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1. 发明授权

US6057369A Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds 失效
标题翻译：取代的（芳基，杂芳基，芳基甲基或杂芳基甲基）异羟肟酸化合物
公开(公告)号：US6057369A
公开(公告)日：2000-05-02
申请号：US928943
申请日：1997-09-12
申请人： Robert D. Groneberg , Kent W. Neuenschwander , Stevan W. Djuric , Gerald M. McGeehan , Christopher J. Burns , Steven M. Condon , Matthew M. Morrissette , Joseph M. Salvino , Anthony C. Scotese , John W. Ullrich
发明人： Robert D. Groneberg , Kent W. Neuenschwander , Stevan W. Djuric , Gerald M. McGeehan , Christopher J. Burns , Steven M. Condon , Matthew M. Morrissette , Joseph M. Salvino , Anthony C. Scotese , John W. Ullrich
IPC分类号： C07D333/24 , A61K31/00 , A61K31/165 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/47 , A61P3/00 , A61P3/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/28 , A61P27/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P33/00 , A61P33/06 , A61P37/00 , C07C215/08 , C07C259/06 , C07C317/44 , C07C323/60 , C07C323/65 , C07D209/48 , C07D215/14 , C07D317/56 , C07D317/62 , A01N37/28
CPC分类号： C07D209/48 , C07C259/06 , C07C317/44 , C07C323/60 , C07D215/14 , C07D317/56 , C07D317/62 , C07C2101/08
摘要： This invention is directed to compounds of formula I: ##STR1## wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. They are especially useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. Compounds within the scope of the present invention may also inhibit an MMP, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting MMPs, such disease states involve tissue breakdown and those associated with a physiologically detrimental excess of TNF. The present invention is therefore also directed to the pharmaceutical use of the compounds, pharmaceutical compositions containing the compounds, intermediates leading thereto and methods for the preparation of the compounds and their intermediates.
摘要翻译：本发明涉及式I化合物：其中变量如本文所述。本发明范围内的化合物具有有用的性质，更具体地说是药物性质。它们特别可用于抑制TNF治疗患有与生理有害过量的肿瘤坏死因子（TNF）相关的疾病状态的患者的生产或生理作用。本发明范围内的化合物还抑制环AMP磷酸二酯酶，并且可用于治疗与通过抑制环AMP磷酸二酯酶调节的病理状况相关的疾病状态，所述疾病状态包括炎性和自身免疫性疾病，特别是IV型环AMP 磷酸二酯酶。本发明范围内的化合物还可以抑制MMP，并且可用于治疗与通过抑制MMP调节的病理状态相关的疾病状态，这种疾病状态涉及组织分解以及与生理上有害的过量TNF相关的疾病状态。因此，本发明还涉及化合物的药物用途，含有这些化合物的药物组合物，导致其的中间体以及制备化合物及其中间体的方法。

2. 发明授权

US07612075B2 Substituted oxoazaheterocyclyl compounds 失效
标题翻译：取代的含氮杂环基化合物
公开(公告)号：US07612075B2
公开(公告)日：2009-11-03
申请号：US10628093
申请日：2003-07-25
申请人： William R. Ewing , Michael R. Becker , Yong Mi Choi-Sledeski , Heinz W. Pauls , Wei He , Stephen M. Condon , Roderick S. Davis , Barbara A. Hanney , Alfred P. Spada , Christopher J. Burns , John Z. Jiang , Michael R. Myers , Wan F. Lau , Aiwen Li , Gregory B. Poli , Mark A. Bobko , Robert L. Morris , Joseph M. Karpinski , Timothy F. Gallagher , Kent W. Neuenschwander , Robert D. Groneberg , Jean-Francois Sabuco
发明人： William R. Ewing , Michael R. Becker , Yong Mi Choi-Sledeski , Heinz W. Pauls , Wei He , Stephen M. Condon , Roderick S. Davis , Barbara A. Hanney , Alfred P. Spada , Christopher J. Burns , John Z. Jiang , Michael R. Myers , Wan F. Lau , Aiwen Li , Gregory B. Poli , Mark A. Bobko , Robert L. Morris , Joseph M. Karpinski , Timothy F. Gallagher , Kent W. Neuenschwander , Robert D. Groneberg , Jean-Francois Sabuco
IPC分类号： A61K31/497 , C07D401/06
CPC分类号： C07D471/04 , C07D241/08 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D495/04
摘要： This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa.
摘要翻译：本发明涉及将因子Xa，抑制因子Xa和因子IIa的含氮杂环化合物，包含这些化合物的药物组合物，可用于制备这些化合物的中间体，抑制因子Xa和直接抑制因子Xa的方法的含氮杂环化合物同时直接抑制因子Xa和因子IIa的方法。

