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1. 发明申请

US20050215895A1 Devices and methods for obtaining three-dimensional images of an internal body site 审中-公开
标题翻译：用于获得内部身体部位的三维图像的装置和方法
公开(公告)号：US20050215895A1
公开(公告)日：2005-09-29
申请号：US10985656
申请日：2004-11-10
申请人： Richard Popp , Ali Hassan , Christian Eversull , Jeremy Johnson , Paul Yock
发明人： Richard Popp , Ali Hassan , Christian Eversull , Jeremy Johnson , Paul Yock
IPC分类号： A61B8/00 , A61B8/12 , A61B8/14 , B06B1/06
CPC分类号： A61B8/12 , A61B6/466 , A61B8/14 , A61B8/445 , A61B8/4494 , B06B1/0607
摘要： Devices and methods for obtaining a three-dimensional image of an internal body site are provided. The subject devices are elongated structures (e.g., catheters) having a plurality of ultrasonic transducers located at their distal end. The configuration of the plurality of ultrasonic transducers may be reversibly changed from a first to a second configuration, where the radial aperture of the plurality of ultrasonic transducers is greater in the second configuration than in the first configuration. A feature of certain embodiments of the subject invention is that the plurality of ultrasonic tranducers are configured in the second configuration as a substantially continuous set of transducers. In using the subject imaging devices, the distal end of the devices is positioned at the internal body site of interest while the plurality of ultrasonic transducers is in the first configuration. The configuration of the ultrasonic transducers in then changed to the second configuration for imaging the internal body site. The subject devices and methods for their use find application in imaging a variety of different internal body sites.
摘要翻译：提供了用于获得内部身体部位的三维图像的装置和方法。主体装置是具有位于其远端的多个超声波换能器的细长结构（例如导管）。多个超声波换能器的结构可以从第一配置可逆地改变，其中多个超声波换能器的径向孔径在第二配置中比在第一配置中更大。本发明的某些实施例的特征在于，多个超声波传感器被配置为第二配置，作为基本连续的换能器组。在使用被摄体成像装置时，在多个超声换能器处于第一构造的同时，装置的远端位于感兴趣的内部身体部位。然后将超声波换能器的结构改变为用于对内部身体部位成像的第二配置。其使用的主题装置和方法可用于对各种不同的内部身体部位进行成像。

2. 发明授权

US09463313B2 Sensor-assisted catheter-based procedures 有权
标题翻译：传感器辅助导管手术
公开(公告)号：US09463313B2
公开(公告)日：2016-10-11
申请号：US11720012
申请日：2005-11-22
申请人： Peter J. Fitzgerald , Ali Hassan , Brian K. Courtney
发明人： Peter J. Fitzgerald , Ali Hassan , Brian K. Courtney
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61N1/056
摘要： Methods, systems and devices for effectively and safely accessing and verifying a target site within a vessel or body cavity undergoing a catheter-based procedure or treatment. The present invention further includes the accurate delivery an instrument, an implantable device and/or materials to the target site. The present invention is particularly useful for transvenously assessing the suitability of a target site within the coronary vasculature for placement of a pacing electrode and transvenously placing the pacing electrode at the target site.
摘要翻译：用于有效和安全地进入和验证经历基于导管的程序或治疗的血管或体腔内的靶位点的方法，系统和装置。本发明还包括将仪器，可植入装置和/或材料准确地输送到目标部位。本发明特别适用于经静脉评估冠状动脉血管内的靶位置适用于放置起搏电极并将起搏电极经常放置在靶位点。

