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1. 发明申请

US20110172121A1 ALLOGENEIC STEM CELL BANK 审中-公开
标题翻译：全息干细胞库
公开(公告)号：US20110172121A1
公开(公告)日：2011-07-14
申请号：US12908143
申请日：2010-10-20
申请人： Robert Chow , Lawrence D. Petz , Rubio R. Punzalan , Denis O. Rodgerson
发明人： Robert Chow , Lawrence D. Petz , Rubio R. Punzalan , Denis O. Rodgerson
IPC分类号： C40B40/02
CPC分类号： A61K35/50 , A61K35/16 , A61K35/28 , G16H50/80
摘要： This invention provides methods for supplying a therapy for individuals exposed to radiation following a nuclear event, through the prospective establishment of an undesignated allogeneic stem cell bank with prospective HLA typing of healthy potential recipients.
摘要翻译：本发明提供了通过预期建立具有健康潜在接受者的预期HLA分型的未指定的同种异体干细胞库来为在核事件之后暴露于辐射的个体提供治疗的方法。

2. 发明申请

US20080227197A1 ALLOGENEIC STEM CELL BANK 审中-公开
标题翻译：全息干细胞库
公开(公告)号：US20080227197A1
公开(公告)日：2008-09-18
申请号：US12110850
申请日：2008-04-28
申请人： Robert Chow , Lawrence D. Petz , Rubio R. Punzalan , Denis O. Rodgerson
发明人： Robert Chow , Lawrence D. Petz , Rubio R. Punzalan , Denis O. Rodgerson
IPC分类号： C12N5/08
CPC分类号： A61K35/50 , A61K35/16 , A61K35/28 , G16H50/80
摘要： This invention provides methods for supplying a therapy for individuals exposed to radiation following a nuclear event, through the prospective establishment of an undesignated allogeneic stem cell bank with prospective HLA typing of healthy potential recipients.
摘要翻译：本发明提供了通过预期建立具有健康潜在接受者的预期HLA分型的未指定的同种异体干细胞库来为在核事件之后暴露于辐射的个体提供治疗的方法。

3. 发明申请

US20100323920A1 ALLOGENEIC STEM CELL BANK 审中-公开
标题翻译：全息干细胞库
公开(公告)号：US20100323920A1
公开(公告)日：2010-12-23
申请号：US12762118
申请日：2010-04-16
申请人： Robert Chow , Lawrence D. Petz , Rubio R. Punzalan , Denis O. Rodgerson
发明人： Robert Chow , Lawrence D. Petz , Rubio R. Punzalan , Denis O. Rodgerson
IPC分类号： C40B40/02
CPC分类号： A61K35/50 , A61K35/16 , A61K35/28 , G16H50/80
摘要： This invention provides methods for supplying a therapy for individuals exposed to radiation following a nuclear event, through the prospective establishment of an undesignated allogeneic stem cell bank with prospective HLA typing of healthy potential recipients.
摘要翻译：本发明提供了通过预期建立具有健康潜在接受者的预期HLA分型的未指定的同种异体干细胞库来为核事件后暴露于辐射的个体提供治疗的方法。

4. 发明申请

US20060275271A1 PLASMA-DEPLETED, NON-RED BLOOD CELL-DEPLETED CORD BLOOD COMPOSITIONS AND METHODS OF USE 有权
标题翻译：等离子体去除，非红血细胞细胞坏死组合物和使用方法
公开(公告)号：US20060275271A1
公开(公告)日：2006-12-07
申请号：US11422017
申请日：2006-06-02
申请人： Robert Chow
发明人： Robert Chow
IPC分类号： A61K35/14 , C12N5/08
CPC分类号： C12N5/0641 , A61K31/19 , A61K31/7004 , A61K31/7076 , A61K35/28 , A61K35/51 , C12N5/0647 , G16H50/80 , Y02A90/24 , A61K2300/00
摘要： The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma depletion with cryopreservation, selection, thawing, and/or transplantation of hematopoietic stem cells to provide superior clinical outcome by maximizing post-processing cell recovery and post-thaw infusion cell dose. Methods for treating a wide variety of malignant diseases and benign diseases associated with the hematopoietic system by administering the UCB compositions of the present invention are also provided.
摘要翻译：本发明的脐带血（UCB）组合物具有从UCB单元基本上耗尽的血浆和不从UCB单元中耗尽的红细胞（RBC）的独特特征。这样的UCB单位可以通过将血浆消耗与造血干细胞的冷冻保存，选择，解冻和/或移植相结合的方法来制备，以通过最大化后处理细胞恢复和解冻后输注细胞剂量来提供优异的临床结果。还提供了通过施用本发明的UCB组合物治疗与造血系统相关的各种恶性疾病和良性疾病的方法。

