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1. 发明申请

US20080058898A1 Implantable Retinal Electrode Array Configuration for Minimal Retinal Damage and Method of Reducing Retinal Stress 有权
标题翻译：植入式视网膜电极阵列配置最小视网膜损伤和减少视网膜压力的方法
公开(公告)号：US20080058898A1
公开(公告)日：2008-03-06
申请号：US11933878
申请日：2007-11-01
申请人： Robert Greenberg , Alfred Mann , James Little , Karl-Heinz Ihrig , Brian Mech , Neil Talbot , DaoMin Zhou
发明人： Robert Greenberg , Alfred Mann , James Little , Karl-Heinz Ihrig , Brian Mech , Neil Talbot , DaoMin Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543
摘要： This invention is a retinal electrode array assembly and methods of using the same that facilitate surgical implant procedures by providing the operating surgeon with visual references and grasping means and with innovations that reduce actual and potential damage to the retina and the surrounding tissue.
摘要翻译：本发明是一种视网膜电极阵列组件及其使用方法，其通过向操作外科医生提供视觉参考和抓握装置以及减少对视网膜和周围组织的实际和潜在损伤的创新来促进手术植入程序。

2. 发明申请

US20070173905A1 Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress 有权
标题翻译：植入式视网膜电极阵列配置，用于最小的视网膜损伤和减少视网膜应力的方法
公开(公告)号：US20070173905A1
公开(公告)日：2007-07-26
申请号：US11728144
申请日：2007-03-23
申请人： Robert Greenberg , Alfred Mann , James Little , Karl-Heinz Ihrig , Brian Mech , Neil Talbot , DaoMin Zhou
发明人： Robert Greenberg , Alfred Mann , James Little , Karl-Heinz Ihrig , Brian Mech , Neil Talbot , DaoMin Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543
摘要： This invention is a retinal electrode array assembly and methods of using the same that facilitate surgical implant procedures by providing the operating surgeon with visual references and grasping means and with innovations that reduce actual and potential damage to the retina and the surrounding tissue.
摘要翻译：本发明是一种视网膜电极阵列组件及其使用方法，其通过向操作外科医生提供视觉参考和抓握装置以及减少对视网膜和周围组织的实际和潜在损伤的创新来促进手术植入程序。

3. 发明授权

US10667404B2 Flexible circuit electrode array 有权
公开(公告)号：US10667404B2
公开(公告)日：2020-05-26
申请号：US11926046
申请日：2007-10-28
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/05 , H05K3/00 , A61N1/36
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

4. 发明申请

US20070270919A1 Retinal prosthesis 有权
标题翻译：视网膜假体
公开(公告)号：US20070270919A1
公开(公告)日：2007-11-22
申请号：US11880009
申请日：2007-07-19
申请人： Robert Greenberg , Neil Talbot , Brian Mech , James Little
发明人： Robert Greenberg , Neil Talbot , Brian Mech , James Little
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046
摘要： The invention is a retinal prosthesis with an improved configuration mounting necessary components within and surrounding the eye. The present invention better allows for the implantation of electronics within the delicate eye structure. The invention further limits the necessary width of a thin film conductor passing through the sclera by use of a multiplexer external to the sclera and a demultiplexer internal to the sclera.
摘要翻译：本发明是具有改进的构造的视网膜假体，其将眼睛内部和周围的必要部件安装。本发明更好地允许在精细的眼睛结构内植入电子装置。本发明通过使用巩膜外部的多路复用器和巩膜内部的解复用器进一步限制穿过巩膜的薄膜导体的必要宽度。

5. 发明申请

US20060247754A1 Flexible circuit electrode array 有权
公开(公告)号：US20060247754A1
公开(公告)日：2006-11-02
申请号：US11207644
申请日：2005-08-19
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/05
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

6. 发明申请

US20060111757A9 Retinal prosthesis 有权
公开(公告)号：US20060111757A9
公开(公告)日：2006-05-25
申请号：US10918112
申请日：2004-08-13
申请人： Robert Greenberg , Neil Talbot , Brian Mech , James Little
发明人： Robert Greenberg , Neil Talbot , Brian Mech , James Little
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046
摘要： The invention is a retinal prosthesis with an improved configuration mounting necessary components within and surrounding the eye. The present invention better allows for the implantation of electronics within the delicate eye structure. The invention further limits the necessary width of a thin film conductor passing through the sclera by use of a multiplexer external to the sclera and a demultiplexer internal to the sclera.

7. 发明授权

US08014878B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08014878B2
公开(公告)日：2011-09-06
申请号：US11207644
申请日：2005-08-19
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/36
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

8. 发明申请

US20080064946A1 Flexible Circuit Electrode Array 审中-公开
标题翻译：柔性电路电极阵列
公开(公告)号：US20080064946A1
公开(公告)日：2008-03-13
申请号：US11928151
申请日：2007-10-30
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Anne-Marie De Merlier Ripley
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Anne-Marie De Merlier Ripley
IPC分类号： A61N1/04
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作用于神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

9. 发明申请

US20070293749A1 Electrode with increased stability and method of manufacturing the same 有权
标题翻译：增加稳定性的电极及其制造方法
公开(公告)号：US20070293749A1
公开(公告)日：2007-12-20
申请号：US11820744
申请日：2007-06-19
申请人： Dao Zhou , Jerry Ok , Neil Talbot , Brian Mech , James Little , Robert Greenberg
发明人： Dao Zhou , Jerry Ok , Neil Talbot , Brian Mech , James Little , Robert Greenberg
IPC分类号： A61B5/04
CPC分类号： A61N1/0543 , A61N1/36046
摘要： The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. The present invention provides A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.
摘要翻译：本发明提供具有增加的稳定性的可植入电极，其具有聚集结构，其中电极的表面被包括填充有棒或柱的开口的材料覆盖。本发明提供了具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。本发明提供一种具有增加的稳定性的电极的制造方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。本发明提供了一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

10. 发明申请

US20070055336A1 Retinal prosthesis with a new configuration 有权
标题翻译：视网膜假体具有新配置
公开(公告)号：US20070055336A1
公开(公告)日：2007-03-08
申请号：US11523965
申请日：2006-09-19
申请人： Robert Greenberg , Matthew McMahon , James Little , Kelly McClure , Brian Mech , Neil Talbot , Jordan Neysmith
发明人： Robert Greenberg , Matthew McMahon , James Little , Kelly McClure , Brian Mech , Neil Talbot , Jordan Neysmith
IPC分类号： A61N1/04
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/37223 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/0014 , H05K3/28 , H05K2201/0133 , H05K2201/09018 , H05K2201/09145 , H05K2201/09909 , H05K2201/2009 , H05K2203/1105 , H05K2203/1476 , H05K2203/302 , Y10T29/49158
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, and cortical stimulation, and many related purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们特别有用于视网膜刺激以产生人造视觉，耳蜗刺激以产生人造听觉和皮质刺激以及许多相关目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

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