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1. 发明授权

US09061150B2 Saliency-based apparatus and methods for visual prostheses 有权
标题翻译：视觉假体的基于显着性的装置和方法
公开(公告)号：US09061150B2
公开(公告)日：2015-06-23
申请号：US12043830
申请日：2008-03-06
申请人： Robert J. Greenberg , Alan Matthew Horsager , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon , Peter Meilstrup , Neha Jagdish Parikh , Arup Roy , James D. Weiland , Chunhong Zhou
发明人： Robert J. Greenberg , Alan Matthew Horsager , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon , Peter Meilstrup , Neha Jagdish Parikh , Arup Roy , James D. Weiland , Chunhong Zhou
IPC分类号： A61N1/36 , A61F9/08 , G06K9/46 , G06K9/60 , G09B21/00
CPC分类号： A61N1/36046 , A61F9/08 , G06K9/4604 , G06K9/4628 , G06K9/605 , G09B21/008
摘要： The present invention is a saliency-based apparatus and methods for visual prostheses. A saliency-based component processes video data output by a digital signal processor before the video data are input to the retinal stimulator. In a saliency-based method, an intensity stream is extracted from an input image, feature maps based on the intensity stream are developed, plural most salient regions of the input image are detected and one of the regions is selected as a highest saliency region.
摘要翻译：本发明是用于视觉假体的基于显眼的装置和方法。基于显眼的组件在将视频数据输入到视网膜刺激器之前处理由数字信号处理器输出的视频数据。在基于显着性的方法中，从输入图像中提取强度流，基于强度流形成特征图，检测输入图像的多个最显着区域，并选择其中一个区域作为最高显着区域。

2. 发明授权

US08239034B2 Visual prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US08239034B2
公开(公告)日：2012-08-07
申请号：US11875760
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method to provide visual current feedback of a retinal stimulation system. The method comprising: providing a retinal stimulation system configured to stimulate neural tissue in a subject's eye, the retinal stimulation system comprising: an electronics package; and at least a first and a second electrode, each associated with the electronics package and configured to apply current to a subject's retina; wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance; and providing a visual interface configured to show impedance of at least one of the electrodes.
摘要翻译：提供视网膜刺激系统的视觉电流反馈的方法。该方法包括：提供构造成刺激受试者眼睛中的神经组织的视网膜刺激系统，所述视网膜刺激系统包括：电子封装; 以及至少第一和第二电极，每个电极与电子封装相关联并且被配置为将电流施加到受试者的视网膜; 其中当所述第一电极具有低于第二电极阻抗的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极; 以及提供被配置为显示至少一个所述电极的阻抗的视觉界面。

3. 发明授权

US08239033B2 Visual prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US08239033B2
公开(公告)日：2012-08-07
申请号：US11875724
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method for stimulating a subject's retina. The method comprising selecting at least a first and a second electrode each configured to apply current to a subject's retina, determining impedance for the at least first electrode and second electrode, and applying current to the subject's retina through the at least first and second electrode, wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：刺激受试者视网膜的方法。所述方法包括选择至少第一和第二电极，每个电极被配置为向对象的视网膜施加电流，确定至少第一电极和第二电极的阻抗，以及通过至少第一和第二电极将电流施加到对象的视网膜，其中，当所述第一电极具有比所述第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极。

4. 发明申请

US20080262570A1 Visual Prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US20080262570A1
公开(公告)日：2008-10-23
申请号：US11875742
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A retinal stimulation system. The retinal stimulation system comprises an electronics package; and at least a first and a second electrode, each associated with the electronics package and configured to apply current to a subject's retina; wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance
摘要翻译：视网膜刺激系统。视网膜刺激系统包括电子封装; 以及至少第一和第二电极，每个电极与电子封装相关联并且被配置为将电流施加到受试者的视网膜; 其中，当所述第一电极具有低于第二电极阻抗的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极

5. 发明授权

US08244363B2 Visual prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US08244363B2
公开(公告)日：2012-08-14
申请号：US11875742
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A retinal stimulation system. The retinal stimulation system comprises an electronics package; and at least a first and a second electrode, each associated with the electronics package and configured to apply current to a subject's retina; wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：视网膜刺激系统。视网膜刺激系统包括电子封装; 以及至少第一和第二电极，每个电极与电子封装相关联并且被配置为将电流施加到受试者的视网膜; 其中，当所述第一电极具有比所述第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极。

6. 发明申请

US20080262571A1 Visual Prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US20080262571A1
公开(公告)日：2008-10-23
申请号：US11875760
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method to provide visual current feedback of a retinal stimulation system. The method comprising: providing a retinal stimulation system configured to stimulate neural tissue in a subject's eye, the retinal stimulation system comprising: an electronics package; and at least a first and a second electrode, each associated with the electronics package and configured to apply current to a subject's retina; wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance; and providing a visual interface configured to show impedance of at least one of the electrodes.
摘要翻译：提供视网膜刺激系统的视觉电流反馈的方法。该方法包括：提供构造成刺激受试者眼睛中的神经组织的视网膜刺激系统，所述视网膜刺激系统包括：电子封装; 以及至少第一和第二电极，每个电极与电子封装相关联并且被配置为将电流施加到受试者的视网膜; 其中当所述第一电极具有低于第二电极阻抗的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极; 以及提供被配置为显示至少一个所述电极的阻抗的视觉界面。

