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1. 发明申请

US20120021951A1 Apparatus for Assay, Synthesis and Storage, and Methods of Manufacture, Use, and Manipulation Thereof 有权
标题翻译：用于测定，合成和储存的装置及其制造，使用和操作方法
公开(公告)号：US20120021951A1
公开(公告)日：2012-01-26
申请号：US13188337
申请日：2011-07-21
申请人： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
发明人： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
IPC分类号： C40B50/00 , C40B40/00
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/0036 , B01J2219/00369 , B01J2219/00387 , B01J2219/00389 , B01J2219/00423 , B01J2219/0043 , B01J2219/00479 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00673 , B01L3/0244 , B01L3/0262 , B01L3/0268 , B01L3/5025 , B01L3/50255 , B01L3/5085 , B01L3/50857 , B01L99/00 , B01L2200/0657 , B01L2300/0845 , C12M23/12 , C40B60/14 , G01N30/466 , G01N30/6091 , G01N30/6095 , G01N30/82 , G01N2030/8417
摘要： The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
摘要翻译：本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。

2. 发明授权

US09314764B2 Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof 有权
标题翻译：用于测定，合成和储存的装置及其制造，使用和操作方法
公开(公告)号：US09314764B2
公开(公告)日：2016-04-19
申请号：US13188337
申请日：2011-07-21
申请人： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
发明人： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
IPC分类号： G01N1/10 , B01J19/00 , B01L3/02 , B01L3/00 , G01N30/46 , B01L99/00 , C40B60/14 , G01N30/60 , G01N30/82 , G01N30/84
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/0036 , B01J2219/00369 , B01J2219/00387 , B01J2219/00389 , B01J2219/00423 , B01J2219/0043 , B01J2219/00479 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00673 , B01L3/0244 , B01L3/0262 , B01L3/0268 , B01L3/5025 , B01L3/50255 , B01L3/5085 , B01L3/50857 , B01L99/00 , B01L2200/0657 , B01L2300/0845 , C12M23/12 , C40B60/14 , G01N30/466 , G01N30/6091 , G01N30/6095 , G01N30/82 , G01N2030/8417
摘要： The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
摘要翻译：本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。

3. 发明申请

US20100261159A1 Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof 审中-公开
标题翻译：用于测定，合成和储存的装置及其制造，使用和操作方法
公开(公告)号：US20100261159A1
公开(公告)日：2010-10-14
申请号：US11503401
申请日：2006-08-10
申请人： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
发明人： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
IPC分类号： C12Q1/68 , C12M1/14 , C12N5/00 , B05D1/36 , C12Q1/02 , C40B30/04 , G01N33/53
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/0036 , B01J2219/00369 , B01J2219/00387 , B01J2219/00389 , B01J2219/00423 , B01J2219/0043 , B01J2219/00479 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00673 , B01L3/0244 , B01L3/0262 , B01L3/0268 , B01L3/5025 , B01L3/50255 , B01L3/5085 , B01L3/50857 , B01L13/02 , B01L99/00 , B01L2200/0657 , B01L2300/0845 , C12M23/12 , C40B60/14 , G01N30/466 , G01N30/6091 , G01N30/6095 , G01N30/82 , G01N2030/8417
摘要： The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
摘要翻译：本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。

4. 发明授权

US06716629B2 Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof 有权
标题翻译：用于测定，合成和储存的装置及其制造，使用和操作方法
公开(公告)号：US06716629B2
公开(公告)日：2004-04-06
申请号：US09975496
申请日：2001-10-10
申请人： Robert A. Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
发明人： Robert A. Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
IPC分类号： C12N502
CPC分类号： B01L99/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/0036 , B01J2219/00369 , B01J2219/00387 , B01J2219/00389 , B01J2219/00423 , B01J2219/0043 , B01J2219/00479 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00673 , B01L3/0244 , B01L3/0262 , B01L3/0268 , B01L3/5025 , B01L3/50255 , B01L3/5085 , B01L2200/0657 , B01L2300/0845 , C40B60/14 , G01N30/466 , G01N30/6091 , G01N30/6095 , G01N30/82 , G01N2030/8417 , Y10T29/301 , Y10T29/49938
摘要： The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
摘要翻译：本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。

5. 发明申请

US20120245038A1 THERMAL CYCLING APPARATUS AND METHOD 有权
标题翻译：热循环装置和方法
公开(公告)号：US20120245038A1
公开(公告)日：2012-09-27
申请号：US13491989
申请日：2012-06-08
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： C40B20/00 , C40B40/06 , C40B60/10
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译：用于容纳至少一个样品和试剂用于分析的系统。该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。框架设置在盖之间，以相对于盖限定内部空间。框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。微流体阵列设置在内部体积中。阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。

