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1. 发明申请

US20080026079A1 Calcium aluminosilicate pharmaceutical 审中-公开
标题翻译：硅铝酸钙制药
公开(公告)号：US20080026079A1
公开(公告)日：2008-01-31
申请号：US11821983
申请日：2007-06-26
申请人： Robert Carpenter , Kevin Hahn , Glen King , Melissa Endicott
发明人： Robert Carpenter , Kevin Hahn , Glen King , Melissa Endicott
IPC分类号： A61K33/06 , A61P1/12
CPC分类号： A61K33/06 , A61K9/0095 , A61K33/00 , A61K33/26 , A61K33/32 , A61K45/06
摘要： A composition and method of treating symptoms of diarrhea that utilize administering an effective amount of an isolated calcium aluminosilicate anti-diarrheal (“CASAD”), wherein the isolated CASAD is substantially free from T4-dioxin and toxic heavy metal contamination, waiting a period of time; and repeating the administration of the composition until the symptoms of diarrhea are mitigated. The symptoms of diarrhea may be associated with chronic or infectious diseases, inflammatory proteins, treatment using drugs, or treatment using a chemotheraputic agent in a subject in need of treatment. The isolated CASAD is capable of binding inflammatory proteins, drug metabolites, and chemotherapeutic agents. The isolated CASAD can be administered in any suitable form, such as in tablet, powder, or suspension form, and can be administered by any suitable route, such as orally.
摘要翻译：一种治疗腹泻症状的组合物和方法，其使用有效量的分离的硅铝酸钙抗腹泻（“CASAD”），其中分离的CASAD基本上不含T4-二恶英和有毒的重金属污染，等待一段时间时间; 并重复施用组合物，直到缓解腹泻症状。腹泻的症状可能与慢性或感染性疾病，炎性蛋白质，使用药物治疗或使用化学治疗剂治疗需要治疗的受试者有关。分离的CASAD能够结合炎症蛋白，药物代谢物和化学治疗剂。分离的CASAD可以任何合适的形式施用，例如以片剂，粉末或悬浮液形式施用，并且可以通过任何合适的途径，例如口服施用。

2. 发明申请

US20090170748A1 Plasmid mediated supplementation for treating chronically ill subjects 有权
标题翻译：质粒介导的补充治疗慢性病患者
公开(公告)号：US20090170748A1
公开(公告)日：2009-07-02
申请号：US11726291
申请日：2007-03-21
申请人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Robert J. Schwartz , Glen King , Kevin Hahn , Malcolm K. Brenner
发明人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Robert J. Schwartz , Glen King , Kevin Hahn , Malcolm K. Brenner
IPC分类号： A61K38/00 , A61P7/06
CPC分类号： A61K38/25 , A61K48/00
摘要： The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and methods are useful for treating anemia and other effects that are commonly associated in cancer bearing animals. Overall, the embodiments of the invention can be accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded gene in the animal. For example, when such a nucleic acid sequence is delivered into the specific cells of the animal tissue specific constitutive expression is achieved.
摘要翻译：本发明涉及用于质粒介导的补充的组合物和方法。组合物和方法可用于治疗贫血和通常与携带癌症的动物相关的其它作用。总的来说，本发明的实施方案可以通过将有效量的编码GHRH或其功能生物等价物的核酸表达构建体递送到动物的组织中并允许编码的基因在动物中表达来实现。例如，当这种核酸序列被递送到动物组织的特定细胞中时，实现了特异性组成型表达。

3. 发明授权

US07241744B2 Treating anemia in subjects by administration of plasmids encoding growth hormone releasing hormone 有权
标题翻译：通过施用编码生长激素释放激素的质粒治疗受试者的贫血
公开(公告)号：US07241744B2
公开(公告)日：2007-07-10
申请号：US10315907
申请日：2002-12-10
申请人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Robert J. Schwartz , Glen King , Kevin Hahn , Malcolm K. Brenner
发明人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Robert J. Schwartz , Glen King , Kevin Hahn , Malcolm K. Brenner
IPC分类号： A01N43/04 , A61K31/70 , A01N63/00 , A01N65/00 , C07H21/02 , C07H21/04 , A61K38/24 , C07K1/00 , C07K17/00
CPC分类号： A61K38/25 , A61K48/00
摘要： The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and method are useful for retarding the growth of the tumor, and retarding cachexia, wasting, anemia and other effects that are commonly associated in cancer bearing animals. Overall, the embodiments of the invention can be accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded. gene in the animal. For example, when such a nucleic acid sequence is delivered into the specific cells of the tissue specific constitutive expression is achieved.
摘要翻译：本发明涉及用于质粒介导的补充的组合物和方法。组合物和方法可用于延缓肿瘤的生长，并缓解通常与携带癌症的动物相关的恶病质，浪费，贫血和其它作用。总的来说，本发明的实施方案可以通过将有效量的编码GHRH或其功能生物等价物的核酸表达构建体递送到动物的组织中并允许编码的表达来实现。基因在动物体内。例如，当这样的核酸序列被递送到组织的特定细胞中时，实现了特异性组成型表达。

