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1. 发明申请

US20070207093A1 Hydrazone derivatives and uses thereof 审中-公开
标题翻译：腙衍生物及其用途
公开(公告)号：US20070207093A1
公开(公告)日：2007-09-06
申请号：US11592228
申请日：2006-11-03
申请人： Robert Bryant , Roy Palmer , Rok Cerne , Karnail Atwal , Seunghun Lee , Anita Atwal
发明人： Robert Bryant , Roy Palmer , Rok Cerne , Karnail Atwal , Seunghun Lee , Anita Atwal
IPC分类号： A61K8/49 , A61K8/40
CPC分类号： A61K31/165 , A23L27/84 , A23L27/86 , A61K8/40 , A61K8/415 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/492 , A61K8/4926 , A61K8/4946 , A61K8/4973 , A61K8/498 , A61K8/69 , A61K8/70 , A61K47/22 , A61Q11/00 , A61Q19/00
摘要： The present invention is directed to the use of a compound having the formula wherein R1, R2, R3, R4, L1, and L2 are defined herein. The compounds of the present invention are useful as inhibitors of certain taste perceptions and functions. The invention is also directed to compositions comprising a compound according to the above formula.
摘要翻译：本发明涉及具有下式的化合物的用途：其中R 1，R 2，R 3，R 4，R 4，，L 1和L 2在本文中定义。本发明的化合物可用作某些味觉和功能的抑制剂。本发明还涉及包含根据上式的化合物的组合物。

2. 发明申请

US20070259875A1 Triaryl substituted imidazole derivatives and taste-inhibiting uses thereof 审中-公开
标题翻译：三芳基取代的咪唑衍生物及其味道抑制用途
公开(公告)号：US20070259875A1
公开(公告)日：2007-11-08
申请号：US11797082
申请日：2007-04-30
申请人： Karnail Atwal , Anita Atwal , Robert Bryant , Seunghun Lee , Roy Palmer , Rok Cerne
发明人： Karnail Atwal , Anita Atwal , Robert Bryant , Seunghun Lee , Roy Palmer , Rok Cerne
IPC分类号： A61K31/53 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/4439 , A61K31/4164
CPC分类号： A61K31/53 , A23L27/84 , A23L33/10 , A23V2002/00 , A61K31/501 , A23V2200/332 , A23V2200/16
摘要： The present invention is directed to compositions containing and methods of using a compound having the formula: wherein R1, Ar1, Ar2, and Ar3 are defined herein. The compounds of the present invention are useful as inhibitors of certain taste perceptions and functions. The invention is also directed to compositions comprising a compound of the above formula.
摘要翻译：本发明涉及含有以下化合物的组合物和使用方法：其中R 1，R 2，Ar 2，和本文定义了Ar 3。本发明的化合物可用作某些味觉和功能的抑制剂。本发明还涉及包含上式化合物的组合物。

3. 发明授权

US08193168B2 Use of a TRPM5 inhibitor to regulate insulin and GLP-1 release 有权
标题翻译：使用TRPM5抑制剂调节胰岛素和GLP-1释放
公开(公告)号：US08193168B2
公开(公告)日：2012-06-05
申请号：US12025488
申请日：2008-02-04
申请人： S. Paul Lee , Peihong Zhou , M. N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
发明人： S. Paul Lee , Peihong Zhou , M. N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
IPC分类号： A61K31/655 , A61K31/415
CPC分类号： A61K31/397 , Y10S514/866
摘要： The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
摘要翻译：本发明涉及增强胰岛素释放，GLP-1释放和胰岛素敏感性的方法，增加胰岛素基因表达的方法，减少胃分泌和排空以及胰高血糖素分泌的方法，以及抑制食物摄取的方法以及治疗方法糖尿病，胰岛素抵抗综合征，高血糖症和肥胖症，包括向受试者施用有效量的TRPM5抑制剂。

