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1. 发明申请

US20120328514A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS 有权
标题翻译： N-烷氧基酰胺作为成像剂
公开(公告)号：US20120328514A1
公开(公告)日：2012-12-27
申请号：US13382689
申请日：2010-07-08
申请人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
发明人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
IPC分类号： A61K49/00 , A61K51/04 , C07D209/20 , C07D213/56 , C07C229/36 , C07D257/02
CPC分类号： A61K51/0497 , A61K49/085 , A61K49/10 , A61K51/0406 , C07C259/06 , C07C271/22 , C07D257/02
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
摘要翻译：本公开涉及化合物，诊断剂和相关方法。在某些情况下，提供了治疗患者的方法。更具体地，本公开提供了用于检测和/或成像和/或监测富含弹性蛋白的组织的化合物，诊断剂和试剂盒。此外，本公开提供了检测和/或成像和/或监测冠状动脉斑块，颈动脉斑块，髂骨/股骨斑块，主动脉斑块，肾动脉斑块，任何动脉血管的斑块，动脉瘤，血管炎，其他疾病的存在的方法的动脉壁，和/或韧带，子宫，肺或皮肤的损伤或结构变化，如总血管壁面积，内腔大小和外动脉周长的变化所示。

2. 发明申请

US20090252676A1 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS 有权
标题翻译： N-烷氧基酰胺作为成像剂
公开(公告)号：US20090252676A1
公开(公告)日：2009-10-08
申请号：US12350628
申请日：2009-01-08
申请人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
发明人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
IPC分类号： A61K49/00 , C07C229/36 , C07D257/02 , C07D213/56 , A61K51/04 , A61K49/04
CPC分类号： C07D257/02 , A61K49/103 , A61K49/106 , A61K51/04 , C07C53/18 , C07C259/06 , C07C259/14 , C07C271/22 , C07C2601/14 , C07D209/20 , C07D213/56 , C07D403/12
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
摘要翻译：本公开涉及化合物，诊断剂和相关方法。在某些情况下，提供了治疗患者的方法。更具体地，本公开提供了用于检测和/或成像和/或监测富含弹性蛋白的组织的化合物，诊断剂和试剂盒。此外，本公开提供了检测和/或成像和/或监测冠状动脉斑块，颈动脉斑块，髂骨/股骨斑块，主动脉斑块，肾动脉斑块，任何动脉血管的斑块，动脉瘤，血管炎，其他疾病的存在的方法的动脉壁，和/或韧带，子宫，肺或皮肤的损伤或结构变化，如总血管壁面积，内腔大小和外动脉周长的变化所示。

3. 发明授权

US08361438B2 N-alkoxyamide conjugates as imaging agents 有权
标题翻译： N-烷氧基酰胺缀合物作为显像剂
公开(公告)号：US08361438B2
公开(公告)日：2013-01-29
申请号：US12350628
申请日：2009-01-08
申请人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
发明人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
IPC分类号： A61K49/00 , A61K49/04
CPC分类号： C07D257/02 , A61K49/103 , A61K49/106 , A61K51/04 , C07C53/18 , C07C259/06 , C07C259/14 , C07C271/22 , C07C2601/14 , C07D209/20 , C07D213/56 , C07D403/12
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
摘要翻译：本公开涉及化合物，诊断剂和相关方法。在某些情况下，提供了治疗患者的方法。更具体地，本公开提供了用于检测和/或成像和/或监测富含弹性蛋白的组织的化合物，诊断剂和试剂盒。此外，本公开提供了检测和/或成像和/或监测冠状动脉斑块，颈动脉斑块，髂骨/股骨斑块，主动脉斑块，肾动脉斑块，任何动脉血管的斑块，动脉瘤，血管炎，其他疾病的存在的方法的动脉壁，和/或韧带，子宫，肺或皮肤的损伤或结构变化，如总血管壁面积，内腔大小和外动脉周长的变化所示。

4. 发明授权

US08877157B2 N-alkoxyamide conjugates as imaging agents 有权
公开(公告)号：US08877157B2
公开(公告)日：2014-11-04
申请号：US13382689
申请日：2010-07-08
申请人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
发明人： Richard R. Cesati , Thomas D. Harris , Simon P. Robinson , Richard J. Looby , Edward H. Cheesman , Padmaja Yalamanchili , David S. Casebier
IPC分类号： A61K49/04 , A61K51/04 , C07C271/22 , C07D257/02 , A61K49/08 , C07C259/06 , A61K49/10
CPC分类号： A61K51/0497 , A61K49/085 , A61K49/10 , A61K51/0406 , C07C259/06 , C07C271/22 , C07D257/02
摘要： The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