3. 发明授权

US06306873B1 Substituted &bgr;-thiocarboxylic acids 有权
标题翻译：取代的β-硫代羧酸
公开(公告)号：US06306873B1
公开(公告)日：2001-10-23
申请号：US09357734
申请日：1999-07-20
申请人： Christopher J. Burns , Richard Labaudiniere , Stephen Condon , Robert D. Groneberg , Rose M. Mathew , Joseph M. Salvino
发明人： Christopher J. Burns , Richard Labaudiniere , Stephen Condon , Robert D. Groneberg , Rose M. Mathew , Joseph M. Salvino
IPC分类号： C07D20948
CPC分类号： C07D209/48 , C07C317/44 , C07C317/46 , C07C317/50 , C07C323/60 , C07C323/62 , C07C2601/08 , C07D207/12 , C07D213/30 , C07D213/62 , C07D213/64 , C07D213/65 , C07D213/70 , C07D215/08 , C07D235/08 , C07D235/12 , C07D271/06 , C07D271/107 , C07D317/60 , C07D333/16 , C07D333/24 , C07D413/04
摘要： This invention relates to compounds of general formula (I): in which Ar is a group selected from: A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and Y represents carboxy or an acid bioisostere. These compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.
摘要翻译：本发明涉及通式（I）的化合物：其中Ar是选自：A1，A2，B，C，D，E，Q1-Q3，R1-R9，Z1和Z2的基团如公开内容中所定义，Y表示羧基或酸式生物电子等排体。这些化合物抑制TNF的产生或生理作用并抑制环AMP磷酸二酯酶。本发明还涉及包含式（I）化合物的药物组合物，其药物用途及其制备方法。

4. 发明授权

US5317015A Azacyclic bisphosphonates as anticholesterolemic agents 失效
标题翻译：偶氮二磷酸盐作为抗胆固醇药
公开(公告)号：US5317015A
公开(公告)日：1994-05-31
申请号：US877574
申请日：1992-05-01
申请人： John W. Ullrich , Raymond D. Youssefyeh , Daniel L. Cheney , Christopher J. Burns
发明人： John W. Ullrich , Raymond D. Youssefyeh , Daniel L. Cheney , Christopher J. Burns
IPC分类号： A61K31/66 , A61K31/675
CPC分类号： A61K31/675 , A61K31/66 , Y10S514/824
摘要： This invention relates to a method of lowering abnormally high serum cholesterol levels in the body without significantly reducing mevalonic metabolite synthesis and to novel pharmacological compositions containing as an active ingredient bisphosphonic acid and ester compounds containing a mono-, bi- or tricyclic ring linked with a bisphosphonate moiety through a basic amino alkylene group. This invention also provides novel bisphosphonate compounds and the processes for their preparation.
摘要翻译：本发明涉及一种降低身体异常高血清胆固醇水平而不显着降低甲羟戊酸代谢物合成的方法，以及含有作为活性成分的双膦酸的新型药物组合物和含有与一个或多个双膦酸酯部分通过碱性氨基亚烷基。本发明还提供了新的双膦酸盐化合物及其制备方法。

5. 发明授权

US08575205B2 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases 有权
公开(公告)号：US08575205B2
公开(公告)日：2013-11-05
申请号：US13427664
申请日：2012-03-22
申请人： Theodore J. Nitz , Janet A. Gaboury , Christopher J. Burns , Sylvie Laguerre , Daniel C. Pevear , Thomas A. Lessen , David J. Rys
发明人： Theodore J. Nitz , Janet A. Gaboury , Christopher J. Burns , Sylvie Laguerre , Daniel C. Pevear , Thomas A. Lessen , David J. Rys
IPC分类号： A61K31/41 , C07D257/06
CPC分类号： C07D275/02 , A61K31/11 , A61K31/136 , A61K31/18 , A61K31/196 , A61K31/222 , A61K31/357 , A61K31/41 , A61K31/425 , A61K31/427 , A61K31/4453 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07C47/565 , C07C69/18 , C07C223/06 , C07C235/16 , C07C235/68 , C07C311/29 , C07D211/32 , C07D257/04 , C07D401/14 , C07D407/10 , C07D417/14
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.

6. 发明申请

US20130233924A1 Smartcard and Computer Quick Connect and Release System 有权
公开(公告)号：US20130233924A1
公开(公告)日：2013-09-12
申请号：US13787196
申请日：2013-03-06
申请人： Christopher J. Burns
发明人： Christopher J. Burns
IPC分类号： G06K7/015 , G06K7/06
CPC分类号： G06K7/0056 , G06K7/0021 , G06K7/015 , G06K7/10366 , G06K19/005 , G06K19/07739 , G06K19/07741 , G06K19/07743 , G06K19/07762
摘要： A smartcard unit includes at least a smartcard and an attachment enabling the smartcard unit to be worn by a user. The smartcard is accessible to an external reader. A reader unit interfaces with the smartcard to enable an external computer to communicate with the smartcard. The smartcard unit or the reader unit has structure to align the reader unit relative to the smartcard unit in an alignment for communicative interfacing while the smartcard unit is being worn. The smartcard unit or the reader unit has a retainer to secure the reader unit in alignment relative to the smartcard so that the smartcard unit is reversibly separable from the reader unit without damage, in response to a force less than is necessary to detach or damage another part of said system, other than along a longitudinal axis of the smartcard or of a pair of components being separated.

