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1. 发明申请

US20080208283A1 Neural Interface System 有权
标题翻译：神经接口系统
公开(公告)号：US20080208283A1
公开(公告)日：2008-08-28
申请号：US11932903
申请日：2007-10-31
申请人： Rio Vetter , Daryl Kipke , David Pellinen , David Anderson , Jamille Hetke
发明人： Rio Vetter , Daryl Kipke , David Pellinen , David Anderson , Jamille Hetke
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61B5/04001 , A61N1/0539 , A61N1/36082
摘要： The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.
摘要翻译：优选实施例的神经接口系统包括具有多个电极位置的电极阵列和支撑电极阵列的载体。电极阵列耦合到载体，使得电极位置沿着载体周向布置并且沿着载体轴向布置。可以同时激活一组电极部位以产生激活模式。优选实施例的系统优选地设计用于深部脑刺激，更具体地，针对具有精细电极位置定位，选择性，可调性和精确激活图案化的深部脑刺激。然而，优选实施例的系统可以替代地在任何合适的环境（例如脊髓，周围神经，肌肉或任何其他合适的解剖学位置）中以及出于任何合适的原因使用。

2. 发明授权

US08731673B2 Neural interface system 有权
标题翻译：神经界面系统
公开(公告)号：US08731673B2
公开(公告)日：2014-05-20
申请号：US11932903
申请日：2007-10-31
申请人： Rio Vetter , Daryl Kipke , David Pellinen , David Anderson , Jamille Hetke
发明人： Rio Vetter , Daryl Kipke , David Pellinen , David Anderson , Jamille Hetke
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61B5/04001 , A61N1/0539 , A61N1/36082
摘要： The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.
摘要翻译：优选实施例的神经接口系统包括具有多个电极位置的电极阵列和支撑电极阵列的载体。电极阵列耦合到载体，使得电极位置沿着载体周向布置并且沿着载体轴向布置。可以同时激活一组电极部位以产生激活模式。优选实施例的系统优选地设计用于深部脑刺激，更具体地，针对具有精细电极位置定位，选择性，可调性和精确激活图案化的深部脑刺激。然而，优选实施例的系统可以替代地在任何合适的环境（例如脊髓，周围神经，肌肉或任何其他合适的解剖学位置）中以及出于任何合适的原因使用。

3. 发明授权

US09008747B2 Neural interface system with an edge array 有权
标题翻译：具有边缘阵列的神经接口系统
公开(公告)号：US09008747B2
公开(公告)日：2015-04-14
申请号：US13416775
申请日：2012-03-09
申请人： John Seymour , Jamille Hetke , Rio Vetter , Daryl Kipke , David Pellinen , Kc Kong
发明人： John Seymour , Jamille Hetke , Rio Vetter , Daryl Kipke , David Pellinen , Kc Kong
IPC分类号： A61B5/04 , A61N1/05 , A61B1/07 , A61M25/00 , H05K3/10 , H05K1/11 , H05K1/02
CPC分类号： A61N1/0534 , A61B1/07 , A61M25/0009 , A61M25/0023 , A61N1/0553 , A61N5/0601 , A61N2005/0632 , H05K1/028 , H05K1/118 , H05K3/10 , H05K2201/051 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155
摘要： The neural interface system of one embodiment includes a cylindrical shaft, a lateral extension longitudinally coupled to at least a portion of the shaft and having a thickness less than a diameter of the shaft, and an electrode array arranged on the lateral extension and radially offset from the shaft, including electrode sites that electrically interface with their surroundings. The method of one embodiment for making the neural interface system includes forming a planar polymer substrate with at least one metallization layer, patterning on at least one metallization layer an electrode array on a first end of the substrate, patterning conductive traces on at least one metallization layer, rolling a portion of the substrate toward the first end of the substrate, and securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft.
摘要翻译：一个实施例的神经接口系统包括圆柱形轴，纵向耦合到轴的至少一部分并且具有小于轴的直径的厚度的横向延伸部和布置在横向延伸部上的径向偏移的电极阵列轴，包括与其周围环境电接触的电极位置。用于制造神经接口系统的一个实施例的方法包括：形成具有至少一个金属化层的平面聚合物衬底，在至少一个金属化层上图案化在衬底的第一端上的电极阵列，在至少一个金属化层将基板的一部分朝向基板的第一端滚动，并且将轧制的基板固定到轴中，其中基板的第一端从轴横向延伸并且电极阵列从轴向径向偏移。

