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1. 发明授权

US06743413B1 Suspension aerosol formulations 失效
标题翻译：悬浮气雾剂配方
公开(公告)号：US06743413B1
公开(公告)日：2004-06-01
申请号：US08455280
申请日：1995-05-31
申请人： Robert K. Schultz , David W. Schultz , Martin J. Oliver , Robert A. Moris , Philip A. Jinks
发明人： Robert K. Schultz , David W. Schultz , Martin J. Oliver , Robert A. Moris , Philip A. Jinks
IPC分类号： A61L904
CPC分类号： A61K9/008 , A61K9/124 , A61K31/137 , A61K31/44
摘要： Pharmaceutical suspension aerosol formulations containing a therapeutically effective amount of a drug and HFC 134a, HFC 227, or a mixture thereof.
摘要翻译：含有治疗有效量的药物和HFC 134a，HFC 227或其混合物的药物悬浮气雾剂制剂。

2. 发明授权

US6054488A Medicinal aerosol formulations of formoterol 失效
标题翻译：福莫特罗的药物气雾剂配方
公开(公告)号：US6054488A
公开(公告)日：2000-04-25
申请号：US88871
申请日：1998-06-02
申请人： Martin J. Oliver , Simon G. Paling , Philip A. Jinks , Sukhbinder K. Jaiswal
发明人： Martin J. Oliver , Simon G. Paling , Philip A. Jinks , Sukhbinder K. Jaiswal
IPC分类号： A61K9/00 , A61K31/167 , A61K31/135
CPC分类号： A61K9/008 , A61K31/167
摘要： A pharmaceutical suspension formulation suitable for aerosol administration having from 0.0025 to 0.1% w/w of micronized Formoterol, or an acid addition salt thereof, from 0.1 to 5.0% w/w ethanol, HFA 134a, HFA 227 or a mixture of HFA 227 and HFA 134a, and optionally a surfactant other than a monoacetylated or diacetylated monoglyceride, the formulation being further characterized in that it exhibits substantially no growth in particle size or change in crystal morphology of the drug over a prolonged period, is substantially and readily redispersible, and upon redispersion does not flocculate so quickly as to prevent reproducible dosing of the drug.
摘要翻译：适用于气溶胶施用的药物悬浮液制剂，其具有0.0025至0.1％w / w的微粉化福莫特罗或其酸加成盐，0.1至5.0％w / w乙醇，HFA 134a，HFA 227或HFA 227和 HFA 134a，以及任选的除了单乙酰化或二乙酰化单酸甘油酯之外的表面活性剂，该制剂的进一步特征在于其在长时间内基本上不显示药物的粒径或晶体形态的变化，基本上和容易可再分散，以及在再分散时不会如此快地絮凝，以防止药物的可重复给药。

3. 发明授权

US08791096B2 Heat sterilization of glucocorticosteroids 有权
标题翻译：糖皮质激素加热灭菌
公开(公告)号：US08791096B2
公开(公告)日：2014-07-29
申请号：US10594861
申请日：2005-05-17
申请人： Adrian Ashley , Paul Lamb , Donald MacDonald , John Miller , Martin J. Oliver , Mathew Pollard
发明人： Adrian Ashley , Paul Lamb , Donald MacDonald , John Miller , Martin J. Oliver , Mathew Pollard
IPC分类号： A61K31/56 , A61L2/00 , C07J5/00
CPC分类号： A61K9/1682 , A61K31/56 , A61K31/573 , A61K31/58 , A61L2/0011 , A61L2/0023 , C07J5/00
摘要： The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine-tuned to fit the condition(s) to be treated while producing fewer side effects.
摘要翻译：本发明提供了一种灭活不稳定糖皮质激素的方法，该方法包括以悬浮液的形式将不稳定的糖皮质激素通过湿热加热灭菌有效时间。根据本发明的方法和组合物可用作预防，逆转和/或减少哺乳动物患者的过敏和/或炎症状况的治疗工具。本发明还提供方法和组合物，其可以被操纵和微调以适应待治疗的状况，同时产生更少的副作用。

