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1. 发明申请

US20130195335A1 AUTOMATIC QUANTIFICATION OF MITRAL VALVE DYNAMICS WITH REAL-TIME 3D ULTRASOUND 有权
标题翻译：用实时三维超声波自动定量麻醉动力学
公开(公告)号：US20130195335A1
公开(公告)日：2013-08-01
申请号：US13580833
申请日：2011-02-25
申请人： Robert C. Gorman , Alison Pouch , Joseph H. Gorman, III , Chandra Sehgal , Paul A. Yushkevich , Benjamin Jackson
发明人： Robert C. Gorman , Alison Pouch , Joseph H. Gorman, III , Chandra Sehgal , Paul A. Yushkevich , Benjamin Jackson
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/174 , G06T2207/10076 , G06T2207/20128 , G06T2207/30048
摘要： A series of rt-3DE images of the mitral valve are quantitatively analyzed so as to enable, for example, prediction of the degree of recurrent ischemic mitral regurgitation (IMR) and comprehensive assessments of leaflet tethering and “tenting” for the entire mitral valve. In accordance with the method, first, the rt-3DE images are registered with symmetric diffeomorphism to obtain information about how the mitral valve deforms over time. Second, the mitral valve is segmented with the level sets or other known segmentation method at each time point in the cardiac cycle with minimal user interaction. Third, the information about mitral valve structure is reduced into a 3D medial model, a compact representation of shape. In other words, a volumetric segmentation of the mitral valve is condensed to a form that is amenable to clinically relevant morphometry.
摘要翻译：定量分析二尖瓣的一系列rt-3DE图像，以便例如预测复发性缺血性二尖瓣反流程度（IMR）的程度，并综合评估整个二尖瓣的小叶束缚和“起搏”。根据该方法，首先，rt-3DE图像以对称不同形态记录，以获得关于二尖瓣随时间变化的信息。其次，在心脏周期的每个时间点，二尖瓣与水平集或其他已知的分割方法分段，最小的用户交互作用。第三，关于二尖瓣结构的信息被简化为3D中间模型，形状的紧凑表示。换句话说，二尖瓣的体积分割被冷凝成适合临床相关形态测定的形式。

2. 发明授权

US09129392B2 Automatic quantification of mitral valve dynamics with real-time 3D ultrasound 有权
标题翻译：用实时三维超声自动量化二尖瓣动态
公开(公告)号：US09129392B2
公开(公告)日：2015-09-08
申请号：US13580833
申请日：2011-02-25
申请人： Robert C. Gorman , Alison Pouch , Joseph H. Gorman, III , Chandra Sehgal , Paul A. Yushkevich , Benjamin Jackson
发明人： Robert C. Gorman , Alison Pouch , Joseph H. Gorman, III , Chandra Sehgal , Paul A. Yushkevich , Benjamin Jackson
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/174 , G06T2207/10076 , G06T2207/20128 , G06T2207/30048
摘要： A series of rt-3DE images of the mitral valve are quantitatively analyzed so as to enable, for example, prediction of the degree of recurrent ischemic mitral regurgitation (IMR) and comprehensive assessments of leaflet tethering and “tenting” for the entire mitral valve. In accordance with the method, first, the rt-3DE images are registered with symmetric diffeomorphism to obtain information about how the mitral valve deforms over time. Second, the mitral valve is segmented with the level sets or other known segmentation method at each time point in the cardiac cycle with minimal user interaction. Third, the information about mitral valve structure is reduced into a 3D medial model, a compact representation of shape. In other words, a volumetric segmentation of the mitral valve is condensed to a form that is amenable to clinically relevant morphometry.
摘要翻译：定量分析二尖瓣的一系列rt-3DE图像，以便例如预测复发性缺血性二尖瓣反流程度（IMR）的程度，并综合评估整个二尖瓣的小叶束缚和“起搏”。根据该方法，首先，rt-3DE图像以对称不同形态记录，以获得关于二尖瓣随时间变化的信息。其次，在心脏周期的每个时间点，二尖瓣与水平集或其他已知的分割方法分段，最小的用户交互作用。第三，关于二尖瓣结构的信息被简化为3D中间模型，形状的紧凑表示。换句话说，二尖瓣的体积分割被冷凝成适合临床相关形态测定的形式。

