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1. 发明公开

US20240189821A1 Method and Device for Trapping at Least One Nucleated Cell Using at Least One Electrode for a Microfluidic Device 审中-公开
公开(公告)号：US20240189821A1
公开(公告)日：2024-06-13
申请号：US18555167
申请日：2022-04-20
申请人： Robert Bosch GmbH
发明人： Thomas Buck , Samir Kadic , Franz Laermer , Michael Dreschmann , Jochen Hoffmann , Anne Serout
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/50273 , B01L2200/0642 , B01L2200/0652 , B01L2200/12 , B01L2300/0645 , B01L2300/0663 , B01L2300/0829 , B01L2400/0424
摘要： A method for trapping at least one nucleated cell using at least one electrode for a microfluidic device is disclosed. The method includes (i) outputting an application signal that causes a sample liquid comprising the at least one nucleated cell to be applied to a carrier substrate of the microfluidic device, and (ii) providing a current signal to an interface with the at least one electrode in order to generate, at or in a microcavity of the carrier substrate, an electric field configured to trap the at least one nucleated cell as a target cell in the microcavity.

2. 发明申请

US20220134335A1 Device for Analysing a Biological Sample 有权
公开(公告)号：US20220134335A1
公开(公告)日：2022-05-05
申请号：US17431376
申请日：2020-02-12
申请人： Robert Bosch GmbH
发明人： Jochen Hoffmann
IPC分类号： B01L3/00 , C12Q1/6869
摘要： A fluidic network for carrying out, in parallel, a plurality of analyses of biological samples is disclosed. The network has a flow cell array with a plurality of reaction chambers. The reaction chambers each have a first channel connection and a second channel connection. The first channel connections are connected to a first supply channel and the second channel connections are connected to a second supply channel. The first supply channel and the second channel connection are interconnected by a circulation line. At least one component is connected to the circulation line so that component test reagents can be introduced into the reaction chambers of the flow cell array.

3. 发明申请

US20210170349A1 Diluting, Mixing and/or Aliquoting Two Fluids in a Microfluidic System 有权
公开(公告)号：US20210170349A1
公开(公告)日：2021-06-10
申请号：US17048093
申请日：2019-04-09
申请人： Robert Bosch GmbH
发明人： Jochen Hoffmann , Tino Frank
IPC分类号： B01F5/10 , B01F3/08 , B01F13/00 , B01F15/04 , B01L3/00
摘要： A method for diluting, mixing, and/or aliquoting two liquids using a microfluidic system with at least two pump chambers first includes filling at least one of the at least two pump chambers with a first liquid. The at least two pump chambers are connected to one another by at least one microfluidic channel. The method then includes pumping the first liquid through the channel. The at least one channel is configured such that at least part of the first liquid remains in the channel after the pumping. The method then includes determining the part of the first liquid that remains in the channel. The method then includes flushing the channel with a second liquid.

4. 发明申请

US20210114024A1 Device and Method for Preparing Sample Material 有权
公开(公告)号：US20210114024A1
公开(公告)日：2021-04-22
申请号：US17041868
申请日：2019-04-24
申请人： Robert Bosch GmbH
发明人： Franz Laermer , Jochen Hoffmann , Tino Frank , Paul Kallenberger
IPC分类号： B01L3/00 , C12M1/26
摘要： A device for preparing sample material is designed as a rotary device by means of which a defined quantity of liquid can be drawn in into a sample receiving chamber for the sample material or can be expelled from the sample receiving chamber for the sample material, by means of a rotary motion.

5. 发明申请

US20190106743A1 Sequencing Device and Method for Operating a Sequencing Device 审中-公开
公开(公告)号：US20190106743A1
公开(公告)日：2019-04-11
申请号：US16190308
申请日：2018-11-14
申请人： Robert Bosch GmbH
发明人： Jochen Hoffmann , Karin Lemuth
IPC分类号： C12Q1/6869 , G01N33/487 , C12N1/06 , B01L3/00
摘要： A sequencing device has at least one sequencing channel configured to fluidically connect a first gap with a second gap. The sequencing channel is formed as a cavity in the region of the first gap and is formed as a pore in the region of the second gap. The pore has a smaller cross section than the cavity.