5. 发明申请

US20100200393A1 SPUTTER DEPOSITION METHOD AND SYSTEM FOR FABRICATING THIN FILM CAPACITORS WITH OPTICALLY TRANSPARENT SMOOTH SURFACE METAL OXIDE STANDOFF LAYER 审中-公开
标题翻译：具有透明透明平面表面金属氧化物层状薄膜的薄膜电容器的溅射沉积方法和系统
公开(公告)号：US20100200393A1
公开(公告)日：2010-08-12
申请号：US12703113
申请日：2010-02-09
申请人： Robert Chow , Alan Ellis
发明人： Robert Chow , Alan Ellis
IPC分类号： C23C14/35 , C23C14/34
CPC分类号： C23C14/0042 , C23C14/083 , C23C14/548
摘要： A sputter deposition method and system for producing a metal oxide film, especially a dielectric standoff layer of a thin film/nanolayer capacitor. A noble gas, such as argon, is used to sputter metal ions from a metal target, such as niobium, in the presence of a partial pressure of oxygen in a vacuum chamber. And an oxygen-to-noble gas flow ratio entering the vacuum chamber is controlled by a flow controller to be within an operating range defined between a predetermined lower limit (such as 30% O2/Ar for niobium oxide) associated with a minimum transparency/stoichiometric threshold and a predetermined upper limit (such as 80% O2/Ar for niobium oxide) associated with a maximum roughness/porosity threshold, so that a reaction between the sputtered metal ions and the oxygen produces a substantially transparent metal oxide film with a substantially smooth non-porous surface.
摘要翻译：用于制造金属氧化物膜，特别是薄膜/纳米层电容器的介电隔离层的溅射沉积方法和系统。在真空室中存在氧分压的情况下，使用诸如氩的惰性气体从金属靶（例如铌）溅射金属离子。并且通过流量控制器控制进入真空室的氧气到惰性气体流量比在与最小透明度/最小值相关联的预定下限（例如，氧化铌的30％O 2 / Ar）之间限定的工作范围内，化学计量阈值和与最大粗糙度/孔隙度阈值相关联的预定上限（例如，氧化铌的80％O 2 / Ar），使得溅射的金属离子和氧之间的反应产生基本上透明的金属氧化物膜，光滑无孔表面。

6. 发明申请

US20080166324A9 PLASMA-DEPLETED, NON-RED BLOOD CELL-DEPLETED CORD BLOOD COMPOSITIONS AND METHODS OF USE 有权
标题翻译：等离子体去除，非红血细胞细胞坏死组合物和使用方法
公开(公告)号：US20080166324A9
公开(公告)日：2008-07-10
申请号：US11422017
申请日：2006-06-02
申请人： Robert Chow
发明人： Robert Chow
IPC分类号： A61K35/14 , C12N5/08
CPC分类号： C12N5/0641 , A61K31/19 , A61K31/7004 , A61K31/7076 , A61K35/28 , A61K35/51 , C12N5/0647 , G16H50/80 , Y02A90/24 , A61K2300/00
摘要： The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma depletion with cryopreservation, selection, thawing, and/or transplantation of hematopoietic stem cells to provide superior clinical outcome by maximizing post-processing cell recovery and post-thaw infusion cell dose. Methods for treating a wide variety of malignant diseases and benign diseases associated with the hematopoietic system by administering the UCB compositions of the present invention are also provided.
摘要翻译：本发明的脐带血（UCB）组合物具有从UCB单元基本上耗尽的血浆和不从UCB单元中耗尽的红细胞（RBC）的独特特征。这样的UCB单位可以通过将血浆消耗与造血干细胞的冷冻保存，选择，解冻和/或移植相结合的方法来制备，以通过最大化后处理细胞恢复和解冻后输注细胞剂量来提供优异的临床结果。还提供了通过施用本发明的UCB组合物治疗与造血系统相关的各种恶性疾病和良性疾病的方法。