4. 发明申请

US20080306030A1 Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release 有权
标题翻译：使用TRPM5抑制剂调节胰岛素和GLP-1释放
公开(公告)号：US20080306030A1
公开(公告)日：2008-12-11
申请号：US12025488
申请日：2008-02-04
申请人： S. Paul Lee , Peihong Zhou , M.N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
发明人： S. Paul Lee , Peihong Zhou , M.N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
IPC分类号： A61K31/15 , A61K31/655 , A61K31/47 , A61K31/4409 , A61K31/438 , A61P3/00 , A61P1/00 , C12N5/00 , A61K31/5375 , A61K31/165 , A61K31/404
CPC分类号： A61K31/397 , Y10S514/866
摘要： The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
摘要翻译：本发明涉及增强胰岛素释放，GLP-1释放和胰岛素敏感性的方法，增加胰岛素基因表达的方法，减少胃分泌和排空以及胰高血糖素分泌的方法，以及抑制食物摄取的方法以及治疗方法糖尿病，胰岛素抵抗综合征，高血糖症和肥胖症，包括向受试者施用有效量的TRPM5抑制剂。

5. 发明申请

US20080050750A1 Screening Assay for Inhibitors of TRPA1 Activation by a Lower Alkyl Phenol 失效
标题翻译：通过低级烷基酚激活TRPA1抑制剂的筛选试验
公开(公告)号：US20080050750A1
公开(公告)日：2008-02-28
申请号：US11828955
申请日：2007-07-26
申请人： Seunghun LEE , Qifeng Yang , Robert Bryant , Tulu Buber
发明人： Seunghun LEE , Qifeng Yang , Robert Bryant , Tulu Buber
IPC分类号： G01N33/48
CPC分类号： G01N33/6872 , G01N2500/04 , G01N2500/10
摘要： The invention relates an assay useful for screening and identifying compounds as modulators of lower alkyl phenol activation of TRPA1. Thymol, a lower alkyl phenol anti-infective and the active ingredient in, e.g., mouthwashes, is stringent and has an objectionable burning taste sensation. Thymol activates the transient receptor potential like ion channel TRPA1. The assay described and claimed herein involves measurement of activation of TRPA1 and enables the screening of compounds that inhibit lower alkyl phenol, or thymol activation of TRPA1. Inhibitors of thymol activation of TRPA1 can be used to prevent the objectionable taste of thymol in medical uses where taste limits acceptance.
摘要翻译：本发明涉及用于筛选和鉴定化合物作为TRPA1的低级烷基苯酚活化调节剂的测定法。麝香草酚，低级烷基苯酚抗感染剂和例如漱口水中的活性成分是严格的并且具有令人不快的燃烧味觉。百里酚激活瞬时受体电位，如离子通道TRPA1。本文描述和要求保护的测定包括测量TRPA1的活化，并且能够筛选抑制低级烷基苯酚的化合物或TRPA1的百里酚激活。 TRPA1的百里酚激活抑制剂可用于防止在味道限制接受的医疗用途中百里酚的令人反感的味道。

6. 发明申请

US20110284699A1 COMMUNICATION SYSTEM AND METHOD FOR A RAIL VEHICLE CONSIST 有权
标题翻译：用于铁路车辆通信的通信系统和方法
公开(公告)号：US20110284699A1
公开(公告)日：2011-11-24
申请号：US13082738
申请日：2011-04-08
申请人： Jared Cooper , Todd Goodermuth , David Peltz , David McKay , Scott C. Sherin , John Brand , Eugene Smith , David Teeter , Robert Bryant , Mark Kraeling
发明人： Jared Cooper , Todd Goodermuth , David Peltz , David McKay , Scott C. Sherin , John Brand , Eugene Smith , David Teeter , Robert Bryant , Mark Kraeling
IPC分类号： B61L99/00
CPC分类号： B61L15/0036 , B61L3/20
摘要： A method for communicating data in a rail vehicle consist includes transmitting first data at a first rail vehicle of the consist over a power supply conductor to a second, different rail vehicle in the consist, where at least one rail vehicle of the consist receives direct electrical power from the power supply conductor. The method also includes monitoring the power supply conductor for second data at the first rail vehicle and receiving the second data over the power supply conductor at the first rail vehicle for use by a first system onboard the first rail vehicle. In one aspect, the transmitting step comprises transmitting the first data over one or more of a catenary line or a third rail that supplies the electrical power.
摘要翻译：一种用于在轨道车辆组件中传送数据的方法包括：将所述组合的第一轨道车辆的第一数据通过电源导体发送到所述组合中的第二不同轨道车辆，其中组合体中的至少一个轨道车辆接收直接电气来自电源导体的电源。该方法还包括监测第一轨道车辆处的第二数据的电源导体，并且在第一轨道车辆的电力供应导体上接收第二数据，以供第一轨道车辆上的第一系统使用。在一个方面，发射步骤包括通过提供电力的悬链线或第三轨道中的一个或多个发送第一数据。

