning the turntable platform in a second direction counter to the first direction, with the resultant material defining the functionalized calcium phosphate. The inorganic material may include calcium phosphates of varying phases, structure, and composition. The organic material may include anionic surfactants, cationic surfactants, neutral surfactants, carboxylic acids, polymers, copolymers, block copolymers, and combinations thereof. Once produced, the additives were added to comestibles, such as in confectionery and foodstuff formats, for delivery to the teeth and dental structures.
摘要翻译：一种美白牙齿的方法，包括通过固态方法生成的官能化磷酸钙添加剂的应用。添加剂通过将预定量的无机和无机材料和研磨介质放置在可旋转地连接到转盘平台的容器中，将一定量的有机材料放入容器中，使容器沿第一方向旋转，同时使转盘平台转动第二方向与第一方向相反，所得材料限定官能化的磷酸钙。无机材料可以包括不同阶段，结构和组成的磷酸钙。有机材料可以包括阴离子表面活性剂，阳离子表面活性剂，中性表面活性剂，羧酸，聚合物，共聚物，嵌段共聚物及其组合。一旦生产，将添加剂添加到食物中，例如糖果和食品形式，用于递送到牙齿和牙科结构。

5. 发明申请

US20160317580A9 COMPOSITION AND METHOD FOR DENTAL REMINERALIZATION 审中-公开
标题翻译：用于牙齿清除的组合物和方法
公开(公告)号：US20160317580A9
公开(公告)日：2016-11-03
申请号：US13711001
申请日：2012-12-11
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K33/42
CPC分类号： A61K33/42 , A61K45/06 , A61K2300/00
摘要： A dental remineralization composition, including a calcium phosphate portion and an organic portion. The calcium phosphate portion is selected from the group including β-TCP and combinations thereof and the β-TCP portion is present in concentrations between about 0.5 ppm to about 10,000 ppm. The organic portion is selected from the group including aspartic acid, glutamic acid, polypeptides, polymers containing functional groups, and combinations thereof and the organic portion is percent in concentrations between about 0.5 ppm to about 10,000 ppm.
摘要翻译：一种牙齿再矿化组合物，包括磷酸钙部分和有机部分。磷酸钙部分选自β-TCP及其组合，β-TCP部分以约0.5ppm至约10,000ppm的浓度存在。有机部分选自天冬氨酸，谷氨酸，多肽，含有官能团的聚合物及其组合，有机部分为约0.5ppm至约10,000ppm的浓度百分数。

6. 发明授权

US09403040B1 Calcium-free composition for dental mineralization 有权
标题翻译：用于牙科矿化的无钙组合物
公开(公告)号：US09403040B1
公开(公告)日：2016-08-02
申请号：US13555673
申请日：2012-07-23
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61Q11/00 , A61K8/21 , A61K8/24 , A61K8/19 , A61K6/00 , A61K8/02
CPC分类号： A61Q11/00 , A61K6/0017 , A61K6/007 , A61K6/0082 , A61K6/027 , A61K8/0216 , A61K8/19 , A61K8/21 , A61K8/24 , A61K2800/30
摘要： A method for the restoration of dentition, including dissolving a phosphate salt in water to define a calcium-free aqueous phosphate solution and applying the aqueous phosphate solution to dentition. The calcium-free aqueous phosphate solution has a phosphate concentration of between about 10 ppm and about 10000 ppm.
摘要翻译：一种恢复牙列的方法，包括将磷酸盐溶解在水中以限定无钙磷酸盐水溶液并将磷酸盐水溶液施用于牙列。无钙磷酸盐水溶液的磷酸盐浓度在约10ppm至约10000ppm之间。

7. 发明授权

US09023373B2 Functionalized calcium phosphate hybrid systems for the remineralization of teeth and a method for producing the same 有权
标题翻译：用于牙齿再矿化的功能化磷酸钙混合体系及其制造方法
公开(公告)号：US09023373B2
公开(公告)日：2015-05-05
申请号：US12465330
申请日：2009-05-13
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K9/68 , A61Q11/00 , A61K8/02 , A61K8/21 , A61K8/55 , A23L1/035 , A23L1/304 , A61K8/11 , A61K8/24 , A61K8/362 , A61K8/46
CPC分类号： A61Q11/00 , A23L29/10 , A23L33/16 , A61K8/0216 , A61K8/11 , A61K8/24 , A61K8/362 , A61K8/463 , A61K2800/92
摘要： A dental remineralizing system, including a functionalized calcium-containing complex having an organic surfactant component mechanochemically attached to a distressed calcium phosphate component and blended with the comestible material.
摘要翻译：一种牙齿再矿化系统，包括具有机械化学连接于苦味的磷酸钙组分并与可食材料混合的有机表面活性剂组分的官能化含钙络合物。

