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1. 发明授权

US08796275B2 Anti-malarial compounds 有权
标题翻译：抗疟药
公开(公告)号：US08796275B2
公开(公告)日：2014-08-05
申请号：US12510593
申请日：2009-07-28
申请人： Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
发明人： Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
IPC分类号： C07D241/04 , C07D209/58 , C07D307/91 , C07D333/76 , A61K31/381
CPC分类号： C07D239/28 , C07C217/90 , C07C317/22 , C07C323/42 , C07C323/44 , C07D207/12 , C07D295/096 , C07D295/135 , C07D333/76 , C07D335/12
摘要： The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
摘要翻译：本发明提供了三环化合物，芳酰胺化合物和其它化合物及其组合物，包含其的用于治疗疟疾的组合物，以及治疗疟疾的方法，包括向动物施用此类化合物。

2. 发明申请

US20100081665A1 Anti-Malarial Compounds 有权
标题翻译：抗疟药
公开(公告)号：US20100081665A1
公开(公告)日：2010-04-01
申请号：US12510593
申请日：2009-07-28
申请人： Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
发明人： Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
IPC分类号： A61K31/496 , C07C237/14 , A61K31/167 , C07D403/12 , A61K31/495 , C07D239/26 , A61P33/06
CPC分类号： C07D239/28 , C07C217/90 , C07C317/22 , C07C323/42 , C07C323/44 , C07D207/12 , C07D295/096 , C07D295/135 , C07D333/76 , C07D335/12
摘要： The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
摘要翻译：本发明提供了三环化合物，芳酰胺化合物和其它化合物及其组合物，包含其的用于治疗疟疾的组合物，以及治疗疟疾的方法，包括向动物施用此类化合物。

3. 发明申请

US20120115877A1 Facially Amphiphilic Compounds, Compositions, And Uses Thereof In Treating Cancer 审中-公开
标题翻译：表面两性化合物，组合物及其用途在治疗癌症
公开(公告)号：US20120115877A1
公开(公告)日：2012-05-10
申请号：US13214177
申请日：2011-08-20
申请人： Richard W. Scott , Dylan Clements , Yongjiang Xu , Haizhong Tang , Carol Mulrooney , Ehab Khalil , Damian Weaver , Xiaodong Fan
发明人： Richard W. Scott , Dylan Clements , Yongjiang Xu , Haizhong Tang , Carol Mulrooney , Ehab Khalil , Damian Weaver , Xiaodong Fan
IPC分类号： A61K31/496 , A61K31/4025 , A61P35/00 , A61K31/343 , A61P35/02 , A61K31/505 , A61K31/381
CPC分类号： A61K31/16 , A61K31/17 , A61K31/34 , A61K31/38
摘要： The present invention discloses compositions of facially amphiphilic compounds and their use in methods for treating or reducing cancers in animals, such as humans.
摘要翻译：本发明公开了表面两亲化合物的组合物及其用于治疗或减少动物如人类的癌症的方法。

4. 发明申请

US20140308317A1 Polymeric Compounds And Methods Of Making And Using The Same 审中-公开
标题翻译：聚合物及其制备及使用方法
公开(公告)号：US20140308317A1
公开(公告)日：2014-10-16
申请号：US14100785
申请日：2013-12-09
申请人： Xiaodong Fan , Yongjiang Xu , Dahui Liu , Michael J. Costanzo
发明人： Xiaodong Fan , Yongjiang Xu , Dahui Liu , Michael J. Costanzo
IPC分类号： C07D279/26 , C07D213/74 , C07D277/28 , C07D261/08 , C07D249/04 , C07D279/28 , C07D209/82 , C07C275/40 , C07C233/80 , C07C279/06 , C07C211/01 , C07C217/62 , C07D265/38 , C07D405/14
CPC分类号： C07D279/26 , C07C211/01 , C07C211/27 , C07C211/28 , C07C211/29 , C07C217/16 , C07C217/20 , C07C217/62 , C07C225/18 , C07C233/75 , C07C233/78 , C07C233/80 , C07C275/40 , C07C279/04 , C07C279/06 , C07C279/08 , C07C2603/18 , C07C2603/32 , C07D209/82 , C07D213/74 , C07D219/14 , C07D249/04 , C07D261/08 , C07D265/38 , C07D271/06 , C07D277/28 , C07D277/30 , C07D279/28 , C07D333/76 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/10 , C07D417/12 , C09B21/00 , C09B57/00
摘要： The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.
摘要翻译：本公开提供了用于抑制微生物生长的化合物或其药学上可接受的盐; 治疗具有微生物感染，疟疾，粘膜炎，眼科感染，耳感染，癌症或分枝杆菌感染的哺乳动物; 杀死或抑制疟原虫种类的生长; 抑制分枝杆菌种的生长; 调节哺乳动物的免疫反应; 或拮抗未分级肝素，低分子量肝素或肝素/低分子量肝素衍生物。

