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1. 发明授权

US08752732B2 Fluid dispensing system 有权
标题翻译：流体分配系统
公开(公告)号：US08752732B2
公开(公告)日：2014-06-17
申请号：US13018609
申请日：2011-02-01
申请人： Robert E. Evans , Wolfgang Mueller , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
发明人： Robert E. Evans , Wolfgang Mueller , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
IPC分类号： B67B7/00
CPC分类号： B05B11/048 , A47K5/1215 , B01L3/523 , B01L2200/0605 , B01L2200/141 , F04B43/08
摘要： An apparatus including a fluid reservoir and a compressible metering chamber including a first end coupled to the fluid reservoir and a second end. The apparatus further including a valve coupled to the second end of the metering chamber and a nozzle coupled to the valve. A system including linearly translatable cartridge mounting assembly having a plurality of fluid dispensing cartridge mounting stations and a plurality of fluid dispensing cartridges mounted to respective fluid dispensing cartridge mounting stations. The system further including a plurality of compression assemblies coupled to respective fluid dispensing cartridges and a receiving assembly positioned beneath the mounting assembly. A method includes positioning a fluid dispensing cartridge comprising a fluid reservoir and a metering chamber over a sample retaining member, applying a compressive force to the metering chamber to eject a predetermined amount of fluid and removing the compressive force to refill the metering chamber.
摘要翻译：一种包括流体储存器和可压缩计量室的装置，包括联接到流体储存器的第一端和第二端。该装置还包括联接到计量室的第二端的阀和连接到阀的喷嘴。一种包括具有多个流体分配盒安装台和安装到相应的流体分配盒安装台的多个流体分配盒的线性平移盒安装组件的系统。该系统还包括耦合到相应流体分配盒的多个压缩组件和位于安装组件下方的接收组件。一种方法包括将包括流体储存器和计量室的流体分配筒定位在样品保持构件上方，向计量室施加压缩力以排出预定量的流体并去除压缩力以重新填充计量室。

2. 发明申请

US20120193376A1 FLUID DISPENSING SYSTEM 有权
标题翻译：流体分配系统
公开(公告)号：US20120193376A1
公开(公告)日：2012-08-02
申请号：US13018609
申请日：2011-02-01
申请人： Robert E. Evans , Wolfgang Mueller , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
发明人： Robert E. Evans , Wolfgang Mueller , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
IPC分类号： B65D37/00 , G01F11/00 , B67D7/70
CPC分类号： B05B11/048 , A47K5/1215 , B01L3/523 , B01L2200/0605 , B01L2200/141 , F04B43/08
摘要： An apparatus including a fluid reservoir and a compressible metering chamber including a first end coupled to the fluid reservoir and a second end. The apparatus further including a valve coupled to the second end of the metering chamber and a nozzle coupled to the valve. A system including linearly translatable cartridge mounting assembly having a plurality of fluid dispensing cartridge mounting stations and a plurality of fluid dispensing cartridges mounted to respective fluid dispensing cartridge mounting stations. The system further including a plurality of compression assemblies coupled to respective fluid dispensing cartridges and a receiving assembly positioned beneath the mounting assembly. A method includes positioning a fluid dispensing cartridge comprising a fluid reservoir and a metering chamber over a sample retaining member, applying a compressive force to the metering chamber to eject a predetermined amount of fluid and removing the compressive force to refill the metering chamber.
摘要翻译：一种包括流体储存器和可压缩计量室的装置，包括联接到流体储存器的第一端和第二端。该装置还包括联接到计量室的第二端的阀和连接到阀的喷嘴。一种包括具有多个流体分配盒安装台和安装到相应的流体分配盒安装台的多个流体分配盒的线性平移盒安装组件的系统。该系统还包括耦合到相应流体分配盒的多个压缩组件和位于安装组件下方的接收组件。一种方法包括将包括流体储存器和计量室的流体分配筒定位在样品保持构件上方，向计量室施加压缩力以排出预定量的流体并去除压缩力以重新填充计量室。

