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    • 5. 发明申请
    • ATM RELATED KINASE ATX, NUCLEIC ACIDS ENCODING SAME AND METHODS OF USE
    • ATM相关激素ATX,编码其的核酸和使用方法
    • US20070117143A1
    • 2007-05-24
    • US11643551
    • 2006-12-20
    • Robert AbrahamDiane Otterness
    • Robert AbrahamDiane Otterness
    • C12Q1/68C07H21/04C12N9/12C12P21/06
    • C07H21/04C07K2319/00C12N9/1205
    • The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypeptide having substantially the same amino acid sequence as SEQ ID NO:2 is further provided as well as an antibody, or antigen binding fragment thereof, which specifically binds to an ATX polypeptide and has an amino acid sequence as referenced in SEQ ID NO:2. A method for identifying an ATX-modulatory compound is additionally provided. The method consists of measuring the level of an ATX polypeptide in the presence of a test compound, wherein a difference in the level of said ATX polypeptide in the presence of said test compound compared to in the absence of said test compound indicating that said test compound is an ATX-modulatory compound, and wherein said ATX-modulatory compound is not caffeine or wortmannin.
    • 本发明提供具有与SEQ ID NO:1基本相同的核苷酸序列的分离的核酸分子。 还提供了具有SEQ ID NO:11所示的核苷酸序列的至少15个连续核苷酸的分离的寡核苷酸。 还提供具有与SEQ ID NO:2基本上相同的氨基酸序列的分离的多肽以及特异性结合ATX多肽并具有SEQ ID NO:2所述的氨基酸序列的抗体或其抗原结合片段 :2。 另外提供了鉴定ATX调节化合物的方法。 所述方法包括在存在测试化合物的情况下测量ATX多肽的水平,其中所述ATX多肽在所述测试化合物存在下的水平与不存在所述测试化合物相比的差异表明所述测试化合物 是ATX调节化合物,其中所述ATX调节化合物不是咖啡因或渥曼青霉素。
    • 7. 发明申请
    • Scraper Blade and Method of Manufacturing the Same
    • 刮刀及其制造方法
    • US20090218196A1
    • 2009-09-03
    • US12083036
    • 2006-10-09
    • Lars GrönvallRobert Abraham
    • Lars GrönvallRobert Abraham
    • B65G45/12B65G45/16B29C39/10
    • B29C70/68B65G45/12B65G45/16
    • A scraper blade adapted to scrape off material from a surface has a scraper tip at one end and a mounting base at its other end and is tapered towards the tip at least in the outer end of the scraper blade, its scraper blade portion which extends from the tip and to a point adjacent to or in the mounting base being made with at least two layers, which extend longitudinally along said scraper blade portion, and is characterised in that at least one first layer is made of polyurethane with a lower hardness and a higher abrasion resistance than at least one second layer which is mainly made of polycarbonate plastic, said at least one second polycarbonate plastic layer being adapted to reinforce and stiffen said at least one first layer, which constitutes a main contact surface against said surface.
    • 适于从表面刮除材料的刮刀具有一端的刮刀尖端和另一端处的安装基座,并且至少在刮刀的外端处朝向尖端逐渐变细,其刮刀部分从 所述尖端以及与所述安装基座相邻或在所述安装基座中的点形成有至少两层,所述至少两层沿所述刮刀部分纵向延伸,其特征在于,至少一个第一层由具有较低硬度的聚氨酯制成, 比主要由聚碳酸酯塑料制成的至少一个第二层更高的耐磨性,所述至少一个第二聚碳酸酯塑料层适于加强和加固所述至少一个第一层,该第一层构成抵靠所述表面的主接触表面。