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1. 发明授权

US07462196B2 Method and apparatus for implant stability 失效
标题翻译：植入物稳定性的方法和装置
公开(公告)号：US07462196B2
公开(公告)日：2008-12-09
申请号：US11359134
申请日：2006-02-21
申请人： Robert Fraser , John Riley Hawkins , Christopher Rogers , Andrew Dooris , Mark Lionetto
发明人： Robert Fraser , John Riley Hawkins , Christopher Rogers , Andrew Dooris , Mark Lionetto
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/00234 , A61B17/025 , A61B2017/0256 , A61F2/4611 , A61F2002/30387 , A61F2002/30563 , A61F2002/30579 , A61F2002/30604 , A61F2002/30823 , A61F2002/30841 , A61F2002/30848 , A61F2002/30884 , A61F2002/4627 , A61F2002/4628 , A61F2002/4635 , A61F2220/0025
摘要： An method and apparatus is provided for achieving stability of an implant in an intervertebral space of the human body, including an implant having a superior surface and an inferior surface, the surfaces having no significant protrusions extending therefrom and at least one modular projection mateable with one of each superior and inferior surface of the implant to achieve stability within the intervertebral space. The implants can be selected form a group of artificial discs and spinal fusion cages.
摘要翻译：提供了一种用于实现植入物在人体的椎间空间中的稳定性的方法和装置，其包括具有上表面和下表面的植入物，所述表面没有从其延伸的明显的突出物，以及至少一个可与一个的植入物的每个上下表面以实现椎间空间内的稳定性。植入物可以选自一组人造椎间盘和脊柱融合笼。

2. 发明授权

US07060097B2 Method and apparatus for implant stability 有权
标题翻译：植入物稳定性的方法和装置
公开(公告)号：US07060097B2
公开(公告)日：2006-06-13
申请号：US10405064
申请日：2003-03-31
申请人： Robert Fraser , John Riley Hawkins , Christopher Rogers , Andrew Dooris , Mark Lionetto
发明人： Robert Fraser , John Riley Hawkins , Christopher Rogers , Andrew Dooris , Mark Lionetto
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/00234 , A61B17/025 , A61B2017/0256 , A61F2/4611 , A61F2002/30387 , A61F2002/30563 , A61F2002/30579 , A61F2002/30604 , A61F2002/30823 , A61F2002/30841 , A61F2002/30848 , A61F2002/30884 , A61F2002/4627 , A61F2002/4628 , A61F2002/4635 , A61F2220/0025
摘要： An method and apparatus is provided for achieving stability of an implant in an intervertebral space of the human body, including an implant having a superior surface and an inferior surface, the surfaces having no significant protrusions extending therefrom and at least one modular projection mateable with one of each superior and inferior surface of the implant to achieve stability within the intervertebral space. The implants can be selected form a group of artificial discs and spinal fusion cages.
摘要翻译：提供了一种用于实现植入物在人体的椎间空间中的稳定性的方法和装置，其包括具有上表面和下表面的植入物，所述表面没有从其延伸的明显的突出物，以及至少一个可与一个的植入物的每个上下表面以实现椎间空间内的稳定性。植入物可以选自一组人造椎间盘和脊柱融合笼。

3. 发明申请

US20060142863A1 Method and apparatus for implant stability 失效
公开(公告)号：US20060142863A1
公开(公告)日：2006-06-29
申请号：US11359134
申请日：2006-02-21
申请人： Robert Fraser , John Hawkins , Christopher Rogers , Andrew Dooris , Mark Lionetto
发明人： Robert Fraser , John Hawkins , Christopher Rogers , Andrew Dooris , Mark Lionetto
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/00234 , A61B17/025 , A61B2017/0256 , A61F2/4611 , A61F2002/30387 , A61F2002/30563 , A61F2002/30579 , A61F2002/30604 , A61F2002/30823 , A61F2002/30841 , A61F2002/30848 , A61F2002/30884 , A61F2002/4627 , A61F2002/4628 , A61F2002/4635 , A61F2220/0025
摘要： An method and apparatus is provided for achieving stability of an implant in an intervertebral space of the human body, including an implant having a superior surface and an inferior surface, the surfaces having no significant protrusions extending therefrom and at least one modular projection mateable with one of each superior and inferior surface of the implant to achieve stability within the intervertebral space. The implants can be selected form a group of artificial discs and spinal fusion cages.

