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1. 发明授权

US5539797A Method and apparatus for digital stereotaxic mammography 失效
标题翻译：数字立体定位乳房X线照相术的方法和装置
公开(公告)号：US5539797A
公开(公告)日：1996-07-23
申请号：US218931
申请日：1994-03-29
申请人： Robert Heidsieck , Jean-Pierre Saladin , Serge Muller
发明人： Robert Heidsieck , Jean-Pierre Saladin , Serge Muller
IPC分类号： A61B6/00 , A61B6/02 , A61B6/04
CPC分类号： A61B6/502 , A61B6/02
摘要： A mammograph is disclosed which includes: a positioning device defining a rotation axis, the positioning device including: an arm .beta..sub.2 ; breast support plate connected to the arm .beta..sub.2 ; a movement device connected to the arm .beta..sub.2 ; and a digital detector connected to the movement device, the digital detector having a detection surface defining a plane .pi.; an arm .beta..sub.1 pivotally connected to the positioning device for pivotally rotating said arm .beta..sub.1 around said rotation axis, the arm .beta..sub.1 having an end; and an X-ray tube movably attached to the end of the arm .beta..sub.1, the X-ray tube defining a beam axis .delta. and being pivotable about the rotation axis so as to move in a first direction that is orthogonal with the rotation axis and direct an X-ray beam, emitted by the X-ray tube, along the beam axis .delta.. Pivoting the X-ray tube within an angle .+-..alpha. causes the movement device to move the digital detector laterally within the plane .pi. along a second direction that is perpendicular to the rotation axis and opposite the first direction so as to accommodate a position of the X-ray tube within the angle .+-..alpha. and define a volume of a breast stereotaxically accessible by the X-ray beam as a polyhedron having a first surface and a second surface, the first surface and the second surface meeting and being defined by an intersection of the beam axis .delta. at an angle .+-..alpha. with the beam axis .delta. at an angle -.alpha., the X-ray beam being entirely incident the digital detector as the movement device moves the digital detector to accommodate pivotal movement of the X-ray tube.
摘要翻译：公开了一种乳房X线照相机，其包括：定义旋转轴的定位装置，所述定位装置包括：臂β2; 乳房支撑板连接到手臂β2; 连接到臂β2的运动装置; 和连接到移动装置的数字检测器，数字检测器具有限定平面pi的检测表面; 臂β1枢转地连接到定位装置，用于围绕所述旋转轴线枢转旋转所述臂β1，所述臂β1具有端部; 以及可移动地附接到臂β1的端部的X射线管，X射线管限定射束轴三角形并且可围绕旋转轴线枢转，以沿与旋转轴线正交的第一方向移动;以及沿着光束轴三角形引导由X射线管发射的X射线束。将X射线管以+/-角度旋转，使得移动装置沿着垂直于旋转轴线并与第一方向相反的第二方向在平面pi内横向移动数字检测器，以便容纳位置所述X射线管在角度+/-α内并且限定由X射线束立体定位可触及的具有第一表面和第二表面的多面体的乳房的体积，所述第一表面和第二表面会聚并被限定通过光束轴δ与角度α-α与光束轴δ的角度的交叉点，X射线束完全入射到数字检测器，随着移动装置移动数字检测器以适应枢轴运动 X光管。

2. 发明授权

US07133490B2 Radiological imaging device, method and program of control associated with the device 有权
标题翻译：放射成像装置，与装置相关的控制方法和程序
公开(公告)号：US07133490B2
公开(公告)日：2006-11-07
申请号：US09825910
申请日：2001-04-04
申请人： Serge Muller , Luc Miotti , Jean-Pierre Saladin
发明人： Serge Muller , Luc Miotti , Jean-Pierre Saladin
IPC分类号： A61B6/04
CPC分类号： A61B6/0414 , A61B6/4494 , A61B6/502
摘要： Radiological imaging device comprising an emitter of an X-ray beam and a receiver of the X-ray beam after it has crossed an organ, the organ being capable of being placed between the receiver and a compression element, capable of being removably fixed on the device. A calculation unit includes a means for optimizing the image quality over a particular area defined by the compression element.
摘要翻译：放射学成像装置包括X射线束的发射器和X射线束在其穿过器官之后的接收器，所述器官能够被放置在接收器和压缩元件之间，能够可移除地固定在设备。计算单元包括用于在由压缩元件限定的特定区域上优化图像质量的装置。

