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1. 发明申请

US20070043040A1 Inhibitors of akt (protein kinase b) 失效
标题翻译： akt抑制剂（蛋白激酶b）
公开(公告)号：US20070043040A1
公开(公告)日：2007-02-22
申请号：US10547969
申请日：2004-03-25
申请人： Rima Al-Awar , David Barda , Albert Dee , Kenneth Henry Jr , Sajan Joseph , Ho-Shen Lin , Jose Lopez , Michael Richett , Carmen Somoza
发明人： Rima Al-Awar , David Barda , Albert Dee , Kenneth Henry Jr , Sajan Joseph , Ho-Shen Lin , Jose Lopez , Michael Richett , Carmen Somoza
IPC分类号： A61K31/5377 , A61K31/4709 , C07D413/02 , C07D401/02
CPC分类号： C07D401/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12 , C07D413/02 , C07D413/12
摘要： The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译：本发明涉及式（I）化合物：作为AKT活性抑制剂，其可用于治疗易感性肿瘤和病毒感染。

2. 发明申请

US20060211755A1 3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors 审中-公开
公开(公告)号：US20060211755A1
公开(公告)日：2006-09-21
申请号：US10544910
申请日：2004-03-25
申请人： Patrick Eacho , Patricia Foxworthy-Mason , Ho-Shen Lin , Jose Lopez , Marian Mosior , Michael Richett
发明人： Patrick Eacho , Patricia Foxworthy-Mason , Ho-Shen Lin , Jose Lopez , Marian Mosior , Michael Richett
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/56 , C07D405/12 , C07D409/12
摘要： The present invention provides a compound of formula I (1) wherein; R, is selected from the group consisting of C5-C13alkyl; C,—C,2haloalkyl, C4C,2alkenyl, C4-C12alkynyl, or C,—C5alkylcycloalkyl, C3-C8cycloalkyl, C, C5alkylheterocyclic, and aryl, wherein the, cycloalkyl, cycloalkenyl, heterocyclic and aryl substituents are optionally substituted with one to three substituents independently selected from C,—C8a)kyl, C,—C8haloalkyl, ′C2-CBalkenyl, C2-C8a)kynyl, phenyl, benzyl, hydroxy, C,—C5 alkoxy, (C}12)m000C,—Csalkyl, (CH2)mNRaRb, and C,C4alkylcycloalkyl; wherein W and Rb are independently selected from hydrogen, C,CBalkyl, C2-CBalkenyl, C2-CBalkynyl, and C,—C5alkylcycloalkyl; R2 is hydrogen; R3, R4, R5, and R6, are independently selected from hydrogen, C,—C12alkyl, C2C,2haloalkyl, C2-C,2 alkenyl, C2-C12alkynyl, C,—C12alkylaryl, C,—C12alkylcyclohexyl, C, C12alkylcyclopentyl, C,—C12alkylheterocyclic, (CH2)m000H, (CH2)mC0(C,—C,o)alkyl, (CH2)m COO(C,—C,o)alkyl, (CH2)mCOO(C1-C,o)alkylaryl, C,—C,oalkylamino, halo, (CH2)mCONH2, (CH2)rCONRaRb, phenyl, or aryl wherein each of the phenyl or aryl groups is optionally substituted with one to three groups independently selected from CBalkyl, C,—CBhaloalkyl, C2-CBalkenyl, CZCBalkynyl, phenyl, benzyl, hydroxy, C,—C5 alkoxy, (CH2)m000C,—Csalkyl, and C,—C4alkylcycloalkyl; and wherein m is 0, 1, 2, or 3; R7 is selected from the group consisting of hydrogen, C,—Cloalkyl, C,C,ohaloalkyl, C2-C,oalkenyl, C2-C,oalkynyl, C,—C6alkylaryl, C,—C6alkylcyclohexyl, C—C6aikylcyclopentyl, C,—C6alkylheterocyclic, or aryl; or a pharmaceutically acceptable sallvate thereofi together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase-mediated diseases.