4. 发明授权

US4727317A Device orientation test method suitable for automatic test equipment 失效
标题翻译：设备方向测试方法适用于自动测试设备
公开(公告)号：US4727317A
公开(公告)日：1988-02-23
申请号：US796351
申请日：1985-11-07
申请人： Martin J. Oliver
发明人： Martin J. Oliver
IPC分类号： G01R31/26 , G01R19/14 , G01R31/28 , G01R31/00
CPC分类号： G01R19/14 , G01R31/2813
摘要： Part of a printed circuit board circuit is made up of three gates (30, 31, 32) each of which are formed on a different device and interconnected by the board print so that connections (35, 36) may be established by means of probes. Associated with the inputs and outputs of each device are phantom diodes (such as diode 32) which are normally connected to circuit ground (38) but which in the case of one gate (31) are connected the supply rail (37), the device of which it forms part having been mounted in the board in the wrong orientation. By the steps of connecting one device power input pin to a test ground potential (38), raising the potential of the other power input pin via connection to a supply rail (37) and lowering the potential of an active pin (33) a diode (302) may be made to conduct current via path (304) indicating that the device (31) is wrongly orientated. The applied low potential is insufficient to bring correctly connected diodes (such as that of device 30) into conduction.
摘要翻译：印刷电路板电路的一部分由三个门（30,31,32）组成，每个栅极形成在不同的装置上并通过板印刷互连，使得可以通过探针建立连接（35,36）。与每个设备的输入和输出相关联的是虚拟二极管（例如二极管32），其通常连接到电路接地（38），但是在一个栅极（31）的情况下连接到供电轨（37）的情况下，该设备其形成部分已经以错误的方向安装在板中。通过将一个设备电源输入引脚连接到测试地电位（38）的步骤，通过连接到电源轨（37）来提高另一个电源输入引脚的电位并降低有源引脚（33）的电位，二极管（302）可以被制成以指示装置（31）错误地定向的电流通路（304）。所施加的低电位不足以使正确连接的二极管（诸如器件30的二极管）导通。

5. 发明申请

US20080139519A1 Heat Sterilization of Glucocorticosteroids 有权
标题翻译：糖皮质激素的热灭菌
公开(公告)号：US20080139519A1
公开(公告)日：2008-06-12
申请号：US10594861
申请日：2005-05-17
申请人： Adrian Ashley , Paul Lamb , Donald MacDonald , John Miller , Martin J. Oliver , Mathew Pollard
发明人： Adrian Ashley , Paul Lamb , Donald MacDonald , John Miller , Martin J. Oliver , Mathew Pollard
IPC分类号： A61K31/575 , C07D317/70 , C07J1/00 , A61K31/58
CPC分类号： A61K9/1682 , A61K31/56 , A61K31/573 , A61K31/58 , A61L2/0011 , A61L2/0023 , C07J5/00
摘要： The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine-tuned to fit the condition(s) to be treated while producing fewer side effects.
摘要翻译：本发明提供了一种灭活不稳定糖皮质激素的方法，该方法包括以悬浮液的形式将不稳定的糖皮质激素通过湿热加热灭菌有效时间。根据本发明的方法和组合物可用作预防，逆转和/或减少哺乳动物患者的过敏和/或炎症状况的治疗工具。本发明还提供方法和组合物，其可以被操纵和微调以适应待治疗的状况，同时产生更少的副作用。

6. 发明授权

US06264923B1 Medicinal aerosol formulation of ciclesonide and related compounds 有权
标题翻译：环丙沙星和相关化合物的药物气雾剂配方
公开(公告)号：US06264923B1
公开(公告)日：2001-07-24
申请号：US09440797
申请日：1999-11-15
申请人： Martin J. Oliver , Kanu M. Fatania , John S. Scott , Helgert Muller
发明人： Martin J. Oliver , Kanu M. Fatania , John S. Scott , Helgert Muller
IPC分类号： A61K912
CPC分类号： A61K9/008 , A61K31/58
摘要： A pharmaceutical aerosol formulation suitable for oral and/or nasal inhalation including an anti-inflammatory steroid of the formula in which: R1 is 1-butyl, 2-butyl, cyclohexyl or phenyl and R2 is acetyl or isobutanoyl, in particular ciclesonide. The formulations also include hydrofluorocarbon propellants such as HFC 134a and/or 227, and cosolvent such as ethanol in an amount sufficient to solubilize the ciclesonide or related steroid (and various optional ingredients, such as surfactant). The formulations exhibit very desirable physical and chemical stability, as well as excellent delivery characteristics.
摘要翻译：适用于口服和/或鼻吸入的药物气溶胶制剂，其包括式为的抗炎类固醇，其R1为1-丁基，2-丁基，环己基或苯基，R 2为乙酰基或异丁酰基，特别是环索奈德。制剂还包括氢氟烃推进剂如HFC 134a和/或227，以及足够溶解环索奈丁或相关类固醇（和各种任选成分，如表面活性剂）的量的共溶剂如乙醇。制剂表现出非常理想的物理和化学稳定性以及优异的递送特性。

