专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060105325A1 Adsorbent with enhanced protein binding capacity and selectivity 审中-公开
标题翻译：具有增强蛋白结合能力和选择性的吸附剂
公开(公告)号：US20060105325A1
公开(公告)日：2006-05-18
申请号：US11273562
申请日：2005-11-14
申请人： Richard Willson , Sindhu Balan , Ajish Potty
发明人： Richard Willson , Sindhu Balan , Ajish Potty
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： B01J20/286 , B01D15/1821 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/287 , B01J20/288 , B01J20/3244 , B01J20/3265 , B01J20/3272 , B01J20/3274 , B01J39/26 , B01J41/20 , B01J45/00 , B01J2220/54 , G01N33/54353
摘要： The invention discloses an adsorbent composition in which each ligand has a cluster of functional groups. This adsorbent composition is designed to enhace binding affinity and specificity for biomolecules. The invention also discloses a method for adsorbing a biomolecule onto the disclosed adsorbent composition. A biomolecule can be adsorbed to the disclosed composition either for qualitative analysis or purification of the biomolecule. The invention also discloses a kit for qualitative analysis or recovery of a biomolecule.
摘要翻译：本发明公开了一种吸附剂组合物，其中每个配体具有一组官能团。该吸附剂组合物被设计成对生物分子具有结合亲和性和特异性。本发明还公开了一种将生物分子吸附到所公开的吸附剂组合物上的方法。可以将生物分子吸附到所公开的组合物上以进行生物分子的定性分析或纯化。本发明还公开了用于定性分析或回收生物分子的试剂盒。

2. 发明授权

US11830517B2 Systems for and methods of intelligent acoustic monitoring 有权
公开(公告)号：US11830517B2
公开(公告)日：2023-11-28
申请号：US17216030
申请日：2021-03-29
申请人： Ioannis Kakadiaris , Richard Willson
发明人： Ioannis Kakadiaris , Richard Willson
IPC分类号： H03G3/20 , G10L25/51 , G06F3/16
CPC分类号： G10L25/51 , G06F3/165
摘要： A system for intelligent acoustic monitoring. The system includes a microphone to capture environmental acoustic data and a processor coupled to the microphone. The processor is configured to receive and perform acoustic analysis on the captured acoustic data to generate an acoustic signature, based on a result of the acoustic analysis, identify an event indicated by the acoustic signature, and perform a remedial action based on the identified event.

3. 发明申请

US20140228227A1 NANOMAGNETIC DETECTOR ARRAY FOR BIOMOLECULAR RECOGNITION 有权
标题翻译：用于生物分子识别的纳米检测器阵列
公开(公告)号：US20140228227A1
公开(公告)日：2014-08-14
申请号：US13762622
申请日：2013-02-08
申请人： Dmitri Litvinov , Richard Willson
发明人： Dmitri Litvinov , Richard Willson
IPC分类号： G01R33/00
CPC分类号： G01R33/00 , G01N2446/00 , G01R33/1269
摘要： A biomolecular sensor system includes an array of magnetoresistive nanosensors designed for sensing biomolecule-conjugated superparamagnetic nanoparticles. Materials and geometry of each sensor element are designed for optimized sensitivity. The system includes magnetic field generators to apply forces to superparamagnetic nanoparticles for 1) nanoparticle manipulation, 2) sensor magnetic biasing, 3) magnetic pull-off measurement for differentiation against non-specific association, and 4) removal of all particles from the sensor array surface.
摘要翻译：生物分子传感器系统包括设计用于感测生物分子结合的超顺磁性纳米粒子的磁阻纳米传感器阵列。每个传感器元件的材料和几何形状设计用于优化灵敏度。该系统包括磁场发生器，以对超顺磁纳米颗粒施加力量1）纳米颗粒操纵，2）传感器磁偏置，3）用于区分非特异性缔合的磁性拉脱测量，以及4）从传感器阵列中去除所有颗粒表面。

4. 发明申请

US20110184163A1 Enzymatic Nucleic Acid Synthesis: Compositions and Methods for Inhibiting Pyrophosphorolysis 审中-公开
标题翻译：酶核酸合成：抑制焦磷酸分解的组合物和方法
公开(公告)号：US20110184163A1
公开(公告)日：2011-07-28
申请号：US12985421
申请日：2011-01-06
申请人： Susan H. Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan H. Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C07H19/207
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译：在γ和/或bgr上含有分子和/或原子标签的核苷酸三磷酸探针; 公开了具有可检测性质的磷酸基和/或碱基部分，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。