3. 发明申请

US20060116409A1 Phospholipase inhibitors 失效
标题翻译：磷脂酶抑制剂
公开(公告)号：US20060116409A1
公开(公告)日：2006-06-01
申请号：US10544908
申请日：2004-03-25
申请人： Patrick Eacho , Patricia Foxworthy-Mason , Ho-Shen Lin , Jose Lopez , Marian Mosior , Michael Richett
发明人： Patrick Eacho , Patricia Foxworthy-Mason , Ho-Shen Lin , Jose Lopez , Marian Mosior , Michael Richett
IPC分类号： A61K31/42 , C07D261/20
CPC分类号： C07D261/20
摘要： A novel class of 3-oxo-3H-benzo[d]isoxazole carboxamide compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases.
摘要翻译：公开了一类新的3-氧代-3H-苯并[d]异恶唑甲酰胺化合物，同时使用这些化合物抑制肝脂肪酶和/或内皮脂肪酶活性用于治疗，改善或预防肝脂肪酶和/或内皮脂肪酶介导的疾病。

4. 发明申请

US20060276522A1 Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors 失效
公开(公告)号：US20060276522A1
公开(公告)日：2006-12-07
申请号：US10550006
申请日：2004-03-25
申请人： Patrick Eacho , Patricia Foxworthy-Mason , Ho-Shen Lin , Jose Lopez , Marian Moslor , Michael Richett
发明人： Patrick Eacho , Patricia Foxworthy-Mason , Ho-Shen Lin , Jose Lopez , Marian Moslor , Michael Richett
IPC分类号： A61K31/425 , C07D275/04
CPC分类号： C07D275/04 , C07D417/12
摘要： A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases. (I)

5. 发明申请

US20060223871A1 Thiophene-and thiazolesulfonamides as antineoplastic agents 失效
标题翻译：噻吩和噻唑磺酰胺作为抗肿瘤药
公开(公告)号：US20060223871A1
公开(公告)日：2006-10-05
申请号：US11447457
申请日：2006-06-06
申请人： Cora Grossman , Philip Hipskind , Ho-Shen Lin , Karen Lobb , Beatriz Lopez de Uralde Garmendia , Jose Lopez , Mary Mader , Michael Richett , Chuan Shih , Alfonso De Dios
发明人： Cora Grossman , Philip Hipskind , Ho-Shen Lin , Karen Lobb , Beatriz Lopez de Uralde Garmendia , Jose Lopez , Mary Mader , Michael Richett , Chuan Shih , Alfonso De Dios
IPC分类号： A61K31/426 , A61K31/381 , C07D333/34
CPC分类号： C07D277/36 , C07D333/34 , C07D333/38
摘要： The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
摘要翻译：本发明提供下式的抗肿瘤化合物和抗肿瘤方法。

6. 发明授权

US08147296B2 Method and grinding machine for dressing of a grinding tool 有权
标题翻译：研磨机的修整方法和研磨机
公开(公告)号：US08147296B2
公开(公告)日：2012-04-03
申请号：US12109627
申请日：2008-04-25
申请人： Jose Lopez
发明人： Jose Lopez
IPC分类号： B24B1/00
CPC分类号： B24B53/085 , B23F5/04 , B23F23/1225 , B24B53/12
摘要： The invention relates to a method and machine for the dressing of a grinding tool (1), which has at least one tooth-shaped profile (2) with a first flank (3) and an opposing second flank (4). A disk-shaped dressing tool (5) used for dressing of the grinding tool (2) has a first abrasive area (6) and a second abrasive area (7). To allow a faster and thus more economical dressing of the grinding tool, the first abrasive area (6) contacts the first flank (3) and the second abrasive area (7) contacts the second flank (4) simultaneously, and the disc-shaped dressing tool (5) and/or the grinding tool (1) are pivoted relatively to another around an axis (A) being arranged perpendicular to the axis of rotation (C) of the grinding tool (1), so that both flanks (3, 4) are dressed simultaneously.
摘要翻译：本发明涉及一种用于修整研磨工具（1）的方法和机器，该研磨工具具有至少一个具有第一侧面（3）和相对的第二侧面（4）的齿形轮廓（2）。用于磨削工具（2）的盘形修整工具（5）具有第一研磨区域（6）和第二磨料区域（7）。为了允许磨削工具更快且因此更经济地修整，第一研磨区域（6）接触第一侧面（3）并且第二磨料区域（7）同时接触第二侧面（4），并且盘形修整工具（5）和/或磨削工具（1）相对于另一个围绕垂直于研磨工具（1）的旋转轴线（C）布置的轴线（A）枢转，使得两侧面，4）同时穿着。