7. 发明申请

US20090112287A1 SALIENCY-BASED APPARATUS AND METHODS FOR VISUAL PROSTHESES 有权
标题翻译：基于SALIENCY的设备和视觉展示的方法
公开(公告)号：US20090112287A1
公开(公告)日：2009-04-30
申请号：US12043830
申请日：2008-03-06
申请人： Robert J. Greenberg , Alan Matthew Horsager , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon , Peter Meilstrup , Neha Jagdish Parikh , Arup Roy , James D. Weiland , Chunhong Zhou
发明人： Robert J. Greenberg , Alan Matthew Horsager , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon , Peter Meilstrup , Neha Jagdish Parikh , Arup Roy , James D. Weiland , Chunhong Zhou
IPC分类号： A61F9/08
CPC分类号： A61N1/36046 , A61F9/08 , G06K9/4604 , G06K9/4628 , G06K9/605 , G09B21/008
摘要： Saliency-based apparatus and methods for visual prostheses are disclosed. A saliency-based component processes video data output by a digital signal processor before the video data are input to the retinal stimulator. In a saliency-based method, an intensity stream is extracted from an input image, feature maps based on the intensity stream are developed, plural most salient regions of the input image are detected and one of the regions is selected as a highest saliency region.
摘要翻译：公开了用于视觉假体的基于显着性的装置和方法。基于显眼的组件在将视频数据输入到视网膜刺激器之前处理由数字信号处理器输出的视频数据。在基于显着性的方法中，从输入图像中提取强度流，基于强度流形成特征图，检测输入图像的多个最显着区域，并选择其中一个区域作为最高显着区域。

8. 发明申请

US20080262569A1 Visual Prosthesis 有权
标题翻译：视觉假体
公开(公告)号：US20080262569A1
公开(公告)日：2008-10-23
申请号：US11875724
申请日：2007-10-19
申请人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
发明人： Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure , Matthew J. McMahon
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method for stimulating a subject's retina. The method comprising selecting at least a first and a second electrode each configured to apply current to a subject's retina, determining impedance for the at least first electrode and second electrode, and applying current to the subject's retina through the at least first and second electrode, wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：刺激受试者视网膜的方法。所述方法包括选择至少第一和第二电极，每个电极被配置为向对象的视网膜施加电流，确定至少第一电极和第二电极的阻抗，以及通过至少第一和第二电极将电流施加到对象的视网膜，其中，当所述第一电极具有比所述第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为高于所述第一电极。

9. 发明申请

US20080288036A1 Flexible Circuit Electrode Array with Wire or Film Support 有权
标题翻译：带电线或薄膜支架的柔性电路电极阵列
公开(公告)号：US20080288036A1
公开(公告)日：2008-11-20
申请号：US12032627
申请日：2008-02-15
申请人： Robert J. Greenberg , Eugene de Juan , Mark S. Humayun , Kelly H. McClure , Neil Hamilton Talbot , Jordan Matthew Neysmith , Brian V. Mech , James Singleton Little , Mohamed Khaldi
发明人： Robert J. Greenberg , Eugene de Juan , Mark S. Humayun , Kelly H. McClure , Neil Hamilton Talbot , Jordan Matthew Neysmith , Brian V. Mech , James Singleton Little , Mohamed Khaldi
IPC分类号： A61N1/04
CPC分类号： A61N1/0543 , A61N1/05 , A61N1/0541 , H05K1/0393 , H05K1/118
摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.
摘要翻译：本发明涉及柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及嵌入在所述阵列中的至少一个支撑。本发明还涉及一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及将电极阵列与互连衬垫连接的折叠柔性电路电缆。本公开还涉及一种制造柔性电路电极阵列的方法，包括：沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 将所述柔性电路电极阵列加热到模具中以在所述柔性电路电极阵列中形成三维形状，至少在基层，顶层或基底与顶层之间嵌入支撑件，和/或折叠柔性电路电缆至少一次将电极阵列与互连衬垫连接在一起。

10. 发明授权

US07571004B2 Neural stimulation for increased persistence 有权
标题翻译：增加持久性的神经刺激
公开(公告)号：US07571004B2
公开(公告)日：2009-08-04
申请号：US11044761
申请日：2005-01-26
申请人： Arup Roy , Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure
发明人： Arup Roy , Robert J. Greenberg , Mark S. Humayun , Kelly H. McClure
IPC分类号： A61N1/00
CPC分类号： A61N1/36046
摘要： The present invention is a method of improving the persistence of electrical neural stimulation, and specifically a method of improving the persistence of an image supplied to a retina, or visual cortex, through a visual prosthesis. A continuously stimulated retina, or other neural tissue, will desensitize after a time period in the range of 20 to 150 seconds. However, an interruption of the stimulation on the order of a few milliseconds will restore the retinal sensitivity without the user perceiving the interruption, or with the user barely perceiving the interruption.
摘要翻译：本发明是一种改善电神经刺激持续性的方法，具体地说，一种改善通过视觉假体提供给视网膜或视觉皮层的图像的持续性的方法。连续刺激的视网膜或其他神经组织将在20至150秒的时间段内脱敏。然而，几毫秒级别的刺激的中断将恢复视网膜灵敏度，而不会使用户感觉到中断，或者用户几乎感觉到中断。

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