5. 发明申请

US20090275036A1 SYSTEMS AND METHODS FOR REAL TIME SINGLE MOLECULE SEQUENCE DETERMINATION 审中-公开
标题翻译：用于实时单分子序列确定的系统和方法
公开(公告)号：US20090275036A1
公开(公告)日：2009-11-05
申请号：US12414417
申请日：2009-03-30
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译：公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。

6. 发明申请

US20070172861A1 Mutant polymerases 审中-公开
标题翻译：突变型聚合酶
公开(公告)号：US20070172861A1
公开(公告)日：2007-07-26
申请号：US11648115
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N1/21 , C12N9/22 , C12N15/74
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译：公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。

7. 发明申请

US20070172860A1 Enzymatic nucleic acid synthesis: compositions and methods 审中-公开
标题翻译：酶的核酸合成：组合物和方法
公开(公告)号：US20070172860A1
公开(公告)日：2007-07-26
申请号：US11648114
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C40B30/06 , C40B40/08 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译：公开了在γ和/或β磷酸基团和/或具有可检测性质的碱基部分上含有分子和/或原子标签的核苷酸三磷酸探针，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。

8. 发明申请

US20070172819A1 Enzymatic nucleic acid synthesis: compositions including pyrophosphorolysis inhibitors 审中-公开
标题翻译：酶促核酸合成：包含焦磷酸分解抑制剂的组合物
公开(公告)号：US20070172819A1
公开(公告)日：2007-07-26
申请号：US11648108
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C12Q1/70 , C12Q1/68 , C07F9/02
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译：公开了在γ和/或β磷酸基团和/或具有可检测性质的碱基部分上含有分子和/或原子标签的核苷酸三磷酸探针，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。

9. 发明授权

US07211414B2 Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity 失效
标题翻译：酶促核酸合成：用于改变单体结合保真度的组合物和方法
公开(公告)号：US07211414B2
公开(公告)日：2007-05-01
申请号：US10007621
申请日：2001-12-03
申请人： Susan H. Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan H. Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C12P19/34 , C12Q1/68 , A01N43/04 , C07H21/04
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译：公开了在γ和/或β磷酸基团和/或具有可检测性质的碱基部分上含有分子和/或原子标签的核苷酸三磷酸探针，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。

10. 发明申请

US20060160093A1 Introduction of structural affinity handles as a tool in selective nucleic acid separations 失效
标题翻译：引入结构亲和力手柄作为选择性核酸分离的工具
公开(公告)号：US20060160093A1
公开(公告)日：2006-07-20
申请号：US10737403
申请日：2003-12-16
申请人： Richard Willson , Luis Cano
发明人： Richard Willson , Luis Cano
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07H21/04 , C12N15/1003
摘要： The method is used for separating nucleic acids and other similar constructs. It involves selective introduction, enhancement, or stabilization of affinity handles such as single-strandedness in the undesired (or desired) nucleic acids as compared to the usual structure (e.g., double-strandedness) of the desired (or undesired) nucleic acids. The undesired (or desired) nucleic acids are separated from the desired (or undesired) nucleic acids due to capture by methods including but not limited to immobilized metal affinity chromatography, immobilized single-stranded DNA binding (SSB) protein, and immobilized oligonucleotides. The invention is useful to: remove contaminating genomic DNA from plasmid DNA; remove genomic DNA from plasmids, BACs, and similar constructs; selectively separate oligonucleotides and similar DNA fragments from their partner strands; purification of aptamers, (deoxy)-ribozymes and other highly structured nucleic acids; Separation of restriction fragments without using agarose gels; manufacture recombinant Taq polymerase or similar products that are sensitive to host genomic DNA contamination; and other applications
摘要翻译：该方法用于分离核酸和其他类似构建体。与所需（或不需要的）核酸的通常结构（例如双链）相比，它涉及亲和手段的选择性引入，增强或稳定，例如不需要的（或所需）核酸中的单链。由于通过包括但不限于固定的金属亲和层析，固定的单链DNA结合（SSB）蛋白和固定的寡核苷酸的方法捕获，将不想要的（或期望的）核酸与期望的（或不需要的）核酸分离。本发明可用于从质粒DNA中去除污染性基因组DNA; 从质粒，BAC和类似构建体中去除基因组DNA; 选择性地将寡核苷酸和类似的DNA片段与其配对链分离; 纯化适体，（脱氧） - 核酶和其他高度结构化的核酸; 不使用琼脂糖凝胶分离限制性片段; 制造对宿主基因组DNA污染敏感的重组Taq聚合酶或类似产品; 和其他应用程序

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式