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1. 发明授权

US5686422A Synthetic inhibitors of mammalian collagenase 失效
标题翻译：哺乳动物胶原酶的合成抑制剂
公开(公告)号：US5686422A
公开(公告)日：1997-11-11
申请号：US468491
申请日：1995-06-06
申请人： Robert D. Gray , Arno F. Spatola , Robert B. Miller , Frank R. Burns , Christopher Paterson
发明人： Robert D. Gray , Arno F. Spatola , Robert B. Miller , Frank R. Burns , Christopher Paterson
IPC分类号： A61K38/00 , C07K5/065 , C07K5/068 , C07K5/087 , A61K37/00
CPC分类号： C07K5/0812 , C07K5/06078 , C07K5/06086 , A61K38/00
摘要： The present invention relates to compounds of the formula: R.sub.1 SCH(R.sub.2)CH(R.sub.3)CO-AA.sub.1 �AA.sub.2 !.sub.m �AA.sub.3 !.sub.n --X or HSCH.sub.2 �CH.sub.2 CH(CH.sub.3).sub.2 !CO--Nal--NH.sub.2 wherein Nal is L-3-(2-naphthyl)alanine; m is the integer 0 or 1; n is an integer from 0-2; AA.sub.1 is a non-polar hydrophobic aromatic amino acid; AA.sub.2 is alanine, glycine, leucine, isoleucine or phenylalanine; AA.sub.3 is one of the twenty naturally occurring amino acids, preferably glutamine or arginine; R.sub.1 is hydrogen, alkyl having from 1-10 carbon atoms, alkanoyl having from 2-10 carbon atoms, or aroyl having from 7-10 carbon atoms; R.sub.2 is hydrogen or alkyl having from 1-6 carbon atoms; R.sub.3 is hydrogen, alkyl having from 2-10 carbon atoms, cycloalkyl having from 3-6 carbon atoms, aryl or arylalkyl, wherein aryl moieties have from 6-10 carbon atoms; X is NH.sub.2, OH, OCH.sub.3 or OCH.sub.2 CH.sub.3 ; and salts thereof.
摘要翻译：本发明涉及下式的化合物：R1SCH（R2）CH（R3）CO-AA1 [AA2] m [AA3] nX或HSCH2 [CH2CH（CH3）2] CO-Nal-NH2，其中Nal是L-3-（2 - 萘基）丙氨酸; m是整数0或1; n是0-2的整数; AA1是非极性疏水性芳香族氨基酸; AA2是丙氨酸，甘氨酸，亮氨酸，异亮氨酸或苯丙氨酸; AA3是二十种天然存在的氨基酸之一，优选为谷氨酰胺或精氨酸; R1是氢，具有1-10个碳原子的烷基，具有2-10个碳原子的烷酰基，或具有7-10个碳原子的芳酰基; R2是氢或具有1-6个碳原子的烷基; R3是氢，具有2-10个碳原子的烷基，具有3-6个碳原子的环烷基，芳基或芳烷基，其中芳基部分具有6-10个碳原子; X是NH 2，OH，OCH 3或OCH 2 CH 3; 及其盐。

2. 发明授权

US5616605A Peptide derivatives of collagenase inhibitor 失效
标题翻译：胶原酶抑制剂的肽衍生物
公开(公告)号：US5616605A
公开(公告)日：1997-04-01
申请号：US287320
申请日：1994-08-08
申请人： Robert D. Gray , Arno F. Spatola , Krzysztof Darlak
发明人： Robert D. Gray , Arno F. Spatola , Krzysztof Darlak
IPC分类号： A61K38/00 , C07C259/06 , C07C317/44 , C07C323/60 , C07K5/065 , C07K5/078 , C07D209/12 , A61K31/405 , C07D209/14
CPC分类号： C07C259/06 , C07C317/44 , C07C323/60 , C07K5/06078 , C07K5/06139 , A61K38/00
摘要： This invention is directed to a collagenase inhibitor of the formula: ##STR1##
摘要翻译：本发明涉及下式的胶原酶抑制剂：

3. 发明授权

US5387610A Peptide derivatives of collagenase inhibitor 失效
标题翻译：胶原酶抑制剂的肽衍生物
公开(公告)号：US5387610A
公开(公告)日：1995-02-07
申请号：US981149
申请日：1992-11-24
申请人： Robert D. Gray , Arno F. Spatola , Krzysztof Darlak
发明人： Robert D. Gray , Arno F. Spatola , Krzysztof Darlak
IPC分类号： A61K38/00 , C07C259/06 , C07C317/44 , C07C323/60 , C07K5/065 , C07K5/078 , A61K37/02 , A61K31/195 , C07C259/10
CPC分类号： C07C259/06 , C07C317/44 , C07C323/60 , C07K5/06078 , C07K5/06139 , A61K38/00
摘要： This invention is directed to a collagenase inhibitor of the formula: ##STR1##
摘要翻译：本发明涉及下式的胶原酶抑制剂：

4. 发明授权

US4888181A Sea food flavored food products 失效
标题翻译：海鲜风味食品
公开(公告)号：US4888181A
公开(公告)日：1989-12-19
申请号：US41469
申请日：1987-04-23
申请人： Robert D. Gray , Thomas J. Gray
发明人： Robert D. Gray , Thomas J. Gray
IPC分类号： A23B4/03 , A23L17/00
CPC分类号： A23B4/03 , A23L17/70
摘要： Processes, methods, food products, and uses for modified surimi containing food products using surimi in novel combinations which include up to about 50% by weight of dehydrated concentrated fish meat, said mixtures prepared under special, controlled conditions using combinations of novel steps to produce novel seafood and/or meat flavored foods.
摘要翻译：所述混合物在特殊的控制条件下使用组合的新型步骤制备的包含高达约50％（重量）的脱水浓缩鱼肉的新型组合的使用鱼糜的食品的改良鱼糜的食品的方法，食品和用途，新鲜的海鲜和/或肉味的食物。