4. 发明申请

US20130090525A1 NEURAL INTERFACE SYSTEM WITH AN EDGE ARRAY 有权
标题翻译：具有边缘阵列的神经接口系统
公开(公告)号：US20130090525A1
公开(公告)日：2013-04-11
申请号：US13416775
申请日：2012-03-09
申请人： John Seymour , Jamille Hetke , Rio Vetter , Daryl Kipke , David Pellinen , Kc Kong
发明人： John Seymour , Jamille Hetke , Rio Vetter , Daryl Kipke , David Pellinen , Kc Kong
IPC分类号： A61N1/05 , A61B1/07 , H05K3/10 , A61M25/00
CPC分类号： A61N1/0534 , A61B1/07 , A61M25/0009 , A61M25/0023 , A61N1/0553 , A61N5/0601 , A61N2005/0632 , H05K1/028 , H05K1/118 , H05K3/10 , H05K2201/051 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155
摘要： The neural interface system of one embodiment includes a cylindrical shaft, a lateral extension longitudinally coupled to at least a portion of the shaft and having a thickness less than a diameter of the shaft, and an electrode array arranged on the lateral extension and radially offset from the shaft, including electrode sites that electrically interface with their surroundings. The method of one embodiment for making the neural interface system includes forming a planar polymer substrate with at least one metallization layer, patterning on at least one metallization layer an electrode array on a first end of the substrate, patterning conductive traces on at least one metallization layer, rolling a portion of the substrate toward the first end of the substrate, and securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft.
摘要翻译：一个实施例的神经接口系统包括圆柱形轴，纵向耦合到轴的至少一部分并且具有小于轴的直径的厚度的横向延伸部和布置在横向延伸部上的径向偏移的电极阵列轴，包括与其周围环境电接触的电极位置。用于制造神经接口系统的一个实施例的方法包括：形成具有至少一个金属化层的平面聚合物衬底，在至少一个金属化层上图案化在衬底的第一端上的电极阵列，在至少一个金属化层将基板的一部分朝向基板的第一端滚动，并且将轧制的基板固定到轴中，其中基板的第一端从轴横向延伸并且电极阵列从轴向径向偏移。

5. 发明申请

US20070123765A1 Modular multichannel microelectrode array and methods of making same 有权
标题翻译：模块化多通道微电极阵列及其制备方法
公开(公告)号：US20070123765A1
公开(公告)日：2007-05-31
申请号：US11545353
申请日：2006-10-10
申请人： Jamille Hetke , Daryl Kipke , David Pellinen , David Anderson
发明人： Jamille Hetke , Daryl Kipke , David Pellinen , David Anderson
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61B2562/0209 , A61B2562/043 , A61N1/0534 , Y10T29/49117 , Y10T29/49147 , Y10T29/49149 , Y10T29/49155 , Y10T29/49211
摘要： Some embodiments of the invention comprise a customizable multichannel microelectrode array with a modular planar microfabricated electrode array attached to a carrier and a high density of recording and/or stimulation electrode sites disposed thereon. Novel methods of making and using same are also disclosed.
摘要翻译：本发明的一些实施例包括可定制的多通道微电极阵列，其具有连接到载体的模块化平面微加工电极阵列和设置在其上的高密度记录和/或刺激电极位置。还公开了制备和使用它们的新方法。

6. 发明申请

US20050143790A1 Intracranial neural interface system 有权
标题翻译：颅内神经接口系统
公开(公告)号：US20050143790A1
公开(公告)日：2005-06-30
申请号：US10970268
申请日：2004-10-21
申请人： Daryl Kipke , Justin Williams , Jamille Hetke , Jaimie Henderson , P. Garell
发明人： Daryl Kipke , Justin Williams , Jamille Hetke , Jaimie Henderson , P. Garell
IPC分类号： A61B5/04 , A61N1/05 , A61N1/375 , A61N1/40 , A61N1/08 , A61N1/10 , A61N1/18 , A61N1/20 , A61N1/32 , A61N1/34
CPC分类号： A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要： In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
摘要翻译：在一些优选实施例中，但不限于，本发明包括可植入的颅内神经接口节点，其是集成的和微创的平台系统，并且支持中枢神经系统中大脑和其他相关结构的交叉模式神经接口。神经接口包括用于神经记录，电刺激，化学递送，化学感测，化学取样，细胞递送，遗传物质递送和/或感兴趣的其它功能的电和化学界面。

7. 发明授权

US08954144B2 Hybrid clustered neural interface system 有权
标题翻译：混合聚类神经接口系统
公开(公告)号：US08954144B2
公开(公告)日：2015-02-10
申请号：US13524989
申请日：2012-06-15
申请人： David Anderson , Daryl R. Kipke , Jamille Hetke , Rio J. Vetter , Kc Kong , John Seymour
发明人： David Anderson , Daryl R. Kipke , Jamille Hetke , Rio J. Vetter , Kc Kong , John Seymour
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0531 , Y10T29/49147
摘要： An apparatus comprises a flexible substrate. The flexible substrate includes a first substrate surface, a surface electrode array that includes a plurality of electrodes disposed on the first substrate surface, one or more flexible neural probes substantially orthogonal to the first substrate surface and insertable into biological tissue, and a penetrating electrode array that includes a plurality of electrodes formed on the one or more flexible neural probes, wherein electrodes of the surface electrode array and the penetrating electrode array are configured to one or both of receive a neural signal from a neural signal source and provide electrical stimulation energy to a neural stimulation target.
摘要翻译：一种装置包括柔性基板。柔性基板包括第一基板表面，包括设置在第一基板表面上的多个电极的表面电极阵列，基本上与第一基板表面正交并可插入到生物组织中的一个或多个柔性神经探针，以及穿透电极阵列其包括形成在所述一个或多个柔性神经探针上的多个电极，其中所述表面电极阵列和所述穿透电极阵列的电极被配置为接收来自神经信号源的神经信号中的一个或两个，并将电刺激能量提供给神经刺激目标。