3. 发明授权

US08932543B2 Automated staining system and reaction chamber 有权
标题翻译：自动染色系统和反应室
公开(公告)号：US08932543B2
公开(公告)日：2015-01-13
申请号：US13238511
申请日：2011-09-21
申请人： Xuan S. Bui , Anthony L. Hartman , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
发明人： Xuan S. Bui , Anthony L. Hartman , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
IPC分类号： B01L3/02 , G01N1/31 , B01L3/00 , B01L9/00
CPC分类号： G01N1/31 , B01L3/502715 , B01L9/52 , B01L2300/0822 , B01L2300/0877 , B01L2400/0409 , B01L2400/0478 , G01N35/00732 , G01N35/02 , G01N2035/00752 , G01N2035/00831 , G01N2035/00851 , Y10T436/11 , Y10T436/112499
摘要： An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations. A method including determining an inventory of an automated sample processing system, downloading a processing protocol from a central controller to the automated sample processing system, operating the automated sample processing system based on the processing protocol and independently of the central controller and dispensing a reagent from the automated sample processing system.
摘要翻译：一种包括试剂盒和反应室的装置，所述试剂盒具有可移除地定位在其中的试剂盒，用于将试剂分配到反应室上。一种包括线性平移安装组件的系统，其具有多个安装台，其尺寸被设计成容纳至少一个流体分配筒，线性可平移体积试剂分配组件，其具有耦合到其上的多个散装试剂分配喷嘴和位于安装组件下方的接收组件和批量试剂分配组件，所述接收组件包括多个反应站。一种方法，包括确定自动化样品处理系统的清单，将处理协议从中央控制器下载到自动化样品处理系统，基于处理协议操作自动化样品处理系统，并且独立于中央控制器并将试剂从自动化样品处理系统。

4. 发明授权

US5338358A Apparatus for dyeing tissues 失效
标题翻译：用于染色组织的装置
公开(公告)号：US5338358A
公开(公告)日：1994-08-16
申请号：US947512
申请日：1992-09-17
申请人： Yoshitada Mizusawa , Matsumi Toya
发明人： Yoshitada Mizusawa , Matsumi Toya
IPC分类号： B01L99/00 , B05B15/02 , B08B9/02 , G01N1/30 , G01N1/31 , G01N33/53 , B05C3/00
CPC分类号： G01N1/312
摘要： Apparatus for dyeing tissues sampled from a living body for the purpose of observing immunoreaction of the tissues has a dyeing tray with a plurality of plateaus arranged in parallel disposition. A slide is so placed over each plateau that a wedge-shaped gap of capillary dimension is formed between the plateau and the undersurface of the slide to which a sampled tissue is attached. A liquid drip surface and a liquid discharge port are formed at one end of the top surface of each plateau. A liquid delivery port is formed on a side wall of the tray so as to communicate with the liquid discharge port. The liquid delivery port and the drip surface are always exposed. A dyeing liquid or a rinsing liquid is dripped onto the exposed drip surface and spreads into the gap for dyeing the tissue or rinse the relevant parts. After the dyeing or rinsing, the used liquid is sucked and discharged by way of the liquid delivery port. Because of the exposure of the drip surface and the liquid delivery port, the operation is easy and the dyeing tray can also be used for manual dyeing. A bank between the liquid discharge port and the drip surface prevents direct flow of the liquid therebetween.
摘要翻译：为了观察组织的免疫反应，从生物体取样的组织染色装置具有平行布置的具有多个平台的染色托盘。将滑块放置在每个平台上，使得在平板和与被采集的组织连接的滑块的下表面之间形成楔形的毛细管尺寸的间隙。在每个平台的顶表面的一端形成有液滴表面和液体排出口。液体输送口形成在托盘的侧壁上，以与液体排出口连通。液体输送口和滴水表面总是暴露在外。将染色液体或冲洗液滴在暴露的滴水表面上并扩散到间隙中以染色组织或冲洗相关部件。染色或漂洗后，用液体通过液体输送口进行吸引和排出。由于滴水表面和液体输送口的暴露，操作容易，染色托盘也可用于人造染色。液体排出口和滴水表面之间的一个堤坝可防止液体间的直接流动。

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