3. 发明申请

US20130072949A1 SUTURE LOCKING DEVICE AND METHODS 有权
标题翻译：闭锁装置和方法
公开(公告)号：US20130072949A1
公开(公告)日：2013-03-21
申请号：US13442517
申请日：2012-04-09
申请人： Jason M. Halac , James A. McCrea , Troy T. White , Bernhard Kaeferlein , Ali Hassan , Zihan Lin
发明人： Jason M. Halac , James A. McCrea , Troy T. White , Bernhard Kaeferlein , Ali Hassan , Zihan Lin
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B2017/0488
摘要： A suture locking device includes a suture locking assembly, a suture cutting member, and an actuator assembly. The actuator assembly includes a first actuator operable longitudinally to lock the suture with the suture locking assembly, and a second actuator operable laterally to concurrently cut the suture with the suture cutting member and disconnect the suture locking assembly from the suture locking device.
摘要翻译：缝合线锁定装置包括缝合线锁定组件，缝线切割构件和致动器组件。致动器组件包括可纵向操作的第一致动器，用缝合线锁定组件锁定缝合线，以及可侧向操作的第二致动器，用缝合线切割构件同时切割缝线，并将缝合线锁定组件从缝合线锁定装置断开。

4. 发明申请

US20130046376A1 METHOD AND DEVICES FOR FLOW OCCLUSION DURING DEVICE EXCHANGES 审中-公开
标题翻译：在设备交换期间流量消耗的方法和装置
公开(公告)号：US20130046376A1
公开(公告)日：2013-02-21
申请号：US13531227
申请日：2012-06-22
申请人： Ali Hassan , Kevin To , Andy Uchida , Jose Garcia , Yi Yang
发明人： Ali Hassan , Kevin To , Andy Uchida , Jose Garcia , Yi Yang
IPC分类号： A61M25/09 , A61M25/098 , A61F2/24 , A61M25/10
CPC分类号： A61M25/09 , A61M25/002 , A61M25/10185 , A61M2025/09008 , A61M2025/09083 , A61M2025/09125 , A61M2025/09175
摘要： A method of reducing the risk of clinical sequelae to catheter induced vascular injuries may include introducing a guide wire into a vascular sheath residing in a blood vessel, proximally retracting the vascular sheath while leaving the wire in place, and observing indicia of the presence or absence of a vascular injury caused to the blood vessel by the vascular sheath or a procedural catheter previously advanced through the vascular sheath. If indicia of a vascular injury are observed, the method may further involve proximally retracting the guide wire to position the inflatable balloon adjacent the injury and inflating the balloon to reduce blood flow past the injury, while leaving the guide wire in place to provide subsequent access to the injury.
摘要翻译：减少导管引起的血管损伤的临床后遗症的风险的方法可包括将引导线引入位于血管中的血管鞘中，使血管鞘向近端缩回，同时留下线的存在或不存在通过血管鞘引起血管的血管损伤或先前通过血管鞘的手术导管。如果观察到血管损伤的标记，则该方法可进一步包括向近端缩回导丝以将可膨胀气囊定位在伤害附近并使气囊膨胀以减少血液流过损伤，同时将引导线放置在适当位置以提供随后的进入受伤。

5. 发明申请

US20090299445A1 SENSOR-ASSISTED CATHETER-BASED PROCEDURES 有权
标题翻译：传感器辅助导管器程序
公开(公告)号：US20090299445A1
公开(公告)日：2009-12-03
申请号：US11720012
申请日：2005-11-22
申请人： Peter J. Fitzgerald , Ali Hassan , Brian K. Courtney
发明人： Peter J. Fitzgerald , Ali Hassan , Brian K. Courtney
IPC分类号： A61N1/05 , A61B5/02
CPC分类号： A61N1/056
摘要： Methods, systems and devices for effectively and safely accessing and verifying a target site within a vessel or body cavity undergoing a catheter-based procedure or treatment. The present invention further includes the accurate delivery an instrument, an implantable device and/or materials to the target site. The present invention is particularly useful for transvenously assessing the suitability of a target site within the coronary vasculature for placement of a pacing electrode and transvenously placing the pacing electrode at the target site.
摘要翻译：用于有效和安全地进入和验证经历基于导管的程序或治疗的血管或体腔内的靶位点的方法，系统和装置。本发明还包括将仪器，可植入装置和/或材料准确地输送到目标部位。本发明特别适用于经静脉评估冠状动脉血管内的靶位置适用于放置起搏电极并将起搏电极经常放置在靶位点。

