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1. 发明授权

US5814813A End cap reflection for a time-of-flight mass spectrometer and method of using the same 失效
标题翻译：飞行时间质谱仪的端盖反射及其使用方法
公开(公告)号：US5814813A
公开(公告)日：1998-09-29
申请号：US677033
申请日：1996-07-08
申请人： Robert J. Cotter , Timothy J. Cornish
发明人： Robert J. Cotter , Timothy J. Cornish
IPC分类号： G01N27/62 , B01D59/46 , H01J49/02 , H01J49/06 , H01J49/40 , B01D59/44 , H01J49/00
CPC分类号： H01J49/405
摘要： A reflectron for use with a mass spectrometer that focuses ions having different energies contains a conductive end cap that is electrically connected to a first voltage. A conductive surface is electrically isolated from the end cap and connected to a second voltage. This conductive surface cooperates with the conductive end cap to establish an inner region in which a non-linear electric field exists. As a result, ions having different energies enter and exit the inner region at a common opening and, when within the inner region, are reflected without penetrating past the conductive surface.
摘要翻译：用于聚焦具有不同能量的离子的质谱仪的反射器包含电连接到第一电压的导电端盖。导电表面与端帽电隔离并连接到第二电压。该导电表面与导电端盖配合以建立存在非线性电场的内部区域。结果，具有不同能量的离子在公共开口处进入和离开内部区域，并且在内部区域内被反射而不穿过导电表面。

2. 发明授权

US5464985A Non-linear field reflectron 失效
标题翻译：非线性场反射镜
公开(公告)号：US5464985A
公开(公告)日：1995-11-07
申请号：US130530
申请日：1993-10-01
申请人： Timothy J. Cornish , Robert J. Cotter
发明人： Timothy J. Cornish , Robert J. Cotter
IPC分类号： H01J49/40
CPC分类号： H01J49/405
摘要： A reflectron capable of focusing an entire mass range of product ions at substantially the same focal point, comprising a plurality of lens plates, each having an opening therein, for generating a non-linear electric field in the reflectron. To generate the non-linear electric field, the voltage applied to each successive lens plate increases non-linearly with respect to its adjacent lens plate. The voltage of the first lens plate having the opening through which the ions first enter the reflectron is set to a low potential and the voltage being applied to each successive lens plate increases in a non-linear manner with the largest voltage being applied to the lens plate furthest from the first lens plate. This non-linear voltage application, to generate the non-linear electric field, can be achieved by coupling a potentiometer between each lens plate and adjusting each potentiometer accordingly. Alternatively, to generate the non-linear electric field, the lens plates may be unequally spaced and an equal voltage may be applied to each lens plate.
摘要翻译：一种反射镜，其能够将基本上相同的焦点处的整个质量范围的产物离子聚焦，包括多个透镜板，每个透镜板在其中具有开口，用于在反射器中产生非线性电场。为了产生非线性电场，施加到每个连续透镜板的电压相对于其相邻的透镜板非线性增加。具有离子首先进入反射器的开口的第一透镜板的电压被设定为低电位，并且施加到每个连续透镜板的电压以非线性方式增加，其中施加到透镜的最大电压板最远离第一透镜板。用于产生非线性电场的非线性电压应用可以通过在每个透镜板之间耦合电位器并相应地调节每个电位器来实现。或者，为了产生非线性电场，透镜板可以不等间隔，并且可以向每个透镜板施加相等的电压。