6. 发明申请

US20170088880A1 Device and Method for Processing a Biological Sample and Analysis System for Analyzing a Biological Specimen 审中-公开
公开(公告)号：US20170088880A1
公开(公告)日：2017-03-30
申请号：US15311142
申请日：2015-04-29
申请人： Robert Bosch GmbH
发明人： Thomas Brettschneider , Jochen Hoffmann , Karin Lemuth
IPC分类号： C12Q1/68 , C12N15/10 , C12N13/00 , B01L3/00
CPC分类号： C12Q1/6806 , B01L3/502715 , B01L3/502753 , B01L2200/0631 , B01L2200/0647 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/087 , B01L2300/0887 , B01L2300/12 , B01L2400/0415 , C12N1/066 , C12N13/00 , C12N15/1017 , G01N2001/4088
摘要： A device for processing a biological sample includes a first substrate having a first cavity, a second substrate having a second cavity, a filter element having a plurality of perforations, and an electrically conductive structure. The first cavity forms a first chamber segment of a chamber for accommodating the biological sample. The second cavity forms a second chamber segment of the chamber for accommodating the biological sample. The filter element is formed between the first cavity and the second cavity in order to hold back a plurality of organic cells of the biological sample on the plurality of perforations when the biological sample moves between the first cavity and the second cavity through the filter element. The electrically conductive structure is arranged on the filter element and is configured to cause lysis of the organic cells and/or to duplicate and/or detect defined segments of exposed DNA.

7. 发明申请

US20160090303A1 MONOLITHIC CMOS-MEMS MICROPHONES AND METHOD OF MANUFACTURING 有权
标题翻译：单片CMOS-MEMS微波阵列及其制造方法
公开(公告)号：US20160090303A1
公开(公告)日：2016-03-31
申请号：US14888606
申请日：2014-05-02
申请人： Robert Bosch GmbH
发明人： John Zinn , Brett Diamond , Jochen Hoffmann
IPC分类号： B81C1/00 , H04R31/00
CPC分类号： B81C1/00246 , B81B2201/0257 , B81C2201/0132 , H04R31/00 , H04R31/003 , H04R2201/003
摘要： Systems and methods are disclosed for manufacturing a CMOS-MEMS device (100). A partial protective layer (401) is deposited on a top surface of a layered structure to cover a circuit region. A first partial etch is performed from the bottom side of the layered structure to form a first gap (501) below a MEMS membrane (207) within a MEMS region of the layered structure. A second partial etch is performed from the top side of the layered structure to remove a portion of a sacrificial layer between the MEMS membrane and a MEMS backplate (215) within the MEMS region. The second partial etch releases the MEMS membrane so that it can move in response to pressures. The deposited partial protective layer prevents the second partial etch from etching a portion of the sacrificial layer positioned within the circuit region of the layered structure and also prevents the second partial etch from damaging the CMOS circuit component (211).
摘要翻译：公开了用于制造CMOS-MEMS器件（100）的系统和方法。部分保护层（401）沉积在层状结构的顶表面上以覆盖电路区域。从分层结构的底侧执行第一部分蚀刻，以在分层结构的MEMS区域内的MEMS膜（207）下方形成第一间隙（501）。从分层结构的顶侧执行第二部分蚀刻以去除MEMS区域内的MEMS膜与MEMS背板（215）之间的牺牲层的一部分。第二部分蚀刻释放MEMS膜，使得其可以响应于压力移动。沉积的部分保护层防止第二部分蚀刻蚀刻位于层状结构的电路区域内的牺牲层的一部分，并且还防止第二部分蚀刻损坏CMOS电路部件（211）。