7. 发明授权

US07024909B2 Non-impact swaging apparatus 有权
标题翻译：无冲击型模具
公开(公告)号：US07024909B2
公开(公告)日：2006-04-11
申请号：US10690409
申请日：2003-10-21
申请人： Cristinel Ovidiu Cobzaru , Robert Bryant
发明人： Cristinel Ovidiu Cobzaru , Robert Bryant
IPC分类号： B21D41/02
CPC分类号： B25B27/10 , B25B27/143 , Y10T29/49911 , Y10T29/49938
摘要： An improved machine for performing a swaging operation includes a mandrel and an expandable collet that are mounted to an actuator such as a conventional pneumatic gun. The mandrel includes a plurality of ramped planar engagement surfaces that are slidably engageable with a plurality of planar reaction surfaces on deflectable segments of the collet. The planar nature of the engagement surfaces and the reaction surfaces avoids unwanted deflection of the segments that would otherwise turn the segments into cutting tools, such as would occur if the surfaces were of certain other shapes. The mandrel is rotatably mounted to the pneumatic gun whereby the engagement surfaces are self-aligning with the reaction surfaces during an initial stage of a swaging operation.
摘要翻译：用于执行模锻操作的改进的机器包括安装在例如常规气动枪的致动器上的心轴和可膨胀夹头。心轴包括多个倾斜的平坦接合表面，其可滑动地与夹头的可偏转段上的多个平面反应表面接合。接合表面和反应表面的平面性质避免了段的不期望的偏转，否则这些部分会将段变成切割工具，例如如果表面具有某些其它形状则会发生。心轴可旋转地安装到气动枪，由此在模锻操作的初始阶段，接合表面与反应表面自对准。

8. 发明申请

US20050235922A1 Hog farrowing system for use in a cold environment and method of use 失效
标题翻译：猪场分娩系统用于寒冷环境和使用方法
公开(公告)号：US20050235922A1
公开(公告)日：2005-10-27
申请号：US10829036
申请日：2004-04-21
申请人： Robert Bryant
发明人： Robert Bryant
IPC分类号： A01K1/02
CPC分类号： A01K1/0218
摘要： A hog farrowing system for use in a cold environment includes a building providing protection from weather elements. The farrowing boxes have an entrance to permit free ingress and egress of female hogs but restrain the piglets. An alley is provided outside the boxes for the female hogs to defecate, urinate, and move to feed and water stations outside the boxes. The boxes have sides which define an inner chamber, a heat system, bedding for the female hogs to nest, and insulation covering an open top during cold environment conditions. The method utilizes the steps of promoting the female hog to utilize natural instincts, promoting the female hog to give birth to piglets close to the heat source, and protecting the piglets from crushing by using a creep area, anti-crush rods and anti-crush boards. The farrowing boxes can be modified for use in a warm season.
摘要翻译：在寒冷环境中使用的猪分娩系统包括提供对天气元素的保护的建筑物。分娩箱有一个入口允许女性猪的自由进入和流出，但是限制了仔猪。在箱子外面设置一个胡同，为女性猪排便，排尿，并移动到箱子外的饲养站和水站。这些盒子具有侧壁，它们限定内部室，热系统，女性猪巢的床上用品，以及在寒冷环境条件下覆盖开放顶部的绝缘体。该方法利用促进雌性猪利用自然本能的步骤，促进雌性猪生产靠近热源的仔猪，并通过使用蠕变面积，抗压碎棒和抗粉碎来保护仔猪不被破碎董事会分娩箱可以在温暖的季节进行修改。