7. 发明授权

US6120752A Medicinal aerosol products containing formulations of ciclesonide and related steroids 失效
标题翻译：药用气溶胶产品含有环索奈德和相关类固醇的配方
公开(公告)号：US6120752A
公开(公告)日：2000-09-19
申请号：US76958
申请日：1998-05-13
申请人： Martin J. Oliver , Kanu M. Fatania , John S. Scott , Helgert Muller
发明人： Martin J. Oliver , Kanu M. Fatania , John S. Scott , Helgert Muller
IPC分类号： A61K9/00 , A61K9/12 , A61K31/573 , A61K31/58 , A61K47/06 , A61K47/10 , A61P11/06 , A61P29/00 , C07J71/00
CPC分类号： A61K9/008 , A61K31/58 , A61K9/124 , Y10S514/826
摘要： A pharmaceutical aerosol formulation suitable for oral and/or nasal inhalation including an anti-inflammatory steroid of the formula ##STR1## in which: R.sub.1 is 1-butyl, 2-butyl, cyclohexyl or phenyl andR.sub.2 is acetyl or isobutanoyl, in particular ciclesonide. The formulations also include hydrofluorocarbon propellants such as HFC 134a and/or 227, and cosolvent such as ethanol in an amount sufficient to solubilize the ciclesonide or related steroid (and various optional ingredients, such as surfactant). The formulations exhibit very desirable physical and chemical stability, as well as excellent delivery characteristics.
摘要翻译：一种适用于口服和/或鼻腔吸入的药物气溶胶制剂，包括下式的抗炎类固醇，其中：R1是1-丁基，2-丁基，环己基或苯基，R2是乙酰基或异丁酰基，特别是环索奈德。制剂还包括氢氟烃推进剂如HFC 134a和/或227，以及足够溶解环索奈丁或相关类固醇（和各种任选成分，如表面活性剂）的量的共溶剂如乙醇。制剂表现出非常理想的物理和化学稳定性以及优异的递送特性。

8. 发明授权

US4827208A Circuit testers 失效
标题翻译：电路测试仪
公开(公告)号：US4827208A
公开(公告)日：1989-05-02
申请号：US013886
申请日：1987-02-12
申请人： Martin J. Oliver , Kevin E. Brazier , Stephen R. Boote
发明人： Martin J. Oliver , Kevin E. Brazier , Stephen R. Boote
IPC分类号： G01R31/28 , G01R31/319 , G06F11/22 , H05K3/00 , G01R15/12
CPC分类号： G06F11/2273 , G01R31/31915
摘要： In circuit testers, notably automatic test equipment for the in circuit testing of digital devices, overheating damage can result if outputs are repeatedly "overdriven", that is, while applying a test input to a first device, an output of a second connected device is forced into a state contrary to that it would normally adopt. Damage is avoided by enforcing a cooling interval between overdriving tests based upon a list of parameters representative of the overdriven device and its environment. In order to reduce the overall test time, a parameter is based on a measurement derived from a circuit of the type under test. A first test results in device heating to a value. A cooling interval is enforced so that a subsequent test which results in further heating of the device, may be made without exceeding device maximum allowable temperature .sup.T max.
摘要翻译：在电路测试器中，特别是用于数字设备的电路测试的自动测试设备，如果输出被重复地“过驱动”，即在将测试输入应用于第一设备的同时，则可能导致过热损坏，第二连接设备的输出被迫成为与通常通过的状态相反的状态。通过基于表示过驱动装置及其环境的参数列表，实施过驱动试验之间的冷却间隔来避免损害。为了减少总体测试时间，参数基于从被测类型的电路得到的测量值。第一个测试结果是将设备加热到一个值。执行冷却间隔使得可以在不超过设备最大允许温度Tmax的情况下进行导致设备进一步加热的随后测试。

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