3. 发明授权

US5202563A Tandem time-of-flight mass spectrometer 失效
标题翻译： TANDEM飞行时间质谱仪
公开(公告)号：US5202563A
公开(公告)日：1993-04-13
申请号：US700697
申请日：1991-05-16
申请人： Robert J. Cotter , Timothy J. Cornish
发明人： Robert J. Cotter , Timothy J. Cornish
IPC分类号： G01N27/62 , H01J49/40
CPC分类号： H01J49/004 , H01J49/406
摘要： A tandem time-of-flight mass spectrometer comprises a grounded vacuum housing, two reflecting-type mass analyzers coupled via a collision chamber, and flight channels electrically floated with respect to the grounded vacuum housing. The first reflecting-type mass analyzer receives ionized molecules (ions). These ions pass through the flight channel of the first reflecting-type mass analyzer and are fragmented in the collision chamber. The fragmented ions pass through the flight channel of the second reflecting-type mass analyzer. Detectors disposed in the collision chamber and in the second reflecting-type mass analyzer detect the spectrum of the first reflecting-type mass analyzer and the spectra of the tandem time-of-flight mass analyzer, respectively.
摘要翻译：串联飞行时间质谱仪包括接地的真空壳体，通过碰撞室耦合的两个反射型质量分析器和相对于接地的真空壳体浮动的飞行通道。第一反射型质量分析仪接收电离分子（离子）。这些离子通过第一反射型质量分析器的飞行通道并在碰撞室中分段。碎片离子通过第二反射型质量分析仪的飞行通道。设置在碰撞室中的检测器和第二反射型质量分析器分别检测第一反射型质量分析器的光谱和串联飞行时间质量分析器的光谱。

4. 发明授权

US06841773B2 Portable time-of-flight mass spectrometer system 有权
标题翻译：便携式飞行时间质谱仪系统
公开(公告)号：US06841773B2
公开(公告)日：2005-01-11
申请号：US10069894
申请日：2001-05-23
申请人： Michael P. McLoughlin , William R. Allmon , Charles W. Anderson , Micah A. Carlson , Nicholas H. Evancich , Wayne A. Bryden , Scott A. Ecelberger , James T. Velky , Daniel J. DeCicco , Timothy J. Cornish
发明人： Michael P. McLoughlin , William R. Allmon , Charles W. Anderson , Micah A. Carlson , Nicholas H. Evancich , Wayne A. Bryden , Scott A. Ecelberger , James T. Velky , Daniel J. DeCicco , Timothy J. Cornish
IPC分类号： G01N27/62 , G01N1/00 , G01N1/02 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16 , H01J49/24 , H01J49/40
CPC分类号： H01J49/0409 , H01J49/0022 , H01J49/40 , Y10T436/24
摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.
摘要翻译：一种现场便携式质谱仪系统，包括样品收集器和样品转运器。样品转运器与样品收集器接口以在其上接收样品沉积物。该系统还包括飞行时间（TOF）质谱仪。飞行时间质谱仪具有可密封的开口，其接收在质谱仪的提取区域中通过样品转运器传送的样品。该系统还包括控制单元，其处理由质谱仪输出的时间序列用于接收的样本，并识别样品中包含的一种或多种试剂。

5. 发明授权

US07115859B2 Time- of flight mass spectrometers for improving resolution and mass employing an impulse extraction ion source 有权
标题翻译：使用脉冲提取离子源提高分辨率和质量的飞行时间质谱仪
公开(公告)号：US07115859B2
公开(公告)日：2006-10-03
申请号：US10486473
申请日：2003-07-17
申请人： Timothy J. Cornish
发明人： Timothy J. Cornish
IPC分类号： B01D55/44 , H01D49/00
CPC分类号： H01J49/0013 , H01J49/164 , H01J49/40
摘要： A miniature time-of-flight mass spectrometer (TOF-MS) and method for increasing the collection efficiency of laser-desorbed ions in a miniature time-of-flight mass spectrometer (TOF-MS) is provided. The method provides a laser pulse generated by an ionization extraction device within the TOF-MS; maintains a sample plate potential at a ground level for a fixed delay period of about 50 ns; and uses a high voltage switch to sharply increase the sample plate potential up to 10 kV/mm.
摘要翻译：提供了一种微型飞行时间质谱仪（TOF-MS）和提高微型飞行时间质谱仪（TOF-MS）中激光解吸离子收集效率的方法。该方法提供由TOF-MS内的电离提取装置产生的激光脉冲; 将采样板电位保持在地电平约50ns的固定延迟时间; 并使用高压开关将样板电位急剧增加到10 kV / mm。