6. 发明授权

US07300429B2 Methods and devices for retrieval of a medical agent from a physiological efferent fluid collection site 失效
公开(公告)号：US07300429B2
公开(公告)日：2007-11-27
申请号：US10962205
申请日：2004-10-07
申请人： Peter J. Fitzgerald , Ali Hassan , Brian K. Courtney
发明人： Peter J. Fitzgerald , Ali Hassan , Brian K. Courtney
IPC分类号： A61M31/00
CPC分类号： A61B5/415 , A61B5/0084 , A61B5/0086 , A61B5/01 , A61B5/0261 , A61B5/418 , A61B5/6853 , A61B8/12 , A61B17/22 , A61B2017/22082 , A61M1/008 , A61M25/0068 , A61M25/007 , A61M25/0074 , A61M25/0082 , A61M25/1002 , A61M2025/0073 , A61M2025/0076
摘要： Methods and devices for selectively removing an agent from a physiological efferent fluid collection site are provided. A feature of the invention is that a non-occlusive aspiration device is employed to selectively remove the target agent from the site only when the target agent is present in the site. Also provided are systems and kits for performing the subject methods. The subject invention finds use in a variety of different applications, including the selective removal of both therapeutic and diagnostic agents from a variety of different physiological sites.

7. 发明授权

US07211073B2 Methods and devices for retrieval of a medical agent from a physiological efferent fluid collection site 失效
标题翻译：用于从生理传出液收集部位检索药剂的方法和装置
公开(公告)号：US07211073B2
公开(公告)日：2007-05-01
申请号：US10803468
申请日：2004-03-17
申请人： Peter J. Fitzgerald , Brian K. Courtney , Ali Hassan
发明人： Peter J. Fitzgerald , Brian K. Courtney , Ali Hassan
IPC分类号： A61M31/00
CPC分类号： A61B5/415 , A61B5/0086 , A61B5/4052 , A61B5/418 , A61B17/22 , A61B2017/22082 , A61F2/013 , A61M1/0031 , A61M1/008 , A61M1/36 , A61M1/3609 , A61M25/007 , A61M2025/1077
摘要： Methods and devices for selectively removing an agent from a physiological efferent fluid collection site are provided. A feature of the invention is that a non-occlusive aspiration device is employed to selectively remove the target agent from the site only when the target agent is present in the site. Also provided are systems and kits for performing the subject methods. The subject invention finds use in a variety of different applications, including the selective removal of both therapeutic and diagnostic agents from a variety of different physiological sites.
摘要翻译：提供了用于从生理传播液收集部位选择性地除去药剂的方法和装置。本发明的一个特征是使用非闭塞抽吸装置，只有当靶剂存在于该部位时，才能从该部位选择性地除去目标试剂。还提供了用于执行主题方法的系统和套件。本发明可用于各种不同的应用，包括从各种不同的生理部位选择性地除去治疗剂和诊断剂。

8. 发明申请

US20130144316A1 LARGE BORE CLOSURE DEVICE AND METHODS 有权
标题翻译：大型封闭装置及方法
公开(公告)号：US20130144316A1
公开(公告)日：2013-06-06
申请号：US13490816
申请日：2012-06-07
申请人： James A. McCrea , Troy T. White , Bernhard Kaeferlein , Ali Hassan , Jason M. Halac , Zihan Lin , Zachary J. Tegels , Martha Escobar , Catherine A. Pipenhagen
发明人： James A. McCrea , Troy T. White , Bernhard Kaeferlein , Ali Hassan , Jason M. Halac , Zihan Lin , Zachary J. Tegels , Martha Escobar , Catherine A. Pipenhagen
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0057 , A61B17/0482 , A61B2017/00663 , A61B2017/0472 , A61B2017/0496 , A61B2017/06042
摘要： A vascular closure system includes a body portion, an anchor, a suture carrying portion, and a plurality of needles. The body portion has a distal end surface. The anchor is positionable through a vessel puncture in a vessel wall of a vessel. The anchor defines a vessel contact surface, wherein withdrawal of the anchor captures a portion of the vessel wall between the vessel contact surface and the distal end surface. The suture carrying portion is positionable through the vessel puncture and carries at least one suture member. The plurality of needles extend through the portion of the vessel wall adjacent to the vessel puncture and are configured to connect to the at least one suture member. Withdrawal of the plurality of needles through the portion of the vessel wall positions the at least one suture member through the portion of the vessel wall.
摘要翻译：血管闭合系统包括主体部分，锚固件，缝合线承载部分和多个针。主体部分具有远端表面。锚固体可通过血管穿刺在血管壁的血管壁中定位。锚固体限定了血管接触表面，其中锚固体的撤回捕获容器接触表面和远端表面之间的血管壁的一部分。缝合线承载部分可定位穿过血管穿刺并携带至少一个缝线构件。多个针延伸穿过与血管穿刺相邻的血管壁的部分，并且构造成连接到至少一个缝合构件。通过血管壁的部分抽出多个针将至少一个缝合构件定位通过血管壁的一部分。

