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1. 发明授权

US5578119A Moldable sculpting medium 失效
标题翻译：可塑成型介质
公开(公告)号：US5578119A
公开(公告)日：1996-11-26
申请号：US465967
申请日：1995-06-06
申请人： Robert E. Short , E. Glenn Tickner
发明人： Robert E. Short , E. Glenn Tickner
IPC分类号： B44C3/04 , C09K3/00 , C08L1/28 , C08L5/04 , C08L101/00
CPC分类号： B44C3/04
摘要： A sculpting medium is provided comprising a filler of polymeric microspheres and optionally, a fibrous filler, a thixotropic hydrogel binder and water, all blended in a proportion such that the color of the medium is due primarily to the color(s) of the polymeric medium.
摘要翻译：提供了一种雕刻介质，其包括聚合物微球体填充剂和任选的纤维填料，触变性水凝胶粘合剂和水，所有这些都以一定比例混合，使得介质的颜色主要是由于聚合物介质的颜色。

2. 发明授权

US06776761B2 Hollow microspheres with controlled fragility for medical use 有权
标题翻译：具有受控脆弱性的中空微球用于医疗用途
公开(公告)号：US06776761B2
公开(公告)日：2004-08-17
申请号：US10225252
申请日：2002-08-20
申请人： Thomas B. Ottoboni , E. Glenn Tickner , Robert E. Short , Ronald K. Yamamoto
发明人： Thomas B. Ottoboni , E. Glenn Tickner , Robert E. Short , Ronald K. Yamamoto
IPC分类号： A61B814
CPC分类号： A61B8/481 , A61B5/4839 , A61B8/04 , A61B8/06 , A61K9/0009 , A61K9/5073 , A61K41/0028 , A61K49/223
摘要： A composition for ultrasonic imaging is described having a microbubble population of controlled fragility. The microbubbles comprise an outer shell and a hollow core. The ratio of shell thickness to microbubble diameter is substantially similar across the population of microbubbles. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.
摘要翻译：描述了一种用于超声成像的组合物，其具有受控脆性的微泡群体。微泡包括外壳和中空芯。壳体厚度与微泡直径的比例在微泡群体上基本相似。描述了使用这种组合物对流体填充腔，容器或组织进行成像的方法。

3. 发明授权

US5278194A Environmentall dispersible syntactic foam 失效
标题翻译：环境可分散的复合泡沫
公开(公告)号：US5278194A
公开(公告)日：1994-01-11
申请号：US36915
申请日：1993-03-25
申请人： E. Glenn Tickner , Robert E. Short
发明人： E. Glenn Tickner , Robert E. Short
IPC分类号： B01J13/12 , B65D65/46 , C08J9/32
CPC分类号： C08J9/32 , B01J13/12 , B65D65/46 , Y02W90/13 , Y10S521/916
摘要： A syntactic foam product having a desired configuration is set forth. The product comprises a plurality of rigid gas filled bubbles arranged in the desired configuration. The bubbles are defined by respective individual and discrete substantially spherical shells preferably formed of a biodegradable shell material. The shells abut one another. They define open spaces where they are not abutting. Attaching material attaches the abutting shells to one another. The open spaces between the shells are not filled by the attaching material. The attaching material is environmentally degradable. It releases the bubbles under ambient conditions after a selected time interval. The shells are in contact with their surroundings and can relatively rapidly biodegrade.
摘要翻译：阐述了具有所需结构的复合泡沫产品。该产品包括以所需构造排列的多个刚性气体填充气泡。气泡由相应的个体和离散的基本上为球形的壳体限定，优选由可生物降解的壳材料形成。壳彼此靠拢。它们定义了不邻接的空位。附着材料将相邻的壳体相互连接起来。壳体之间的开放空间未被附着材料填充。附着材料是环境可降解的。在选定的时间间隔后，它会在环境条件下释放气泡。壳体与其周围环境接触并能相对快速地生物降解。

4. 发明申请

US20110165088A1 NANOBUBBLES USEFUL AS AN ULTRASONIC CONTRAST AGENT FOR LYMPHATIC SYSTEM 审中-公开
标题翻译：作为超声对比剂用于淋巴系统的纳米颗粒有用
公开(公告)号：US20110165088A1
公开(公告)日：2011-07-07
申请号：US12194304
申请日：2008-08-19
申请人： Thomas B. Ottoboni , Robert E. Short , Jeffrey D. Gabe
发明人： Thomas B. Ottoboni , Robert E. Short , Jeffrey D. Gabe
IPC分类号： A61K49/22
CPC分类号： A61B8/481 , A61K41/0028 , A61K49/223
摘要： A composition is provided accompanying nonoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
摘要翻译：提供了一种组合物，其具有直径在约100至800纳米范围内的具有中空芯和具有机械性能的外壳的非直径的组合物，使得它们在暴露于预定超声能量时破裂。该组合物可用于鉴定前哨淋巴结。