7. 发明授权

US08119672B2 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases 有权
标题翻译：用于治疗或预防肺病毒感染和相关疾病的化合物，组合物和方法
公开(公告)号：US08119672B2
公开(公告)日：2012-02-21
申请号：US10524313
申请日：2003-08-11
申请人： David J. Rys , Theodore J. Nitz , Janet A Gaboury , Christopher J. Burns , Daniel C. Pevear , Thomas A. Lessen , Torsten Herbertz
发明人： David J. Rys , Theodore J. Nitz , Janet A Gaboury , Christopher J. Burns , Daniel C. Pevear , Thomas A. Lessen , Torsten Herbertz
IPC分类号： A61K31/41 , C07D43/02
CPC分类号： C07D257/04 , A61K31/41 , A61K38/21 , A61K39/395
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.
摘要翻译：提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

8. 发明授权

US06599918B2 Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans 失效
公开(公告)号：US06599918B2
公开(公告)日：2003-07-29
申请号：US10081113
申请日：2002-02-22
申请人： Christopher J. Burns , William P. Dankulich , Daniel G. McGarry , Francis A. Volz
发明人： Christopher J. Burns , William P. Dankulich , Daniel G. McGarry , Francis A. Volz
IPC分类号： A61K31443
CPC分类号： C07D405/12 , C07D307/81 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D471/04
摘要： This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor IIa (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).

9. 发明授权

US09321739B2 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases 有权
公开(公告)号：US09321739B2
公开(公告)日：2016-04-26
申请号：US13216106
申请日：2011-08-23
申请人： David J. Rys , Theodore J. Nitz , Janet A. Gaboury , Christopher J. Burns , Daniel C. Pevear , Thomas A. Lessen , Torsten Herbertz
发明人： David J. Rys , Theodore J. Nitz , Janet A. Gaboury , Christopher J. Burns , Daniel C. Pevear , Thomas A. Lessen , Torsten Herbertz
IPC分类号： A61K31/41 , A61K38/21 , A61K39/395 , A61K31/7056 , A61K31/14 , C07D257/04
CPC分类号： C07D257/04 , A61K31/41 , A61K38/21 , A61K39/395
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

10. 发明授权

US09135478B2 Smartcard and computer quick connect and release system 有权
标题翻译：智能卡和电脑快速连接和释放系统
公开(公告)号：US09135478B2
公开(公告)日：2015-09-15
申请号：US13787196
申请日：2013-03-06
申请人： Christopher J. Burns
发明人： Christopher J. Burns
IPC分类号： G06K7/06 , G06K7/015 , G06K19/077 , G06K19/00 , G06K7/00
CPC分类号： G06K7/0056 , G06K7/0021 , G06K7/015 , G06K7/10366 , G06K19/005 , G06K19/07739 , G06K19/07741 , G06K19/07743 , G06K19/07762
摘要： A smartcard unit includes at least a smartcard and an attachment enabling the smartcard unit to be worn by a user. The smartcard is accessible to an external reader. A reader unit interfaces with the smartcard to enable an external computer to communicate with the smartcard. The smartcard unit or the reader unit has structure to align the reader unit relative to the smartcard unit in an alignment for communicative interfacing while the smartcard unit is being worn. The smartcard unit or the reader unit has a retainer to secure the reader unit in alignment relative to the smartcard so that the smartcard unit is reversibly separable from the reader unit without damage, in response to a force less than is necessary to detach or damage another part of said system, other than along a longitudinal axis of the smartcard or of a pair of components being separated.
摘要翻译：智能卡单元至少包括智能卡和使得智能卡单元能够被用户佩戴的附件。智能卡可由外部读卡器访问。读卡器单元与智能卡连接，以使外部计算机与智能卡通信。智能卡单元或读取器单元具有将读取器单元相对于智能卡单元对准的结构，以便在智能卡单元被穿着的同时进行通信接口。智能卡单元或读取器单元具有固定器以固定读取器单元相对于智能卡的对准，使得智能卡单元可响应于小于分离或损坏另一个所需的力而不受损坏地与读取器单元可逆地分离所述系统的一部分，除了沿智能卡的纵向轴线或分离的一对部件之外。

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