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    • 9. 发明授权
    • Method and system for improving the effectiveness of medical stents by the application of gas cluster ion beam technology
    • 应用气体离子束技术提高医疗支架有效性的方法和系统
    • US06676989B2
    • 2004-01-13
    • US09901204
    • 2001-07-09
    • Allen R. KirkpatrickRobert K. BeckerAvrum Freytsis
    • Allen R. KirkpatrickRobert K. BeckerAvrum Freytsis
    • B05D300
    • C23F3/00A61F2/91H01J2237/0812
    • Numerous studies suggest that the current popular designs of coronary stents are functionally equivalent and suffer a 16 to 22 percent rate of restenosis. Although the use of coronary stents is growing, the benefits of their use remain controversial in certain clinical situations or indications due to their potential complications. The application of gas cluster ion beam (GCIB) surface modification such as smoothing or cleaning appears to reduce these complications and lead to genuine cost savings and an improvement in patient quality of life. The present invention is directed to the use of GCIB surface modification to overcome prior problems of thrombosis and restenosis. The atomic level surface smoothing of stents utilizing GCIB substantially reduces undesirable surface micro-roughness in medical coronary stents.
    • 许多研究表明,目前流行的冠状动脉支架设计在功能上是相当的,并且再狭窄率为16%至22%。 虽然冠状动脉支架的使用正在增长,但由于其潜在的并发症,其使用的益处在某些临床情况或适应证中仍然存在争议。 气体簇离子束(GCIB)表面改性(如平滑或清洁)的应用似乎可以减少这些并发症,并导致真正的成本节约和改善患者的生活质量。 本发明涉及使用GCIB表面修饰来克服血栓形成和再狭窄的先前问题。 使用GCIB的支架的原子水平表面平滑化大大降低了医疗冠状动脉支架中不期望的表面微粗糙度。