4. 发明申请

US20100125072A1 SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS 有权
公开(公告)号：US20100125072A1
公开(公告)日：2010-05-20
申请号：US12650196
申请日：2009-12-30
申请人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
发明人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
IPC分类号： A61K31/5377 , C07D491/10 , A61K31/407 , A61K31/4439 , A61K31/506
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

5. 发明申请

US20060252812A1 Spiro-oxindole compounds and their uses as therapeutic agents 有权
标题翻译：螺 - 羟吲哚化合物及其作为治疗剂的用途
公开(公告)号：US20060252812A1
公开(公告)日：2006-11-09
申请号：US11402310
申请日：2006-04-11
申请人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
发明人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
IPC分类号： A61K31/407 , C07D491/10
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
摘要翻译：本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R 1，R 2a，R 2b， >，R 2c，R 2d，R 3a，R 3b，R 3c， >和R“>如本文所定义，作为其立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。还公开了包含化合物的药物组合物以及制备和使用化合物的方法。

6. 发明申请

US20060021982A1 Container Closure 审中-公开
标题翻译：集装箱关闭
公开(公告)号：US20060021982A1
公开(公告)日：2006-02-02
申请号：US11191000
申请日：2005-07-28
申请人： Ihab Hekal , Robert Fraser
发明人： Ihab Hekal , Robert Fraser
IPC分类号： B65D17/34
CPC分类号： B65D17/508 , B65D17/506 , B65D81/266 , B65D2517/5045 , B65D2517/5056 , B65D2517/5083
摘要： A container closure (10) including a peripheral ring member (20) for securing the closure to a container or can body (not shown), and including a molded, polymer ring member (14) and central end panel (12) that are removable from the peripheral ring member for opening the end of the container or can body. The polymer ring member is adhesively bonded to a vertical wall portion (24) of the peripheral ring member and includes an integral lip portion (28) for covering a raw terminal edge of wall portion 24. The adhesive is formulated so that the bond fails cohesively during removal of the polymer ring member. The polymer ring member contains an oxygen-scavenging additive for reducing oxygen inside the container and reducing oxygen ingress into the closed container.
摘要翻译：一种容器封闭件（10），其包括用于将所述封闭件固定到容器或罐体（未示出）的外围环构件（20），并且包括模制的聚合物环构件（14）和中心端板（12）从外围环构件开口容器或罐体的端部。聚合物环构件粘合到外围环构件的垂直壁部分（24）上，并且包括用于覆盖壁部分24的原始末端边缘的整体唇部（28）。配制粘合剂，使得粘合剂在去除聚合物环构件期间内聚失效。聚合物环构件含有用于减少容器内的氧气并减少氧气进入密闭容器的氧气清除添加剂。

7. 发明申请

US20050085913A1 Spinal fixation plate 有权
标题翻译：脊柱固定板
公开(公告)号：US20050085913A1
公开(公告)日：2005-04-21
申请号：US10927778
申请日：2004-08-27
申请人： Robert Fraser , John Malone , Hassan Serhan , Richard Techiera
发明人： Robert Fraser , John Malone , Hassan Serhan , Richard Techiera
IPC分类号： A61B17/70 , A61B17/80 , A61F2/00 , A61F2/30 , A61F2/44
CPC分类号： A61B17/7059 , A61B17/8047 , A61B17/86 , A61B2017/564 , A61B2017/681 , A61F2/4455 , A61F2002/30228 , A61F2002/30331 , A61F2002/30504 , A61F2002/30563 , A61F2002/30578 , A61F2002/30604 , A61F2002/30904 , A61F2002/4475 , A61F2220/0025 , A61F2220/0033
摘要： Spinal fixation plates for maintaining adjacent vertebrae in and fixed position are provided. In an exemplary embodiment, the plate includes opposed superior and inferior portions that are angled in a direction anterior to an anterior face of a mid-portion of the plate. The plate also includes a curvature formed therein about a longitudinal axis in a sagittal plane thereof. In use, when the plate is attached to adjacent vertebrae, the angle of the superior and inferior portions and the curvature in the plate are effective to position one or more thru-bores formed in the superior and inferior portions at the anterior rims of the adjacent vertebrae. In another embodiment, a spinal fixation plate is provided that is adapted to engage and mate to a fusion cage or other vertebral implant disposed between adjacent vertebra. The present invention also provides spinal fixation kits or assemblies, and methods for implanting the same.
摘要翻译：提供用于将相邻椎骨保持在固定位置的脊椎固定板。在一个示例性实施例中，板包括相对的上部和下部，其在板的中间部分的前表面的前方的方向成角度。该板还包括围绕其矢状平面中的纵向轴线形成的曲率。在使用中，当板附接到相邻的椎骨时，上部和下部的角度和板中的曲率有效地将形成在上部和下部的一个或多个穿孔定位在相邻的前边缘椎骨在另一个实施例中，提供脊柱固定板，其适于接合并配合到设置在相邻椎骨之间的融合笼或其它椎骨植入物。本发明还提供了脊柱固定套件或组件，以及用于植入它们的方法。