6. 发明授权

US06854344B2 Sample retrieval device for aerosol collection 失效
标题翻译：用于气溶胶收集的样品检索装置
公开(公告)号：US06854344B2
公开(公告)日：2005-02-15
申请号：US10728297
申请日：2003-12-04
申请人： Timothy J. Cornish , Frederick P. Gick
发明人： Timothy J. Cornish , Frederick P. Gick
IPC分类号： G01N1/22 , G01N1/24 , H01J49/04 , G01N1/00
CPC分类号： G01N1/2252 , G01N1/2202 , G01N1/24 , G01N2001/2223 , H01J49/04
摘要： A modular aerosol sample detection system is provided comprising a sample collector couplable to an aerial vehicle and provided with at least one retrievable collection sample plate, which controllably rotates to collect aerosol samples on a multiplicity of collection spots arranged in multiple concentric tracks on the collection disk, and a multi-channel TOF removably couplable to the collection sampler to analyze the collected samples.
摘要翻译：提供了一种模块化气溶胶样品检测系统，其包括可与飞行器耦合的样品收集器，并且设置有至少一个可收集的收集样品板，其可控地旋转以在集合盘上布置在多个同心轨道中的多个收集点上收集气溶胶样品，以及多通道TOF可拆卸地耦合到收集采样器以分析收集的样品。

7. 发明授权

US06607414B2 Method of making an ion reflectron comprising a flexible circuit board 有权
标题翻译：制造包括柔性电路板的离子反射镜的方法
公开(公告)号：US06607414B2
公开(公告)日：2003-08-19
申请号：US10055273
申请日：2002-01-23
申请人： Timothy J. Cornish , Harry K. Charles , Paul D. Wienhold
发明人： Timothy J. Cornish , Harry K. Charles , Paul D. Wienhold
IPC分类号： H01J102
CPC分类号： H01J49/405 , G21K1/06 , H05K1/118 , H05K3/0014 , H05K2201/09018 , H05K2203/1327
摘要： A novel technique utilizing the precision of printed circuit board design and the physical versatility of thin, flexible substrates is disclosed to produce a new type of ion reflector. A precisely defined series of thin conductive strips (traces) are etched onto a flat, flexible circuit board substrate. Preferably, the thin conductive strips are further apart at one end of the substrate and get increasingly closer towards the other end of the substrate. The flexible substrate is then rolled into a tube to form the reflector body, with the conductive strips forming the rings of the ion reflector. The spacing between the traces, and hence the ring spacing, can be readily varied by adjusting the conductor pattern on the substrate sheet during the etching process. By adjusting the spacing between the rings, the characteristics of the field created by the reflectron can be easily customized to the needs of the user.
摘要翻译：公开了一种利用印刷电路板设计的精确性和薄的柔性基板的物理通用性的新技术，以产生新型的离子反射器。将精确定义的一系列薄导电条（迹线）蚀刻到平坦，柔性的电路板基板上。优选地，薄导电条在衬底的一端处进一步分开，并且越来越靠近衬底的另一端。然后将柔性基材卷成管以形成反射体，导电条形成离子反射体的环。通过在蚀刻工艺期间调节衬底片上的导体图案，可以容易地改变迹线之间的间隔以及因此的环间隔。通过调整环之间的间距，可以根据用户的需要轻松定制由反射镜产生的场的特性。

8. 发明授权

US06977381B2 Gating grid and method of making same 失效
标题翻译：门格栅及其制作方法
公开(公告)号：US06977381B2
公开(公告)日：2005-12-20
申请号：US10451860
申请日：2003-01-29
申请人： Harry K. Charles, Jr. , Arthur S. Francomacaro , Allen C. Keeney , David M. Lee , Timothy J. Cornish
发明人： Harry K. Charles, Jr. , Arthur S. Francomacaro , Allen C. Keeney , David M. Lee , Timothy J. Cornish
IPC分类号： H01F7/06 , H01J1/46 , H01J9/12 , H01J37/147 , H01J49/06 , H01J49/40 , H04R17/00 , H05K3/06
CPC分类号： H01J49/061 , H01J37/147 , H01J49/06 , H01J49/40 , H01J2237/151 , H04R17/00 , Y10T29/4902 , Y10T29/49117 , Y10T29/49155
摘要： A gating grid for deflecting ions includes an insulating substrate (16), a conducting layer (28) adhered to the insulating substrate (16), and interdigitated electrodes (14) patterned in the conducting layer by a photolithographic process. A hole (18) in the insulating substrate beneath the interdigitated electrodes allows ions to pass through the hole in the substrate. A process for making a gating grid for deflecting ions includes adhering a conducting layer (28) to an insulating substrate (16), forming interdigitated electrodes (14) on the conducting layer (28), and then forming a hole (18) in the insulating substrate beneath the interdigitated electrodes.
摘要翻译：用于偏转离子的选通栅格包括绝缘衬底（16），粘附到绝缘衬底（16）的导电层（28）和通过光刻工艺在导电层中图案化的交错电极（14）。在交叉电极下方的绝缘基板中的孔（18）允许离子穿过衬底中的孔。制造用于偏转离子的选通栅格的方法包括将导电层（28）粘附到绝缘基板（16）上，在导电层（28）上形成交错电极（14），然后在导电层（28）中形成孔绝缘衬底在交叉电极下面。