7. 发明申请

US20050220772A1 Stem cell screening and transplantation therapy for hiv infection 审中-公开
标题翻译：干细胞筛选和移植治疗HIV感染
公开(公告)号：US20050220772A1
公开(公告)日：2005-10-06
申请号：US10498450
申请日：2002-11-27
申请人： Robert Chow , Denis Rodgerson , Rubio Punzalan , Lawrence Petz
发明人： Robert Chow , Denis Rodgerson , Rubio Punzalan , Lawrence Petz
IPC分类号： A61K48/00 , A61K35/12 , A61K38/00 , A61P31/18 , A61P37/04 , C12N5/0789
CPC分类号： C12N5/0647 , A61K2035/124
摘要： This invention provides methods for preventing or treating any disease arising from HIV infection, including AIDS and AIDS-related complex (ARC). The method comprises screening a plurality of donors to identify stem cells with a beneficial gene or genes and then transplanting the therapeutic stem cells into a patient. In preferred embodiments, the beneficial gene encodes a polymorphism that renders cells refractory to HIV infection. The polymorphism may be for a gene that encodes a ligand of a receptor for HIV entry, a product of the HLA complex, or a receptor for HIV entry. The Invention also provides isolated populations of stem cells with beneficial genes for resisting infections.
摘要翻译：本发明提供了预防或治疗HIV感染引起的任何疾病的方法，包括AIDS和AIDS相关复合物（ARC）。该方法包括筛选多个供体以鉴定具有有益基因或基因的干细胞，然后将治疗性干细胞移植到患者体内。在优选的实施方案中，有益基因编码使得细胞难以感染HIV的多态性。多态性可以是编码HIV进入受体的配体的基因，HLA复合物的产物或HIV进入的受体。本发明还提供具有用于抵抗感染的有益基因的分离的干细胞群。

8. 发明授权

US08062837B2 Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making 有权
标题翻译：血浆贫血，不是红细胞耗竭，脐带血组成和制备方法
公开(公告)号：US08062837B2
公开(公告)日：2011-11-22
申请号：US11422017
申请日：2006-06-02
申请人： Robert Chow
发明人： Robert Chow
IPC分类号： A01N1/02
CPC分类号： C12N5/0641 , A61K31/19 , A61K31/7004 , A61K31/7076 , A61K35/28 , A61K35/51 , C12N5/0647 , G16H50/80 , Y02A90/24 , A61K2300/00
摘要： The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma depletion with cryopreservation, selection, thawing, and/or transplantation of hematopoietic stem cells to provide superior clinical outcome by maximizing post-processing cell recovery and post-thaw infusion cell dose. Methods for treating a wide variety of malignant diseases and benign diseases associated with the hematopoietic system by administering the UCB compositions of the present invention are also provided.
摘要翻译：本发明的脐带血（UCB）组合物具有从UCB单元基本上耗尽的血浆和不从UCB单元中耗尽的红细胞（RBC）的独特特征。这样的UCB单位可以通过将血浆消耗与造血干细胞的冷冻保存，选择，解冻和/或移植相结合的方法来制备，以通过最大化后处理细胞恢复和解冻后输注细胞剂量来提供优异的临床结果。还提供了通过施用本发明的UCB组合物治疗与造血系统相关的各种恶性疾病和良性疾病的方法。

9. 发明申请

US20150328260A1 BLOOD CELL PREPARATIONS AND RELATED METHODS (GEN 8) 审中-公开
标题翻译：血液细胞制备及相关方法（GEN 8）
公开(公告)号：US20150328260A1
公开(公告)日：2015-11-19
申请号：US14653201
申请日：2013-11-18
申请人： Robert CHOW
发明人： Robert Chow
IPC分类号： A61K35/18 , A61K35/15
CPC分类号： A61K35/18 , A61K35/15 , A61K2035/124 , C12N5/0634
摘要： The disclosure provides preparations of cells that are enriched in white blood cells, methods for separating cells into different fractions, and methods for administering the different cell fractions into a recipient subject.
摘要翻译：本公开提供了富含白细胞的细胞的制备，将细胞分离成不同级分的方法，以及将不同细胞部分投予受体受试者的方法。

10. 发明申请

US20080008693A1 PLASMA-DEPLETED, NON-RED BLOOD CELL-DEPLETED CORD BLOOD COMPOSITIONS AND METHODS OF USE 有权
公开(公告)号：US20080008693A1
公开(公告)日：2008-01-10
申请号：US11771942
申请日：2007-06-29
申请人： Robert Chow
发明人： Robert Chow
IPC分类号： A61K35/18 , A61K35/14 , A61P35/00 , A61P35/02 , A61K35/16
CPC分类号： C12N5/0647 , A61K31/00 , A61K35/28 , A61K35/51 , C12N5/0641
摘要： The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma depletion with cryopreservation, selection, thawing, and/or transplantation of hematopoietic stem cells to provide superior clinical outcome by maximizing post-processing cell recovery and post-thaw infusion cell dose. Methods for treating a wide variety of malignant diseases and benign diseases associated with the hematopoietic system by administering the UCB compositions of the present invention are also provided.

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