5. 发明授权

US09388125B2 Compositions, methods, and systems for the synthesis and use of imaging agents 有权
标题翻译：用于合成和使用成像剂的组合物，方法和系统
公开(公告)号：US09388125B2
公开(公告)日：2016-07-12
申请号：US13697287
申请日：2011-05-11
申请人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
发明人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
IPC分类号： A61K51/00 , A61M36/14 , C07C277/08 , A61K51/04 , C07B59/00 , C07C53/06 , C07C217/58 , C07C255/54 , C07C279/10 , C07C279/24 , C07C309/65 , C07C309/66 , C07C309/73 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C303/28 , C07C303/30 , C07C309/04 , C07C309/30 , C07C277/00
CPC分类号： C07C303/30 , A61K51/00 , A61K51/04 , A61K51/0406 , C07B59/001 , C07B2200/05 , C07C53/06 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C217/58 , C07C255/54 , C07C277/00 , C07C277/08 , C07C279/10 , C07C279/24 , C07C303/28 , C07C309/04 , C07C309/30 , C07C309/65 , C07C309/66 , C07C309/73 , C07C279/08
摘要： The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
摘要翻译：本发明一般涉及可用于医学成像的新型合成方法，系统，试剂盒，盐和前体。在一些实施方案中，本发明提供了包含可以使用本文所述的合成方法形成的成像剂前体的组合物。可以使用本文所述的方法将成像剂转化成成像剂。在某些情况下，成像剂富集于18F。在一些情况下，包括盐形式的成像剂（例如抗坏血酸盐）可用于对受试者感兴趣的区域进行成像，包括但不限于心脏，心血管系统，心脏血管，脑和其他器官。

6. 发明申请

US20130149244A1 COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS 有权
标题翻译：用于合成和成像剂使用的组合物，方法和系统
公开(公告)号：US20130149244A1
公开(公告)日：2013-06-13
申请号：US13697287
申请日：2011-05-11
申请人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
发明人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
IPC分类号： C07C277/08 , C07C213/02 , C07C309/73 , C07C309/66 , C07C53/18 , C07B59/00 , C07C53/10 , C07C63/08 , C07C309/04 , C07C303/30 , C07C303/28 , A61K51/04 , C07C309/30
CPC分类号： C07C303/30 , A61K51/00 , A61K51/04 , A61K51/0406 , C07B59/001 , C07B2200/05 , C07C53/06 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C217/58 , C07C255/54 , C07C277/00 , C07C277/08 , C07C279/10 , C07C279/24 , C07C303/28 , C07C309/04 , C07C309/30 , C07C309/65 , C07C309/66 , C07C309/73 , C07C279/08
摘要： The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
摘要翻译：本发明一般涉及可用于医学成像的新型合成方法，系统，试剂盒，盐和前体。在一些实施方案中，本发明提供了包含可以使用本文所述的合成方法形成的成像剂前体的组合物。可以使用本文所述的方法将成像剂转化成成像剂。在某些情况下，成像剂富集于18F。在一些情况下，包括盐形式的成像剂（例如抗坏血酸盐）可用于对受试者感兴趣的区域进行成像，包括但不限于心脏，心血管系统，心脏血管，脑和其他器官。

7. 发明授权

US5397902A Apparatus and method for the preparation of a radiopharmaceutical formulation 失效
标题翻译：用于制备放射性药物制剂的装置和方法
公开(公告)号：US5397902A
公开(公告)日：1995-03-14
申请号：US167685
申请日：1993-12-15
申请人： James F. Castner , Bobby E. Corry , Thomas D. Harris , Richard J. Looby
发明人： James F. Castner , Bobby E. Corry , Thomas D. Harris , Richard J. Looby
IPC分类号： G21G4/08 , A61K51/00 , G21F5/015 , G21K5/00 , G21F5/00
CPC分类号： G21F5/015
摘要： Apparatus and method for producing a radiopharmaceutical formulation utilize a radiation-shielding container for receiving a vial having the non-radioactive components necessary to form a radiopharmaceutical formulation therein. A mixture of such non-radioactive components and a radioactive liquid added thereto is both heated and cooled using a thermoelectric element. The container comprises a hollow outer shielding member formed from a radiation shielding material and a vial holder formed from a highly heat conductive material received therewithin. The vial holder includes a skirt portion that defines a socket. The socket is sized to receive in an intimate heat transmissive relationship a mounting projection that is itself connected in thermally conductive contact with the thermoelectric element. Using the thermoelectric heating and cooling element, heat is both applied to and removed from the radioactive liquid and the non-radioactive components within the vial while the vial is held within the vial holder within the radiation shielding container, thereby to produce a radiopharmaceutical formulation within the vial.
摘要翻译：用于制备放射性药物制剂的装置和方法利用辐射屏蔽容器来接收具有在其中形成放射性药物制剂所必需的非放射性成分的小瓶。使用热电元件将这种非放射性组分和加入其中的放射性液体的混合物加热和冷却。容器包括由辐射屏蔽材料形成的中空外屏蔽构件和由其中容纳的高导热材料形成的小瓶支架。瓶保持器包括限定插座的裙部。插座的尺寸被设计成以紧密的热传导关系接收安装突起，该安装突起本身与热电元件的导热接触连接。使用热电加热和冷却元件，当将小瓶保持在辐射屏蔽容器内的小瓶保持器内时，热量被施加到放射性液体和小瓶内的非放射性组分中并从其中移除，由此产生放射性药物制剂小瓶。

