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1. 发明申请

US20090012010A1 Amino acid derivatives as calcium channel blockers 审中-公开
标题翻译：氨基酸衍生物作为钙通道阻滞剂
公开(公告)号：US20090012010A1
公开(公告)日：2009-01-08
申请号：US12152488
申请日：2008-05-14
申请人： Robert Galemmo, JR. , Richard Holland , Yanbing Ding , Lingyun Zhang , Gabriel Hum , Navjot Chahal , Joseph Duffy , Christian Stevenson , Andrew Ullman
发明人： Robert Galemmo, JR. , Richard Holland , Yanbing Ding , Lingyun Zhang , Gabriel Hum , Navjot Chahal , Joseph Duffy , Christian Stevenson , Andrew Ullman
IPC分类号： A61K38/05 , C07C233/87 , C07D265/30 , A61P25/16 , A61P25/18 , A61P35/00 , A61P3/10
CPC分类号： A61K31/166 , A61K31/277 , A61K31/4453 , A61K31/5375
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both an amino acid functionality and multiple aromatic rings are disclosed of the general formula (1) where X is benzhydryl, or an aromatic or heteroaromatic ring.
摘要翻译：公开了有效改善特征在于不需要的钙通道活性，特别是不需要的N型和/或T型钙通道活性的病症的方法和化合物。具体地，公开了一系列含有氨基酸官能团和多个芳环的化合物，其通式（1）其中X是二苯甲基或芳族或杂芳族环。

2. 发明申请

US20070213853A1 System and method for implementing safety instrumented systems in a fieldbus architecture 失效
标题翻译：在现场总线架构中实施安全仪表系统的系统和方法
公开(公告)号：US20070213853A1
公开(公告)日：2007-09-13
申请号：US11656883
申请日：2007-01-22
申请人： David Glanzer , Joseph Duffy , Stephen Mitschke , Ram Ramachandran , John Carl Gabler , L. Jonas Berge
发明人： David Glanzer , Joseph Duffy , Stephen Mitschke , Ram Ramachandran , John Carl Gabler , L. Jonas Berge
IPC分类号： G05B9/02
CPC分类号： G05B9/02 , G05B11/01 , G05B15/02 , G05B19/042 , G05B2219/13127 , G05B2219/15068 , G05B2219/23256 , G05B2219/25085 , G05B2219/25428 , G05B2219/31118 , H04L67/125 , H04L67/325 , H04L69/08
摘要： An apparatus, system and process is provided for communicating safety-related data, over an open system, from a sender to a receiver. Safety-related components, including function blocks, flexible function blocks, resource blocks and transducer blocks, as well as, safety-related objects are provided. Also, an extended safety-related protocol provides for authenticating communications between safety-related components over an existing black channel, such as one using a fieldbus Architecture.
摘要翻译：提供了一种装置，系统和过程，用于通过开放系统从发送器传送安全相关数据到接收器。提供与安全相关的组件，包括功能块，灵活功能块，资源块和传感器块，以及与安全相关的对象。此外，扩展的安全相关协议提供了通过现有黑色通道（例如使用现场总线架构）的安全相关组件之间的通信认证。

3. 发明申请

US20070142939A1 System and method for implementing time synchronization monitoring and detection in a safety instrumented system 失效
标题翻译：在安全仪表化系统中实现时间同步监测和检测的系统和方法
公开(公告)号：US20070142939A1
公开(公告)日：2007-06-21
申请号：US11642498
申请日：2006-12-19
申请人： Joseph Duffy , Ram Ramachandran , John Gabler
发明人： Joseph Duffy , Ram Ramachandran , John Gabler
IPC分类号： G05B11/01
CPC分类号： G06F1/12
摘要： An apparatus, system and process is provided for communicating safety-related data, over an open system, from a sender to a receiver. Safety-related components, including function blocks, flexible function blocks, resource blocks and transducer blocks, as well as, safety-related objects are provided. Also, a time synchronization monitor is provided for monitoring timing distributions and determining when such distributions have drifted beyond an acceptable limit.
摘要翻译：提供了一种装置，系统和过程，用于通过开放系统从发送器传送安全相关数据到接收器。提供与安全相关的组件，包括功能块，灵活功能块，资源块和传感器块，以及与安全相关的对象。此外，提供时间同步监视器用于监视定时分布，并确定这些分布何时漂移超过可接受的极限。

