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1. 发明申请

US20120059165A1 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：用于合成药物代理的中间体化合物及其生产方法
公开(公告)号：US20120059165A1
公开(公告)日：2012-03-08
申请号：US13255748
申请日：2010-03-09
申请人： Rikizou Furuya , Hiroki Ozawa , Eiji Toyofuku , Shinichi Kusaka , Hiroshi Iwamura , Daiki Sakai , Kazuki Nakayama , Kazutoshi Watanabe
发明人： Rikizou Furuya , Hiroki Ozawa , Eiji Toyofuku , Shinichi Kusaka , Hiroshi Iwamura , Daiki Sakai , Kazuki Nakayama , Kazutoshi Watanabe
IPC分类号： C07D413/10 , C07D413/14
CPC分类号： C07D413/10 , C07D413/14
摘要： A production method of an optically active 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine which is useful as an intermediate for synthesizing a pharmaceutical agent is provided and the method comprises the following steps 1) to 4): 1) reacting a bromophenylmorpholine with a hexacyanoferrate(II) or a hydrate thereof at a temperature of from 110° C. to 140° C. in a reaction mixture comprising a Na2CO3, an organophosphorus compound, and a palladium catalyst in a polar aprotic solvent alone or combination of a polar aprotic solvent and other polar aprotic solvent or hydrocarbon solvent to give a cyanophenylmorpholine; 2) reacting the cyanophenylmorpholine with hydroxylamine or hydroxylamine hydrochloride at a temperature of from 10° C. to 40° C. in an aprotic polar solvent to give a hydroxylamine derivative; 3) reacting the hydroxylamine derivative with an acylation reagent selected from the group consisting of aliphatic acyl halides, aromatic acyl halides, aliphatic acyl anhydrides and aromatic anhydrides; and 4) keeping the mixture obtained after step 3) at a temperature of from 60° C. to 140° C. to give a 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine.
摘要翻译：提供了可用作合成药剂的中间体的光学活性2- {4-（5-取代 - 恶二唑基）苯基}吗啉的制备方法，该方法包括以下步骤1）至4）：1）在包含Na 2 CO 3，有机磷化合物和钯催化剂的反应混合物中，在单极极性非质子溶剂中使溴苯基吗啉与六氰基铁酸盐（II）或其水合物在110℃至140℃的温度下反应，或极性非质子溶剂和其他极性非质子溶剂或烃溶剂的组合，得到氰基苯基吗啉; 2）使氰基苯基吗啉与羟胺或羟胺盐酸盐在非质子极性溶剂中在10℃至40℃的温度下反应，得到羟胺衍生物; 3）使羟胺衍生物与选自脂族酰基卤，芳族酰基卤，脂族酰基酸酐和芳族酸酐的酰化试剂反应; 和4）将步骤3）后获得的混合物保持在60℃至140℃的温度下，得到2- {4-（5-取代 - 恶二唑基）苯基}吗啉。

2. 发明授权

US07994315B2 Intermediate compound for synthesizing pharmaceutical agent and production method thereof 失效
标题翻译：用于合成药剂的中间体化合物及其制备方法
公开(公告)号：US07994315B2
公开(公告)日：2011-08-09
申请号：US11996205
申请日：2006-07-21
申请人： Masahiro Okuyama , Fumiaki Uehara , Hiroshi Iwamura , Kazutoshi Watanabe
发明人： Masahiro Okuyama , Fumiaki Uehara , Hiroshi Iwamura , Kazutoshi Watanabe
IPC分类号： C07D265/30
CPC分类号： C07D265/30 , C07D265/32
摘要： Production method of an optically active morpholine compound represented by the formula 10, or a compound represented by the formula 55, which includes the following steps: or wherein each symbol is as defined in the specification. An optically active 2-aryl-substituted morpholine compound and 3-oxo-3-(pyrimidin-4-yl)propionate, which are important as starting materials for synthesizing 2-(2-arylmorpholin-4-yl)-1-methyl-1H-[4,4′]bipyrimidinyl-6-one having a tau protein kinase 1 inhibitory activity and useful as a therapeutic drug for Alzheimer's disease and the like, can be produced in a high yield by an industrially advantageous method.
摘要翻译：由式10表示的光学活性吗啉化合物的制备方法或由式55表示的化合物，其包括以下步骤：或其中每个符号如说明书中所定义。光学活性的2-芳基取代的吗啉化合物和3-氧代-3-（嘧啶-4-基）丙酸酯，其作为合成2-（2-芳基吗啉-4-基）-1-甲基 - 可以通过工业上有利的方法以高产率制备具有tau蛋白激酶1抑制活性并且可用作阿尔茨海默氏病等的治疗药物的1H- [4,4']联嘧啶基-6-酮。

