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1. 发明授权

US06624219B1 Surface active random radical (co)polymer and dispersion method for using the same 失效
标题翻译：表面活性无规自由基（共）聚合物及其分散方法
公开(公告)号：US06624219B1
公开(公告)日：2003-09-23
申请号：US09640093
申请日：2000-08-17
申请人： Robert Heger , Wolfgang Schrof , Michael Seufert , Helmut Auweter , Walter Mächtle , Rüdiger Iden , Dieter Horn , Ralph Nielsen , Eric Carlson , Chang Han-Ting , Sigrid Kuebler , Petro Miroslav
发明人： Robert Heger , Wolfgang Schrof , Michael Seufert , Helmut Auweter , Walter Mächtle , Rüdiger Iden , Dieter Horn , Ralph Nielsen , Eric Carlson , Chang Han-Ting , Sigrid Kuebler , Petro Miroslav
IPC分类号： C08K541
CPC分类号： B82Y30/00 , C08F212/04 , C08F220/34 , C09B67/0085 , C09D11/106 , C09D11/30 , C09D133/14 , C09D135/06 , C09D139/08
摘要： The present invention relates to a set of (co)polymers, dispersion formulations, solid solutions and formulation conditions able to disperse a dye selected from the group of a monoazo dye, quinophthalone dye and an anthraquinone dye in a stable nanoparticular form in an aqueous medium.
摘要翻译：本发明涉及一种（共）聚合物，分散体配制剂，固溶体和配制条件，其能够将稳定的纳米颗粒形式的选自单偶氮染料，喹酞酮染料和蒽醌染料的染料分散在水性介质中。

2. 发明申请

US20070077657A1 Apparatuses and methods for creating and testing pre-formulations and systems for same 审中-公开
标题翻译：用于创建和测试预配制和相同系统的设备和方法
公开(公告)号：US20070077657A1
公开(公告)日：2007-04-05
申请号：US11389621
申请日：2006-03-24
申请人： Eric Carlson , Peijun Cong , William Chandler , Henry Chau , Earl Danielson , Peter Desrosiers , Robert Doolen , Luping Wu , C. Ramberg , Thomas Crevier , Ralph Nielsen , Colin Masui , John Varni
发明人： Eric Carlson , Peijun Cong , William Chandler , Henry Chau , Earl Danielson , Peter Desrosiers , Robert Doolen , Luping Wu , C. Ramberg , Thomas Crevier , Ralph Nielsen , Colin Masui , John Varni
IPC分类号： G01N31/00
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00364 , B01J2219/00373 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L7/00 , B01L2300/0829 , B01L2300/185 , C40B40/04 , C40B40/10 , C40B60/10 , C40B60/14 , G01N5/045 , G01N21/23 , G01N21/65 , G01N25/04 , G01N33/15 , G01N33/54366 , G01N35/028 , G01N2013/006 , G01N2021/651 , G01N2500/00 , G16C20/20 , G16C20/90 , Y10T117/10
摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.
摘要翻译：本发明提供了用于进行候选药物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。本发明旨在增强用于药物开发的预配制发现过程。特别地，提供了确定基本上发现可从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。另一种装置可以过滤合成的溶液以提供可以进行盐或多晶型测试的基本上纯的混合物。可以使用另一种装置将混合物在基底上结晶，使得结晶的混合物可以被一个或多个筛选装置筛选。

3. 发明申请

US20060133968A1 Parallel reactor with internal sensing and method of using same 审中-公开
公开(公告)号：US20060133968A1
公开(公告)日：2006-06-22
申请号：US11272249
申请日：2005-11-10
申请人： G. Dales , Johannes van Beek , Damian Hajduk , Ralph Nielsen , Paul Mansky , Leonid Matsiev , Eric McFarland
发明人： G. Dales , Johannes van Beek , Damian Hajduk , Ralph Nielsen , Paul Mansky , Leonid Matsiev , Eric McFarland
IPC分类号： B01J19/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

4. 发明授权

US06994827B2 Parallel semicontinuous or continuous reactors 有权
公开(公告)号：US06994827B2
公开(公告)日：2006-02-07
申请号：US09873176
申请日：2001-06-01
申请人： Adam Safir , Ralph Nielsen , Thomas H. McWaid , Richard Tiede , Lynn Van Erden
发明人： Adam Safir , Ralph Nielsen , Thomas H. McWaid , Richard Tiede , Lynn Van Erden
IPC分类号： G01N33/00 , B01N3/02 , B01N3/00 , B01J10/00 , B32B27/04
CPC分类号： B01F7/167 , B01F7/00258 , B01F7/00266 , B01F7/00291 , B01F7/00416 , B01F7/00575 , B01F15/00207 , B01F2215/0037 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00335 , B01J2219/00337 , B01J2219/00342 , B01J2219/00353 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , C40B40/14 , C40B60/14 , G01N35/1079
摘要： Parallel semi-continuous or continuous reactors are disclosed. The parallel reactors preferably comprise four or more reaction vessels. The reaction vessels are preferably small volume reaction vessels, preferably pressure reaction vessels, and/or preferably integral with a common reactor block. The reaction vessels can comprise shaft-driven stirrers. At least two, preferably at least three or at least four liquid feed lines can provide selective fluid communication between each of the reaction vessels and one or more liquid reagent sources. Additional features, suitable in connection with parallel reactors or with single reaction vessels are also disclosed.