3. 发明授权

US07092490B2 Filter system for radiological imaging 失效
标题翻译：放射成像过滤系统
公开(公告)号：US07092490B2
公开(公告)日：2006-08-15
申请号：US10757932
申请日：2004-01-15
申请人： Jean Pierre Saladin , Serge Muller , Celine Pawlak
发明人： Jean Pierre Saladin , Serge Muller , Celine Pawlak
IPC分类号： G21K3/00 , G02B7/00
CPC分类号： A61B6/502 , A61B6/4035 , G21K1/04 , G21K1/10
摘要： A filtering system for use in, for example, a radiological imaging in a mammography apparatus. The system has a roundabout carrying a set of filtration plates. Each filtration plate is held on the roundabout by a joint. In a parked or stationary position, each plate is vertically suspended and does not contribute to any unacceptable increase in the horizontal space requirement of an X-ray tube. Each filtration plate may be presented in turn before a window for the emission of X-rays from the tube. At this position, the plate is rectified about its joint in order to occupy one position, among several possible positions, that also makes it possible, in this way, to modulate the filtration capacity of the plate.
摘要翻译：一种用于例如乳房X线照相术装置中的放射成像的过滤系统。该系统具有携带一套过滤板的回旋处。每个过滤板通过接头保持在回旋处。在停放或静止的位置，每个板垂直悬挂，并不影响X射线管的水平空间要求的任何不可接受的增加。每个过滤板可以在用于从管发射X射线的窗口之前依次呈现。在该位置，板在其接头周围被整流，以便在几个可能的位置中占据一个位置，这也使得可以以这种方式调节板的过滤能力。

4. 发明授权

US06845146B2 Mammography apparatus and method 失效
标题翻译：乳房X线摄影仪和方法
公开(公告)号：US06845146B2
公开(公告)日：2005-01-18
申请号：US10218829
申请日：2002-08-14
申请人： Andreas Rick , Serge Muller , Jean-Pierre Saladin
发明人： Andreas Rick , Serge Muller , Jean-Pierre Saladin
IPC分类号： A61B6/00 , A61B6/04
CPC分类号： A61B6/502 , A61B6/0414 , A61B6/466
摘要： A mammography apparatus and method having an X-ray tube, an image receiver, the image receiver having one edge in contact with a patient, a compression paddle between the tube and the receiver, able to be moved up and down parallel to a direction of propagation of the X-rays, means for keeping the compression paddle in position in the radiation propagation direction, the compression paddle, in its compression position, being movable in at least one direction perpendicular to the direction of X-ray propagation and parallel to the contact edge of the image receiver. This allows a patient's breast to be rolled and presented to the image receiver in different positions thereby reducing ambiguities in possible detection of a lesion due to layers of tissue overlapping when images are taken.
摘要翻译：一种具有X射线管，图像接收器，具有与患者接触的一个边缘的图像接收器，管与接收器之间的压缩桨，能够平行于 X射线的传播是用于将压缩桨保持在辐射传播方向上的位置的装置，压缩桨在其压缩位置可沿至少一个垂直于X射线传播方向的平行方向移动，图像接收器的接触边缘。这允许患者的乳房在不同的位置滚动并呈现给图像接收器，从而减少了在拍摄图像时由于组织层重叠而可能检测到病变的模糊性。

5. 发明授权

US06687331B1 Method and device for making radiographic images 有权
标题翻译：用于制作放射照相图像的方法和装置
公开(公告)号：US06687331B1
公开(公告)日：2004-02-03
申请号：US09450917
申请日：1999-11-29
申请人： Serge Muller , Jean-Pierre Saladin , Luc Miotti
发明人： Serge Muller , Jean-Pierre Saladin , Luc Miotti
IPC分类号： H05G164
CPC分类号： A61B6/0414 , A61B6/04
摘要： Device for taking radiologic images, of the type comprising a means of emission of an X-ray beam and a means of reception of the X-ray beam after it has passed through an organ to be studied. The means of emission and the means of reception are supported by an arm pivoting about at least one shaft supported by a frame. The device comprises a means for detecting the angle of swivel of the arm, a means for entering data relative to the organ to be studied, a processing means capable of determining the type of image that will be taken as a function of the angle of swivel and of the said data relative to the organ, and a means for displaying on the image the type of image determined by the said processing means.
摘要翻译：用于拍摄放射学图像的装置，其类型包括发射X射线束的装置和在X射线束通过待研究的器官之后的接收装置。发射装置和接收装置由围绕由框架支撑的至少一个轴枢转的臂支撑。该装置包括用于检测臂的旋转角度的装置，用于输入相对于要研究的器官的数据的装置，能够确定作为旋转角度的函数的图像的类型的处理装置以及相对于器官的所述数据，以及用于在图像上显示由所述处理装置确定的图像的类型的装置。