7. 发明申请

US20070244792A1 Execution monitoring system for financial instruments 审中-公开
标题翻译：金融工具执行监控系统
公开(公告)号：US20070244792A1
公开(公告)日：2007-10-18
申请号：US11403725
申请日：2006-04-13
申请人： Frederic Couperier , Christopher Dacre-Wright , Jose Lopez
发明人： Frederic Couperier , Christopher Dacre-Wright , Jose Lopez
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04
摘要： A computerized method of monitoring compliance comprises: (a) receiving information regarding an order for a financial instrument which was executed at a first one of a plurality of automated trading centers against a protected quotation of said first trading center, the information including at least an order time at which the order was placed, an identifier sufficient to identify said financial instrument, a volume of the order, an identifier sufficient to identify said first trading center; and a price of the order; (b) receiving market data for said financial instrument, said market data including each protected quotation for the financial instrument at each of the plurality of automated trading centers during a grace period extending from a second time, which is prior to said order time, to said order time; (c) comparing said protected quotation of said first trading center at the order time to each other protected quotation for the financial instrument at the order time, and: (1) if none of the other protected quotations is a better quotation than said protected quotation, identifying the order as compliant; (2) if any of the other protected quotations is a better quotation than said protected quotation, searching the market data for the financial instrument during said grace period, and: (i) if at any time during the grace period none of the other protected quotations had a better quotation than said protected quotation, identifying the order as compliant, and, if not, identifying the order as an order for which compliance has not been demonstrated.
摘要翻译：一种监测合规性的计算机化方法包括：（a）接收关于在多个自动交易中心的第一个执行的金融工具的订单的信息针对所述第一交易中心的受保护的报价，所述信息至少包括发出订单的订单时间，足以识别所述金融工具的标识符，订单量，足以识别所述第一交易中心的标识符; 和订单的价格; （b）接收所述金融工具的市场数据，所述市场数据包括在从所述订单时间之前的第二时间延伸的宽限期期间在所述多个自动交易中心中的每一个的金融工具的每个受保护报价到说订单时间（c）在命令时间将所述第一交易中心的受保护报价与金融工具的相互保护报价进行比较，以及：（1）如果其他受保护报价中没有一个比所述受保护报价更好的报价，将订单确定为合规; （2）如果任何其他受保护的报价是比所述受保护的报价更好的报价，则在所述宽限期内搜索金融工具的市场数据，以及：（i）如果在宽限期内的任何时间没有其他受保护的报价引用报价比所述受保护的报价更好，将订单确定为合规，如果不是，则将订单确定为尚未证明合规性的订单。

8. 发明申请

US20080264401A1 METHOD AND GRINDING MACHINE FOR DRESSING OF A GRINDING TOOL 有权
标题翻译：研磨工具的磨削方法和研磨机
公开(公告)号：US20080264401A1
公开(公告)日：2008-10-30
申请号：US12109627
申请日：2008-04-25
申请人： Jose Lopez
发明人： Jose Lopez
IPC分类号： B24B53/053
CPC分类号： B24B53/085 , B23F5/04 , B23F23/1225 , B24B53/12
摘要： The invention relates to a method and machine for the dressing of a grinding tool (1), which has at least one tooth-shaped profile (2) with a first flank (3) and an opposing second flank (4). A disk-shaped dressing tool (5) used for dressing of the grinding tool (2) has a first abrasive area (6) and a second abrasive area (7). To allow a faster and thus more economical dressing of the grinding tool, the first abrasive area (6) contacts the first flank (3) and the second abrasive area (7) contacts the second flank (4) simultaneously, and the disc-shaped dressing tool (5) and/or the grinding tool (1) are pivoted relatively to another around an axis (A) being arranged perpendicular to the axis of rotation (C) of the grinding tool (1), so that both flanks (3, 4) are dressed simultaneously.
摘要翻译：本发明涉及一种用于修整研磨工具（1）的方法和机器，该研磨工具具有至少一个具有第一侧面（3）和相对的第二侧面（4）的齿形轮廓（2）。用于磨削工具（2）的盘形修整工具（5）具有第一研磨区域（6）和第二磨料区域（7）。为了允许磨削工具更快且因此更经济地修整，第一研磨区域（6）接触第一侧面（3）并且第二磨料区域（7）同时接触第二侧面（4），并且盘形修整工具（5）和/或磨削工具（1）相对于另一个围绕垂直于研磨工具（1）的旋转轴线（C）布置的轴线（A）枢转，使得两侧面，4）同时穿着。