5. 发明申请

US20080319320A1 METHOD OF IMAGING LYMPHATIC SYSTEM USING NANOCAPSULE COMPOSITIONS 审中-公开
标题翻译：使用纳米组合物成像淋巴系统的方法
公开(公告)号：US20080319320A1
公开(公告)日：2008-12-25
申请号：US12195066
申请日：2008-08-20
申请人： Thomas B. Ottoboni , Robert E. Short , Jeffrey D. Gabe
发明人： Thomas B. Ottoboni , Robert E. Short , Jeffrey D. Gabe
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61K41/0028 , A61K49/223
摘要： A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
摘要翻译：提供了一种组合物，其伴随着直径在约100至800纳米范围内的纳米颗粒，空心芯和具有机械性能的外壳，使得它们在暴露于预定的超声能量时破裂。该组合物可用于鉴定前哨淋巴结。

6. 发明申请

US20080181853A1 NANOBUBBLES USEFUL AS AN ULTRASONIC CONTRAST AGENT FOR THE LYMPHATIC SYSTEM 审中-公开
标题翻译：纳豆酮作为淋巴系统的超声对比剂有效
公开(公告)号：US20080181853A1
公开(公告)日：2008-07-31
申请号：US11781209
申请日：2007-07-20
申请人： Thomas B. Ottoboni , Robert E. Short , Jeffrey D. Gabe
发明人： Thomas B. Ottoboni , Robert E. Short , Jeffrey D. Gabe
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61K41/0028 , A61K49/223
摘要： A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
摘要翻译：提供了一种组合物，其伴随着直径在约100至800纳米范围内的纳米颗粒，空心芯和具有机械性能的外壳，使得它们在暴露于预定的超声能量时破裂。该组合物可用于鉴定前哨淋巴结。

7. 发明申请

US20160206761A9 Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents 审中-公开
标题翻译：可重构的微球组合物可用作超声波对比剂
公开(公告)号：US20160206761A9
公开(公告)日：2016-07-21
申请号：US13712192
申请日：2012-12-12
申请人： Thomas B. Ottoboni , Robert E. Short
发明人： Thomas B. Ottoboni , Robert E. Short
IPC分类号： A61K49/22
CPC分类号： A61K49/225
摘要： Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
摘要翻译：提供的方法和悬浮液可用于制备易于复原的干燥的微球或纳米球的组合物。干组合物可用于诸如超声成像的诊断应用中。悬浮液包括特定量的叔丁醇和/或无定形糖（或无定形糖的混合物）中的一种或两种，以减少包含悬浮液的颗粒的聚集。

8. 发明申请

US20090274628A1 RECONSTITUTABLE MICROSPHERE COMPOSITIONS USEFUL AS ULTRASONIC CONTRAST AGENTS 审中-公开
标题翻译：可重复使用的微波组合物作为超声对比剂
公开(公告)号：US20090274628A1
公开(公告)日：2009-11-05
申请号：US12329202
申请日：2008-12-05
申请人： Thomas B. Ottoboni , Robert E. Short
发明人： Thomas B. Ottoboni , Robert E. Short
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K9/10 , A61K9/1647 , A61K9/1658 , A61K9/19 , A61K9/5052 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K47/10 , A61K47/183 , A61K47/26 , A61K49/225
摘要： Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugars) in specified amounts that reduce aggregation of the particles comprising the suspension.
摘要翻译：提供的方法和悬浮液可用于制备易于复原的干燥的微球或纳米球的组合物。干组合物可用于诸如超声成像的诊断应用中。悬浮液包括特定量的叔丁醇和/或无定形糖（或无定形糖的混合物）中的一种或两种，以减少包含悬浮液的颗粒的聚集。

9. 发明授权

US06193951B1 Microparticles useful as ultrasonic contrast agents 失效
标题翻译：微粒可用作超声造影剂
公开(公告)号：US06193951B1
公开(公告)日：2001-02-27
申请号：US09070474
申请日：1998-04-30
申请人： Thomas B. Ottoboni , Robert E. Short , Ronald K. Yamamoto
发明人： Thomas B. Ottoboni , Robert E. Short , Ronald K. Yamamoto
IPC分类号： A61B813
CPC分类号： A61K49/223 , A61K41/0028 , A61K47/6925 , A61K49/225
摘要： Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
摘要翻译：提供了微粒，其包括生物相容性材料的外层的外壳和可生物降解的聚合物的内层。微粒的核心含有用于药物递送的气体，液体或固体，或用作超声造影成像的造影剂。微粒能够通过受试者的毛细管系统。

10. 发明申请

US20140161726A1 Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents 审中-公开
标题翻译：可重构的微球组合物可用作超声波对比剂
公开(公告)号：US20140161726A1
公开(公告)日：2014-06-12
申请号：US13712192
申请日：2012-12-12
申请人： Thomas B. Ottoboni , Robert E. Short
发明人： Thomas B. Ottoboni , Robert E. Short
IPC分类号： A61K49/22
CPC分类号： A61K49/225
摘要： Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
摘要翻译：提供的方法和悬浮液可用于制备易于复原的干燥的微球或纳米球的组合物。干组合物可用于诸如超声成像的诊断应用中。悬浮液包括特定量的叔丁醇和/或无定形糖（或无定形糖的混合物）中的一种或两种，以减少包含悬浮液的颗粒的聚集。

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