5. 发明申请

US20130218866A1 MULTIMODAL GRAPH MODELING AND COMPUTATION FOR SEARCH PROCESSES 审中-公开
标题翻译：多模式图形建模与搜索过程的计算
公开(公告)号：US20130218866A1
公开(公告)日：2013-08-22
申请号：US13400130
申请日：2012-02-20
申请人： Richard J. Qian , Xiaodong Fan
发明人： Richard J. Qian , Xiaodong Fan
IPC分类号： G06F17/30
CPC分类号： G06F16/338
摘要： Architecture that includes a multimodal graph modeling and computation system employed in a search framework. The framework utilizes entities to diversify and explore the results page. The multimodal graph modeling paradigm can include web modeling by way of a click graph, a web graph, a social graph, a geospatial graph, and an entity graph, for example. These graphs are then joined based on common properties such as links, clicks, and document entities. Computation can then be performed over the joined graphs to generate a related entity list and a related page list. These lists are then processed by a recommendation engine to provide recommendations to the user.
摘要翻译：包括在搜索框架中使用的多模态图建模和计算系统的架构。该框架利用实体多样化并探索结果页面。多模式图形建模范例可以包括例如通过点击图形，网络图，社交图，地理空间图和实体图的网络建模。然后，这些图形将基于常用属性（如链接，点击和文档实体）进行连接。然后可以通过连接图执行计算，以生成相关的实体列表和相关的页面列表。这些列表然后由推荐引擎处理，以向用户提供建议。

6. 发明授权

US08429110B2 Pattern tree-based rule learning 有权
标题翻译：基于树型的规则学习
公开(公告)号：US08429110B2
公开(公告)日：2013-04-23
申请号：US12813171
申请日：2010-06-10
申请人： Rui Cai , Lei Zhang , Jiang-Ming Yang , Yan Ke , Xiaodong Fan , Wei-Ying Ma
发明人： Rui Cai , Lei Zhang , Jiang-Ming Yang , Yan Ke , Xiaodong Fan , Wei-Ying Ma
IPC分类号： G06F17/00 , G06N5/00
CPC分类号： G06F17/30864 , G06F17/30625
摘要： A pattern tree is constructed based on a plurality of key-value pairs representing portions of a data set. In some implementations, the pattern tree may be used for learning one or more rules for interacting with a source of the data set.
摘要翻译：基于表示数据集的部分的多个键值对来构造模式树。在一些实现中，模式树可以用于学习用于与数据集的源交互的一个或多个规则。

7. 发明申请

US20080103129A1 HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS 失效
标题翻译：杂环衍生的金属蛋白酶抑制剂
公开(公告)号：US20080103129A1
公开(公告)日：2008-05-01
申请号：US11858972
申请日：2007-09-21
申请人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence Wilson , Prabha Karnachi
发明人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence Wilson , Prabha Karnachi
IPC分类号： A61K31/55 , A61P35/00 , A61P25/00 , C07D403/02 , C07D223/02
CPC分类号： C07D413/06 , C07D211/94 , C07D213/69 , C07D213/89 , C07D223/12 , C07D225/02 , C07D243/08 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要翻译：本发明提供下式的新型杂环衍生基质金属蛋白酶抑制剂：包含其的药物组合物，可用于治疗通过拮抗基质金属蛋白酶而改善的病症。本发明还提供了使用本发明的药物组合物的治疗和预防方法。

