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1. 发明授权

US07586088B2 Mass spectrometer and method of mass spectrometry 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US07586088B2
公开(公告)日：2009-09-08
申请号：US10176072
申请日：2002-06-21
申请人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
发明人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/40 , G01N27/624 , H01J49/004 , H01J49/4215
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer in combination with a quadrupole mass filter which is scanned in synchronization with the pulsing of ions into the ion mobility spectrometer thereby enabling ions having a particular charge state to be preferentially transmitted. Another embodiment replaces the quadrupole mass filter with an axial time of flight mass filter and an injection electrode.
摘要翻译：公开了一种质谱仪，其包括与四极质量过滤器组合的离子迁移谱仪，其与离子脉冲离子扫描到离子迁移谱仪中，从而使具有特定电荷状态的离子能够被优先传输。另一实施例用轴向飞行时间质量过滤器和注入电极取代四极质量过滤器。

2. 发明授权

US06838662B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06838662B2
公开(公告)日：2005-01-04
申请号：US10693874
申请日：2003-10-28
申请人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/16 , H01J49/26 , H01J49/42
CPC分类号： H01J49/4235
摘要： A mass spectrometer is disclosed comprising a mass filter for separating ions according to their mass to charge ratio. The mass filter comprises a plurality of electrodes wherein ions are radially confined within the mass filter by the application of AC or RF voltages to the electrodes. One or more transient DC voltages or one or more transient DC voltage waveforms are progressively applied to the electrodes so that ions having a certain mass to charge ratio are separated from other ions having different mass to charge ratios which remain radially confined within the mass filter.
摘要翻译：公开了一种质谱仪，其包括用于根据其质荷比分离离子的质量过滤器。质量过滤器包括多个电极，其中通过向电极施加AC或RF电压，离子径向地限制在质量过滤器内。一个或多个瞬态直流电压或一个或多个瞬态直流电压波形逐渐地施加到电极，使得具有一定质荷比的离子与具有不同质量与电荷比的其它离子分离，这些离子保持径向地限制在质量过滤器内。

3. 发明授权

US06992283B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06992283B2
公开(公告)日：2006-01-31
申请号：US10739041
申请日：2003-12-19
申请人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
发明人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , G01N27/622 , H01J49/0036 , H01J49/004
摘要： A mass spectrometer is disclosed wherein ions are passed through an ion mobility separator and are then mass analysed by a Time of Flight mass analyzer. Multiple sets of mass spectral data are obtained which are then post-processed so that mass spectral data relating to ions having undesired charge state(s) is filtered out. The resultant mass spectrum comprises ions having a desired charge state.
摘要翻译：公开了一种质谱仪，其中离子通过离子迁移率分离器，然后通过飞行时间质量分析仪进行质量分析。获得多组质谱数据，然后对其进行后处理，从而滤出与具有不期望的电荷状态的离子相关的质谱数据。所得质谱包括具有所需电荷状态的离子。

4. 发明授权

US06884995B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06884995B2
公开(公告)日：2005-04-26
申请号：US10610677
申请日：2003-07-02
申请人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle
发明人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle
IPC分类号： H01J49/02 , H01J49/26
CPC分类号： H01J49/005 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a collision cell wherein ions having substantially different mass to charge ratios are arranged to be transmitted through at least a portion of the collision cell at substantially the same time and with substantially the same velocity preferably by means of one or more transient DC voltages or one or more transient DC voltage waveforms which are applied to the electrodes forming the collision cell so that ions are urged through the collision cell at a constant controlled velocity. By appropriate setting of the velocity of the DC voltage or DC voltage waveform passing along the length of the collision cell an efficient collision cell is provided which is able to fragment ions having considerably different mass to charge ratio at substantially the same time in an optimal manner.
摘要翻译：公开了一种质谱仪，其包括碰撞池，其中具有基本上不同的质荷比的离子被布置成在基本相同的时间和基本上相同的速度下通过至少一部分的碰撞池传播通过一个或多个瞬态DC电压或一个或多个瞬态DC电压波形，其被施加到形成碰撞电池的电极，使得离子以恒定的受控速度被迫穿过碰撞池。通过适当设定沿着碰撞电池的长度通过的直流电压或直流电压波形的速度，提供了一种有效的碰撞电池，其能够以最佳方式在基本上相同的时间将具有相当不同质荷比的离子分解。