8. 发明授权

US09155795B2 CXCR4 receptor compounds 有权
标题翻译： CXCR4受体化合物
公开(公告)号：US09155795B2
公开(公告)日：2015-10-13
申请号：US13580775
申请日：2011-02-25
申请人： Richard J. Looby , Boris Tchernychev
发明人： Richard J. Looby , Boris Tchernychev
IPC分类号： C07K7/08 , C07K14/00 , A61K47/48 , C07K14/715 , A61K38/00
CPC分类号： A61K47/48046 , A61K38/00 , A61K47/543 , A61K47/554 , C07K14/7158
摘要： The invention relates generally to compounds which are allosteric modulators {e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease (e.g., cancer), auto-immune disease (e.g., rheumatoid arthritis), fibrosis disease (e.g., pulmonary), AIDS infection, cardiovascular disease, uveitis, inflammatory diseases, celiac disease HIV infection and stem cell-based regenerative medicine.
摘要翻译：本发明一般涉及用于间质衍生因子1（SDF-1）（也称为CXCR4受体）的G蛋白偶联受体的变构调节剂（例如，正和负变构调节剂和变构兴奋剂）的化合物。 CXCR4受体化合物衍生自CXCR4受体的细胞内环和结构域。本发明还涉及这些CXCR4受体化合物和包含CXCR4受体化合物的药物组合物在治疗与CXCR4调节相关的疾病和病症如骨髓移植，化学敏化，癌症，转移性疾病（例如癌症），自动化免疫性疾病（例如类风湿性关节炎），纤维化疾病（例如肺部），艾滋病感染，心血管疾病，葡萄膜炎，炎性疾病，腹腔疾病HIV感染和干细胞再生医学。

9. 发明申请

US20130005944A1 CXCR4 Receptor Compounds 有权
标题翻译： CXCR4受体化合物
公开(公告)号：US20130005944A1
公开(公告)日：2013-01-03
申请号：US13580775
申请日：2011-02-25
申请人： Richard J. Looby , Boris Tchernychev
发明人： Richard J. Looby , Boris Tchernychev
IPC分类号： C07K7/08 , C07K14/00
CPC分类号： A61K47/48046 , A61K38/00 , A61K47/543 , A61K47/554 , C07K14/7158
摘要： The invention relates generally to compounds which are allosteric modulators {e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease (e.g., cancer), auto-immune disease (e.g., rheumatoid arthritis), fibrosis disease (e.g., pulmonary), AIDS infection, cardiovascular disease, uveitis, inflammatory diseases, celiac disease HIV infection and stem cell-based regenerative medicine.
摘要翻译：本发明一般涉及用于间质衍生因子1（SDF-1）（也称为CXCR4受体）的G蛋白偶联受体的变构调节剂（例如，正和负变构调节剂和变构兴奋剂）的化合物。 CXCR4受体化合物衍生自CXCR4受体的细胞内环和结构域。本发明还涉及这些CXCR4受体化合物和包含CXCR4受体化合物的药物组合物在治疗与CXCR4调节相关的疾病和病症如骨髓移植，化学敏化，癌症，转移性疾病（例如癌症），自动化免疫性疾病（例如类风湿性关节炎），纤维化疾病（例如肺部），艾滋病感染，心血管疾病，葡萄膜炎，炎性疾病，腹腔疾病HIV感染和干细胞再生医学。

10. 发明公开

US20240115744A1 FIBRIN-BINDING COMPOUNDS FOR IMAGING AND TREATMENT 审中-公开
公开(公告)号：US20240115744A1
公开(公告)日：2024-04-11
申请号：US17767956
申请日：2020-10-23
申请人： Peter CARAVAN , Thomas J. MCMURRY , Richard J. LOOBY , Collagen Medical, LLC
发明人： Peter Caravan , Thomas J. McMurry , Richard J. Looby
IPC分类号： A61K51/08 , A61K45/06 , A61K51/04
CPC分类号： A61K51/088 , A61K45/06 , A61K51/0482
摘要： This disclosure relates to compounds of Formula IV: for fibrin imaging, wherein the compounds comprise an imaging or therapeutic radioisotope.

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