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2. 发明授权

US5169773A Monoclonal antibodies to cyclosporins 失效
标题翻译：环孢菌素单克隆抗体
公开(公告)号：US5169773A
公开(公告)日：1992-12-08
申请号：US265374
申请日：1988-10-31
申请人： Joachim Rosenthaler , Roland Wenger , Philipp E. Ball , Max H. Schreier , Valerie Quesniaux
发明人： Joachim Rosenthaler , Roland Wenger , Philipp E. Ball , Max H. Schreier , Valerie Quesniaux
IPC分类号： C07K7/64 , C07K16/44 , C12N5/20
CPC分类号： C07K7/645 , C07K16/44
摘要： Novel monoclonal antibodies capable of distinguishing between cyclosporins, e.g. Cyclosporine, and metabolites, e.g. Cyclosporins 17 and 18, are produced, e.g. starting from novel cyclosporins having an activated coupling group, e.g. activated carboxy group, e.g. (i) [(O-succinimidooxysuccinyl)-Thr].sup.2 -Cyclosporine and (ii) [(N-.epsilon.-succinimidooxysuccinyl)-(D)Lys].sup.8 -Cyclosporine. Cyclosporin starting materials required for the production of cyclosporins of type (ii), e.g. [(D)Lys].sup.8 -Cyclosporine are also new and additionally have utility in the preparation of novel labelled cyclosporin derivatives, as well as antibodies and antisera generally. Also claimed are novel antigenic conjugates and hybridoma cell lines used in the production of antibodies and antisera as aforesaid as well as assay kits comprising novel antisera, antibodies and/or labelled cyclosporins as aforesaid.
摘要翻译：能区分环孢菌素的新型单克隆抗体，例如环孢霉素和代谢物，例如产生环孢菌素17和18，例如，从具有活化偶联基团的新型环孢菌素开始，例如，活化的羧基，例如（i）[（O-琥珀酰亚胺氧基琥珀酰基）-Thr] 2-环孢菌素和（ii）[（N-ε-琥珀酰亚氨基氧代琥珀酰基） - （D）Lys] 8-环孢霉素。用于生产（ii）型环孢菌素所需的环孢菌素起始物质，例如 [（D）Lys] 8-环孢菌素也是新的，并且另外可用于制备新型标记的环孢菌素衍生物，以及抗体和抗血清。还要求保护的是用于生产前述的抗体和抗血清的新型抗原偶联物和杂交瘤细胞系，以及包含如上所述的新型抗血清，抗体和/或标记的环孢菌素的测定试剂盒。

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