5. 发明授权

US4405653A Dehydrated fish concentrate and process for same 失效
标题翻译：脱水鱼精和过程相同
公开(公告)号：US4405653A
公开(公告)日：1983-09-20
申请号：US287858
申请日：1981-07-29
申请人： Robert D. Gray
发明人： Robert D. Gray
IPC分类号： A23B4/03 , A22C25/00 , A23B4/04
CPC分类号： A23B4/03
摘要： A product which comprises essentially dry, storable, dehydrated fibrous fish products and process for making same from various raw materials including without limitation underutilized fish species or deboned fresh or frozen fish scrap and various parts. The process for making the novel product includes mincing, followed by a one-step, controlled, dehydration under conditions of reduced pressure and in the absence of an oxidizing atmosphere such as air, and at elevated temperatures of up to 95.degree. C., and in the absence of any other added ingredients.
摘要翻译：包含基本上干燥的，可储存的，脱水的纤维鱼制品的产品以及由各种原料制成的方法，包括但不限于未充分利用的鱼类或脱骨的新鲜或冷冻的鱼废料和各种部分。制造新产品的方法包括在减压条件下和在没有氧化气氛例如空气的条件下，在高达95℃的升高的温度下进行一步法控制脱水，然后进行一步控制的脱水，以及在没有任何其他添加成分的情况下。

6. 发明授权

US3992777A Tool for releasing a nut threaded onto a bolt 失效
标题翻译：用于释放螺母拧到螺栓上的工具
公开(公告)号：US3992777A
公开(公告)日：1976-11-23
申请号：US669226
申请日：1976-03-22
申请人： Lee E. Perkins , Robert D. Gray , Ernest P. Parra
发明人： Lee E. Perkins , Robert D. Gray , Ernest P. Parra
IPC分类号： B23D29/00 , B26B17/00
CPC分类号： B23D29/007
摘要： There is disclosed a tool comprising a body having an opening which may be moved over a nut threaded onto a bolt and a surface on the opening to support the flat side of the nut, a bore in the body connected at one end with the opening opposite the supporting surface, and a rod having a cutting edge longitudinally reciprocal within the bore toward and away from the nut in the opening. The rod is so reciprocated by an operating system which includes a piston on the rod reciprocable within a cylinder on the body connecting with the other end of the bore.
摘要翻译：公开了一种工具，其包括具有开口的主体，该开口可以在螺纹上旋转的螺母上移动并且在开口上的表面以支撑螺母的平坦侧，主体中的孔在一端与开口相对支撑表面，以及具有在孔内朝向和远离开口中的螺母纵向倒转的切削刃的杆。杆通过操作系统往复运动，该操作系统包括在杆上的活塞，活塞可在与孔的另一端连接的主体上的气缸内往复运动。

7. 发明授权

US3935057A Apparatus for securing the free end of a roll of fibrous web material 失效
标题翻译：用于固定纤维网材料卷的自由端的装置
公开(公告)号：US3935057A
公开(公告)日：1976-01-27
申请号：US501146
申请日：1974-08-28
申请人： Robert D. Gray
发明人： Robert D. Gray
IPC分类号： B65B51/02 , B65H19/29 , B65C11/04 , B05C11/00
CPC分类号： B65H19/29 , B65B51/026 , B65H2301/414427 , Y10T156/1798
摘要： Disclosed is an apparatus for securing the free end of a roll of fibrous web material to the body of the roll while the roll is uninterruptedly conveyed through the apparatus. The apparatus is particularly useful for securing the free end of fibrous web material which has a pattern-disposition of blockable bonding material disposed in the web for bonding fibers together. The apparatus, in its preferred embodiment, includes a knurled wheel mounted for rotation in a reservoir of moisture for applying moisture to the outside surface of the free end while held against the roll, electrically heated bars positioned for applying heat to the moistened portion of the free end, pressure members positioned opposite the heated bars for passage of the roll between the pressure members and the heated bars to cause pressure to be applied to the roll by the heated bars, a pair of stationarily positioned, spaced-apart elongated guide members for guiding the roll in its axial direction past and into operative contact with the knurled wheel, with the heated bars, and with the pressure members, and paddle means for moving the roll uninterruptedly through the apparatus.
摘要翻译：公开了一种用于将卷筒纤维网材料的自由端固定到卷筒体上的装置，同时不间断地将卷筒输送通过该装置。该装置对于固定纤维网材料的自由端特别有用，该纤维网材料具有布置在幅材中的可阻挡粘合材料的图案，用于将纤维粘合在一起。该装置在其优选实施例中包括滚花轮，该滚花轮安装成用于在水分储存器中旋转，以将水分施加到自由端的外表面，同时保持抵靠辊，定位用于将热量施加到湿润部分自由端，压力构件定位成与被加热的杆相对，用于在压力构件和加热的杆之间通过辊，以通过加热的杆施加压力以施加到辊上，一对静止定位的间隔开的细长导向构件，将辊沿着其轴向方向导向，并与滚花轮，加热棒，以及压力构件和用于不间断地移动辊的桨装置的操作接触。

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