5. 发明授权

US06717130B2 Methods and apparatus for mass spectrometry 有权
标题翻译：质谱方法和仪器
公开(公告)号：US06717130B2
公开(公告)日：2004-04-06
申请号：US09876122
申请日：2001-06-08
申请人： Robert Harold Bateman , John Brian Hoyes , Edward James Clayton
发明人： Robert Harold Bateman , John Brian Hoyes , Edward James Clayton
IPC分类号： B01D5944
CPC分类号： H01J49/0045
摘要： A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source are incident upon a collision cell which alternately and repeatedly switches between a first mode wherein the ions are substantially fragmented to produce daughter ions and a second mode wherein the ions are not substantially fragmented. Mass spectra are taken in both modes, and at the end of an experimental run parent and daughter ions are recognized by comparing the mass spectra obtained in the two different modes. Daughter ions are matched to particular parent ions on the basis of the closeness of fit of their elution times, and this enables parent ions to then be identified.
摘要翻译：公开了一种通过匹配发现在母体离子从混合物中洗脱出的基本上同时产生的子离子来鉴定亲本离子的方法。从离子源发射的离子入射到碰撞单元上，该碰撞单元在离子基本上分裂以产生子离子的第一模式之间交替重复地切换，而第二模式其中离子基本上不分段。在两种模式下都采用质谱，在实验运行结束时，通过比较两种不同模式中获得的质谱来识别母体和子离子。基于其洗脱时间的拟合程度，子离子与特定的母体离子相匹配，这使母体离子能够被识别。

6. 发明授权

US07205538B2 Mass spectrometer 有权
公开(公告)号：US07205538B2
公开(公告)日：2007-04-17
申请号：US11472278
申请日：2006-06-22
申请人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle , Jeff Brown
发明人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle , Jeff Brown
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.

7. 发明授权

US07071467B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07071467B2
公开(公告)日：2006-07-04
申请号：US10633702
申请日：2003-08-05
申请人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle , Jeff Brown
发明人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle , Jeff Brown
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.
摘要翻译：公开了一种质谱仪，其包括离子阱，其中根据其质荷比或离子迁移率暂时分离的离子进入离子阱。一旦至少一些离子已经进入离子阱，沿着离子阱的长度产生多个离子捕获区域，以分离离子。或者，离子可以被接收在一个或多个沿着离子阱平移的轴向捕获区域中，其速度逐渐减小到零。

8. 发明授权

US06586727B2 Methods and apparatus for mass spectrometry 有权
标题翻译：质谱方法和仪器
公开(公告)号：US06586727B2
公开(公告)日：2003-07-01
申请号：US09796544
申请日：2001-03-02
申请人： Robert Harold Bateman , John Brian Hoyes
发明人： Robert Harold Bateman , John Brian Hoyes
IPC分类号： H01J4940
CPC分类号： H01J49/0045 , H01J49/4215
摘要： An improved method of parent ion scanning is disclosed. In one embodiment a quadrupole mass filter 3 upstream of a collision cell 4 is arranged to operate in a highpass mode. Parent ions transmitted by the mass filter 3 are fragmented in the collision cell 4 and detected by an orthogonal time of flight analyser 5 which obtains a daughter ion mass spectrum. Ions having a mass to charge ratio below the cutoff of the mass filter 3 are identified as daughter ions, and candidate parent ions may then be discovered and their identity confirmed by obtaining corresponding daughter ion spectra. In a second embodiment, the collision cell 4 alternates between high and low fragmentation and candidate parent ions can additionally be identified on the basis of the loss of a predetermined ion or neutral particle.
摘要翻译：公开了改进的亲离子扫描方法。在一个实施例中，碰撞单元4上游的四极质量过滤器3布置成以高通模式操作。由质量过滤器3传递的亲本离子在碰撞池4中被分段，并且通过获得子离子质谱的飞行分析仪5的正交时间检测。具有低于质量过滤器3的截止值的质荷比的离子被鉴定为子离子，然后可以通过获得相应的子离子光谱来发现候选母体离子并且确定它们的身份。在第二实施例中，碰撞单元4在高和低碎片之间交替，并且候选母离子可以另外根据预定离子或中性粒子的损失来识别。