9. 发明申请

US20050261713A1 Methods and devices for producing turbulence in vascular blood flow 审中-公开
标题翻译：用于产生血管血流紊流的方法和装置
公开(公告)号：US20050261713A1
公开(公告)日：2005-11-24
申请号：US11115969
申请日：2005-04-26
申请人： Ali Hassan , Brian Courtney , Peter Fitzgerald
发明人： Ali Hassan , Brian Courtney , Peter Fitzgerald
IPC分类号： A61B17/12 , A61F2/01 , A61F2/06 , A61M29/00
CPC分类号： A61B17/12 , A61F2/01 , A61F2002/068
摘要： Methods and devices for producing turbulence in vascular blood flow are provided. In practicing the subject methods, a blood flow modulator is positioned on an external site of a blood vessel at a location in relation to, e.g., at least proximal to a branched vascular site in a manner sufficient to produce turbulence in blood flow at a target site, e.g., at or immediately proximal to the branched vascular site. Representative blood flow modulation devices that find use in the subject methods are devices that can be positioned on an external site of a blood vessel to produce an annular structure around the blood vessel, where the annular structure includes an inner surface protuberance of sufficient dimensions to produce turbulence in the blood vessel. Also provided are kits and systems for practicing the subject methods. The subject methods and devices find use in a variety of applications, including applications to reduce the risk of emboli entering branch blood vessels from a main blood vessel.
摘要翻译：提供了用于产生血管血流紊流的方法和装置。在实施本发明的方法中，血流调节剂位于血管外部位置处，例如至少在支管血管部位附近，以足以产生目标血液流动紊乱的方式位点，例如，在支链血管部位处或直接近端。在本发明方法中使用的代表性的血液流动调节装置是可以位于血管的外部位置上以在血管周围产生环形结构的装置，其中环形结构包括具有足够尺寸的内表面突起以产生血管紊乱。还提供了用于实践主题方法的套件和系统。主题方法和装置可用于各种应用，包括降低栓塞从主血管进入分支血管的风险的应用。

10. 发明授权

US08545414B2 Methods and devices for modulation of heart valve function 有权
公开(公告)号：US08545414B2
公开(公告)日：2013-10-01
申请号：US11587765
申请日：2005-04-29
申请人： Peter J. Fitzgerald , Ali Hassan , Brian K. Courtney , Nicolas A. F. Chronos , Richard G. Cartledge , Leonard Y. Lee
发明人： Peter J. Fitzgerald , Ali Hassan , Brian K. Courtney , Nicolas A. F. Chronos , Richard G. Cartledge , Leonard Y. Lee
IPC分类号： A61B5/02
CPC分类号： A61F2/2442 , A61F2/2445 , A61N1/36514 , A61N1/36528 , A61N1/36571
摘要： Methods and devices for modulating heart valve function are provided. In the subject methods, a heart valve is first in structurally modified. Blood flow through the structurally modified heart valve is then monitored, and the heart is paced in response to the monitored blood flow. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods find use in a variety of applications.

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