6. 发明申请

US20090062134A1 ASSAY IMAGING APPARATUS AND METHODS 审中-公开
标题翻译：测定成像装置和方法
公开(公告)号：US20090062134A1
公开(公告)日：2009-03-05
申请号：US12245027
申请日：2008-10-03
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： C40B30/00
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect.
摘要翻译：提供了对多个样品进行测定的方法。该方法包括以下步骤：在具有大于100个样品位点的样品阵列中的每个样品位置处进行测定，同时使用一个或多个LED照亮每个样品位点，并且同时对每个样品位点成像以产生与光学相关的成像数据每个网站的效果。每个测定提供光学效果。

7. 发明申请

US20090062152A1 THERMAL CYCLING APPARATUS AND METHOD 审中-公开
标题翻译：热循环装置和方法
公开(公告)号：US20090062152A1
公开(公告)日：2009-03-05
申请号：US12243503
申请日：2008-10-01
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： C40B60/12
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.
摘要翻译：提供热循环装置和热循环方法。热循环装置包括流体装置系统，壳体和循环头部。流体输送系统产生受控温度流体的流动。该壳体具有用于保持微流体阵列的流体密封腔。阵列包括具有一对相对表面的厚度的材料片和穿过表面之间的厚度的多个通孔。循环头部保持壳体，并将流体流过壳体。

8. 发明授权

US07682565B2 Assay apparatus and method using microfluidic arrays 有权
标题翻译：使用微流控阵列的测定装置和方法
公开(公告)号：US07682565B2
公开(公告)日：2010-03-23
申请号：US10744580
申请日：2003-12-22
申请人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
发明人： John Linton , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya S. Kanigan , Kristine Friesen , Arrin Katz , Colin Brenan , Tom Morrison , Javier Garcia
IPC分类号： G01N31/22 , G01N21/01 , G01N21/77
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译：用于容纳至少一个样品和试剂用于分析的系统。该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。框架设置在盖之间，以相对于盖限定内部空间。框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。微流体阵列设置在内部体积中。阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。

9. 发明授权

US08697452B2 Thermal cycling assay apparatus and method 有权
标题翻译：热循环测定装置和方法
公开(公告)号：US08697452B2
公开(公告)日：2014-04-15
申请号：US13491989
申请日：2012-06-08
申请人： John Linton , Arrin Katz , Colin Brenan , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya Kanigan , Kristine Friesen , Thomas Morrison , Javier Garcia
发明人： John Linton , Arrin Katz , Colin Brenan , Karl Yoder , Robert Hess , Leila Hasan , Robert Ellis , Tanya Kanigan , Kristine Friesen , Thomas Morrison , Javier Garcia
IPC分类号： G01N21/00 , G01N1/10
CPC分类号： C12Q1/6858 , B01L3/5025 , B01L3/5027 , B01L3/508 , B01L3/50853 , B01L3/50857 , B01L7/52 , B01L2200/16 , B01L2300/021 , B01L2300/0609 , B01L2300/0636 , B01L2300/0819 , B01L2300/0829 , B01L2300/16 , B01L2300/1822 , B01L2300/1838 , G01N21/03 , G01N21/15 , G01N21/253 , G01N2021/0346 , G01N2021/056 , G01N2021/158 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.
摘要翻译：用于容纳至少一个样品和试剂用于分析的系统。该系统包括一对平行的盖，其至少一个是透光的，其中一对透光盖形成顶部，并且其中一对形成底部。框架设置在盖之间，以相对于盖限定内部空间。框架和盖子彼此相关联以形成壳体，该壳体基本上与液体紧密。微流体阵列设置在内部体积中。阵列包括具有一对相对表面的厚度的材料片，以及穿过表面之间的厚度的多个通孔，通孔包含至少一个样品和试剂。

10. 发明申请

US20060105453A1 Coating process for microfluidic sample arrays 审中-公开
标题翻译：微流体样品阵列的涂布工艺
公开(公告)号：US20060105453A1
公开(公告)日：2006-05-18
申请号：US11198882
申请日：2005-08-04
申请人： Colin Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
发明人： Colin Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
IPC分类号： C12N5/00
CPC分类号： B01J19/0046 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01L3/0244 , B01L3/5025 , B01L3/50857 , B01L2200/12 , B01L2200/16 , B01L2300/16
摘要： A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
摘要翻译：一种用于进行多个纳米体积规定的反应的差异涂覆的装置，所述装置包括具有至少一个被修饰至指定理化特性的外表面的压板，多个纳米体积通道，每个纳米体积通道具有至少一个与所述至少一个外表面连通的内表面，其被选择性地涂覆有物理吸附到至少一个内表面上的任选可溶解的涂覆剂，其中所述任选可溶解的涂覆剂包含涂层剂和用于多个特定反应的第一组分。还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列登记分配器阵列的位置的方法。分配器阵列和微流体阵列中的第一个可相对于框架移动，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架是固定的。确定与分配器阵列和微流体阵列之一上的对准位置到固定位置的矢量位移有关的量。这样确定的量用于引导分配器阵列相对于微流体阵列的定位。

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