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1. 发明申请

US20110038941A1 Lipid Nanoparticle Compositions and Methods of Making and Using the Same 审中-公开
标题翻译：脂质纳米颗粒组合物及其制备和使用方法
公开(公告)号：US20110038941A1
公开(公告)日：2011-02-17
申请号：US12810900
申请日：2008-12-23
申请人： Robert J. Lee , Bo Yu , L. James Lee
发明人： Robert J. Lee , Bo Yu , L. James Lee
IPC分类号： A61K9/00 , A61K31/7088 , B01J19/00 , A61K39/395 , A61P35/00 , B32B37/16
CPC分类号： C12N15/88 , A61K48/00
摘要： Oligonucleotide-lipid nanoparticles made of at least one oligonucleotide, at least one lipid and at least one complexation agent for the oligonucleotide, methods of making and using, and devices for making the same are disclosed.
摘要翻译：公开了由至少一种寡核苷酸，寡核苷酸，至少一种脂质和至少一种寡核苷酸络合剂制备的寡核苷酸 - 脂质纳米颗粒，其制备和使用方法及其制备方法。

2. 发明申请

US20110280913A1 Methods and Compositions for Delivering Therapeutic Agents in the Treatment of B-Cell Related Disorders 审中-公开
标题翻译：在治疗B细胞相关疾病中提供治疗药物的方法和组合物
公开(公告)号：US20110280913A1
公开(公告)日：2011-11-17
申请号：US13056009
申请日：2009-07-28
申请人： John C. Byrd , Natarajan Muthusamy , Robert J. Lee , James L. Lee , Rosa Lapalombella , Bo Yu
发明人： John C. Byrd , Natarajan Muthusamy , Robert J. Lee , James L. Lee , Rosa Lapalombella , Bo Yu
IPC分类号： A61K9/00 , C12N5/0781 , A61P37/04 , G01N33/566 , A61K35/02 , A61K39/395 , C12Q1/02
CPC分类号： A61K9/0019 , A61K31/454 , A61K39/39558 , A61K2300/00
摘要： Methods and compositions for treating and/or diagnosing a B-cell malignancy are described.
摘要翻译：描述了用于治疗和/或诊断B细胞恶性肿瘤的方法和组合物。

3. 发明授权

US08005072B2 Synchronization of multiple base stations in a wireless communication system 失效
标题翻译：无线通信系统中多个基站的同步
公开(公告)号：US08005072B2
公开(公告)日：2011-08-23
申请号：US11392806
申请日：2006-03-30
申请人： Anders Hebsgaard , David R. Dworkin , Lisa V. Denney , Robert J. Lee , Thomas J. Quigley
发明人： Anders Hebsgaard , David R. Dworkin , Lisa V. Denney , Robert J. Lee , Thomas J. Quigley
IPC分类号： H04L12/66
CPC分类号： H04L25/03343 , H04B1/1036 , H04J3/0664 , H04J3/067 , H04J3/0682 , H04L12/2801 , H04L2025/03808
摘要： A plurality of CMTS devices are linked together and synchronized to facilitate communication between the respective CMTS devices and respective downstream cable modems. According to one embodiment of the invention, one of the CMTS devices is designated as a master device, and the other CMTS devices are designated as slave devices. The respective CMTS devices are connected to each other by means of a synchronization bus. The master CMTS device then generates and broadcasts a future time stamp value, which is received by the respective slave CMTS devices. When the time stamp counter in the master CMTS device reaches the transmitted value, a control signal is broadcast over the synchronization bus. The slave CMTS devices then retrieve the time stamp value and reset their respective local time stamp counters to the received value. In this manner, the CMTS devices are synchronized.
摘要翻译：多个CMTS设备被链接在一起并被同步以促进各个CMTS设备和相应的下游电缆调制解调器之间的通信。根据本发明的一个实施例，CMTS设备中的一个被指定为主设备，并且其他CMTS设备被指定为从设备。相应的CMTS设备通过同步总线相互连接。然后，主CMTS设备生成并广播由相应从属CMTS设备接收的将来的时间戳值。当主CMTS设备中的时间戳计数器达到发送值时，通过同步总线广播控制信号。从属CMTS设备然后检索时间戳值并将其各自的本地时间戳计数器重置为接收的值。以这种方式，CMTS设备被同步。