8. 发明申请

US20150273470A1 Microfluidic Device and Method for Analyzing a Sample of Biological Material 有权
标题翻译：微流控装置及分析生物材料样品的方法
公开(公告)号：US20150273470A1
公开(公告)日：2015-10-01
申请号：US14672316
申请日：2015-03-30
申请人： Robert Bosch GmbH
发明人： Jochen Hoffmann
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01L3/5025 , B01L3/502738 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0864 , B01L2300/0874 , B01L2300/0877 , B01L2400/0487 , G01N2015/0065 , G01N2035/00158
摘要： A microfluidic device is configured to analyze a sample of biological material. The microfluidic device includes a fluid guide structure constructed in order to divide a sample introduced into the microfluidic device into a plurality of subquantities. The microfluidic device further includes a plurality of reaction chambers each of which is fluidically connected to the fluid guide structure. Each of the reaction chambers has a filter configured to filter out target cells from the sample, and each of the reaction chambers is constructed to receive a sample subquantity. In each of the reaction chambers, a result of a reaction between a target-cell-specific active substance that is different for each of the reaction chambers and the target cells of the sample subquantity that is taken up is acquirable.
摘要翻译：微流体装置被配置为分析生物材料的样品。微流体装置包括流体引导结构，其构造成将引入微流体装置的样品分成多个子部件。微流体装置还包括多个反应室，每个反应室流体连接到流体引导结构。每个反应室具有被配置为从样品中过滤掉靶细胞的过滤器，并且每个反应室被构造成接收样品量。在每个反应室中，可以获得对每个反应室不同的靶细胞特异性活性物质和被摄取的样品量的靶细胞之间的反应的结果。

9. 发明公开

US20240201195A1 Process for Detecting Nucleus-Containing Cells in a Sample Liquid of a Patient using a Microfluidic Device and Microfluidic Device 审中-公开
公开(公告)号：US20240201195A1
公开(公告)日：2024-06-20
申请号：US18555486
申请日：2022-04-20
申请人： Robert Bosch GmbH
发明人： Samir Kadic , Tianxing Du , Franz Laermer , Jochen Hoffmann , Anne Serout
IPC分类号： G01N33/574 , B01L3/00 , G01N33/569
CPC分类号： G01N33/57496 , B01L3/502715 , B01L3/502761 , G01N33/56966 , B01L2200/025 , B01L2200/0652 , B01L2200/10 , B01L2200/16 , B01L2300/0819 , B01L2400/0487
摘要： A process for detecting nucleus-containing cells in a sample liquid of a patient using a microfluidic device is disclosed. The process includes (i) providing a mixing signal to a mixing device, wherein the mixing signal causes mixing of the sample liquid with a lysis buffer in a mixing chamber of the microfluidic device in order to obtain a lysate, (ii) outputting an application signal which causes application of the lysate onto a carrier substrate of the microfluidic device in order to obtain a cell sediment and cell suspension of the lysate, and (iii) identifying the nucleus-containing cells from the cell sediment.

10. 发明公开

US20240018568A1 Microfluidic Analysis Device and Method for the Operation Thereof 审中-公开
公开(公告)号：US20240018568A1
公开(公告)日：2024-01-18
申请号：US18250689
申请日：2021-10-27
申请人： Robert Bosch GmbH
发明人： Yvonne Beyl , Franz Laermer , Stefanie Wagner , Anke Timm , Jochen Hoffmann , Martina Budde , Daniel Sebastian Podbiel
IPC分类号： C12Q1/6806 , C12Q1/6844 , B01L7/00 , B01L3/00
CPC分类号： C12Q1/6806 , C12Q1/6844 , B01L7/525 , B01L3/5027 , B01L2200/0647 , B01L2300/0861
摘要： The disclosure relates to a microfluidic analysis device and to a method for operating the microfluidic analysis device. The method comprises the following steps: providing a sample containing DNA, performing a PCR pre-amplification of the sample, dividing the sample into at least two reaction compartments, and performing at least one singleplex detection in each of the at least two reaction compartments. The singleplex detection is performed in each case by means of an isothermal amplification system.

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