4. 发明申请

US20060025872A1 System and method for implementing safety instrumented systems in a fieldbus architecture 有权
公开(公告)号：US20060025872A1
公开(公告)日：2006-02-02
申请号：US11240939
申请日：2005-09-30
申请人： David Glanzer , Joseph Duffy , Stephen Mitschke , Ram Ramachandran , John Gabler , L. Berge
发明人： David Glanzer , Joseph Duffy , Stephen Mitschke , Ram Ramachandran , John Gabler , L. Berge
IPC分类号： G05B11/01 , G05B9/02
CPC分类号： G05B9/02 , G05B11/01 , G05B15/02 , G05B19/042 , G05B2219/13127 , G05B2219/15068 , G05B2219/23256 , G05B2219/25085 , G05B2219/25428 , G05B2219/31118 , H04L67/125 , H04L67/325 , H04L69/08
摘要： An apparatus, system and process is provided for communicating safety-related data, over an open system, from a sender to a receiver. Safety-related components, including function blocks, flexible function blocks, resource blocks and transducer blocks, as well as, safety-related objects are provided. Also, an extended safety-related protocol provides for authenticating communications between safety-related components over an existing black channel, such as one using a fieldbus Architecture.

5. 发明授权

US06518519B1 Method and apparatus for determining a weight of a payload 失效
标题翻译：用于确定有效载荷的重量的方法和装置
公开(公告)号：US06518519B1
公开(公告)日：2003-02-11
申请号：US09651173
申请日：2000-08-30
申请人： Carl D. Crane, III , Joseph Duffy
发明人： Carl D. Crane, III , Joseph Duffy
IPC分类号： G01G1908
CPC分类号： E02F9/264
摘要： Methods and apparatuses for determining a mass of a payload in a work machine. The work machine has a chassis, a cab coupled with the chassis, and a boom coupled with the cab. A first actuator is coupled with the boom and the cab and moves the boom relative to the cab. The work machine has a stick coupled with the boom, and a second actuator coupled with the stick and the boom that moves the stick relative to the boom. The work machine also has a bucket operable to receive the payload. The bucket is coupled with the stick, and a third actuator is coupled with the bucket and the stick and moves the bucket relative to the stick. A first joint angle of the boom relative to the cab is determined at at least two instances in time. A second joint angle of the stick relative to the boom is determined at at least two instances in time. A third joint angle of the bucket relative to the stick is determined at at least two instances in time. A first actuator force exerted on the first actuator is determined at at least two instances in time. A second actuator force exerted on the second actuator is determined at at least two instances in time. A third actuator force exerted on the third actuator is determined at at least two instances in time. A plurality of physical characteristics of the work machine is determined. The mass of the bucket and payload is determined as a function of the first joint angles, the second joint angles, the third joint angles, the first actuator forces, the second actuator forces, the third actuator forces, and the plurality of predetermined physical characteristics.
摘要翻译：用于确定作业机器中的有效载荷的质量的方法和装置。工作机具有底盘，与底盘连接的驾驶室以及与驾驶室联动的动臂。第一致动器与动臂和驾驶室联接，并使悬臂相对于驾驶室移动。工作机具有与吊杆结合的杆，以及与杆和悬臂相耦合的第二致动器，其相对于悬臂移动杆。工作机器还具有可操作以接收有效载荷的铲斗。铲斗与杆联接，第三执行器与铲斗和棍子联接，并相对于棒移动铲斗。在至少两个时间上确定起重臂相对于驾驶室的第一关节角度。在至少两个时间的情况下确定棒相对于吊杆的第二关节角度。在至少两个时间上确定桶相对于棒的第三关节角度。在至少两个时间上确定施加在第一致动器上的第一致动器力。在至少两个时间的情况下确定施加在第二致动器上的第二致动器力。在至少两个时间上确定施加在第三致动器上的第三致动器力。确定作业机器的多个物理特性。铲斗和有效载荷的质量根据第一关节角度，第二关节角度，第三关节角度，第一致动器力，第二致动器力，第三致动器力和多个预定物理特性来确定。