4. 发明申请

US20110200048A1 Modem with Voice Processing Capability 失效
标题翻译：具有语音处理能力的调制解调器
公开(公告)号：US20110200048A1
公开(公告)日：2011-08-18
申请号：US13092255
申请日：2011-04-22
申请人： James C. Thi , Theodore F. Rabenko , David Hartman , Robert M. Lukas , Kenneth J. Unger , Ramin Borazjani , Shane P. Lansing , Robert J. Lee , Todd L. Brooks , Kevin L. Miller
发明人： James C. Thi , Theodore F. Rabenko , David Hartman , Robert M. Lukas , Kenneth J. Unger , Ramin Borazjani , Shane P. Lansing , Robert J. Lee , Todd L. Brooks , Kevin L. Miller
IPC分类号： G10L21/02 , H04L12/56
CPC分类号： H04M7/0087 , H04B3/23 , H04B3/234 , H04J3/0632 , H04J3/0638 , H04L12/2801 , H04L12/2834 , H04L12/5692 , H04L12/66 , H04L29/06027 , H04L65/1069 , H04M7/006 , H04M7/125 , H04N7/10 , H04N21/2383 , H04N21/4382
摘要： A system is configured to facilitate bidirectional voice communication between a number of data and/or telephony devices.
摘要翻译：系统被配置为促进多个数据和/或电话设备之间的双向语音通信。

5. 发明授权

US07782855B2 Method and apparatus for the reduction of upstream request processing latency in a cable modem termination system 有权
标题翻译：用于减少有线调制解调器终端系统中的上游请求处理延迟的方法和装置
公开(公告)号：US07782855B2
公开(公告)日：2010-08-24
申请号：US11121116
申请日：2005-05-04
申请人： Lisa V. Denney , Anders Hebsgaard , Robert J. Lee
发明人： Lisa V. Denney , Anders Hebsgaard , Robert J. Lee
IPC分类号： H04L12/28
CPC分类号： H04L47/2441 , H04L12/2801 , H04L12/66 , H04L47/15 , H04L47/35 , H04L47/70 , H04L47/788 , H04L47/821
摘要： Upstream requests such a bandwidth requests, are processed by CMTS out of order on a priority basis to reduce latency in responding to the request. Specifically, a cable modem termination system (CMTS) is connected to a plurality of cable modems by a cable plant. The CMTS has a burst receiver adapted to be connected to the cable plant to process upstream data packet units and bandwidth requests transmitted by the cable modems. Each packet includes a header that uniquely distinguishes the bandwidth requests from other data types. Packet data units are arranged in a first memory queue. Bandwidth requests are arranged in a second memory queue. The headers of the packets processed by the burst receiver are inspected as they arrive at the CMTS to determine if the packets are packet data units or bandwidth requests. Packet data units are routed to the first memory queue. Bandwidth requests are routed to the second memory queue. Bandwidth allocation MAP messages are generated from the bandwidth requests stored in the second queue and transmitted downstream to the cable modems. The packet data units stored in the first queue are coupled to a data output for further distribution.
摘要翻译：上行请求这样的带宽请求由CMTS按优先级顺序处理，以减少响应请求的延迟。具体来说，电缆调制解调器终端系统（CMTS）由电缆设备连接到多个电缆调制解调器。 CMTS具有适于连接到电缆设备的突发接收器，以处理由电缆调制解调器发送的上行数据分组单元和带宽请求。每个数据包包括一个能够唯一区分带宽请求与其他数据类型的头。分组数据单元被布置在第一存储器队列中。带宽请求被排列在第二个存储器队列中。由突发接收器处理的分组的报头在到达CMTS时进行检查，以确定分组是分组数据单元还是带宽请求。分组数据单元被路由到第一个存储器队列。带宽请求被路由到第二个内存队列。带宽分配MAP消息是从存储在第二个队列中的带宽请求产生的，并向下游发送到电缆调制解调器。存储在第一队列中的分组数据单元被耦合到数据输出用于进一步分配。