4. 发明授权

US08178504B2 Gene therapy expression of GHRH for increasing RBC count in subjects 有权
标题翻译：基因治疗GHRH表达增加受试者的RBC计数
公开(公告)号：US08178504B2
公开(公告)日：2012-05-15
申请号：US11726291
申请日：2007-03-21
申请人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Robert J. Schwartz , Glen King , Kevin Hahn , Malcolm K. Brenner
发明人： Ruxandra Draghia-Akli , Robert H. Carpenter , Douglas R. Kern , Robert J. Schwartz , Glen King , Kevin Hahn , Malcolm K. Brenner
IPC分类号： A61K48/00 , A01N63/00 , A01N65/00
CPC分类号： A61K38/25 , A61K48/00
摘要： The present invention pertains to compositions and methods useful for treating anemia and other effects that are commonly associated in cancer bearing animals. The invention is accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded gene in the animal.
摘要翻译：本发明涉及可用于治疗贫血的组合物和方法以及通常与携带癌症的动物相关的其它作用。本发明通过将有效量的编码GHRH或其功能生物等价物的核酸表达构建体递送到动物的组织中并允许编码的基因在动物中表达来实现。

5. 发明授权

US07010946B2 Latch apparatus 有权
标题翻译：锁定装置
公开(公告)号：US07010946B2
公开(公告)日：2006-03-14
申请号：US10441974
申请日：2003-05-19
申请人： Kevin Hahn
发明人： Kevin Hahn
IPC分类号： E05B59/00
CPC分类号： E05B55/00 , E05B17/2038 , E05C1/16 , Y10T70/5243 , Y10T70/5372 , Y10T70/5407 , Y10T70/5465 , Y10T70/55 , Y10T292/0977 , Y10T292/0982
摘要： The invention generally relates to a latch apparatus having a locking live bolt. One embodiment of the invention is a latch apparatus having a housing with opposed plates that are spaced apart and secured to each other by support arms formed from the plates. A live bolt of the apparatus is slidably mounted in the housing and horizontally actuated between an extended and a retracted position. A live bolt hub is mounted in the housing and actuates the live bolt. A slide, actuated by a rotatable cam, is mounted in the housing and moves vertically between a first position and a second position. In the first position the slide is disengaged from the live bolt, and in the second position the slide locks the live bolt in an extended position.
摘要翻译：本发明一般涉及一种具有锁定活动螺栓的闩锁装置。本发明的一个实施例是具有壳体的闩锁装置，该壳体具有相对的板，其间隔开并且通过由板形成的支撑臂彼此固定。装置的活动螺栓可滑动地安装在壳体中并且在延伸和缩回位置之间水平致动。活动螺栓毂安装在壳体中并致动活动螺栓。由可旋转凸轮致动的滑块安装在壳体中并在第一位置和第二位置之间垂直移动。在第一位置，滑块与活动螺栓脱离，并且在第二位置，滑块将活动螺栓锁定在延伸位置。

6. 发明申请

US20110265399A1 Universal block with recessed knock-out panels 审中-公开
标题翻译：通用块与嵌入式敲门板
公开(公告)号：US20110265399A1
公开(公告)日：2011-11-03
申请号：US12799796
申请日：2010-05-03
申请人： Kevin Hahn
发明人： Kevin Hahn
IPC分类号： F21V33/00 , E04C1/42 , E04C1/00
CPC分类号： E04C1/395 , F21S2/005 , F21S8/083 , F21W2131/109
摘要： A universal concrete or masonry block with four walls, a hollow center within the four walls, and a recessed knockout panel on each wall. Each recessed knockout panel is half the height of the block and has recessed cutting slots partially through the wall on either side of the recessed panel. The recessed knockout panels may be removed to leave an opening as desired on any or all of the four sides of the block. The opening(s) may be used to support a fence rail, a light or a plant.
摘要翻译：具有四壁的通用混凝土或砖石块，四壁内的中空中心，以及每个墙上的凹入的敲击面板。每个凹进的敲除面板是块的高度的一半，并且具有凹陷的切割槽部分地穿过凹入板的任一侧上的壁。可以移除凹入的敲除面板以在块的四个侧面中的任何一个或全部根据需要留下开口。开口可用于支撑围栏栏杆，灯或植物。

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