3. 发明授权

US05997477A Apparatus for imaging an element within a tissue and method therefor 失效
标题翻译：用于对组织内元素进行成像的装置及其方法
公开(公告)号：US05997477A
公开(公告)日：1999-12-07
申请号：US837160
申请日：1997-04-14
申请人： Chandra Sehgal
发明人： Chandra Sehgal
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/0825
摘要： Methods and apparatus for detecting microcalcifications in breasts. The methods and apparatus will greatly improve detection of breast microcalcifications and concomitantly increase the early detection of breast cancers. The methods and apparatus described herein activate the resonance frequency of a breast microcalcification, thereby allowing for detection of small masses.
摘要翻译：检测乳腺微钙化的方法和装置。方法和装置将大大提高乳腺微钙化检测，同时增加乳腺癌的早期检测。本文所述的方法和装置激活乳房微钙化的共振频率，从而允许检测小质量。

4. 发明申请

US20120116221A1 METHODS AND SYSTEMS FOR IMAGE-GUIDED TREATMENT OF BLOOD VESSELS 审中-公开
标题翻译：血管图像引导治疗方法与系统
公开(公告)号：US20120116221A1
公开(公告)日：2012-05-10
申请号：US13263133
申请日：2010-04-09
申请人： Chandra Sehgal , Andrew Kenneth Wood
发明人： Chandra Sehgal , Andrew Kenneth Wood
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/00 , A61B2090/378 , A61N2007/0039 , A61N2007/0078
摘要： Methods and systems of treating at least one blood vessel involves the application of therapy ultrasound to the blood vessel(s) using one or more dosing conditions. An image of the region of interest is acquired responsive to the applied therapy ultrasound. A change in vascularity of the blood vessel(s) is estimated, responsive to the applied therapy ultrasound, using the acquired image to determine whether to adjust at least one of the dosing conditions. The therapy ultrasound is applied with an intensity to modify the blood vessel(s) without damaging a surrounding tissue. A method of treating a tumor comprises introducing a therapeutic agent into a bloodstream and applying therapy ultrasound to blood vessel(s). The therapy ultrasound, along with an agent, disrupts the blood vessel(s) to limit flow to and from the tumor, thereby retaining the therapeutic agent within the tumor.
摘要翻译：治疗至少一个血管的方法和系统包括使用一个或多个给药条件向血管施加治疗超声波。响应于所施加的治疗超声波获取感兴趣区域的图像。根据所应用的治疗超声波，使用所获取的图像来估计血管的血管分布变化，以确定是否调节至少一个给药条件。施加治疗超声波具有改善血管的强度，而不损伤周围组织。治疗肿瘤的方法包括将治疗剂引入血流并将治疗超声波应用于血管。治疗超声波与药剂一起破坏血管以限制流出肿瘤的流体，从而将治疗剂保留在肿瘤内。

5. 发明申请

US20100041989A1 USE OF ULTRASOUND AS AN ANTIVASCULAR AGENT 审中-公开
标题翻译：超声波作为抗菌剂使用
公开(公告)号：US20100041989A1
公开(公告)日：2010-02-18
申请号：US12442597
申请日：2007-10-01
申请人： Chandra Sehgal , Andrew K. W. Wood
发明人： Chandra Sehgal , Andrew K. W. Wood
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61B8/0833 , A61N7/02
摘要： A method for detecting and disrupting fragile blood vessels formed as a result of tumor angiogenesis by manipulating an extent of tissue vascularity in vivo, the method includes targeting a region in need of manipulating the extent of vascularity of the tissue by a diagnostic imaging; visualizing said fragile blood vessels in the tissue; obtaining a characteristic of the tissue; and contacting the tissue with a therapeutic ultrasound producing an unfocused or mildly focused ultrasound beam having an intensity below 2.6 W/cm2, wherein the therapeutic ultrasound is emitted from an ultrasound unit in accordance with the characteristic of the tissue and thereby reducing the extent of vascularity of the tissue and disrupting said fragile blood vessels formed to support the tumor in the region of interest.
摘要翻译：用于通过操纵体内组织血管的程度来检测和破坏作为肿瘤血管生成结果而形成的易碎血管的方法，所述方法包括通过诊断成像靶向需要操纵组织血管程度的区域; 使组织中的脆弱血管可视化; 获得组织的特征; 并使组织与治疗性超声波接触，产生强度低于2.6W / cm 2的未聚焦或轻度聚焦的超声波束，其中根据组织的特征从超声单元发射治疗超声波，从而减少血管的程度的组织并破坏形成以支持感兴趣区域中的肿瘤的所述易碎血管。

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