8. 发明授权

US06723097B2 Surgical trial implant 失效
标题翻译：手术试验植入
公开(公告)号：US06723097B2
公开(公告)日：2004-04-20
申请号：US10200890
申请日：2002-07-23
申请人： Robert Fraser , Mark Boomer
发明人： Robert Fraser , Mark Boomer
IPC分类号： A61B1770
CPC分类号： A61F2/4684 , A61F2/3094 , A61F2/30965 , A61F2/442 , A61F2002/30062 , A61F2002/3008 , A61F2002/30115 , A61F2002/30172 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30242 , A61F2002/30261 , A61F2002/30616 , A61F2210/0004 , A61F2230/0006 , A61F2230/0052 , A61F2230/0058 , A61F2230/0069 , A61F2230/0071 , A61F2230/0082 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00047 , A61F2310/00179
摘要： A trial implant and trial implant kit for assisting a physician in selecting an appropriately sized prosthesis is provided. In one embodiment, the trial medical implant device includes a body formed from a radio-lucent material and having a size and shape adapted to fit within or adjacent to an interstitial space, and at least one marker associated with the body and formed from a radio-opaque material. The at least one marker is configured to provide an x-ray visible reference to indicate the position and/or alignment of the body with respect to an anatomical structure when the trial medical implant device is positioned within an interstitial space.
摘要翻译：提供了一种用于辅助医师选择适当尺寸的假体的试验植入物和试验植入物套件。在一个实施例中，试验医疗植入装置包括由放射性透光材料形成并且具有适于安装在间隙空间内或邻近间隙空间的尺寸和形状的主体，以及与身体相关联并由无线电形成的至少一个标记不透明材料。所述至少一个标记被配置为当所述试验医疗植入装置位于间隙空间内时提供X射线可见参考以指示所述身体相对于解剖结构的位置和/或对准。

9. 发明授权

US5185654A Electrostatic RF absorbant circuit carrier assembly and method for making the same 失效
标题翻译：静电RF吸收电路载体组件及其制造方法
公开(公告)号：US5185654A
公开(公告)日：1993-02-09
申请号：US799235
申请日：1991-11-27
申请人： Mark D. Mosher , Robert Fraser , Ronald D. Fuller
发明人： Mark D. Mosher , Robert Fraser , Ronald D. Fuller
IPC分类号： H01L23/60 , H01L23/66 , H01Q17/00 , H05K9/00
CPC分类号： H05K9/0079 , H01L23/60 , H01L23/66 , H01Q17/00 , H01L2924/0002 , H01L2924/1616 , H01L2924/3011 , Y10T29/49126
摘要： An electrostatic RF absorbant circuit carrier assembly (200) is described as having a plastic support structure (100) which consists of an integrally fashioned base (180) and surrounding sidewalls (170) which together form an internal cavity (185). A plurality of conductor paths (125,165) are disposed within the cavity (185). The assembly (200) is completed by a polymeric cover (110) having a surface integrally fashioned to comprise wall members (145) for making contact with conductive paths (165) within the cavity (185). In order to facilitate RF isolation and electrostatic dissipation, the cover (110) is layered with a surface material comprising:a thermosetting matrix system;a non-conductive RF absorbing filler comprising 25 to 87 percent by weight loading of the thermosetting matrix system; anda conductive filler comprising 1 to 4 percent by weight loading of the thermosetting matrix system and the RF absorbing filler.
摘要翻译：静电RF吸收剂回路载体组件（200）被描述为具有塑料支撑结构（100），该塑料支撑结构由一体形成的基部（180）和围绕的侧壁（170）组成，这些侧壁一起形成内部空腔（185）。多个导体路径（125,165）设置在空腔（185）内。组件（200）由聚合物盖（110）完成，聚合物盖（110）具有整体形式的表面，包括用于与空腔（185）内的导电路径（165）接触的壁构件（145）。为了促进RF隔离和静电耗散，盖（110）用表面材料层压，包括：热固性基体系; 一种非导电RF吸收填料，其包含25-87重量％的热固性基体系的负荷; 以及包含1至4重量％的热固性基体系和RF吸收填料的导电填料。

10. 发明授权

US07700641B2 Spiro-oxindole compounds and their uses as therapeutic agents 有权
标题翻译：螺 - 羟吲哚化合物及其作为治疗剂的用途
公开(公告)号：US07700641B2
公开(公告)日：2010-04-20
申请号：US11402310
申请日：2006-04-11
申请人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
发明人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
IPC分类号： A61K31/407 , C07D491/107
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
摘要翻译：本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义，作为立体异构体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。还公开了包含化合物的药物组合物以及制备和使用化合物的方法。

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