3. 发明申请

US20090156804A1 INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF 失效
标题翻译：用于合成药物代理的中间体化合物及其生产方法
公开(公告)号：US20090156804A1
公开(公告)日：2009-06-18
申请号：US11996205
申请日：2006-07-21
申请人： Masahiro Okuyama , Fumiaki Uehara , Hiroshi Iwamura , Kazutoshi Watanabe
发明人： Masahiro Okuyama , Fumiaki Uehara , Hiroshi Iwamura , Kazutoshi Watanabe
IPC分类号： C07D413/14 , C07C211/43 , C07D265/30 , C07D265/32 , C07D239/24
CPC分类号： C07D265/30 , C07D265/32
摘要： The present invention relates to a production method of an optically active morpholine compound represented by the formula 10, which includes the following steps: wherein each symbol is as defined in the specification.The present invention also relates to a production method of an compound represented by the formula 55, which includes the following steps: wherein each symbol is as defined in the specification.According to the production method of the present invention, an optically active 2-aryl-substituted morpholine compound and 3-oxo-3-(pyrimidin-4-yl)propionate, which are important as starting materials for synthesizing 2-(2-arylmorpholin-4-yl)-1-methyl-1H-[4,4′]bipyrimidinyl-6-one having a tau protein kinase 1 inhibitory activity and useful as a therapeutic drug for Alzheimer's disease and the like, can be produced in a high yield by an industrially advantageous method.
摘要翻译：本发明涉及由式10表示的光学活性吗啉化合物的制备方法，其包括以下步骤：其中每个符号如说明书中所定义。本发明还涉及由式55表示的化合物的制备方法，其包括以下步骤：其中每个符号如说明书中所定义。根据本发明的制备方法，光学活性2-芳基取代的吗啉化合物和3-氧代-3-（嘧啶-4-基）丙酸酯作为合成2-（2-芳基吗啉） -4-基）-1-甲基-1H- [4,4']二嘧啶基-6-酮，其具有tau蛋白激酶1抑制活性，可用作阿尔茨海默氏病等的治疗药物，可以以高通过工业上有利的方法得到。

4. 发明授权

US07187844B1 Information recording apparatus 失效
标题翻译：信息记录装置
公开(公告)号：US07187844B1
公开(公告)日：2007-03-06
申请号：US09627304
申请日：2000-07-27
申请人： Kyoichi Terao , Hiroshi Iwamura , Shigeru Adachi
发明人： Kyoichi Terao , Hiroshi Iwamura , Shigeru Adachi
IPC分类号： H04N5/93
CPC分类号： G11B27/038 , G11B20/10527 , G11B27/034 , H04N5/85 , H04N9/8042 , H04N9/8063
摘要： An information recording apparatus include: a processing unit for processing recording information to be recorded and for generating processed information; a storage unit for temporarily storing the processed information; a recording unit for recording the processed information onto an information storage medium; a position storing unit for storing, at a time of interrupting recording of the processed information, an interruption storage position which is a storage position in the storage unit of the processed information corresponding to a timing at which interruption is instructed; an interrupting unit for interrupting recording of the processed information after storing the interruption storing position; and a restart unit for restarting the recording of the processed information based on the stored interruption storage position.
摘要翻译：一种信息记录装置，包括：处理单元，用于处理要记录的记录信息并产生处理信息; 用于临时存储处理的信息的存储单元; 记录单元，用于将处理的信息记录到信息存储介质上; 位置存储单元，用于在中断所处理的信息的记录时存储作为指示了中断的定时的处理信息的存储单元中的存储位置的中断存储位置; 中断单元，用于在存储所述中断存储位置之后中断所述处理信息的记录; 以及重新启动单元，用于基于存储的中断存储位置重新开始记录处理的信息。