8. 发明申请

US20130144365A1 NEURAL DEVICE WITH MODULAR ELECTRODE ARRAY 有权
标题翻译：具有模块电极阵列的神经器件
公开(公告)号：US20130144365A1
公开(公告)日：2013-06-06
申请号：US13556715
申请日：2012-07-24
申请人： Daryl R. Kipke , Rio J. Vetter , Kc Kong , Jamille Hetke , David Anderson
发明人： Daryl R. Kipke , Rio J. Vetter , Kc Kong , Jamille Hetke , David Anderson
IPC分类号： A61N1/04 , A61N1/05 , A61N5/06
CPC分类号： A61N1/0476 , A61B5/0059 , A61B5/04001 , A61B5/0478 , A61B5/4064 , A61B5/4094 , A61B2562/0209 , A61B2562/046 , A61N1/0502 , A61N1/0531 , A61N1/36064 , A61N5/06 , A61N5/0622 , Y10T29/49117
摘要： An apparatus comprises a flexible substrate including a modular electrode array disposed on the flexible substrate. The modular electrode array includes a plurality of electrode modules, where an electrode module includes a plurality of electrodes. The flexible substrate also includes a spatial separation between the electrode modules of the modular electrode array, and conductive interconnect coupled to the electrodes of the plurality of electrodes.
摘要翻译：一种装置包括柔性基板，其包括设置在柔性基板上的模块化电极阵列。模块化电极阵列包括多个电极模块，其中电极模块包括多个电极。柔性基板还包括模块化电极阵列的电极模块与耦合到多个电极的电极的导电互连之间的空间间隔。

9. 发明授权

US09248269B2 Neural device with modular electrode array 有权
标题翻译：具有模块电极阵列的神经元件
公开(公告)号：US09248269B2
公开(公告)日：2016-02-02
申请号：US13556715
申请日：2012-07-24
申请人： Daryl R. Kipke , Rio J. Vetter , Kc Kong , Jamille Hetke , David Anderson
发明人： Daryl R. Kipke , Rio J. Vetter , Kc Kong , Jamille Hetke , David Anderson
IPC分类号： A61B5/0478 , A61N1/05 , A61N1/04 , A61B5/04 , A61N1/36 , A61N5/06 , A61B5/00
CPC分类号： A61N1/0476 , A61B5/0059 , A61B5/04001 , A61B5/0478 , A61B5/4064 , A61B5/4094 , A61B2562/0209 , A61B2562/046 , A61N1/0502 , A61N1/0531 , A61N1/36064 , A61N5/06 , A61N5/0622 , Y10T29/49117
摘要： An apparatus comprises a flexible substrate including a modular electrode array disposed on the flexible substrate. The modular electrode array includes a plurality of electrode modules, where an electrode module includes a plurality of electrodes. The flexible substrate also includes a spatial separation between the electrode modules of the modular electrode array, and conductive interconnect coupled to the electrodes of the plurality of electrodes.
摘要翻译：一种装置包括柔性基板，其包括设置在柔性基板上的模块化电极阵列。模块化电极阵列包括多个电极模块，其中电极模块包括多个电极。柔性基板还包括模块化电极阵列的电极模块与耦合到多个电极的电极的导电互连之间的空间间隔。

10. 发明申请

US20120323288A1 HYBRID CLUSTERED NEURAL INTERFACE SYSTEM 有权
标题翻译：混合聚合神经接口系统
公开(公告)号：US20120323288A1
公开(公告)日：2012-12-20
申请号：US13524989
申请日：2012-06-15
申请人： David Anderson , Daryl R. Kipke , Jamille Hetke , Rio J. Vetter , Kc Kong , John Seymour
发明人： David Anderson , Daryl R. Kipke , Jamille Hetke , Rio J. Vetter , Kc Kong , John Seymour
IPC分类号： A61N1/36 , A61N5/06 , A61M37/00
CPC分类号： A61N1/0531 , Y10T29/49147
摘要： An apparatus comprises a flexible substrate. The flexible substrate includes a first substrate surface, a surface electrode array that includes a plurality of electrodes disposed on the first substrate surface, one or more flexible neural probes substantially orthogonal to the first substrate surface and insertable into biological tissue, and a penetrating electrode array that includes a plurality of electrodes formed on the one or more flexible neural probes, wherein electrodes of the surface electrode array and the penetrating electrode array are configured to one or both of receive a neural signal from a neural signal source and provide electrical stimulation energy to a neural stimulation target.
摘要翻译：一种装置包括柔性基板。柔性基板包括第一基板表面，包括设置在第一基板表面上的多个电极的表面电极阵列，基本上与第一基板表面正交并可插入到生物组织中的一个或多个柔性神经探针，以及穿透电极阵列其包括形成在所述一个或多个柔性神经探针上的多个电极，其中所述表面电极阵列和所述穿透电极阵列的电极被配置为接收来自神经信号源的神经信号中的一个或两个，并将电刺激能量提供给神经刺激目标。

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