6. 发明申请

US20100135329A1 Methods To Suppress And Expand Packet Header Information In A Wireless Communication System 有权
标题翻译：在无线通信系统中抑制和扩展数据包报头信息的方法
公开(公告)号：US20100135329A1
公开(公告)日：2010-06-03
申请号：US12696836
申请日：2010-01-29
申请人： John D. HORTON, JR. , Robert J. Lee , David M. Pullen
发明人： John D. HORTON, JR. , Robert J. Lee , David M. Pullen
IPC分类号： H04L29/06
CPC分类号： H04L65/608 , H04L29/06027 , H04L69/04 , H04L69/22 , H04Q11/04 , H04Q2213/13034 , H04Q2213/1305 , H04Q2213/13166 , H04Q2213/13202 , H04Q2213/13296 , H04Q2213/13389 , H04W28/06
摘要： Data packets transmitted over a wireless network are suppressed by hardware at the transmitting end and expanded on the receiving end. This conserves bandwidth as well as reduces the processing resource requirements in both the subscriber station and the base station. An extended header element is added to a data packet that is to be transmitted over the wireless network. The extended header element contains an index that is used along with an identifier to access a rule. The rule is used to determine which bytes are to be suppressed at the transmitter and expanded at the receiver.
摘要翻译：通过无线网络发送的数据分组被发送端的硬件抑制，并在接收端扩展。这节省了带宽以及减少了用户站和基站的处理资源需求。扩展头元素被添加到将通过无线网络发送的数据分组。扩展头元素包含与标识符一起使用以访问规则的索引。该规则用于确定在发射机处将要抑制哪些字节并在接收机处扩展。

7. 发明授权

US07933295B2 Cable modem with voice processing capability 失效
标题翻译：具有语音处理能力的电缆调制解调器
公开(公告)号：US07933295B2
公开(公告)日：2011-04-26
申请号：US09949811
申请日：2001-09-12
申请人： James C. Thi , Theodore F. Rabenko , David Hartman , Robert M. Lukas , Kenneth J. Unger , Ramin Borazjani , Shane P. Lansing , Robert J. Lee , Todd L. Brooks , Kevin L. Miller
发明人： James C. Thi , Theodore F. Rabenko , David Hartman , Robert M. Lukas , Kenneth J. Unger , Ramin Borazjani , Shane P. Lansing , Robert J. Lee , Todd L. Brooks , Kevin L. Miller
IPC分类号： H04J1/02 , H04L12/66 , H04M9/08 , H04N7/173
CPC分类号： H04M7/0087 , H04B3/23 , H04B3/234 , H04J3/0632 , H04J3/0638 , H04L12/2801 , H04L12/2834 , H04L12/5692 , H04L12/66 , H04L29/06027 , H04L65/1069 , H04M7/006 , H04M7/125 , H04N7/10 , H04N21/2383 , H04N21/4382
摘要： A network gateway is configured to facilitate on line and off line bi-directional communication between a number of near end data and telephony devices with far end data termination devices via a hybrid fiber coaxial network and a cable modem termination system. The described network gateway combines a QAM receiver, a transmitter, a DOCSIS MAC, a CPU, a voice and audio processor, a voice synchronizer, an Ethernet MAC, and a USB controller to provide high performance and robust operation.
摘要翻译：网络网关被配置为通过混合光纤同轴网络和电缆调制解调器终端系统来促进多个近端数据与具有远端数据终端设备的电话设备之间的在线和离线双向通信。所描述的网络网关组合了QAM接收机，发射机，DOCSIS MAC，CPU，语音和音频处理器，语音同步器，以太网MAC和USB控制器，以提供高性能和鲁棒的操作。

8. 发明授权

US06909715B1 Method and apparatus for the reduction of upstream request processing latency in a cable modem termination system 有权
标题翻译：用于减少有线调制解调器终端系统中的上游请求处理延迟的方法和装置
公开(公告)号：US06909715B1
公开(公告)日：2005-06-21
申请号：US09652718
申请日：2000-08-31
申请人： Lisa V. Denney , Anders Hebsgaard , Robert J. Lee
发明人： Lisa V. Denney , Anders Hebsgaard , Robert J. Lee
IPC分类号： H04L12/28 , H04L12/56
CPC分类号： H04L47/2441 , H04L12/2801 , H04L12/66 , H04L47/15 , H04L47/35 , H04L47/70 , H04L47/788 , H04L47/821
摘要： Upstream requests such a bandwidth requests, are processed by CMTS out of order on a priority basis to reduce latency in responding to the request. Specifically, a cable modem termination system (CMTS) is connected to a plurality of cable modems by a cable plant. The CMTS has a burst receiver adapted to be connected to the cable plant to process upstream data packet units and bandwidth requests transmitted by the cable modems. Each packet includes a header that uniquely distinguishes the bandwidth requests from other data types. Packet data units are arranged in a first memory queue. Bandwidth requests are arranged in a second memory queue. The headers of the packets processed by the burst receiver are inspected as they arrive at the CMTS to determine if the packets are packet data units or bandwidth requests. Packet data units are routed to the first memory queue. Bandwidth requests are routed to the second memory queue. Bandwidth allocation MAP messages are generated from the bandwidth requests stored in the second queue and transmitted downstream to the cable modems. The packet data units stored in the first queue are coupled to a data output for further distribution.
摘要翻译：上行请求这样的带宽请求由CMTS按优先级顺序处理，以减少响应请求的延迟。具体来说，电缆调制解调器终端系统（CMTS）由电缆设备连接到多个电缆调制解调器。 CMTS具有适于连接到电缆设备的突发接收器，以处理由电缆调制解调器发送的上行数据分组单元和带宽请求。每个数据包包括一个能够唯一区分带宽请求与其他数据类型的头。分组数据单元被布置在第一存储器队列中。带宽请求被排列在第二个存储器队列中。由突发接收器处理的分组的报头在到达CMTS时进行检查，以确定分组是分组数据单元还是带宽请求。分组数据单元被路由到第一个存储器队列。带宽请求被路由到第二个内存队列。带宽分配MAP消息是从存储在第二个队列中的带宽请求产生的，并向下游发送到电缆调制解调器。存储在第一队列中的分组数据单元被耦合到数据输出用于进一步分配。