5. 发明授权

US5303060A Apparatus for recording and/or reproducing HDTV signals 失效
标题翻译：用于记录和/或再现HDTV信号的装置
公开(公告)号：US5303060A
公开(公告)日：1994-04-12
申请号：US25345
申请日：1993-03-03
申请人： Hiroshi Iwamura , Takehiko Shioda
发明人： Hiroshi Iwamura , Takehiko Shioda
IPC分类号： H04N5/92 , H04N9/797 , H04N9/80 , H04N9/81 , H04N9/79
CPC分类号： H04N9/797 , H04N9/81
摘要： An HDTV signal (dot density: 2N dots/line) is converted into a luminance signal and a line sequential color signal, and the resulting signals are both subjected to vertical interpolation and vertical filtering to derive a sequential scanning luminance signal and a sequential scanning color signal. The resulting sequential scanning luminance signal and sequential scanning color signal are subjected to frame thinning to reduce the frequency thereof to a half. Then, subsampling is performed to reduce the dot density to N dots/line. Next, dot rearranging for distributing adjacent dots to adjacent lines is performed to double the number of frames, whereby the dot density of each frame is reduced to N/2 dots/line. These consequently derived frames are encoded for recording. In this manner, the frequency bandwidth required to a recording medium for recording HDTV signals can be reduced.
摘要翻译：将HDTV信号（点密度：2N点/线）转换为亮度信号和行顺序彩色信号，并且对所得到的信号进行垂直内插和垂直滤波以得到顺序扫描亮度信号和顺序扫描颜色信号。所得到的顺序扫描亮度信号和顺序扫描彩色信号经历帧间间隔以将其频率降低到一半。然后，进行子采样以将点密度降低到N点/线。接下来，执行用于将相邻点分布到相邻行的点重新排列以使帧的数量加倍，由此将每帧的点密度减小到N / 2个点/行。这些因此导出的帧被编码用于记录。以这种方式，可以减少用于记录HDTV信号的记录介质所需的频率带宽。

6. 发明授权

US07424128B2 Electronic watermark embedding apparatus, electronic watermark embedding method, record medium having electronic watermark and manufacturing method of record medium 失效
标题翻译：电子水印嵌入装置，电子水印嵌入方法，具有电子水印的记录介质和记录介质的制造方法
公开(公告)号：US07424128B2
公开(公告)日：2008-09-09
申请号：US10409685
申请日：2003-04-09
申请人： Hiroshi Iwamura , Yoshiaki Moriyama
发明人： Hiroshi Iwamura , Yoshiaki Moriyama
IPC分类号： H04K1/00
CPC分类号： G06T1/005 , G06T1/0028 , G06T2201/0064 , G06T2201/0065 , G06T2201/0202 , H04N1/32144 , H04N1/32208 , H04N1/32229 , H04N1/32245 , H04N1/32251 , H04N19/467 , H04N2201/3233 , H04N2201/327
摘要： An object of the present invention is to provide an electronic watermark embedding apparatus, an electronic watermark embedding method, a record medium having an electronic watermark capable of securely detecting the watermark in the case of performing the noise reduction process or data compression process to the information on the contents and a manufacturing method of record medium. The electronic watermark embedding apparatus is provided with an embedding device for embedding an electronic watermark comprised of a signal generated based on a predetermined rule into contents comprised of digital information; a variation device for varying intensity of the electronic watermark to be embedded into the contents; and a controlling device for controlling the variation device so as to change the intensity of the electronic watermark, and wherein the controlling device for controlling the variation means so as to increase the intensity of the electronic watermark at intervals are provided.
摘要翻译：本发明的目的是提供一种电子水印嵌入装置，电子水印嵌入方法，具有电子水印的记录介质，该电子水印能够在对该信息执行降噪处理或数据压缩处理的情况下可靠地检测水印关于记录介质的内容和制造方法。该电子水印嵌入装置具有嵌入装置，用于将由基于预定规则生成的信号组成的电子水印嵌入到由数字信息构成的内容中; 用于改变要嵌入到内容中的电子水印强度的变化装置; 以及用于控制变化装置以便改变电子水印的强度的控制装置，并且其中提供了用于控制变化装置以便间隔地增加电子水印的强度的控制装置。

7. 发明授权

US5914752A Band-division signal processing system 失效
标题翻译：频分信号处理系统
公开(公告)号：US5914752A
公开(公告)日：1999-06-22
申请号：US855211
申请日：1997-05-13
申请人： Hiroshi Iwamura , Kyoichi Terao , Hidehiro Ishii
发明人： Hiroshi Iwamura , Kyoichi Terao , Hidehiro Ishii
IPC分类号： H03M7/30 , H03M7/36 , H04N7/26
CPC分类号： H04N19/30
摘要： A band-division signal processing system includes a coding unit and a decoding unit. The coding unit includes: an extracting unit for extracting a part of an original signal to produce a partial band signal; a first quantizer for quantizing the partial band signal to produce a quantized partial band signal; a subtracter for subtracting the quantized partial band signal from the original signal to produce a differential signal; and a first output unit for outputting the partial band signal and the differential signal. The decoding unit includes: a second quantizer having an identical configuration to the first quantizer and for quantizing the partial band signal outputted from the first output unit to produce the quantized partial band signal; an adder for adding the quantized partial band signal produced by the second quantizer to the differential signal outputted from the first output unit to produce the original signal; and a second output unit for outputting the original signal produced by the adder.
摘要翻译：带分信号处理系统包括编码单元和解码单元。编码单元包括：提取单元，用于提取原始信号的一部分以产生部分频带信号; 用于量化所述部分频带信号以产生量化的部分频带信号的第一量化器; 用于从原始信号中减去量化的部分频带信号以产生差分信号的减法器; 以及用于输出部分频带信号和差分信号的第一输出单元。解码单元包括：第二量化器，具有与第一量化器相同的配置，并且用于量化从第一输出单元输出的部分频带信号以产生量化的部分频带信号; 加法器，用于将由第二量化器产生的量化部分频带信号与从第一输出单元输出的差分信号相加以产生原始信号; 以及第二输出单元，用于输出由加法器产生的原始信号。