6. 发明授权

US06480566B2 Method and apparatus for mammography 失效
公开(公告)号：US06480566B2
公开(公告)日：2002-11-12
申请号：US10007810
申请日：2001-11-09
申请人： Serge Muller , Andreas Rick , Jean-Pierre Saladin
发明人： Serge Muller , Andreas Rick , Jean-Pierre Saladin
IPC分类号： A61B604
CPC分类号： A61B6/502 , A61B6/4423 , A61B6/481
摘要： Method and apparatus for medical radiology and, in particular, galactography in the field of mammography. The method of obtaining radiological images in galactography comprises acquiring of a first radiological image of the breast in a compressed state: introducing a contrast medium in a part of the breast; acquiring at least a second radiological image of the breast in the compressed state and with contrast medium; and partial or complete subtraction of the first image in relation to the second image, or vice versa. An apparatus for use of the method comprises means for maintaining a breast compressed or immobilized and means for holding a catheter or the like for introducing a contrast medium in the breast.

7. 发明授权

US07035450B1 Method for locating an element of interest contained in a three-dimensional object, in particular during a stereotactic investigation in the X-ray examination of the breast 失效
标题翻译：用于定位包含在三维物体中的感兴趣元素的方法，特别是在乳房X线检查中的立体定向调查期间
公开(公告)号：US07035450B1
公开(公告)日：2006-04-25
申请号：US09214822
申请日：1999-01-11
申请人： Serge Muller , Michel Grimaud , Robert Heidsieck , Thierry Salmon Legagneur , Sylvie Bothorel
发明人： Serge Muller , Michel Grimaud , Robert Heidsieck , Thierry Salmon Legagneur , Sylvie Bothorel
IPC分类号： G06K9/00
CPC分类号： G06K9/3233 , G06K2209/053 , G06T7/32 , G06T7/593 , G06T2207/30068
摘要： The stereotaxic images being digitized, a target pixel in a target region of interest is selected, a target window of chosen dimensional characteristics and containing the said target region of interest is generated around the selected target pixel, a set of pixels is determined in a second image, according to a predetermined selection criterion, a second window, of the same dimensional characteristics as the said target window, is generated around each selected pixel, a correlation processing between the grey-scale levels of the pixels of each second window and the grey-scale levels of the pixels of the target window is carried out so as to obtain a correlation value for each second window, and the region of interest homologous to the target region of interest is identified on the basis of the analysis of the set of correlation values thus obtained, so as to minimize the risks of matching error between the homologous regions of interest. The element of interest is then located on the basis of the positions of the two homologous regions.
摘要翻译：数字化的立体定位图像，目标感兴趣区域中的目标像素被选择，选择的维度特征的目标窗口并且包含所述目标感兴趣区域的周围围绕所选择的目标像素生成，在一秒钟内确定一组像素根据预定的选择标准，在每个所选择的像素周围生成与所述目标窗口相同的尺寸特性的第二窗口，每个第二窗口的像素的灰度级与灰度之间的相关处理执行目标窗口的像素的级别以便获得每个第二窗口的相关值，并且基于相关集合的分析来识别与目标感兴趣区域同源的兴趣区域从而最小化感兴趣的同源区域之间匹配误差的风险。感兴趣的元素然后基于两个同源区域的位置。