9. 发明授权

US07688826B2 Methods to suppress and expand packet header information in a wireless communication system 有权
标题翻译：在无线通信系统中抑制和扩展分组报头信息的方法
公开(公告)号：US07688826B2
公开(公告)日：2010-03-30
申请号：US11723687
申请日：2007-03-21
申请人： John D. Horton, Jr. , Robert J. Lee , David M. Pullen
发明人： John D. Horton, Jr. , Robert J. Lee , David M. Pullen
IPC分类号： H04L12/28
CPC分类号： H04L65/608 , H04L29/06027 , H04L69/04 , H04L69/22 , H04Q11/04 , H04Q2213/13034 , H04Q2213/1305 , H04Q2213/13166 , H04Q2213/13202 , H04Q2213/13296 , H04Q2213/13389 , H04W28/06
摘要： Data packets transmitted over a wireless network are suppressed by hardware at the transmitting end and expanded on the receiving end. This conserves bandwidth as well as reduces the processing resource requirements in both the subscriber station and the base station. An extended header element is added to a data packet that is to be transmitted over the wireless network. The extended header element contains an index that is used along with an identifier to access a rule. The rule is used to determine which bytes are to be suppressed at the transmitter and expanded at the receiver.
摘要翻译：通过无线网络发送的数据分组被发送端的硬件抑制，并在接收端扩展。这节省了带宽以及减少了用户站和基站的处理资源需求。扩展头元素被添加到将通过无线网络发送的数据分组。扩展头元素包含与标识符一起使用以访问规则的索引。该规则用于确定在发射机处将要抑制哪些字节并在接收机处扩展。

10. 发明授权

US07433352B2 System for the suppression and expansion of packet header information therefor 失效
标题翻译：用于抑制和扩展数据包头信息的系统
公开(公告)号：US07433352B2
公开(公告)日：2008-10-07
申请号：US10900382
申请日：2004-07-28
申请人： John D. Horton, Jr. , Robert J. Lee , David M. Pullen
发明人： John D. Horton, Jr. , Robert J. Lee , David M. Pullen
IPC分类号： H04L12/56
CPC分类号： H04L65/608 , H04L29/06027 , H04L69/04 , H04L69/22 , H04Q11/04 , H04Q2213/13034 , H04Q2213/1305 , H04Q2213/13166 , H04Q2213/13202 , H04Q2213/13296 , H04Q2213/13389 , H04W28/06
摘要： Data packets transmitted over a cable network are suppressed by hardware at the transmitting end and expanded on the receiving end. This conserves bandwidth as well as reduces the processing resource requirements in both the CM and the CMTS. An extended header element is added to a data packet that is to be transmitted over the cable network. The extended header element contains an index that is used along with the SID to access a rule. The rule is used to determine which bytes are to be suppressed at the transmitter and expanded at the receiver.
摘要翻译：通过有线网络传输的数据包在发送端被硬件抑制，并在接收端扩展。这节省了带宽，并减少了CM和CMTS中的处理资源需求。扩展头元素被添加到要通过有线网络传输的数据包。扩展头元素包含与SID一起用于访问规则的索引。该规则用于确定在发射机处将要抑制哪些字节并在接收机处扩展。

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