9. 发明授权

US6107623A Methods and apparatus for tandem mass spectrometry 有权
标题翻译：串联质谱法的方法和装置
公开(公告)号：US6107623A
公开(公告)日：2000-08-22
申请号：US138152
申请日：1998-08-21
申请人： Robert Harold Bateman , John Brian Hoyes
发明人： Robert Harold Bateman , John Brian Hoyes
IPC分类号： H01J49/26 , H01J49/40 , H01J49/42 , B01D59/44
CPC分类号： H01J49/004 , H01J49/4215
摘要： The invention provides methods and apparatus for tandem mass spectrometry (MS/MS) in which parent ions generated from a sample are passed through a mass filter (2) and are fragmented into daughter ions in fragmentation means (3), the daughter ions being passed through a discontinuous output mass analyser, such as a time-of-flight analyzer (16) or an ion storage device (29). The range of possible parent mass-to-charge ratios is split into a plurality of smaller ranges, and the mass filter (2) is set to pass ions of each smaller range in turn. A flag is set for each smaller range which produces daughter ions of interest, and the mass filter (2) is set to pass each mass-to-charge ratio of the flagged ranges so that the mass-to-charge ratios of the fragmented ions produced for each of the mass-to-charge ratios passed may be determined using the discontinuous analyser (16, 29). The flagged ranges may be themselves split into a plurality of still smaller ranges, which are correspondingly flagged.
摘要翻译：本发明提供串联质谱法（MS / MS）的方法和装置，其中从样品产生的亲本离子通过质量过滤器（2），并在碎片装置（3）中碎裂成子离子，子离子通过通过不连续输出质量分析器，例如飞行时间分析器（16）或离子存储装置（29）。可能的母体质荷比的范围被分成多个较小的范围，并且质量过滤器（2）被设置为依次通过每个较小范围的离子。对于产生感兴趣的子离子的每个较小的范围设置标志，并且质量过滤器（2）被设置为通过标记范围的每个质荷比，使得碎裂离子的质荷比可以使用不连续分析仪（16,29）来确定通过的每个质荷比。标记的范围本身可以分成多个相应标记的较小范围。

10. 发明授权

US07635841B2 Method of mass spectrometry 有权
标题翻译：质谱法
公开(公告)号：US07635841B2
公开(公告)日：2009-12-22
申请号：US10498046
申请日：2002-12-12
申请人： Robert Harold Bateman , John Brian Hoyes , Jason Lee Wildgoose , Anthony James Gilbert
发明人： Robert Harold Bateman , John Brian Hoyes , Jason Lee Wildgoose , Anthony James Gilbert
IPC分类号： H01J49/00
CPC分类号： H01J49/062 , Y10T436/24
摘要： A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P×T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.
摘要翻译：公开了一种质谱法，其中在产品PxT至少为1毫巴的压力下，在保持在压力P的AC或RF离子导向器内捕获离子一段时间T。捕获根据优选实施方案的离子的效果是，可以例如包含不想要的背景离子的单电荷离子从捕获阱基本上丢失，而多电荷分析物离子保持在离子阱内，然后可以释放以用于随后的质量分析。

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