8. 发明授权

US5544219A Procedure for automatic position-finding of points of interest during a mammography examination using stereotactic technique 失效
标题翻译：使用立体定位技术在乳房X线照相检查期间自动定位感兴趣的程序
公开(公告)号：US5544219A
公开(公告)日：1996-08-06
申请号：US332743
申请日：1994-11-01
申请人： Serge Muller , Michel Grimaud , Robert Heidsieck
发明人： Serge Muller , Michel Grimaud , Robert Heidsieck
IPC分类号： A61B19/00 , G06T5/20 , G06T5/30 , G06T7/00 , H04N13/00 , A61B6/12
CPC分类号： G06T5/30 , A61B90/10 , G06T7/0042 , G06T2207/10012 , G06T2207/30068 , H04N2013/0074
摘要： A process is disclosed which involves automatic position-finding for a point of interest of an object that exhibits high contrast as compared with surrounding tissues, the process being carried out by means of a stereotactic photographic device that includes a digital image acquisition system. The process includes a number of steps for each image belonging to the pair of stereotactic images. An initial analysis of a histogram of the image pixels are made, and a subsequent determination is made of a threshold corresponding to the difference between the high contrast objects and the surrounding tissues. A subsequent determination is made of the threshold of the image, in order to obtain a binary image incorporating two gray levels. This is followed by the filtering of the threshold determined image in the preceding step, based on morphological criteria of the object in which the point of interest is located. This operation is designed to obtain a segmented projection of the object of interest. This is followed by the localization of the point of interest in the image reference mark. Utilization of the process is for stereotactic examinations performed during mammography.
摘要翻译：公开了一种涉及与周围组织相比显示高对比度的物体的感兴趣点的自动位置查找的过程，该过程通过包括数字图像采集系统的立体定向照相装置进行。该过程包括属于一对立体定向图像的每个图像的多个步骤。进行图像像素的直方图的初始分析，并且随后确定对应于高对比度对象与周围组织之间的差的阈值。随后确定图像的阈值，以便获得并入两个灰度级的二进制图像。接下来是基于目标位置的对象的形态标准对前一步骤中的阈值确定图像的过滤。该操作被设计为获得感兴趣对象的分段投影。接下来是图像参考标记中的兴趣点的本地化。该过程的利用是在乳房X线照相术期间进行的立体定向检查。

9. 发明授权

US09468411B2 Compact mechanism for moving a compression paddle 有权
标题翻译：用于移动压缩桨的紧凑机构
公开(公告)号：US09468411B2
公开(公告)日：2016-10-18
申请号：US14241916
申请日：2012-08-28
申请人： Serge Muller , Aurelie Boudier , Regis Gerard Elle Personnelli , Francois Lenfant
发明人： Serge Muller , Aurelie Boudier , Regis Gerard Elle Personnelli , Francois Lenfant
IPC分类号： A61B6/04 , A61B6/02 , A61B6/00
CPC分类号： A61B6/0457 , A61B6/025 , A61B6/0414 , A61B6/502
摘要： A mammography or tomosynthesis apparatus, comprising a mechanism configured to move a paddle, relative to a detector platform fixed to a main body of the apparatus, to compress a patient's breast against the detector platform to form a surface. The mechanism comprises a post that is mobile relative to the detector platform and/or to the body and configured so that maximum extension of the post relative to the surface follows the movements of the paddle relative to the detector platform.
摘要翻译：一种乳房摄影术或层析融合装置，包括被配置为相对于固定到所述装置的主体的检测器平台移动桨叶的机构，以将患者的乳房压靠在所述检测器平台上以形成表面。该机构包括相对于检测器平台和/或主体移动的柱，并且被配置为使得柱相对于表面的最大延伸跟随桨相对于检测器平台的移动。

10. 发明授权

US08958527B2 Method for acquiring morphology of a breast 有权
标题翻译：获取乳房形态的方法
公开(公告)号：US08958527B2
公开(公告)日：2015-02-17
申请号：US13397211
申请日：2012-02-15
申请人： Serge Muller , Sylvie Puong , Ann-Katherine Carton , Razvan Iordache
发明人： Serge Muller , Sylvie Puong , Ann-Katherine Carton , Razvan Iordache
IPC分类号： A61B6/00 , A61B6/02 , A61B6/04
CPC分类号： A61B6/482 , A61B6/025 , A61B6/032 , A61B6/0414 , A61B6/481 , A61B6/502
摘要： An imaging method performed by a device comprising an X-ray emitting source, a receiver positioned facing the source, and a support on which a subject or organ to be imaged is positioned, the method comprises defining a first set of orientations of the source and a second set of orientations of the source, and acquiring images at the defined orientations of the source, wherein if the first set of orientations comprises an orientation that the second set of orientations does not comprise, only one image is acquired at the orientation, and if both the first set of orientations and the second set of orientations comprise the same orientation, at least two images are acquired at distinct acquisition parameters at the orientation.
摘要翻译：一种由包括X射线发射源，面向源极的接收器以及待成像对象或器官定位在其上的支撑件的装置执行的成像方法，所述方法包括限定所述源的第一组取向和源的取向的第二集合，并且在所述源的所定义的取向处获取图像，其中如果所述第一组取向包括所述第二组取向不包括的取向，则在所述取向处仅获取一个图像，以及如果第一组取向和第二组取向都包括相同的取向，则在取向处以不同的采集参数获取至少两个图像。

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