8. 发明申请

US20100034756A1 GRINDING METHOD FOR THE MANIPULATION OR PRESERVATION OF CALCIUM PHOSPHATE HYBRID PROPERTIES 有权
标题翻译：用于操作或保留磷酸钙混合物性质的研磨方法
公开(公告)号：US20100034756A1
公开(公告)日：2010-02-11
申请号：US12186940
申请日：2008-08-06
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K8/21 , C07F9/00 , A61K8/55 , A61Q11/00
CPC分类号： A61K9/16 , A61K6/0052 , A61K8/19 , A61K8/20 , A61K8/24 , A61K8/25 , A61K8/42 , A61K9/1611 , A61K9/1617 , A61Q11/00 , C01F11/00 , C08K2003/325
摘要： A solid state method of encouraging the physical interfacing of an organic component to a substantially crystalline inorganic component, including adding predetermined amounts of a substantially crystalline inorganic precursor and a predetermined amount of an organic precursor to yield an admixture, maintaining the admixture in a substantially liquid-free environment, and impacting the precursors together with sufficient energy to fuse the precursors into hybrid compounds. The so-formed hybrid compounds substantially retain the long range crystalline order characteristics of the substantially crystalline inorganic precursor.
摘要翻译：鼓励将有机组分物理接合到基本上结晶的无机组分的固体方法，包括加入预定量的基本上结晶的无机前体和预定量的有机前体以产生混合物，将混合物保持在基本上液体中并且将前体与足够的能量一起冲击前体以将前体融合成杂化化合物。如此形成的杂化化合物基本上保持了基本上结晶的无机前体的长程结晶顺序特征。

9. 发明申请

US20080187500A1 HYBRID ORGANIC/INORGANIC CHEMICAL HYBRID SYSTEMS, INCLUDING FUNCTIONALIZED CALCIUM PHOSPHATE HYBRID SYSTEMS, AND A SOLID-STATE METHOD FOR PRODUCING THE SAME 有权
标题翻译：混合有机/无机化学混合系统，包括功能化的磷酸钙混合系统，以及用于生产它们的固态方法
公开(公告)号：US20080187500A1
公开(公告)日：2008-08-07
申请号：US12018627
申请日：2008-01-23
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K6/08 , A61Q11/00
CPC分类号： A61K9/16 , A61K6/0082 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/86 , A61K9/1611 , A61K9/1617 , A61Q11/00 , B23C2220/00 , C01B25/32 , C01F11/00 , C08K2003/325 , Y10T409/30
摘要： A solid-state method of producing functionalized moieties, including placing predetermined amounts of inorganic and inorganic materials and milling media into a vessel rotatably connected to a turntable platform, an amount of an organic material into the vessel, rotating the vessel in a first direction while turning the turntable platform in a second direction counter to the first direction, milling the inorganic and organic materials into smaller respective organic and inorganic particles, and fusing portions of organic particles to inorganic parties to define functionalized moieties. The inorganic material may include calcium phosphates of varying phases, structure, and composition. The organic material may include anionic surfactants, cationic surfactants, neutral surfactants, carboxylic acids, polymers, copolymers, block copolymers, and combinations thereof.
摘要翻译：一种制备官能化部分的固态方法，包括将预定量的无机和无机材料和研磨介质放置在可旋转地连接到转盘平台的容器中，将一定量的有机材料装入容器中，使容器沿第一方向旋转同时将转盘平台沿与第一方向相反的第二方向转动，将无机和有机材料研磨成更小的各自的有机和无机颗粒，并将有机颗粒的部分熔融到无机聚合物中以限定官能化部分。无机材料可以包括不同阶段，结构和组成的磷酸钙。有机材料可以包括阴离子表面活性剂，阳离子表面活性剂，中性表面活性剂，羧酸，聚合物，共聚物，嵌段共聚物及其组合。

10. 发明授权

US10130561B2 Functionalized calcium phosphate hybrid systems for confectionery and foodstuff applications 有权
公开(公告)号：US10130561B2
公开(公告)日：2018-11-20
申请号：US12507989
申请日：2009-07-23
申请人： Robert L. Karlinsey
发明人： Robert L. Karlinsey
IPC分类号： A61K6/033
摘要： A method for repairing dentition, including milling beta tricalcium phosphate with sufficiently high energy to substantially distressed its lattice structure, mechanochemically chelating an edible acid thereto to yield functionalized calcium phosphate moieties, and incorporating the functionalized calcium phosphate moieties into an edible material to yield a calcium phosphate delivery system. The calcium phosphate delivery system is introduced into an oral environment and dentition is repaired. The functionalized calcium phosphate moiety is characterized by weakly bonded fumaric acid at least partially wrapped around distressed calcium phosphate particles, and dentition repair occurs at a dentition depth of at least 10 microns below the surface.

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