6. 发明授权

US07273876B2 Substituted bicylic thiophene derivatives, compositions containing such compounds and methods of use 失效
标题翻译：取代的二元噻吩衍生物，含有这些化合物的组合物和使用方法
公开(公告)号：US07273876B2
公开(公告)日：2007-09-25
申请号：US10527762
申请日：2003-09-08
申请人： Joseph Duffy , Elizabeth Louise Campbell , Rui Liang , Zenon Konteatis
发明人： Joseph Duffy , Elizabeth Louise Campbell , Rui Liang , Zenon Konteatis
IPC分类号： A61K31/4365 , A61K31/381 , C07D495/04
CPC分类号： C07D409/04 , C07D333/68 , C07D409/12 , C07D417/12 , C07D495/04 , C07D495/10
摘要： The present invention addresses substituted thiophene derivatives, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.
摘要翻译：本发明涉及取代的噻吩衍生物，以及含有这些化合物的组合物和治疗方法。本发明中的化合物是胰高血糖素拮抗剂。该化合物阻断胰高血糖素在其受体上的作用，从而降低提供糖尿病治疗的血浆葡萄糖水平。

7. 发明申请

US20060111336A1 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
标题翻译：苯丙氨酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病
公开(公告)号：US20060111336A1
公开(公告)日：2006-05-25
申请号：US10537476
申请日：2003-11-26
申请人： Joseph Duffy , Robert Mathvink , Ann Weber , Jinyou Xu
发明人： Joseph Duffy , Robert Mathvink , Ann Weber , Jinyou Xu
IPC分类号： A61K31/426 , A61K31/401 , A61K31/397 , C07D277/56
CPC分类号： C07D295/185 , A61K31/40 , C07D207/10 , C07D207/16 , C07D277/04
摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

8. 发明申请

US20050239865A1 Substituted bicyclic thiophene derivatives, compositions containing such compounds and methods of use 失效
标题翻译：取代的双环噻吩衍生物，含有这些化合物的组合物和使用方法
公开(公告)号：US20050239865A1
公开(公告)日：2005-10-27
申请号：US10527762
申请日：2003-09-08
申请人： Joseph Duffy , Elizabeth Campbell , Rui Liang , Zenon Konteatis
发明人： Joseph Duffy , Elizabeth Campbell , Rui Liang , Zenon Konteatis
IPC分类号： A61K31/381 , A61K31/407 , C07D333/68 , C07D409/04 , C07D409/12 , C07D417/12 , C07D495/04 , C07D495/10 , C07D498/02
CPC分类号： C07D409/04 , C07D333/68 , C07D409/12 , C07D417/12 , C07D495/04 , C07D495/10
摘要： The present invention addresses substituted thiophene derivatives, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.
摘要翻译：本发明涉及取代的噻吩衍生物，以及含有这些化合物的组合物和治疗方法。本发明中的化合物是胰高血糖素拮抗剂。该化合物阻断胰高血糖素在其受体上的作用，从而降低提供糖尿病治疗的血浆葡萄糖水平。