8. 发明授权

US08440720B2 Methods of use of antiviral compounds 失效
标题翻译：抗病毒化合物的使用方法
公开(公告)号：US08440720B2
公开(公告)日：2013-05-14
申请号：US12881038
申请日：2010-09-13
申请人： Jizhou Wang , Xiaodong Fan , Lidia Cristian
发明人： Jizhou Wang , Xiaodong Fan , Lidia Cristian
IPC分类号： A61K31/185 , A61K31/13 , A61K31/16 , A61K31/015
CPC分类号： A61K31/13 , A61K31/133 , A61K31/155 , A61K31/357 , A61K31/415 , A61K31/4164 , A61K31/4196 , C07C205/08 , C07C205/10 , C07C205/18 , C07C205/33 , C07C211/19 , C07C211/38 , C07C215/42 , C07C217/52 , C07C251/44 , C07C255/47 , C07C279/16 , C07C323/30 , C07C325/02 , C07C2603/74 , C07D233/06 , C07D233/64 , C07D249/08 , C07D249/14 , C07D317/72 , Y02A50/389
摘要： The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.
摘要翻译：本发明部分涉及治疗，预防和抑制病毒性疾病的方法。一方面，本发明涉及流感病毒（例如甲型流感病毒）和其它类似的维生素（例如，埃博拉病毒VP24和马尔堡病毒;以及Bluetongue的NS3蛋白质）的M2质子通道的抑制。本发明还特别涉及已显示具有抗病毒活性，特别是抑制流感病毒的M2质子通道的化合物。

9. 发明申请

US20120026756A1 CONTROL CIRCUIT, CONTROL METHOD, AND POWER SUPPLY DEVICE 有权
标题翻译：控制电路，控制方法和电源装置
公开(公告)号：US20120026756A1
公开(公告)日：2012-02-02
申请号：US13270045
申请日：2011-10-10
申请人： Xiaodong Fan , Lei Feng , Fugao Zhao , Zhihua Liu
发明人： Xiaodong Fan , Lei Feng , Fugao Zhao , Zhihua Liu
IPC分类号： H02M3/335
CPC分类号： H02M3/33592 , H02M1/32 , H02M3/33515 , Y02B70/1475
摘要： A control circuit, a control method, and a power supply device are provided. The control circuit includes an obtaining sub-circuit, adapted to obtain a voltage signal from a reverse surge current when the reverse surge current appears on a primary side of a switch power circuit of a synchronous rectification circuit; a maintaining sub-circuit, adapted to continuously output a first control signal in a preset first time period when the voltage signal is greater than a preset first voltage threshold; and a control sub-circuit, adapted to control and switch off switch tubes of the secondary side of the switch power circuit of the synchronous rectification circuit according to the first control signal. Thus, a reverse current surge of the switch power circuit of the synchronous rectification circuit can be effectively suppressed, and the safety of a switch power supply of the synchronous rectification circuit can be effectively protected.
摘要翻译：提供控制电路，控制方法和电源装置。所述控制电路包括获取子电路，用于当所述反向浪涌电流出现在同步整流电路的开关电源电路的初级侧时，从反向浪涌电流获得电压信号; 维持子电路，适于当所述电压信号大于预设的第一电压阈值时，在预设的第一时间段内连续地输出第一控制信号; 以及控制子电路，适于根据第一控制信号来控制和关断同步整流电路的开关电源电路的次级侧的开关管。因此，能够有效地抑制同步整流电路的开关电源电路的反向电流浪涌，能够有效地保护同步整流电路的开关电源的安全性。

10. 发明申请

US20100279986A1 HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：杂环衍生的金属蛋白酶抑制剂
公开(公告)号：US20100279986A1
公开(公告)日：2010-11-04
申请号：US12834283
申请日：2010-07-12
申请人： Yue-Mei ZHANG , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
发明人： Yue-Mei ZHANG , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
IPC分类号： A61K31/55 , A61K31/635 , A61K31/4412 , A61K31/5377 , A61K31/45 , A61K31/4436 , A61K31/551 , A61K31/541 , A61P9/00 , A61P9/14 , A61P35/00 , A61P29/00 , A61P25/00 , A61P25/28 , A61P25/14 , A61P19/02 , A61P1/04
CPC分类号： C07D413/06 , C07D211/94 , C07D213/69 , C07D213/89 , C07D223/12 , C07D225/02 , C07D243/08 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要翻译：本发明提供下式的新型杂环衍生基质金属蛋白酶抑制剂：包含其的药物组合物，可用于治疗通过拮抗基质金属蛋白酶而改善的病症。本发明还提供了使用本发明的药物组合物的治疗和预防方法。

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