9. 发明申请

US20050236086A1 Extended mobility tire with variable rigidity sidewalls 失效
标题翻译：具有可变刚度侧壁的延伸移动轮胎
公开(公告)号：US20050236086A1
公开(公告)日：2005-10-27
申请号：US11165351
申请日：2005-06-24
申请人： Jose Lopez
发明人： Jose Lopez
IPC分类号： B60C9/02 , B60C9/09 , B60C13/00 , B60C17/00 , B60C3/00 , B60C15/00
CPC分类号： B60C13/00 , B60C9/02 , B60C9/09 , Y10T152/10819 , Y10T152/10864
摘要： A tire comprising at least one sidewall support means exhibiting a substantially progressive increase in rigidity, disposed in the substantially median portion of said sidewalls: according to a first embodiment, said means comprises a circumferential cord of resilient type; in a second example, said means comprises a circumferential cord disposed in undulating manner in the sidewalls. At rated pressure, the structural rigidity of the sidewalls is that of a standard tire, while at reduced pressure the sidewalls rigidify in such a way as to be able to bear the load.
摘要翻译：一种包括至少一个侧壁支撑装置的轮胎，其布置在所述侧壁的基本中间部分中，呈现出基本上逐渐增加的刚性;根据第一实施例，所述装置包括弹性类型的圆周帘线; 在第二示例中，所述装置包括以波浪方式设置在侧壁中的周向绳索。在额定压力下，侧壁的结构刚度是标准轮胎的刚度，而在减压下，侧壁以能够承受负载的方式固化。

10. 发明申请

US20050081972A1 Wear-adaptable running tread 有权
标题翻译：磨损适应性跑步
公开(公告)号：US20050081972A1
公开(公告)日：2005-04-21
申请号：US10984850
申请日：2004-11-10
申请人： Jose Lopez
发明人： Jose Lopez
IPC分类号： B29D30/06 , B60C11/00 , B60C11/03 , B60C11/04 , B60C11/12 , B60C11/13 , B60C11/117 , B60C19/00
CPC分类号： B60C11/13 , B29D30/0606 , B29D2030/061 , B60C11/00 , B60C11/03 , B60C11/032 , B60C11/0323 , B60C11/12 , Y10S152/03
摘要： A tread of a total thickness E for tires, comprising, when new: a running surface intended to be in contact with the roadway during travel; a plurality of first cutouts of a depth of less than the thickness of the tread and defining tread pattern elements of a height less than the total thickness of the tread; a plurality of cavities subjacent the running surface when new and extending over an average length L, each of these cavities being intended to form at least one new groove or incision after partial wear of the tread; each cavity delimited by the rubber of the tread having an upper generatrix beneath the running surface when new; this tread being characterized in that, for each cavity, the upper generatrix follows an undulating profile having a series of recesses and elevations, the amplitude of these recesses and elevations being at least 10% of the depth of the new grooves or incisions created.
摘要翻译：轮胎总厚度E的胎面，当新的时候，包括在行驶期间旨在与道路接触的行驶表面; 多个第一切口，其深度小于胎面的厚度，并限定高度小于胎面总厚度的胎面花纹元件; 当新的并且延伸超过平均长度L时，位于运行表面下面的多个空腔，这些空腔中的每一个都旨在在胎面部分磨损之后形成至少一个新的凹槽或切口; 当新的时候，由跑道表面下方具有上母线的胎面橡胶界定的每个腔室; 该胎面的特征在于，对于每个空腔，上母线遵循具有一系列凹陷和高度的波状轮廓，这些凹陷和高度的幅度为创建的新凹槽或切口的深度的至少10％。

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