9. 发明授权

US06943344B2 Microchannel plate detector assembly for a time-of-flight mass spectrometer 有权
标题翻译：用于飞行时间质谱仪的微通道板检测器组件
公开(公告)号：US06943344B2
公开(公告)日：2005-09-13
申请号：US10030397
申请日：2001-05-23
申请人： Timothy J. Cornish , Scott A. Ecelberger
发明人： Timothy J. Cornish , Scott A. Ecelberger
IPC分类号： H01J49/02 , H01J49/40 , B01D59/44 , H01J49/00
CPC分类号： H01J43/246 , H01J49/025 , H01J49/40
摘要： A method is provided for reducing signal ringing in a microchannel plate detector assembly having a cylindrical mount with a center tube extending through at least a portion of the assembly, in a mass spectrometer including the steps of providing the microchannel plate detector assembly with a pin anode extending from the cylindrical mount and located in proximity to the center tube; holding a front portion of the assembly at ground potential; setting a middle portion of the assembly between the front portion and a rear portion to a first voltage potential for accelerating ions; holding the rear portion of the assembly to a second voltage potential; holding the pin anode at a third voltage potential; and accelerating electrons emitted from the middle portion of the assembly toward the pin anode. The third voltage potential is established by an amplifier of an oscilloscope connected to the detector assembly.
摘要翻译：提供了一种用于减小微通道板检测器组件中的信号振铃的方法，所述微通道板检测器组件具有圆柱形安装件，所述圆柱形安装件具有延伸穿过所述组件的至少一部分的中心管，质谱仪包括以下步骤：为所述微通道板检测器组件提供引脚阳极从圆柱形支架延伸并位于中心管附近; 将组件的前部部分保持在地电位; 将组件的前部和后部之间的中间部分设置为用于加速离子的第一电压电位; 将组件的后部保持在第二电压电位; 将引脚阳极保持在第三电压电位; 并且将从组件的中间部分发射的电子加速到针状阳极。第三电压电位由连接到检测器组件的示波器的放大器建立。

10. 发明授权

US06614020B2 Gridless, focusing ion extraction device for a time-of-flight mass spectrometer 有权
公开(公告)号：US06614020B2
公开(公告)日：2003-09-02
申请号：US10220865
申请日：2002-09-06
申请人： Timothy J. Cornish
发明人： Timothy J. Cornish
IPC分类号： B01D5544
CPC分类号： H01J49/40
摘要： A miniature time-of-flight mass spectrometer (TOF-MS) is provided having (1) a gridless, focusing ionization extraction device allowing for the use of very high extraction energies in a maintenance-free design, (2) a miniature flexible circuit-board reflector using rolled flexible circuit-board material, and (3) a low-noise, center-hole microchannel plate detector assembly that significantly reduces the noise (or “ringing”) inherent in the coaxial design. A method is also provided for increasing the collection efficiency of laser-desorbed ions in the TOF-MS. The method includes the steps of providing within the TOF-MS an ionization extraction device having an unobstructed central chamber having a first region and a second region; creating an ion acceleration/extraction field within the first region; accelerating ions within the first region; de-accelerating the ions in the second region; and drifting the ions in a drift region to cause ion dispersion.

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