9. 发明申请

US20060035958A1 Method of treating diabetes and related conditions 审中-公开
标题翻译：治疗糖尿病及相关病症的方法
公开(公告)号：US20060035958A1
公开(公告)日：2006-02-16
申请号：US10527652
申请日：2003-09-08
申请人： Joseph Duffy , Elizabeth Campbell , Sajjad Qureshi , Bei Zhang , James Tata , Zenon Konteatis , Rui Liang
发明人： Joseph Duffy , Elizabeth Campbell , Sajjad Qureshi , Bei Zhang , James Tata , Zenon Konteatis , Rui Liang
IPC分类号： A61K31/381
CPC分类号： A61K31/381
摘要： The present invention addresses the use of substituted thiophene derivatives, as well as compositions containing such compounds for treating type 2 diabetes mellitus. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.
摘要翻译：本发明涉及取代的噻吩衍生物的用途，以及含有这些化合物用于治疗2型糖尿病的组合物。本发明中的化合物是胰高血糖素拮抗剂。该化合物阻断胰高血糖素在其受体上的作用，从而降低提供糖尿病治疗的血浆葡萄糖水平。

10. 发明授权

US5179525A Method and apparatus for controlling geometrically simple parallel mechanisms with distinctive connections 失效
标题翻译：用于控制具有独立连接的几何简单并行机制的方法和装置
公开(公告)号：US5179525A
公开(公告)日：1993-01-12
申请号：US517371
申请日：1990-05-01
申请人： Michael W. Griffis , Joseph Duffy
发明人： Michael W. Griffis , Joseph Duffy
IPC分类号： G09B9/08 , B23Q1/54 , B25J9/16 , B25J17/02 , G09B9/14
CPC分类号： B25J9/1623 , B23Q1/5462 , B25J17/0216 , G09B9/14 , F16F2230/0052 , G05B2219/37177 , G05B2219/41301 , G05B2219/50162
摘要： A system, method and apparatus for controlling, via a closed-form forward displacement computation, the position and orientation of a movable platform of a parallel mechanism. A movable platform is supported above a base platform by a plurality of parallel support legs such as linear actuators. The dimensions of the base platform and the movable platform, as well the lengths of the support legs, are provided to a control system. The control system is operative to compute at least one closed-form forward displacement solution of the geometry of a polyhedron (an octahedron for the disclosed embodiments) formed by the movable platform, the base platform, and the support legs. The control system determines a final position and orientation of the movable platform by eliminating imaginary roots of the closed-form solutions and roots which would result in discontinuous paths of travel for the movable platform. A novel special 6-6 parallel mechanism is also disclosed. The control system is suitable for controlling known 3-3 or 6-3 Stewart platforms in a novel manner, as well as controlling the novel special 6-6 parallel mechanism. The special 6-6 parallel mechanism is distinguished from a general 6-6 by the fact that it is geometrically reducible to an octahedron, and therefore it has a simple geometry, even though its legs possess distinct connections. Also disclosed is a method for reducing the novel special 6-6 parallel mechanism to a Stewart platform equivalent, which is then controlled by the disclosed closed-form forward displacement control system.
摘要翻译：一种用于通过封闭式向前位移计算来控制并联机构的可移动平台的位置和方位的系统，方法和装置。可移动平台通过诸如线性致动器的多个平行支撑腿支撑在基座平台上。基座平台和可移动平台的尺寸以及支撑腿的长度被提供给控制系统。控制系统可操作以计算由可移动平台，基座平台和支撑腿形成的多面体（所公开的实施例的八面体）的几何形状的至少一个闭合形式的向前位移解。控制系统通过消除封闭形式的解决方案和根的假想根来确定可移动平台的最终位置和方向，这将导致可移动平台的不连续行进路径。还公开了一种新颖的特殊6-6并联机构。控制系统适用于以新颖的方式控制已知的3-3或6-3 Stewart平台，以及控制新颖的特殊6-6并行机制。特殊的6-6平行机构与一般的6-6不同之处在于它几何可缩减为八面体，因此它具有简单的几何形状，即使它的腿具有不同的连接。还公开了一种用于将新的特殊6-6并联机构减小到斯图尔特平台等效物的方法，然后由公开的封闭式前向位移控制系统控制。

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