8. 发明申请

US20090180670A1 BLOCKER IMAGE IDENTIFICATION APPARATUS AND METHOD 失效
标题翻译：拦截器图像识别装置和方法
公开(公告)号：US20090180670A1
公开(公告)日：2009-07-16
申请号：US12300070
申请日：2007-04-26
申请人： Hiroshi Iwamura
发明人： Hiroshi Iwamura
IPC分类号： G06K9/00 , G06K9/36 , H04N5/228
CPC分类号： G06T7/215
摘要： Frequency analysis is performed on an image signal on a pixel by pixel basis or on a block by block basis, each block including a plurality of pixels, for each frame of the image signal. Then, a motion level or blur level is calculated on a pixel by pixel basis or on a block by block basis in accordance with a result of the frequency analysis. After the calculated motion level or blur level is converted into a binary value, 2-dimensional continuous regions are detected and a large region is extracted from the detected regions. It is then determined whether the large region is a blocker part based on at least one of an area ratio, a shape, and a position of the large region.
摘要翻译：针对图像信号的每一帧，逐像素地逐帧地对图像信号进行频率分析，每个块包括多个像素。然后，根据频率分析的结果，逐像素地或逐块地计算运动水平或模糊水平。在计算的运动水平或模糊水平被转换为二进制值之后，检测二维连续区域，并从检测到的区域提取大区域。然后，基于大区域的面积比，形状和位置中的至少一个来确定大区域是否是阻挡部分。

9. 发明授权

US5903482A Sampling frequency converting system and a method thereof 失效
标题翻译：采样频率转换系统及其方法
公开(公告)号：US5903482A
公开(公告)日：1999-05-11
申请号：US963826
申请日：1997-11-04
申请人： Hiroshi Iwamura , Kyoichi Terao
发明人： Hiroshi Iwamura , Kyoichi Terao
IPC分类号： H03M1/66 , G06F17/17 , H03H17/00 , H03H17/02
CPC分类号： G06F17/17 , H03H17/0685
摘要： An over-sampling device is provided for double over-sampling the input signal and for outputting as a sampling signal. The sampling signal is filtered at one of conversion rates of 147/160, 160/147, and 1/1 by using a prototype filter, based on the first sampling frequency and the second sampling frequency, and a filtering signal is produced. The filtering signal is filtered by a low pass filter having a predetermined cutoff frequency band, and a low frequency signal is produced. A down-sampling device is provided for down-sampling the low frequency signal by one half.
摘要翻译：提供过采样装置用于对输入信号进行双重过采样并作为采样信号输出。基于第一采样频率和第二采样频率，通过使用原型滤波器以147/160,160 / 147和1/1的转换速率之一对采样信号进行滤波，并产生滤波信号。滤波信号由具有预定截止频带的低通滤波器滤波，产生低频信号。提供下采样装置用于将低频信号下采样一半。

10. 发明授权

US08311269B2 Blocker image identification apparatus and method 失效
标题翻译：阻塞图像识别装置及方法
公开(公告)号：US08311269B2
公开(公告)日：2012-11-13
申请号：US12300070
申请日：2007-04-26
申请人： Hiroshi Iwamura
发明人： Hiroshi Iwamura
IPC分类号： G06K9/00
CPC分类号： G06T7/215
摘要： Frequency analysis is performed on an image signal on a pixel by pixel basis or on a block by block basis, each block including a plurality of pixels, for each frame of the image signal. Then, a motion level or blur level is calculated on a pixel by pixel basis or on a block by block basis in accordance with a result of the frequency analysis. After the calculated motion level or blur level is converted into a binary value, 2-dimensional continuous regions are detected and a large region is extracted from the detected regions. It is then determined whether the large region is a blocker part based on at least one of an area ratio, a shape, and a position of the large region.
摘要翻译：针对图像信号的每一帧，逐像素地逐帧地对图像信号进行频率分析，每个块包括多个像素。然后，根据频率分析的结果，逐像素地或逐块地计算运动水平或模糊水平。在计算的运动水平或模糊水平被转换为二进制值之后，检测二维连续区域，并从检测到的区域提取大区域。然后，基于大区域的面积比，形状和位置中的至少一个来确定大区域是否是阻挡部分。

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