5. 发明申请

US20050158879A1 Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto 审中-公开
标题翻译：用于将分子固定在表面上并具有水溶性或水分散性区段的聚合物刷和与其结合的探针
公开(公告)号：US20050158879A1
公开(公告)日：2005-07-21
申请号：US11012416
申请日：2004-12-15
申请人： Gerrit Klaerner , Ralph Nielsen , Paul Mansky , Didier Benoit , Dominique Charmot , Bernd Jandeleit , Laura Mazzola
发明人： Gerrit Klaerner , Ralph Nielsen , Paul Mansky , Didier Benoit , Dominique Charmot , Bernd Jandeleit , Laura Mazzola
IPC分类号： C08F4/00 , C08F220/54 , C08F220/58 , G01N27/447 , G01N33/543 , C12Q1/68
CPC分类号： G01N33/54353 , C08F4/00 , C08F220/54 , C08F220/58 , G01N27/44747 , Y10T428/8305 , Y10T436/10
摘要： Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
摘要翻译：用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包含具有表面的基底，所述基底具有用水分散性或水溶性聚合物链段修饰，所述水分散性或水溶性聚合物链段具有结合探针。合成这种传感器的方法优选包括使用受控的自由基聚合技术，特别是使用引发剂，其允许可控结构聚合物改性基材的表面。以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。

6. 发明申请

US20050016276A1 Frequency encoding of resonant mass sensors 审中-公开
标题翻译：谐振质量传感器的频率编码
公开(公告)号：US20050016276A1
公开(公告)日：2005-01-27
申请号：US10861583
申请日：2004-06-04
申请人： Shenheng Guan , Ralph Nielsen
发明人： Shenheng Guan , Ralph Nielsen
IPC分类号： G01N27/00 , G01N29/00 , G01N29/02 , G01N29/036 , G01N29/04
CPC分类号： G01N29/036 , G01N29/022 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2291/0428 , G01N2291/106
摘要： A method for the detection of analytes using resonant mass sensors or sensor arrays comprises frequency encoding each sensor element, acquiring a time-domain resonance signal from the sensor or sensor array as it is exposed to analyte, detecting change in the frequency or resonant properties of each sensor element using a Fourier transform or other spectral analysis method, and classifying, identifying, and/or quantifying analyte using an appropriate data analysis procedure. Frequency encoded sensors or sensor arrays comprise sensor elements with frequency domain resonance signals that can be uniquely identified under a defined range of operating conditions. Frequency encoding can be realized either by fabricating individual sensor elements with unique resonant frequencies or by tuning or modifying identical resonant devices to unique frequencies by adding or removing mass from individual sensor elements. The array of sensor elements comprises multiple resonant structures that may have identical or unique sensing layers. The sensing layers influence the sensor elements' response to analyte. Time-domain signal is acquired, typically in a single data acquisition channel, and typically using either (1) a pulsed excitation followed by acquisition of the free oscillatory decay of the entire array or (2) a rapid scan acquisition of signal from the entire array in a direct or heterodyne configuration. Spectrum analysis of the time domain data is typically accomplished with Fourier transform analysis. The methods and sensor arrays of the invention enable rapid and sensitive analyte detection, classification and/or identification of complex mixtures and unknown compounds, and quantification of known analytes, using sensor element design and signal detection hardware that are robust, simple and low cost.
摘要翻译：使用谐振质量传感器或传感器阵列检测分析物的方法包括对每个传感器元件进行频率编码，在暴露于分析物时从传感器或传感器阵列获取时域共振信号，检测频率或谐振特性的变化每个传感器元件使用傅里叶变换或其他光谱分析方法，并且使用适当的数据分析程序对分析物进行分类，鉴定和/或定量。频率编码的传感器或传感器阵列包括具有频域共振信号的传感器元件，其可以在规定的操作条件范围内唯一地识别。频率编码可以通过制造具有独特谐振频率的各个传感器元件或通过从各个传感器元件中添加或去除质量来将相同的谐振装置调谐或修改为独特的频率来实现。传感器元件阵列包括可具有相同或唯一感测层的多个谐振结构。传感层影响传感器元件对分析物的响应。时域信号被采集，通常在单个数据采集通道中，并且通常使用（1）脉冲激励，随后获取整个阵列的自由振荡衰减，或（2）从整个信号中快速扫描信号阵列以直接或外差配置。时域数据的频谱分析通常通过傅立叶变换分析完成。使用鲁棒，简单和低成本的传感器元件设计和信号检测硬件，本发明的方法和传感器阵列能够实现复杂混合物和未知化合物的快速和敏感的分析物检测，分类和/或鉴定和已知分析物的定量。

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