9. 发明申请

US20050144894A1 Concrete outsourcing methods 失效
标题翻译：混凝土外包方式
公开(公告)号：US20050144894A1
公开(公告)日：2005-07-07
申请号：US11013874
申请日：2004-12-15
申请人： Frederic Grimes , Michael Caler , Robert Pittard , Robert Bryant , Jon Bryant
发明人： Frederic Grimes , Michael Caler , Robert Pittard , Robert Bryant , Jon Bryant
IPC分类号： E04B1/00 , G06Q30/00
CPC分类号： G06Q30/06 , G06Q30/018 , G06Q30/0613 , G06Q30/0635
摘要： Included are methods for providing concrete to at least one purchaser. The method may include securing at least one outsourcing agreement with at least one concrete supplier, and providing at least one order menu screen through computer logic. The order menu screen may be configured to receive at least one concrete order, and the concrete order may include order data. Also included in the methods are receiving the concrete order, displaying at least one potential concrete supplier based on the order data, receiving data indicating at least one selected concrete supplier, and outsourcing the concrete order to the selected concrete supplier.
摘要翻译：包括为至少一个购买者提供混凝土的方法。该方法可以包括至少与一个混凝土供应商确保至少一个外包协议，并通过计算机逻辑提供至少一个订单菜单屏幕。订单菜单屏幕可以被配置为接收至少一个具体订单，并且具体订单可以包括订单数据。方法中还包括具体的订单，根据订单数据显示至少一个潜在的混凝土供应商，接收指示至少一个选定的混凝土供应商的数据，并将具体订单外包给选定的混凝土供应商。

10. 发明授权

US6157450A Automated optical surface profile measurement system 失效
标题翻译：自动光学表面轮廓测量系统
公开(公告)号：US6157450A
公开(公告)日：2000-12-05
申请号：US37202
申请日：1998-03-09
申请人： Silvio P. Marchese-Ragona , Robert Bryant , Matthew E. Seelig , Dag Lindquist , Donald P. McClimans , Edward J. Merritt, Jr. , John E. Stephan , John A. Teleska
发明人： Silvio P. Marchese-Ragona , Robert Bryant , Matthew E. Seelig , Dag Lindquist , Donald P. McClimans , Edward J. Merritt, Jr. , John E. Stephan , John A. Teleska
IPC分类号： G01B11/03 , G01B11/30 , G01B11/24 , G01B11/00 , G01N21/00
CPC分类号： G01B11/306
摘要： A fully automated surface profiling system having a loading chamber and an adjacent measurement chamber containing a phase differential laser optical scanning system and a five-axis positioner having a vacuum chuck for holding and orienting a wafer for surface profile measurement. The positioner can displace a mounted wafer lengthwise and crosswise of the chamber, can rotate the wafer about vertical and horizontal axes through the positioner, and can rotate the wafer about its own axis. Each motion is motor-driven and can be carried out independently of all the others or in compound motion as needed. The positioner can accommodate a series of replaceable chucks for holding wafers of different diameters. The loading chamber has a cassette dock for receiving a cassette containing wafers to be tested, a robotic server, and a prealigner. All operations within the profilometer are controlled by a programmable CPU at a control station. Test results and analysis can be displayed on an onboard monitor or printed out or stored or transmitted. In operation, the robotic server selects a wafer from the cassette, presents the wafer to the prealigner for centering and orientation, and transfers the wafer through a slot into the measurement chamber and installs the wafer on the positioner for measurement. The positioner orients the wafer responsive to program commands from the CPU, and the desired surface profile measurements are made. When all measurements have been completed on a wafer, the robotic server removes the wafer from the positioner, returns it to the cassette, and selects another wafer for testing.
摘要翻译：一种完全自动化的表面轮廓系统，具有装载室和相邻的测量室，其包含相位差激光光学扫描系统和具有用于保持和定向用于表面轮廓测量的晶片的真空卡盘的五轴定位器。定位器可以沿着室的纵向和横向移位安装的晶片，可以使晶片围绕垂直和水平轴旋转通过定位器，并且可以围绕其自身的轴线旋转晶片。每个运动都是电机驱动的，可以根据需要独立于其他运动或复合运动进行运动。定位器可以容纳一系列用于保持不同直径的晶片的可替换卡盘。装载室具有用于接收包含要测试的晶片的盒的盒式基座，机器人服务器和预对准器。轮廓仪内的所有操作由控制台上的可编程CPU控制。测试结果和分析可以显示在车载显示器上，或打印出来或存储或传输。在操作中，机器人服务器从盒子中选择晶片，将晶片呈现给预对准器进行定心和取向，并将晶片通过狭槽传送到测量室中，并将晶片安装在定位器上用于测量。定位器响应于来自CPU的程序命令来定向晶片，并且进行所需的表面轮廓测量。当所有测量在晶片上完成时，机器人服务器从定位器中取出晶片，将其返回到盒子，并选择另一个晶片进行测试。

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